Organic Sulfonate, Sulfate Or Sulfite Containing Patents (Class 514/942)
  • Patent number: 8569218
    Abstract: A gelled cleaning composition is provided that includes a standard temperature and pressure (STP) liquid oil or STP malleable wax present from 0.1 to 9.9 total weight percent. An emulsifier is present from 0.01 to 10 total weight percent, along with an alkylene glycol present from 0.002 to 11 total weight percent. A microemulsion is present in the composition from 0.2 to 15 total weight percent. Water forms a majority of the composition such that the composition is monophasic for at least 4 months storage at 20° Celsius. The composition is well suited for use in a process to remove a lipophilic substance from hands or an inanimate substrate by applying the composition and after allow sufficient time for the substance to be softened or solubilized, removing the composition and at least a portion of the substance. Silicone gaskets, as well as other cured resins and paints are readily removed.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: October 29, 2013
    Assignee: Illinois Tool Works, Inc.
    Inventor: Claudia E. Britton
  • Patent number: 8182795
    Abstract: An oil-in-water emulsified sunscreen cosmetic which contains: (A) Containing the following three types of surfactants (A-1)-(A-3); (A-1) A POE stearic ester having a POE mole number of 20-120; (A-2) sorbitan tristearate; and (A-3) glyceryl stearate having a HLB of 5-8; (B) bis-ethylhexyloxyphenolmethoxyphenyltriazine and/or tert-butylmethoxybenzoylmethane, oil soluble ultraviolet absorbents, solid at room temperatures; (C) ethylhexyl methoxycinnamate and/or octocrylene, oil soluble ultraviolet absorbents, liquid at room temperature; (D) phenylbenzimidazolesulfonic acid, a water soluble ultraviolet absorbent; and (E) a higher alcohol having 14-24 carbon atoms.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: May 22, 2012
    Assignee: Shiseido Co., Ltd.
    Inventors: Yoshihito Takakura, Kazuaki Suzuki, Takayuki Omura
  • Patent number: 7943155
    Abstract: A self-reversible reverse microlatex composition comprising an oil phase, an aqueous phase, a water-in-oil surfactant(s), a oil-in-water surfactant(s) and 15% to 40% by weight by weight of a branched or crosslinked polyelectrolyte. The polyelectrolyte is based on a monomer containing a strong or weak acid function, which is partially or totally salified, a copolymer of at least one monomer containing a strong acid function and at least one monomer containing a weak acid function or at least one neutral monomer, a copolymer of at least one monomer containing a weak acid function and at least one neutral monomer, or a copolymer of at least one monomer containing a strong acid function, a monomer containing at least one weak acid function and at least one neutral monomer. The surfactants have a total HLB number of 8.5 to 11. Uses in cosmetics and as an industrial emulsifier and/or thickener.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: May 17, 2011
    Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques (SEPPIC)
    Inventors: Olivier Braun, Paul Mallo, Guy Tabacchi
  • Patent number: 7348016
    Abstract: A self-reversible reverse microlatex composition comprising an oil phase, an aqueous phase, at least one W/O surfactant, at least one O/W surfactant, and a branched or a crosslinked polyelectrolyte, wherein the W/O surfactant and the O/W surfactant mixture have a HLB from about 9.5 to about 10, and the polyelectrolyte is either a homopolymer or copolymer or a combination thereof based on at least one monomer containing a strong or weak acid function. Further, the composition may be used in the cosmetic, dermopharmaceutical, pharmaceutical, textile, paper, and/or paint industries, or as a thickener for printing pastes based on pigments or dyes.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: March 25, 2008
    Assignee: Societe d Exploitation de Produits pour les Industries Chimiques Seppic
    Inventors: Olivier Braun, Paul Mallo, Guy Tabacchi
  • Patent number: 7271200
    Abstract: A novel emulsion comprising a material which is stabilised by a polymer resin precursor having interface active molecules incorporated therein by reaction from poorly or non-surface active materials is disclosed. The process for producing such emulsions is likewise disclosed.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: September 18, 2007
    Assignee: Syngenta Limited
    Inventors: Herbert Benson Scher, Patrick Joseph Mulqueen, Nicholas David Green, Catherine Julia Piper
  • Patent number: 6946426
    Abstract: Provided is a method of formulating hydrophobic pesticides comprising emulsifying an aqueous phase and a water-immiscible phase to form a formulation; wherein the aqueous phase is comprised of water and optionally a freeze/thaw agent, one or more emulsifiers, or combinations thereof, and the water-immiscible phase comprises the hydrophobic pesticide and one or more emulsifiers.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: September 20, 2005
    Assignee: FMC Corporation
    Inventors: Timothy M. Martin, MaryEllen Lavin
  • Patent number: 6710092
    Abstract: A novel emulsion comprising a material which is stabilized by a polymer resin precursor having interface active molecules incorporated therein by reaction from poorly or non-surface active materials is disclosed. The process for producing such emulsions is likewise disclosed.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: March 23, 2004
    Assignee: Syngenta Limited
    Inventors: Herbert Benson Scher, Patrick Joseph Mulqueen, Nicholas David Green, Catherine Julia Piper
  • Patent number: 6627603
    Abstract: A method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterized in that the multiple emulsion comprises an invert emulsion Ei with an aqueous phase A1 containing at least a hydrophilic active principle. The emulsion Ei is dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilized by at least a surfactant, present in their respective continuous phases. The multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: September 30, 2003
    Assignee: Centre National de la Recherche Scientifiquue (C.N.R.S.)
    Inventors: Jérôme Bibette, Marie-Françoise Ficheux, Fernando Leal Calderon, Lida Bonnakdar
  • Patent number: 6541018
    Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45° C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: April 1, 2003
    Assignee: L'Oreal
    Inventors: Jean-Thierry Simonnet, Odile Sonneville, Sylvie Legret
  • Patent number: 6531500
    Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: March 11, 2003
    Assignee: Alwyn Company, Inc.
    Inventor: Elliott Farber
  • Patent number: 6458383
    Abstract: A delayed release pharmaceutical dosage form for oral administration of a hydrophilic drug, e.g., a polysaccharide drug such as low molecular weight heparin, are provided. The dosage form comprises a composition of: (a) a therapeutically effective amount of low molecular weight heparin; (b) a bile salt or bile acid; (c) at least one surfactant selected from hydrophilic surfactants, lipophilic surfactants, and mixtures thereof; and a means for delaying release of the composition from the dosage form following oral administration. Osmotic drug delivery systems for oral administration of a hydrophilic drug are also provided, wherein an osmotically activated device houses the drug, a bile salt or bile acid, and at least one surfactant selected from the group consisting of hydrophilic surfactants, lipophilic surfactants, and mixtures thereof. Methods for administering hydrophilic drugs, particularly polysaccharide drugs such as low molecular weight heparin, are also provided.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: October 1, 2002
    Assignee: Lipocine, Inc.
    Inventors: Feng-Jing Chen, Mahesh V. Patel, David T. Fikstad
  • Patent number: 6451339
    Abstract: The present invention relates to triglyceride-free pharmaceutical compositions for delivery of hydrophobic therapeutic agents. Compositions of the present invention include a hydrophobic therapeutic agent and a carrier, where the carrier is formed from a combination of a hydrophilic surfactant and a hydrophobic surfactant. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the surfactants containing the therapeutic agent. The invention also provides methods of treatment with hydrophobic therapeutic agents using these compositions.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: September 17, 2002
    Assignee: Lipocine, Inc.
    Inventors: Mahesh V. Patel, Feng-Jing Chen
  • Patent number: 6335022
    Abstract: The present invention relates to a nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from sorbitan fatty esters and oxyethylenated sorbitan fatty esters, (2) at least one oil having a molecular weight of greater than 400 and (3) at least one ionic amphiphilic lipid chosen from the group formed by the alkaline salts of dicetyl and dimyristyl phosphate, the alkaline salts of cholesterol sulphate, the alkaline salts of cholesterol phosphate, lipoamino acids, the sodium salts of phosphatidic acid, cationic amphiphilic lipids and alkylsulfonic derivatives, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The surfactant used is, for example, chosen from sorbitan monostearate, sorbitan monopalmitate and sorbitan 20 EO tristearate. The emulsion obtained is transparent and stable on storage.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: January 1, 2002
    Assignee: L'Oreal
    Inventors: Jean-Thierry Simonnet, Odile Sonneville, Sylvie Legret
  • Patent number: 6309663
    Abstract: The present invention relates to pharmaceutical compositions, pharmaceutical systems, and methods for enhanced absorption of hydrophilic therapeutic agents. Compositions and systems of the present invention include an absorption enhancing carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. A hydrophilic therapeutic agent can be incorporated into the composition, or can be co-administered with the composition as part of a pharmaceutical system. The invention also provides methods of treatment with hydrophilic therapeutic agents using these compositions and systems.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: October 30, 2001
    Assignee: Lipocine Inc.
    Inventors: Mahesh V. Patel, Feng-Jing Chen
  • Patent number: 6217887
    Abstract: The present invention relates to a leave-on antimicrobial composition comprising from about 0.001% to about 5% of an antimicrobial active; from about 0.5% to about 10% of an anionic surfactant; from about 0.1% to about 10% of a proton donating agent, wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid; and from about 0% to about 98.85% of water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the leave-on antimicrobial composition has a One-wash Immediate Germ Reduction Index of greater than about 50%; and wherein the leave-on antimicrobial composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for moisturizing skin, reducing germs on the skin, and providing residual effectiveness versus Gram positive bacteria using these products.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: April 17, 2001
    Assignee: The Procter & Gamble Company
    Inventors: Peter William Beerse, Jeffrey Michael Morgan, Kathleen Grieshop Baier, Theresa Anne Bakken Schuette, Raymond Wei Chen
  • Patent number: 6162453
    Abstract: A stable monophasic liquid composition characterized by the ability to solubilize increased amounts of surfactant into the composition while retaining a monophasic state, the composition comprising: one or more surfactants selected from the group consisting of cationic surfactants, anionic surfactants, amphoteric surfactants, nonionic surfactants, and mixtures thereof; a hydrophobic material; and one or more coupling agents selected from the group consisting of straight, branched and cyclic alkanes containing 7 to 12 carbon atoms and substituted with two hydroxyl groups, and alkoxylates thereof containing up to 20 alkoxy units each of which is ethoxy, propoxy, or butoxy, and mixtures thereof, in an amount of the one or more coupling agents effective to increase the amount of the one or more surfactants that can be solubilized in the monophasic composition.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: December 19, 2000
    Assignee: Witco Corporation
    Inventor: Robert O. Keys
  • Patent number: 6106851
    Abstract: The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 6% to about 16%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 100:0 to about 1.5:1; from about 2% to about 4%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75, wherein the proton donating agent is such that the composition is essentially free of C.sub.4 -C.sub.20 alkyl fatty acid, and wherein from about 0.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: August 22, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Peter William Beerse, Jeffrey Michael Morgan, Kathleen Grieshop Baier, Robert Gregory Bartolo, Theresa Anne Bakken Schuette
  • Patent number: 6096225
    Abstract: A method is disclosed for controlling biofouling in an aqueous medium by treating the aqueous medium with an oil-in-water emulsion comprising an antimicrobial oil phase and at least one emulsifier. This method efficiently controls biofouling in the aqueous medium by specifically targeting the antimicrobial oil phase directly to biofilms, cell surfaces and cell aggregates in a concentrated form.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: August 1, 2000
    Assignee: Nalco Chemical Company
    Inventors: Shunong Yang, Michael V. Enzien, May M. Wu, William F. McCoy
  • Patent number: 6069173
    Abstract: Insecticidal compositions comprising a synthetic surfactant and capsaicin or other capsaicinoid exhibit synergistic effects against numerous insects, not only as to activity-enhancement effect but more importantly as to activity-extending effect, especially against Fall Army Worms, Alfalfa Weevils, Corn Ear Worms, Corn Leaf Aphids, True Army Worms, Grasshoppers, Potato Leaf Hoppers, Beanleaf Beetles, and Soybean Thrips, when applied to the insect or its habitat, especially as an aqueous solution, suspension, or emulsion. Effective kill levels are observed as long as fourteen days after application whereas, using the individual components, effective kill levels do not ordinarily extend beyond 24 hours after application.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: May 30, 2000
    Assignee: Kalamzoo Holdings, Inc.
    Inventor: Gary C. Hainrihar
  • Patent number: 6066328
    Abstract: The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or oligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: May 23, 2000
    Assignee: L'Oreal
    Inventors: Alain Ribier, Jean-Thierry Simonnet, Jacques Michelet
  • Patent number: 6001346
    Abstract: A sprayable or solid biodegradable wax carrier for insect pheromones and a method for constant release rate of the pheromone from the biodegradable wax. A composition comprising a pheromone and paraffin wax formulated as an aqueous emulsion or a solid suitable for application to a surface of a tree or crop for mating disruption of insect pests. Pheromone is released by diffusion or by partitioning from the biodegradable wax carrier or by pheromone exposure due to the biodegradable wax carrier degradation.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: December 14, 1999
    Assignee: The Regents of the University of California
    Inventors: Michael Delwiche, John M. Krochta, Richard E. Rice, Cynthia Atterholt
  • Patent number: 5925364
    Abstract: The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or aligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: July 20, 1999
    Assignee: L'Oreal
    Inventors: Alain Ribier, Jean-Thierry Simonnet, Jacques Michelet
  • Patent number: 5925681
    Abstract: Concentrated aqueous liquid disinfectant compositions which exhibit a blooming effect when diluted in a larger volume of water are provided. The concentrate compositions include non-phenolic constituents to provide a disinfecting effect, and are non pine-oil containing. Working strength dilutions of the concentrated aqueous liquid disinfectant compositions are effective against gram positive type pathogenic bacteria such as Staphylococcus aureus, as well as gram negative type pathogenic bacteria such as Salmonella choleraesuis.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: July 20, 1999
    Assignee: Reckitt & Colman Inc.
    Inventors: Michael George Crisanti, Dennis Thomas Smialowicz
  • Patent number: 5905072
    Abstract: Adjuvants for systemic fungicides in the form of a stable microemulsion comprise water, a mixture of methyl esters of fatty acids obtained by the transesterification of vegetable oils, an anionic surface-active agent, at least one non-ionic surface-active agent with an HLB of between 13-18 and a cloud point of >65.degree. and at least one non-ionic surface-active agent with an HLB of between 10 and 12. These adjuvants, which can additionally contain conventional components and/or formulation additives, improve the activity of systemic fungicides belonging to different chemical groups.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: May 18, 1999
    Assignee: Isagro S.p.A.
    Inventors: Luigi Capuzzi, Mario Ferri, Ernesto Signorini, Nicola Stramacchia, Claude Delestre, Luigi Mirenna
  • Patent number: 5785950
    Abstract: This invention relates to compositions comprising highly fluorinated, chloro-substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of making and using them. More particularly, this invention relates to emulsions comprising those highly fluorinated, chloro-substituted organic compounds. This invention also related to emulsion comprising noncyclic perfluorochlorethers having 7 to 10 carbon atoms, preferably 7 to 9 carbon atoms. These novel emulsions have various medical and oxygen transport applications. They are especially useful medically as contrast media, for various biological imaging modalities such as nuclear magnetic resonance, ultrasound, x-ray, computed tomography, .sup.19 F-magnetic resonance imaging, and position emission tomography, as oxygen transport agents or "artificial bloods," in the treatment of heart attack, stroke, and other vascular obstructions, as adjuvants to coronary angioplasty and in cancer radiation treatment and chemotherapy.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: July 28, 1998
    Assignees: HemaGen/PFC, Minnesota Mining & Manufacturing Co.
    Inventors: Robert J. Kaufman, Thomas J. Richard, George G. I. Moore, Richard M. Flynn
  • Patent number: 5679351
    Abstract: A clove oil formulation which inhibits soil-borne fungal diseases is disclosed. The formulation includes about 70-90% by weight rectified clove oil, and about 2-30% by weight surfactant. The surfactant includes about 15-95% by weight nonionic compounds such as ethoxylated monoglycerides, ethoxylated diglycerides, ethoxylated alcohols, silicone glycol copolymers, sorbitan fatty acid esters, ethoxylated alkyl phenols, ethylene oxide block copolymers, and propylene oxide block copolymers. The surfactant further includes about 5-85% by weight anionic compounds such as amine alkylaryl sulfonate, calcium alkylaryl sulfonate and phosphate esters. The formulation may also include up to about 30% by weight of a solvent such as alcohol, esters, glycol ethers, mineral oil, methyl esters and hydrocarbon solvents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 21, 1997
    Assignee: Thermo Trilogy Corporation
    Inventors: James Frederic Walter, James Charles Locke, Michele Carter Normoyle
  • Patent number: 5668183
    Abstract: Novel, stable, cold water-dispersible preparations of fat-soluble substances contain a water-soluble or water-dispersible lignin derivative as the matrix component. These preparations are manufactured by preparing an aqueous emulsion of the fat-soluble substance(s) and the water-soluble or water-dispersible lignin derivative and, if desired, converting this emulsion into a dry powder. The preparations in accordance with the invention can be used not only for animal nutrition but also for human nutrition.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: September 16, 1997
    Assignee: Roche Vitamins Inc.
    Inventor: Bruno Leuenberger
  • Patent number: 5607660
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodophenoxy alkane, iodophenyl alkenylalkyl ether or an iodophenyl alkynylalkyl ether x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: March 4, 1997
    Assignee: Sterling Winthrop Inc.
    Inventors: Robert W. Lee, Carl R. Illig, Thomas J. Caulfield
  • Patent number: 5543132
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a barium salt in a pharmaceutically acceptable carrier comprising a cellulose derivative; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: August 6, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Robert W. Lee, John L. Toner, Carl R. Illig
  • Patent number: 5531979
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: July 2, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Mary E. Roberts, Gregory L. McIntire, Eugene R. Cooper, Edward R. Bacon
  • Patent number: 5525327
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000.mu. wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR1## wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier comprising a cellulose derivative.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: June 11, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Robert W. Lee, Carl R. Illig, John L. Toner
  • Patent number: 5484585
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodobenzoic acid derivatives as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: January 16, 1996
    Assignee: Sterling-Winthrop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, Brent D. Douty, Eugene R. Cooper
  • Patent number: 5476646
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: December 19, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, John L. Toner
  • Patent number: 5466440
    Abstract: Nanoparticulate crystalline substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline substances and the gastrointestinal tract. These formulations have improved safety profiles, a low potential for absorption, are not viscous and are not contraindicated for GI perforations or intestinal obstructions. The properties of the surfactant stabilizers are independent of the crystalline drug used and largely determine the extent to which the formulation coats the GI tract.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: November 14, 1995
    Assignee: Eastman Kodak Company
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge, Eugene R. Cooper
  • Patent number: 5443814
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: August 22, 1995
    Assignee: Sterling Winthrop, Inc.
    Inventors: Carl R. Illig, John L. Toner, Robert W. Lee, Edward J. Baker
  • Patent number: 5444078
    Abstract: Microemulsions of water-insoluble active ingredients, employing a special surfactant system and solvent system. These microemulsions remain thermodynamically stable over a wide range of water dilutions.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: August 22, 1995
    Assignee: Rohm and Haas Company
    Inventors: Bing Yu, John R. Mattox
  • Patent number: 5441732
    Abstract: Reversibly gelling aqueous and oil emulsions are disclosed which can be modified to incorporate oil soluble pharmaceutical compounds for delivery to physiological systems in a soluble form and which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer, at least one temperature-sensitive reversibly gelling polymer and at least one organic oil. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds.
    Type: Grant
    Filed: March 18, 1992
    Date of Patent: August 15, 1995
    Assignee: Allergan, Inc.
    Inventors: Anne L. Hoeg, David L. Meadows
  • Patent number: 5405600
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and a nonionic x-ray producing agent in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: April 11, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, John L. Toner
  • Patent number: 5403575
    Abstract: This invention relates to compositions comprising highly fluorinated, chloro-substituted, non-cyclic organic compounds having 7 to 9 carbon atoms and to processes of making and using them. More particularly, this invention relates to emulsions comprising those highly fluorinated, chloro-substituted organic compounds. These novel emulsions have various medical and oxygen transport applications. They are especially useful medically as contrast media, for various biological imaging modalities such as nuclear magnetic resonance, ultrasound, x-ray, computed tomography, .sup.19 F-magnetic resonance imaging, and position emission tomography, as oxygen transport agents or "artificial bloods," in the treatment of heart attack, stroke, and other vascular obstructions, as adjuvants to coronary angioplasty and in cancer radiation treatment and chemotherapy.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: April 4, 1995
    Assignee: HemaGen/PFC
    Inventors: Robert J. Kaufman, Thomas J. Richard
  • Patent number: 5403587
    Abstract: The present invention provides an aqueous antimicrobial composition containing one or more essential oils which exhibit antimicrobial properties and which can be combined with a water carrier and a solubilizing or dispersing agent to form a solution or a dispersion of the essential oil in the water carrier, said essential oil exhibiting antimicrobial properties when incorporated in said water carrier.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: April 4, 1995
    Assignee: Eastman Kodak Company
    Inventors: Karen A. McCue, Dennis T. Smialowicz
  • Patent number: 5393461
    Abstract: A process for preparing an emulsion of water-insoluble particles useful in the cosmetic, pharmaceutical, paint and ink industries comprising:treating the water-insoluble particles with a wetting agent in an organic solvent;combining the water-insoluble particles with an oily or polymeric substance to obtain an oily suspension;preparing an aqueous solution of a combination of surface active agents; andcombining the aqueous solution with the oily suspension to form an emulsion.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: February 28, 1995
    Assignee: RTD Corporation
    Inventor: Irina V. Fillipova
  • Patent number: 5389297
    Abstract: What is provided herein is an inert matrix composition (IMC), and a microemulsifiable concentrate (MEC) in the form of a free-flowing, high-melting solid, suitable for making an aqueous microemulsion (AME) of an agriculturally active chemical (AAC) with dilution water. The inert matrix composition comprises about 10-50% of a C.sub.6 -C.sub.18 alkylpyrrolidone, about 10-50% of an anionic surfactant and about 10-70% of a complexing agent characterized by being an organic compound having a melting point >100.degree. C., a molecular weight .ltoreq.500, a water solubility of at least 10% by weight, and being capable of hydrogen-bonding with the alkylpyrrolidone component of the composition. The MEC comprises the IMC and about 1-20% of the agriculturally active ingredient (AAI). Upon dilution with water an AMC is provided having a few ppm to 1% AAI.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: February 14, 1995
    Assignee: ISP Investments Inc.
    Inventor: Kolazi S. Narayanan
  • Patent number: 5368837
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline contrast agent in a pharmaceutically acceptable carrier comprising a cellulose derivative; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: November 29, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Robert W. Lee, Eugene R. Cooper, John L. Toner, Carl R. Illig
  • Patent number: 5360604
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline organic constrast agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: November 1, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Mary E. Roberts, Gregory L. McIntire, Eugene R. Cooper, Carl R. Illig
  • Patent number: 5352434
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and a barium salt in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: October 4, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl B. Illig, John L. Toner
  • Patent number: 5342605
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material in combination with a divalent cation capable of forming a coating on the gastrointestinal tract and iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000.mu. wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR1## wherein A is a repeating organic unit in the backbone chain of the polymer; andX is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: August 30, 1994
    Assignee: Sterling Winthrop Inc.
    Inventor: Carl R. Illig
  • Patent number: 5336484
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy,n is 1-5;y is 0-4; andw is 1-4.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: August 9, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward R. Bacon, Sol J. Daum, Kimberly G. Estep, Kurt A. Josef, Brent D. Douty, Carl R. Illig
  • Patent number: 5334585
    Abstract: Stable pyrethroid microemulsion compositions having from 0.1% to 95% by weight/weight of at least one pyrethroid in liquid form; from 2% to 90% by weight/weight of a three-component surfactant system having at least one anionic surfactant, at least one nonionic surfactant and at least one co-surfactant chosen from aliphatic alcohols, cycloaliphatic alcohols, arylaliphatic alcohols, ether-alcohols and aliphatic carboxylic acids; and water.The ratio by weight of anionic surfactant/nonionic surfactant is from 10/90 to 90/10, and the ratio by weight of co-surfactant/anionic and nonionic surfactants is from 0.1 to 1.5.The microemulsion compositions are applied directly or after dilution with water to plants (crops) or wood for controlling insects.
    Type: Grant
    Filed: February 21, 1992
    Date of Patent: August 2, 1994
    Assignee: Rhone-Poulenc Chimie
    Inventors: Paul-Joel Derian, Gilles Guerin
  • Patent number: 5330681
    Abstract: Stable diphase emulsions consisting of:a) perfluoropolyethers having perfluoroalkyl end groups;b) a conventional surfactant, dispersed inc) a continuous dispersing phase consisting of glycerol or of a polyhydroxylated compound containing at least three hydroxyl groups, selected from polyalcohols and saccharides, dissolved in a hydrophile solvent and/or water.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: July 19, 1994
    Assignee: Ausimont S.r.l.
    Inventors: Fabio Brunetta, Giovanni Pantini
  • Patent number: 5330769
    Abstract: Fatty acid sanitizer concentrates and diluted final solutions are provided which include individual amounts of germicidally effective fatty acid, hydrotrope, strong acid sufficient to lower the pH of the final solutions to about 1-5, and a concentrate stabilizing weak acid component selected from the group consisting of propionic, butyric and valeric acids and mixtures thereof. The concentrate stabilizing component enhances the room and low temperature phase stability of the concentrates, even when used at very low levels typically ranging from 2.5%-15% by weight. Preferably, the fatty acid is a mixture of nonanoic and decanoic acids, whereas the strong acid is selected from the group consisting of orthophosphoric, sulfuric and mixtures thereof.
    Type: Grant
    Filed: October 5, 1993
    Date of Patent: July 19, 1994
    Assignee: West Agro, Inc.
    Inventors: Michael D. McKinzie, Murray W. Winicov