Abstract: Methods for treating a movement disorder by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A.

Abstract: A perfume-containing water-in-oil microemulsion is provided which is capable of being mixed with an aqueous fabric softener base composition to provide perfume thereto. The use of the defined microemulsion enables the addition of perfume as well as other cosmetic attributes to an aqueous base composition under conditions of low shear while avoiding any problems of gelation or physical instability in the finished fabric softener product.

Abstract: Cosmetic or dermatological preparations, which are finely dispersed systems of the oil-in-water or water-in-oil type, comprising 1. an oil phase, 2. an aqueous phase, 3. at least one kind of microfine polymer particles which (a) are in the form of solids in the preparation and which (b) have both hydrophilic and lipophilic properties, i.e. have an amphiphilic character, and are dispersible both in water and in oil, and 4. at most 0.5% by weight of one or more emulsifiers and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active ingredients.

Abstract: Spontaneously formed highly stable clear water-in-oil microemulsions containing only small amounts of water can be prepared by combining and simply hand shaking (i) 0.1 to 9 percent by weight of water; (ii) greater than 80 percent by weight of a volatile cyclic alkyl siloxane or volatile linear alkyl siloxane; and (iii) 3 to 10 percent by weight of certain silicone polyether surfactants. The microemulsions are useful in personal care applications.

Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

Abstract: Provided is a sustained release composition for sustained release of a pharmaceutical substance. The composition includes a biocompatible polymer that is highly amorphous and a pharmaceutical substance in a hydrophobic ion complex with an amphiphilic material. Also provided is a compressed antisolvent method for manufacturing the composition, various product forms incorporating the composition and various uses for the composition.

Abstract: A therapeutic composition comprising (i) at least one antigen or at least one in vivo generator of a compound comprising an amino acid sequence and (ii) at least one adjuvant comprising at least one pharmaceutically acceptable and water-soluble salt of an organic anion and a metal cation.

Abstract: There are disclosed novel quaternary ammonium functional silicone based emulsions and other formulations, as well as methods to make such emulsions and formulations. These materials have uses in personal care and other applications.

Abstract: A composition in the form of a water-in-oil emulsion containing fibers, at least one silicone surfactant and at least one clay. The composition may be used, for example, for caring for, treating, making up or cleansing the skin, the lips, the eyelashes and/or the hair.

Abstract: An aerated composition comprising, in a physiologically acceptable medium, an oily phase dispersed in an aqueous phase, characterized in that it contains air or inert gas in a sufficient amount to have a relative density ranging from 0.2 to 0.8 and in that it comprises at least one amphiphilic polymer and at least one anionic surfactant. The composition exhibits a very fine texture and good cosmetic properties, while remaining very stable over time. In particular, it can constitute a cosmetic composition intended especially for treating and/or cleansing the skin, including the scalp, nails and/or hair and for making up the skin.

Abstract: The present invention provides a more efficient method of delivering therapeutically effective amounts of ascorbic acid and acetone to the dermal layer of the skin via the topical application of 5,6-O-isopropylidene L-ascorbic acid. This invention further provides a stable, cosmetically acceptable vehicle in which the 5,6-O-isopropylidene L-ascorbic acid can be applied to the skin.

Abstract: The use of one or more compounds chosen from the compounds of the formulae Ia and Ib the physiologically compatible salts of the compounds of the formulae Ia and Ib and the stereoisomeric forms of the compounds of the formulae Ia and Ib, where R1, R2, R3, R4 and n have the meanings given in claim 1, for the preparation of a cosmetic formulation is advantageously suitable, e.g., for protecting cells, proteins and/or biomembranes of the human skin, for protecting the microflora of the human skin, and/or for stabilizing the skin barrier.

Abstract: An optically clear, transparent or translucent hair conditioner in the form of a water-in-silicone oil emulsion is described. Said hair conditioner contains a silicone surfactant, a hydrophobic, nonsurfactant silicone compound present in the hair conditioner in liquid form, a basic or cationic nitrogen atom-containing hair-conditioning compound, a nonionic, silicone-free surfactant, a polyhydric alcohol and an electrolyte. The hair conditioner can be used as a leave-in hair treatment or as a hair rinse.

Abstract: A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a process for the preparation and the use thereof.

Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Abstract: Stable, topically applicable water-in-oil emulsions, well suited for therapeutically treating irritated/sensitive skins and having high electrolyte content, comprise (a) at least 26 by weight of at least one water-soluble metal salt, (b) at least one hydrophobic gelling agent, (c) less than 5% by weight of at least one emulsifying agent, and, advantageously, at least one biologically active agent, for example an active agent that modulates skin differentiation and/or proliferation and/or pigmentation, an anti-inflammatory, an antibacterial, an antifungal, etc., and/or at least one keratolytic active agent, neuropeptide antagonist and/or inflammation-mediator antagonist.

Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Abstract: A method for the prophylaxes and treatment of psoriasis, allergies and auto-immune disorders of the skin, the treatment of sensitive skin, or a combination thereof, which comprises applying cis-6-hexadecenoic acid, or a salt or ester thereof.

Abstract: Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase, (2) a water phase, (3) at least one type of microfine particles which a) have an average particle size of less than 200 nm, which b) display both hydrophilic and lipophilic properties, and are dispersible both in water and in oil and which c) have optionally been coated on the surface, (4) at least one electrolyte and (5) at most 0.5% by weight of one or more emulsifiers.

Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Abstract: Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase which comprises at least 0.5% by weight, based on the weight of the oil phase, of at least one oil component selected from the group consisting of oils having viscosities of less than 30 mPa·s, (2) a water phase, (3) at least one type of microfine particles which a) have an average particle size of less than 200 nm, which b) display both hydrophilic and lipophilic properties, and are dispersible both in water and in oil and which c) have optionally been coated on the surface, and (4) at most 0.5% by weight of one or more emulsifiers.

Abstract: Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase which contains a wax and/or an oil thickener, (2) a water phase, (3) at least one type of microfine particles which a) have an average particle size of less than 200 nm, which b) display both hydrophilic and lipophilic properties, i.e. which have amphiphilic character, and are dispersible both in water and in oil and which c) have optionally been coated on the surface, (4) at least one type of non-amphiphilic metal oxide pigments and (5) at most 0.5% by weight of one or more emulsifiers.

Abstract: The present invention is concerned with a plant extract comprising a mixture of di-O-D-galactosyl-di-O-acylglyceride with phytosphingolipids and phospholipids, as well as with a method for the preparation thereof through a physical extraction in the presence of water and ethanol. Such an extract can be used, in particular, in pharmaceutical, cosmetic and food compositions.

Abstract: There is provided an emulsion having a substantially non-aqueous phase, a substantially aqueous phase, a vitamin C component and a pigment. Such an emulsion is both cosmetically and aesthetically acceptable.

Abstract: Agonists of chlorine/potassium channel receptor, for example taurine, gamma-aminobutyric acid (GABA), isoguvacin, isonipecotic acid, 4,5,6,7-tetrahydroisoxazolo-(5,4-c)pyrid-3(2H)-one, a benzodiazepine, steroids, and cromakalim, pinacidil, nicorandil and minoxidil, are well suited for treating sensitive human skin and are especially useful for treating/eliminating skin itching, pruritus, tautness, tingling and/or erythema.

Abstract: The invention relates to a process for the production of morphologically uniform microcapsules that contain peptides, proteins or other water-soluble biologically active substances as active ingredients as well as microcapsules that are produced according to this process with a degree of concentration of between 3 to 30% by weight and a diameter ≦8 &mgr;m. According to the invention, biodegradable polymers are dissolved in a halogen-free solvent or solvent mixture, and the buffered active ingredient solution, which has a pH of between 6.0 to 8.0, is dispersed into this solution. Then, an aqueous solution that contains a surfactant (W/O/W-emulsion) is added to this W/O-emulsion, and the solvent is removed. The microcapsules that are produced with this process do not show any tendency toward agglomeration. The encapsulation efficiency of the process is approximately 90 to 95%.

Abstract: The invention relates to a stable emulsifiable concentrate (EC) for crop protection active compounds which comprises (a) one or more crop protection active compounds, (b) 150 to 500 g/l of one or more adjuvants, (c) optionally one or more organic, non-polar solvents, (d) an emulsifying surfactant system forming an oil in water emulsion when the formulation is added to water, which essentially consists of one or more non-ionic surfactants, and one or more anionic surfactants, (e) a water-miscible polar aprotic solvent or one or more dimethyl dicarboxylates, and (f) optionally an antifoam agent, and to the use of such a suspension as a pesticide.

Abstract: A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic phase and a surfactant. The composition is stable and provides high absorption efficiency.

Abstract: A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried. The powder containing tocotrienol, which has excellent storage stability and free flowability, can be used in preparing a tablet which comprises the powder compressed into a tablet form.

Abstract: A cosmetic composition having improved transfer resistance comprising: a) from about 0.1-60% by weight of trimethylated silica, b) from about 0.1-60% by weight of a volatile solvent having a viscosity of 0.5 to 100 centipoise at 25° C., c) 0.1-60% by weight of a nonvolatile oil having a viscosity of 200 to 1,000,000 centipoise at 25° C. d) 0.1-80% of a cosmetically acceptable carrier.

Abstract: The present provides a composition that includes, in a physiologically acceptable medium: an aqueous phase dispersed in an oily phase with a silicone emulsifier; wherein the aqueous phase represents at least 80% by weight relative to the total weight of the composition; wherein the silicone emulsifier is an alkyldimethicone copolyol comprising an HLB of less than 8; and wherein a weight ratio of the oily phase to the silicone emulsifier is greater than or equal to 5. The present invention also provides a cosmetic, which includes the above-mentioned composition and methods of using the above-mentioned composition for treating, protecting, caring for, or removing make-up from the skin, lips or hair, cleansing the skin, lips or hair, and making up the skin or lips, treating, protecting, and caring for the scalp, and treating greasy skin. The composition can be used in particular in cosmetics and/or dermatology.

Abstract: Emulsifier-free cosmetic or dermatological preparations, which are finely dispersed systems of the oil-in-water type, comprising 1. an oil phase, 2. an aqueous phase and 3. one or more types of micronized, inorganic pigments which a) have an average particle size of less than 200 nm, and whose particles b) have both hydrophilic and lipophilic properties, i.e. have an amphiphilic character, and thus position themselves at the water/oil interface, and which c) are selected from the group consisting of metal oxides, which d) are optionally coated on the surface and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active ingredients.

Abstract: Compositions containing at least one organic phospholipid capable of forming bilayers in aqueous solution; at least one amphoteric surfactant; and at least one nonionic surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; where the phospholipid and surfactants are present in a combined amount sufficient to allow at least one water-insoluble ingredient selected from waxes and unneutralized and partially neutralized water-insoluble polymers, resins, and latexes to be incorporated into an aqueous solution. A delivery system containing the composition and methods for styling hair and for treating keratinous substances are also disclosed.

Abstract: Methylphenidate or other drugs are provided in a formulation for oral administration that releases the drug in two or more pharmacokinetic spikes, by combining different release forms in a single formulation. In a preferred embodiment for methylphenidate, the first pharmacokinetic spike is achieved by the release of taste-masked methylphenidate which is not enterically coated, while a second pharmacokinetic spike is achieved by the release of methylphenidate in a finely divided form from enterically coated pellets or microparticles formulated for rapid release following dissolution of the enteric coating. A critical aspect of the formulation is the inclusion of excipients that create a burst release following the initial rapid release and uptake. The formulation can be administered as a paste, jelly, suspension, or fast dissolving wafer. To manipulate the dose, the formulation can be provided, for example, as a paste packaged in a tube similar to those used to dispense toothpaste.

Abstract: The present invention relates to topical compositions for effecting an immediate improvement in the appearance and feel of skin, in addition to providing chronic improvements in skin appearance. The compositions comprise from 0.5% to 25% of a first particulate material having a refractive index of from 1.3 to 1.7, the particulate material being dispersed in the composition and having a median particle size of from 2 to 30 um, and an active effective for chronically regulating skin condition selected from Vitamin B3 compounds, retinoids, and mixtures thereof. Preferred emobodiments are oil in water emulsions further comprising a second particulate material having a larger particle size than the first.

Abstract: The present invention refers to a two-phase cosmetic composition including an aqueous phase and an oily phase wherein the aqueous phase contains an emulsifying system comprising at least one surfactant selected from the group of cationic surfactants and at least one surfactant selected from the group of non-ionic surfactants, and wherein the total surfactant concentration is lower than 0.1%, by weight, based on the total weight of the composition.

Abstract: 10-Hydroxy-2-decenoic acid compounds, particularly the 10-hydroxydec-2-enoates, are well suited for promoting desquamation of human skin and/or stimulating epidermal renewal and thus combating intrinsic and/or extrinsic cutaneous aging.

Abstract: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.

Abstract: Syrup formulations comprising water and compacted granulates which are mixture of amoxycillin and clavulanic acid, together with an intra-granular disintegrant.

Abstract: The invention provides a composition of matter comprising a stable oil-in-glycerin emulstion containing at least one oil, at least one emulsifier and glycerin.

Abstract: The present invention describes the use of finely divided dye-containing polymers PD in the form of an aqueous polymer dispersion or a polymer powder obtainable therefrom, the polymer matrix of which comprises at least one organic dye D in homogeneously dispersed form, as color-imparting constituent in cosmetic compositions. The present invention also describes cosmetic compositions which comprise a color-containing polymer in an amount of from 0.1 to 50% by weight, based on the total weight of the cosmetic composition, and additives customary for cosmetic compositions.

Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45° C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract: The present invention relates to a method to produce suspension concentrates of pesticides, pharmaceuticals, biocides, and similar materials, using a melt emulsification process. The method is particularly applicable to pesticides which have a low water solubility. The particle size can be controlled to give particles from less than 5 microns (&mgr;) to less than 1&mgr;.

Abstract: Cosmetic composition for topical application to the skin comprise a cyclodextrin compound and a salicylic acid or salicylic acid derivative, wherein the composition is in the form of a water-in-silicone emulsion having a continuous silicone oil-containing phase and a discontinuous aqueous phase. The compositions herein provide improved anti-acne/anti-inflammatory activity together with reduced skin irritation.

Abstract: The invention relates to a novel biologically active composition which comprises a biologically active agent composition which comprises a biologically active agent to be released therefrom, said biologically active agent being dissolved and/or dispersed in a supersaturated state within a carrier, which carrier comprises a liquid and/or solid non-crystalline ester and/or polyester matrix, and where the precipitation of said biologically active agent is substantially, or completely, inhibited therein. Said supersaturated states is obtainable by subjecting one or more carrier staring substances(s) to such chemical reaction(s) that an ester and/or polyester matrix is provided, the biologically active agent being added after said chemical reaction(s) has (have) been completed.

Abstract: An O/W medical fat emulsion for oral administration, which is capable of increasing the bioavailability of a medicine or the blood level thereof. The emulsion is composed of fat emulsion particles containing an oil component, an emulsifier and a medicine as the indispensable constituents and dispersed in water, characterized in that the average diameter of the particles in the fat emulsion ranges from 5 to 50 nm. A freeze-dried preparation of the emulsion is also included in the invention.

Abstract: There are provided topical compositions having reversible visible change in color in response to change in light. The compositions comprise color changing capability provided by photochromic material and a vehicle acceptable for topical application to the skin or hair.

Abstract: The present invention relates to an oil-in-water emulsion containing tretinoin and the use thereof in mitigating skin disorders such as acne, photodamaged skin, wrinkles, mottled hyperpigmentation, tactile roughness, and yellowing of facial skin.

Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.

Abstract: The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di- unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.