Abstract: The present invention is a cosmetic composition comprising, component (A) and component (B), wherein, (A) is carboxylic acid ester of inulin and/or hydrolyzed inulin whose degree of substitution by acyl group is larger than 1, and (B) is cyclic silicone oil, and the present invention is the oily cosmetic compound further containing oleophilic component. More over, the present invention is the W/O type emulsified cosmetic composition prepared by further adding aqueous component and an emulsifier to above mentioned cosmetic compound. In the present invention, acyl group composing component (A) is desirable to be an acyl group of carbon number 14 to 22. Further, a part or all of acyl group composing component (A) is desirable to be palmiroyl group and/or stearoyl group. Furthermore, the above mentioned cosmetic composition can contain dextrin carboxylic acid ester whose degree of substitution by acyl group is 1.6 to 2.5.

Abstract: The present invention relates to the discovery of a transdermal delivery system that can deliver high molecular weight pharmaceuticals and cosmetic agents to skin cells. A novel transdermal delivery system with therapeutic and cosmetic application and methods of use of the foregoing is disclosed.

Abstract: A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeating pyrrolidone/alkylene groups wherein the alkylene groups contain at least 10 carbon atoms, and a hydrophilic polymer composition including repeating carboxylic groups and/or repeating hydroxyl groups. A topical composition precursor and methods for manufacturing and using a topical composition are provided by the invention.

Abstract: Disclosed are compositions and methods for the facile perfusion of a tissue with active agents following direct intra-tissue injection. Targets may consist of cells, cellular components, and/or extracellular components. The high perfusion efficiency permits high concentrations of active agents to be delivered to tissue targets resulting in high degrees of efficacy and in some instances the production of novel pharmacological activities of an active agent previously unknown or previously unattainable in vivo.

Abstract: Structured antiperspirant emulsion formulations for topical application to human skin in a cosmetic method for controlling sweat and body odor generation can suffer from problems of impaired sensory properties and impaired efficacy (sweat reduction), which are ameliorated or overcome in structured antiperspirant emulsions in which (%s by weight of the emulsion) i) the hydrophilic phase comprises 25 to 55%; ii) the hydrophilic phase contains 0 to 15% polyhydric alcohol; iii) the emulsifier comprises an alkyl dimethicone copolyol; iv) the weight ratio of the hydrophilic phase to the emulsifier is selected in the range of at least 60:1 v) the structurant comprises an acylated sugar and vi) the water-immiscible oil and the structurant are present in a weight ratio of 1.5:1 to 8.5:1.

Abstract: The use of a composition comprising at least one organometallic compound which may be obtained by partial or total hydrolysis, and partial or total condensation, of at least one metallic precursor, to at least one of protect and strengthen a keratin material.

Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.

Abstract: The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a modified polyoxometalate, wherein the modified polyoxometalate comprises the admixture of (1) a polyoxometalate and (2) a cerium compound, a silver compound, a gold compound, a platinum compound, or a combination thereof.

Abstract: An analgesic composition that can be applied topically comprises boric acid and a suitable carrier. The inventive analgesic composition can be used to provide pain relief to a person suffering from arthritis and any general pain associated with muscles or joints.

Abstract: The invention relates to an agent for treating skin diseases and/or functional disorders of the skin on the basis of different medicaments and/or auxiliary substances through promotion of penetration from topical formulations into the skin. According to the invention, the agent is composed of a hyaluronate lyase produced by microbial means and a medicament, preferably a hydrophilic medicament and/or auxiliary substances in different galenic formulations including colloidal carrier systems. The areas of application for the invention in human and veterinary medicament relate to the treatment, prophylaxis and/or metaphylaxis of skin diseases, functional disorders of the skin, the processes of skin ageing and dry skin conditions.

Abstract: The present invention relates to a process for inhibiting or eliminating the growth of microorganisms in pesticide suspensions. More particularly, the process of the present invention includes the addition of a combination of peracetic acid, hydrogen peroxide, and water to the pesticide suspension. Further, the process of the present invention includes the application of the peracetic acid, hydrogen peroxide, and water combination to the interior surface of the vessel in which the pesticide suspension is contained. Still further, the process of the present invention includes the application of the peracetic acid, hydrogen peroxide, and water combination to a surface in which the pesticide suspension is in contact.

Abstract: A cosmetic composition for slimming which includes, in combination with a cosmetically acceptable excipient, at least one compound having the formula (I) where R1 is a group bound by a peptidic bond and selected from the group consisting of a hydrogen atom, a hydroxyl group, an acyl group, acyloxy group and a substituted or unsubstituted aminoacid; R2 is a group bond by a peptidic bond and selected from the group consisting of a hydroxyl group, an amine group, an alkoxy group, an alkylamine group, a silyloxy group or a substituted or unsubstituted aminoacid; and n is 3 or 4.

Abstract: The invention features a method preventing or treating long-term UVB-induced wrinkles in a subject. The method includes inhibiting angiogenesis in the skin of the subject.

Abstract: The invention concerns liquid or pasty thixotropic compositions containing an active substance for filling capsules at room temperature. The compositions become fluid by the effect of shearing when they pass through the filling nozzle, then recover their consistency with sufficient intensity and rapidity to prevent, after filling any leak between the two capsule parts. Said compositions are characterized in that their rheological properties are specially adapted for filling and for optimal recovery of consistency. They are preferably in the form of dispersions supporting amphiphilic excipients. Said compositions enable the formulation of active liquid, pasty and even solid substances.

Abstract: Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase, (2) a water phase, (3) at least one type of microfine particles which a) have an average particle size of less than 200 nm, which b) display both hydrophilic and lipophilic properties, i.e. which have amphiphilic character, and are dispersible both in water and in oil and which c) have optionally been coated on the surface, (4) at least one cyclodextrin and (5) at most 0.5% by weight of one or more emulsifiers.

Abstract: Cosmetic or dermatological preparations, which are finely dispersed systems of the oil-in-water or water-in-oil type, comprising 1. an oil phase, 2. an aqueous phase, 3. at least one modified polysaccharide which (a) has both hydrophilic and lipophilic properties, i.e. has amphiphilic character, and is thus dispersible both in water and in oil, and which (b) has no thickening properties, and 4. at most 0.5% by weight of one or more emulsifiers. and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active substances.

Abstract: The present application relates to cosmetic compositions containing, in a cosmetically acceptable aqueous medium, at least one polyorganosiloxane and an acrylic terpolymer, as well as to the use of these compositions for treating keratinous material, in particular the skin or the hair. The acrylic terpolymer comprises: a) about 20 to 70% by weight of a carboxylic acid containing &agr;,&bgr;-monoethylenic unsaturation; b) about 20 to 80% by weight of a non-surfactant monomer containing monoethylenic unsaturation, which is different from a), and c) about 0.5 to 60% by weight of a nonionic urethane monomer which is the product of reaction of a monohydric nonionic surfactant with a monoisocyanate containing monoethylenic unsaturation. The polyorganosiloxane is preferably a non-volatile silicone.

Abstract: Rinsable skin conditioning compositions comprising high internal phase emulsions and being substantially free of surfactant provide superior deposition on skin of conditioning agents, skin benefit agents and/or other conventional cosmetic or skin care ingredients. Such rinsable skin conditioning compositions have much improve aesthetics as well.

Abstract: Described is a method for preparing sunscreening compositions that contain chlorphenesin as a biocidal preservative, wherein the chlorphenesin is dissolved in water-insoluble components.

Abstract: Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase which contains a wax and/or an oil thickener, (2) a water phase, (3) at least one type of microfine particles which a) have an average particle size of less than 200 nm, which b) display both hydrophilic and lipophilic properties, i.e. which have amphiphilic character, and are dispersible both in water and in oil and which c) have optionally been coated on the surface, (4) at least one type of non-amphiphilic metal oxide pigments and (5) at most 0.5% by weight of one or more emulsifiers.

Abstract: A skin care product is formed of 1-10% by weight of an evening primrose powder with a particle size raning between 70 and 150 mesh, 89.9-98.6% by weight of a solid, liquid, or powered detergent base, and 0.1-0.4% by weight of a prfume. The skin care product is effetive in cleansing skin without injuring the skin. The evening primrose powder contains linolenic acid which is capable of reducing the contents of sugar and fat of the blood. The particles of the evening primrose powder are capable of a direct friction with the skin, thereby resulting in an effective removal of dead skin cells, skin cutin, and skin filth.

Abstract: Ectoparasites, such as fleas, ticks, mites and lice, are removed from a human or animal host after applying a composition to the affected area that causes desiccation of the organism. In one embodiment, treatment is effected by applying a substantially anhydrous composition that has a strong affinity for water. As the composition hydrates, it desiccates the pests and facilitates their mechanical removal, such as by combing.

Abstract: The invention relates to an agent for the treatment, prophylaxis and metaphylaxis of functional and structural disorders of the skin caused by external factors. The agent contains a hyaluronic acid partially digested with a microbiological hyaluronate lyase. The hyaluronic acid fragment mixture is incorporated in different galenic formulations to which other hydrophilic and/or lipophilic active substances and/or auxiliary substances can be added. Fields of application of the invention in human and veterinary medicine relate to the treatment and/or the prophylaxis of skin damage caused by environmental factors including UV, dry skin conditions and skin ageing.

Abstract: The present invention relates to orally administered suspensions of pharmaceutical active substances of the NSAID type, particularly the antirheumatic agent Meloxicam, which are stabilized by the addition of small amounts of highly dispersed silicon dioxide using high shear forces and adding small amounts of hydrophilic polymers to form a three-dimensional siloid structure, and a process for the preparation thereof.

Abstract: A composition suitable for topical application, which contains: a liquid fatty phase, at least one coloring agent, at least 2% by weight, with respect to the total weight of the composition, of a polymer which is dispersible in the liquid fatty phase, and a polymer which is soluble in the liquid fatty phase. In preferred embodiments, the composition may be provided in the form of a cast product or of a gel containing at least one coloring material, in particular pulverulent coloring material, a dispersion of polymer particles which are stabilized at the surface in a liquid fatty phase and a fat-soluble polymer of the vinylpyrrolidone copolymer type. In addition, according to the amount of polymer, it is possible to obtain, on the lips or skin, a supple film having notable transfer-free properties while being extremely comfortable. The invention also relates to the use of this dispersion in such a composition.

Abstract: An oiliness agent comprising a carboxylate of a composite metal hydroxide having a chemical composition represented by the following general formula (1), M2aM3x(OH)y(A)z.nH2O  (1) wherein, M2 indicates a divalent metal, M3 indicates a trivalent metal, A indicates an anion of an aliphatic carboxylic acid, a, x, y, and z are numbers satisfying the following formulas: a>0, 3x+2a−y−mz=0 (wherein m is a valency of anion A), 0.3≦a/x≦2.5 1.5≦y/(a+x)≦3.0 1.0≦(a+x)/z≦20.0, and n is a number not larger than 7. The oiliness agent exhibits excellent emulsifying properties such as dispersion stability and moisture retaining property without emitting odor and without a tendency of being colored, and is very useful for forming a water-in-oil emulsion which can be effectively used as a base material for cosmetics.

Abstract: The aqueous suspension can be prepared by incorporating, in an aqueous suspension of a hardly soluble drug, a water-soluble polymer within the concentration range from the concentration at which the surface tension of the aqueous suspension of the drug begins to decrease up to the concentration at which the reduction in surface tension ceases. The resulting aqueous suspension shows ready redispersibility and will not undergo aggregation of dispersed particles or caking. Because of its good redispersibility, the suspension is useful as a parenteral preparation, eye drops, nasal drops, a preparation for oral administration, a lotion or the like.

Abstract: The invention relates to an oil-in-water emulsion comprising, as an active ingredient, &agr;-tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive emulsion is used in order to attain a protective action against damages to human organs resulting from peroxidation. The emulsion contains a &agr;-tocopherol content, with regard to action, of 1.48 g/l to 30 g/l RRR-g(a)-tocopherol, 0-25 g/l of an oil which is compatible with I.V. administration, and 0.25 g/l to 3 g/l of a phospholipid. The emulsion is preferably administered as an infusion and is especially used to reduce damages resulting from peroxidation due to ischemia and /or reperfusion and, among other things, during an organ transplantation.

Abstract: A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a bioactive agent in or on the surface of the outer monolayer of the emulsion; the ligand being conjugated directly or indirectly to the emulsion and the composition providing facilitated delivery of the bioactive agent through prolonged association and increased contact of the ligand-bound lipid encapsulated emulsion particles with the lipid bilayer of the target tissues or cells. The composition may also comprise a lipid encapsulated oil in water emulsion and a combination site-specific targeting ligand/bioactive agent. Methods for improved delivery of a bioactive agent to targeted tissues or cells are also disclosed.

Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.

Abstract: Microemulsion gels a) based on water in oil type microemulsions, comprising an oil phase which is essentially composed of not easily volatile components, an aqueous phase containing one or more polyethoxylated W/O emulsifiers and/or one or more polypropoxylated W/O emulsifiers and/or one or more polyethoxylated and polypropoxylated W/O emulsifiers and/or one or more monoesters, diesters, polyesters of polyols as W/O emulsifiers and/or one or more monoethers, diethers, polyethers of polyols as W/O emulsifiers and/or one or more dimethicone copolyols as W/O emulsifiers and/or one or more fatty alcohols or fatty acids as W/O emulsifiers and/or one or more sorbitan esters as W/O emulsifiers and/or one or more methyl glucose esters as W/O emulsifiers, and also comprising if desired one or more O/W emulsifiers, obtained in such a way that a mixture of basic components comprising an aqueous phase, an oil phase, one or more inventive emulsifiers is produced, being the HLB value of the emulsifier or emulsifier combina

Abstract: The present invention refers to water-in-silicone type cosmetic emulsion which comprises particulate solid cosmetic components and includes as emulsifying system an association of a primary emulsifier selected from the group comprising copoliols and a secondary emulsifier selected from lipophilic stearic acids, wherein such particulate solid cosmetic components have a maximum particle size and a degree of repellence among the particles and the environment in which they are dispersed sufficient to guarantee their stability in relation to the environment in which they are dispersed.

Abstract: A stable, solid product of selected starches, active agricultural agents and optionally surfactants and or adjuvants which is readily dispersible in aqueous medium and compatible when dispersed.

Abstract: A lip care moisturizing product in the form of a water-in-oil emulsion, containing at least one fatty acid ester, at least one wax, the total of said at least one fatty acid ester and said at least one wax being at least about 1.0%, liposomes containing water therein, and an emulsifier. The emulsifier is preferably a mixture of behenoyl stearate and sodium borate, and the liposomes preferably contain a mixture of water and glycerin.

Abstract: A cosmetic composition comprising a lipophilic clay gel and a hydrophilic clay gel. The two gels are combined or formed in situ to create a gel matrix. This matrix functions like an emulsion to deliver water and oil to the skin or other surface, but can be substantially free of surfactants, emulsifiers and waxes. A method for the preparation of a clay gel matrix is also revealed.

Abstract: A controlled release composition for a biologically active material, which composition is liquid or liquid crystalline and comprises at least one medium or long-chain fatty acid ester of diglycerol as a carrier for said biologically active material, said biologically active material being dissolved or dispersed in said carrier. Said composition is especially useful as a medical composition.

Abstract: Formulations have been developed for regional delivery of drugs, for example, into a cavity such as the pelvic region, peritoneal region, or directly on organs of interest. Regional delivery increases comfort and bioavailability of the drug, resulting in rapid and relatively high blood levels in the regions to be treated in the substantial absence of side effects due to the high levels required for efficacy following systemic delivery. In the preferred embodiment, these formulations consist of drug micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or polymeric carrier. The excipient or polymer may be used to manipulate release rates and to increase adhesion to the affected region. The drug formulation can be applied as a dried powder, a liquid suspension or dispersion, or as a topical ointment, creme, lotion, foam or suppository.

Abstract: The invention relates to a tanning preparation for the skin comprising at least one tyrosine derivative of formula 1, where R<1>=—H, —(CH2)x-CH3, x being an integer from 1 to 20, R<2>=CH3CO—, CH3—(CH2)yCO—, y being an integer from 1 to 20, and an activator consisting of an aliphatic polyol having at least 10 C atoms in the molecule. The aliphatic polyol preferably consists of a hexadecanetriol, in particular phytantriol. Expediently, the tanning preparation is a gel, lotion, cream, foam, spray or emulsion.

Abstract: A stable composition including a water-sensitive pharmacologically active agent, such as an enzyme, an antibiotic or a vitamin, a hydrophilic non-polar primary solvent, an optional hydrophilic non-polar secondary solvent and optional pharmaceutical or cosmetic adjuvants to enhance appearance for topical use. Where the water-sensitive or water-degradable component is L-Ascorbic acid and the principal solvent is N-methyl-2-pyrrolidone (“NMP”) the composition is stable for many months at a concentration of L-Ascorbic acid of up to about 40 % w/v. This composition using NMP as a solvent and enhancer of skin penetration together with appropriate adjuvants is useful for preparing dermatological topical dosage for cosmetic and therapeutic purposes.

Abstract: The invention provides water-soluble polymers preparable by free-radical copolymerization of A) one or more macromonomers containing an end-group capable of polymerization, a hydrophilic moiety based on polyalkylene oxides, and a hydrophobic moiety which comprises hydrogen or a saturated or unsaturated, linear or branched, aliphatic, cycloaliphatic or aromatic (C1-C30)-hydrocarbon radical, and B) one or more olefinically unsaturated comonomers which contain oxygen, nitrogen, sulfur, phosphorus, chlorine and/or fluorine. The polymers are suitable as thickeners, dispersing agents, emulsifiers, suspending agents, stabilizers and/or bodying agents for aqueous preparations, emulsions and suspensions, in particular for cosmetic and pharmaceutical compositions.

Abstract: A composition capable of forming a film that ionically bonds to the skin comprising: one or more active agents; a nonionic or substantially nonionic first film forming component; one or more cationic surfactants comprising one or more fatty moieties that are soluble in the first film forming component; and a liquid carrier. Also provided are stable emulsions of such compositions, compositions that are especially adapted to delivering medicinal agents to the surface of the skin, and methods for preparing such compositions.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of Cyclosporin, in association with a pharmaceutical carrier, said carrier comprising a cyclosporin solubilizing effective amount of a propylene glycol monoester of C6-C18 fatty acid having at least 60% by weight monoester based on the total weight of the propylene glycol ester and a non-ionic surfactant.

Abstract: Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.

Abstract: Disclosed are hair styling compositions which comprise from about 5% to about 90% by weight of a polyalkylene glycol styling agent that is substantially free of polyalkylene glyceryl ethers, and that has a number average molecular weight of from about 190 to about 1500 and from about 5 to about 35 repeating alkylene oxide radicals wherein each of the repeating alkylene oxide radicals has from 2 to 6 carbon atoms; from about 1% to about 90% by weight of a liquid carrier which can comprise water, an organic solvent, or combinations thereof; and, optionally, from about 5% to about 40% by weight of a propellant.

Abstract: The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs.

Abstract: The present invention provides a low-irritant pesticidal emulsifiable concentrate comprising (a) 1 to 60% by weight of at least one pesticidal active ingredient compound selected from the group consisting of pyriproxyfen and a pyrethroid compound, (b) 2 to 15% by weight of at least one surfactant and (c) 15 to 90% by weight of at least one aromatic ester solvent represented by the formula: Ar—X—COOR  [1] or the formula: RCOO—X—Ar  [2] [wherein R represents non-aromatic group having 1 to 6 carbon atoms; Ar represents an aromatic group; and X represents a single bond or an alkylene group having 1 to 6 carbon atoms]. The pesticidal emulsifiable concentrate of the present invention can be used as an emulsion which is superior in emulsion stability when using after diluting with water, and has low irritation.

Abstract: A description is given of the use of a nanodispersion, which comprises

Abstract: A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke, and peripheral vascular disease comprising administering to a human or animal an amount of dutasteride sufficient to decrease atherosclerosis and its complications.

Abstract: The present invention is directed to a non-dusting copper pyrithione dispersion, comprising an admixture of: from about 20 to about 99 wt % of copper pyrithione; from about 0.05 to about 30 wt % of a dust-inhibiting agent selected from the group consisting of surfactants, polymer resins, binders, and combinations thereof; and from about 0.05 wt. % to about 80 wt % of a dispersant; wherein all weight percents are based on the total weight of the dispersion.

Abstract: A method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterized in that the multiple emulsion comprises an invert emulsion Ei with an aqueous phase A1 containing at least a hydrophilic active principle. The emulsion Ei is dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilized by at least a surfactant, present in their respective continuous phases. The multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.