Abstract: Oral and dental hygiene preparations containing quaternary ammonium compounds of the formula ##STR1## wherein R.sup.1 is an n-alkyl group, preferably containing from 8 to 12 carbon atoms, R.sup.2 is hydrogen, a CH.sub.3 -group or a CH.sub.2 OH-group and R.sup.3 is a CH.sub.3 -group or a group of the formula --CH.sub.2 --CH(OH)--R.sup.2, A is an inorganic or organic acid anion and n is the basicity of the anion. The quaternary ammonium compounds of formula I can have a plaque inhibiting effect and show only slight antimicrobial activity. R.sup.1 is preferably an n-decyl group, R.sup.2 is hydrogen and R.sup.3 is a CH.sub.3 -group or a 2-hydroxyethyl group. The oral and dent al hygiene preparations also preferably contain fluorides and/or organophosphonates as the anion A.

Abstract: This invention relates to pharmaceutical compositions comprising anaerobe-selective antibacterial agents which are substituted or unsubstituted 1,12-dodecanedioic peroxy acids, or their pharmaceutically-acceptable salts or esters. The pharmaceutical compositions of the present invention are especially suitable for oral administration in the form of mouth rinses and toothpastes. These anaerobe-selective antibacterial compositions are useful for treating or preventing anaerobic bacterial infections, especially diseases of the oral cavity, in humans or lower animals.The present invention further relates to a method for treating or preventing anaerobic bacterial infections such as acne, and especially diseases of the oral cavity such as gingivitis and periodontal disease, in humans or lower animals.

Abstract: Method of inhibiting bone resorption and collagenase release in mammalian periodontal subjects using a benzo-c-phenanthridine alkaloid compound.

Abstract: A method is disclosed for the prevention and treatment of periodontal disease and alveolar bone loss by administering an effective amount of tolrestat to a human subject.

Abstract: This invention relates to oral compositions comprising certain organic peroxy acid antigingivitis agents and a source of F.sup.- fluoride ions as an anticaries agent. Organic peroxy acid-based antigingivitis agents useful in the present invention include monoperphthalic acid and its derivatives, and 1,12-dodecanedioic peroxy acid and its derivatives. Sources of F.sup.- fluoride ions for use in the present invention include sodium fluoride, stannous fluoride, strontium fluoride, indium fluoride, and amine fluorides.The present invention further relates to methods for treating or preventing diseases of the oral cavity in humans or lower animals with reduced staining of the teeth or dentures. These methods comprise topically applying to the oral surfaces of the human or lower animal a safe and effective amount of a composition of the present invention.

Abstract: A pharmaceutical composition stably containing minocycline for treating periodontal diseases which comprises minocycline or a pharmaceutically acceptable salt thereof and a base composed of a polyhydric alcohol containing a magnesium compound. Optionally, the base can further contain a water soluble high molecular weight compound, ethyl methacrylate/chlrortrimethylammnoniumethyl methacrylate copolymer and its solubilizer. A method for treating periodontal diseases comprising topically applying the composition to the oral cavity is also disclosed.

Abstract: An oral composition which prevents periodontal disease such as gingivitis, periodontitis and alveolar pyorrhoea through the prevention of the colonization of Bacteroides gingivalis comprises an antibody obtained by immunizing a mammal with an antigen selected from Bacteroides gingivalis, its pilus and capsule fractions.

Abstract: A novel composition to counter by preventing and controlling breath odor containing as the essential agents, a salt which provides zinc ions, and an ionone ketone terpene derivative.

Abstract: Disclosed is a method for cleaning teeth including extruding a first semi-solid component including hydrogen peroxide as an active ingredient, and extruding a second semi-solid component comprising sodium bicarbonate as an active ingredient, the first and second components being suitable for oral use. The first component and the second component are placed in contact with each other on a toothbrush. The teeth are brushed using the first and second components concurrently as a cleaning medium.

Abstract: This invention relates to a method for treating or preventing anaerobe infections in humans and lower animals. This invention further relates to compositions and kits useful for treating or preventing anaerobe infections according to the method of the present invention.

Abstract: A method and composition for treatment of tissue degenerative inflammatory disease in animals and humans afflicted with such disease or disposed to development thereof is disclosed. The method comprises oral administration of ascorbic acid, a source of biologically available calcium, a precursor or stimulant of epinephrine or nor-epinephrine selected from tyrosine and phenylalanine, and an anti-inflammatory substance selected from anti-inflammatory sugars, amino sugars and biocompatible acid addition salts thereof, and anti-inflammatory amino acids. Treatment in accordance with the present method reduces or prevents tissue degenerative effects of the inflammatory disease and promotes connective tissue regrowth.

Abstract: A composition for preventing and treating periodontal disease, comprising bone meal, ascorbic acid, tyrosine, and either glucosamine or cysteine.

Abstract: A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical preparation comprising a water-soluble polymeric substance having a Young's modulus of 10 to 250 Kg/mm.sup.2 as determined at a temperature of 25.degree. C. and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20.degree. C. and a medicinal agent for remedy of periodontal diseases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic solvent by drying to obtain a pharmaceutical preparation in the form of a film or sheet.

Abstract: An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix comprises a mixture of calcium stearate, dextran and castor oil.

Abstract: A novel compound bis-(N,N-dimethyl-N-carbodecyloxymethyl-N-ethyleneammonium)-sulphide dichloride of the formula ##STR1## A method for preparing said novel compound comprising quaternization of bis-(.beta.-dimethylaminoethyl)-sulphide with monochloroacetic acid decyl ester, molar ratio of said reagents being not more than 1:2.A chemotherapeutic antimicrobial preparation comprising said novel compound as an active principle in combination with a pharmaceutical carrier.A plant growth regulator in the form of an aqueous solution of said novel compound in a concentration of from 0.0001 to 0.1 wt. %.