Abstract: The present invention provides a method of producing a composition, suitable for use in pharmaceutical or cosmetic compositions, comprising a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of 0.1 to 30% by weight of an alkyl polyglucoside having the formula C.sub.n H.sub.2n+1 O(C.sub.6 H.sub.10 O.sub.5).sub.x H, in which n is an integer ranging from 8 to 16 and x is the mean polymerization level of the glucoside moiety (C.sub.6 H.sub.10 O.sub.5) and ranges from 1.4 to 1.6, or an ester thereof.

Abstract: The present invention is directed to topical compositions for regulating the oil and/or shiny appearance of mammalian skin which comprise: a) from about 1% to about 10% of an active for regulating the oil and/or shiny appearance of mammalian skin which consists essentially of one or more compounds selected from the group consisting of niacinamide, panthenol, and pantothenic acid; and b) a cosmetically acceptable carrier for the active.

Abstract: Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

Abstract: Compositions which contain an agonist substance of one or a number of receptors associated with a chlorine channel are useful for slackening and/or relaxing cutaneous tissue, and in particular for the purpose of treating wrinkles and fine lines of the skin. Such compositions can be administered topically or by injection. Preferred agonists include glycine, serine, taurine, .beta.-alanine, N-(benzyloxycarbonyl)glycine (Z-glycine), gamma-aminobutyric acid (GABA), isoguvacine, isonipecotic acid, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyrid-3(2H)-one, benzodiazepines, steroids, and barbiturates. The composition can additionally contain a retinoid and/or a hydroxy acid.

Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.

Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

Abstract: A method of using a topically applied skin sensitizer dispersed in a manually applied vehicle which substantially increases tissue sensation. The principal ingredient is benzalkonium chloride in a water soluble gel which includes sorbitol, glycerin, hydroxethylcellulose and propylene glycol.

Abstract: The present invention relates to a dimeric urethane compounds derived from monohydric alcohols, generally fatty alcohols, and a diisocyanate according to the following reaction scheme: ##STR1## wherein R.sub.1 is selected from the group of saturated or halogen substituted linear, cyclic or branch-chained hydrocarbons and R.sub.2 is a linear, cyclic or branch-chained alkyl or aminoalkyl group ranging from two to 200 carbon atoms, preferably two to 50 carbons, more preferably 6 to 36 carbons, said urethane compound being substantially free from terminal hydroxyl groups.

Abstract: Extracts of the plant Commiphora mukul are used as pigmenting agents and melanocyte culture agents, and for the manufacture of cosmetic and pharmaceutical compositions. Particularly preferred are extracts of the formula IIa, designated Commipherol, and abstracts of the formula IIb designated Commipherin.

Abstract: The present invention relates to a mixture of a silicone wax, a silicone fluid and two long chain lactate molecules which is effective in reducing the tacky feel of compositions. The present invention is suitable for use in creams, gels, lotions and salves that are applied to the skin.

Abstract: A method for treating allergic rhinitis in a patient is disclosed which comprises applying an anti-allergic rhinitis effective amount of a steroid in ointment or creme carrier to the lining of the vestibules of the patient.

Abstract: This process for preparing a collagen-based composition, comprises grinding collagen fibers to a particle size of between 10 and 100 microns and mixing them with water in a sufficient quantity to give a gel.

Abstract: Stable, topically applicable cosmetic/dermatological compositions well suited for artificially tanning or browning human skin and appropriately packaged, comprise at least one dihydroxyacetone (DHA) derivative convertible into DHA and, advantageously, at least one active species for effecting such conversion.

Abstract: A fine particulate cross-linked N-vinylamide resin having an average particle size of not more than 10 .mu.m comprising a compound (I) and a compound (II) cross-linked by a cross-linking agent: ##STR1## wherein, R.sup.1 to R.sup..ident. may be the same or different and represent a hydrogen atom, methyl group, or ethyl group, X is a C.sub.2 or C.sub.3 alkylene group, and n is an integer of 2 to 30 and the weight ratio of (I):(II) is 70 to 99.9:30 to 0.1, and the microgel composed thereof.

Abstract: The invention relates to a novel derivative of kojic acid of formula (I) and to its use, in a composition for topical application as a depigmenting and/or bleaching agent for skin: ##STR1## The invention also relates to a process for depigmenting and/or bleaching skin, which includes applying to the skin a composition that contains 5-hydroxy-4-oxo-4H-pyran-2-ylmethyl 2-oxothiazolidine-4-carboxylate of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The freshness of meat, vegetables and fruits in a refrigerator or food storage box can be retained for a long period of time by using (1) a freshness retaining gel composition which comprises a freshness retainer component comprising an isothiocyanic acid compound and an aliphatic carboxylic acid or (2) a freshness retaining gel composition which comprises a freshness retainer component comprising an isothiocyanic acid compound, a nonionic surfactant or a fatty acid ester, and a gelling agent.

Abstract: The invention relates to the use of an ethylenediamine derivative as a substance P antagonist and/or as a local analgesic in, or for the preparation of, a cosmetic or dermatological composition for treating sensitive skin-types. The invention relates in particular to the use of this derivative for preventing and/or combating skin irritations and/or dartres and/or erythema and/or dysaesthesic sensations and/or sensations of inflammation and/or pruritus of the skin and/or the mucous membranes including the eyes. The invention also relates to a composition containing a product having an irritant side effect and this derivative, so as to reduce this irritant effect or even to remove it altogether.

Abstract: Disclosed are anhydrous antiperspirant gel-solid sticks which comprise from about 0.5% to about 60% by weight of antiperspirant active; from about 1% to about 15% by weight of a gellant; from about 1% to about 50% by weight of nonpolar volatile hydrocarbon solvent having a solubility parameter of less than 8 (cal/cm.sup.3).sup.0.5, a vapor pressure of from about 0.0 1 mmHg to about 6 mmHg, and an average boiling point of less than about 250.degree. C.; and from about 0.01% to about 10% by weight of a polar, water-miscible solvent having a solubility parameter of from 12.5 (cal/cm.sup.3).sup.0.5 to about 25 (cal/cm.sup.3).sup.0.5 ; wherein the composition has a visible residue index of from about 11 to about 30 L-value, a product hardness of from about 500 gram.cndot.force to about 5,000 gram.cndot.force, and a ratio of an elastic to viscous moduli of from about 0.1 to about 100.

Abstract: Cosmetic and/or dermatological compositions containing a non-photocatalytic metal oxide and tocopherol and, optionally, a metal-inactivating complexing agent are effective for inhibiting the light-induced peroxidation of lipids, and in particular lipids of sebaceous origin such as squalene.

Abstract: A protective cosmetic particulate gel delivery system for a topically applied active agent employs an agar gel and a restraining polymer to retain the actve agent in the gel. The particles have an average particle diameter of at least 0.05 mm while the restraining polymer has a molecular weight of at least 50,000 daltons and has retention groups to bind the active agent. The restraining polymers can be selected from the group consisting of polyquaternium 24, laurdimonium hydroxyethylcellulose, cocodimonium hydroxyethylcellulose, steardimonium hydroxyethylcellulose, quaternary ammonium substituted water-soluble polysaccharides, alleyl quaternary celluloses and polypeptides having or provided with retention groups to retain the active agent. The gel particles of the invention are manually crushable on the skin to increase the surface area of the gel particle material and expose the restraining polymer to the skin or other body surface for release of the active agent.

Abstract: The invention relates to a gel containing an aqueous phase, a hydrophilic polymer as a gelling agent, a coloring material which is soluble or dispersible in the aqueous phase and at least one organopolysiloxane solubilized in the aqueous phase. This gel is usable in the cosmetics field for making up both the face and the human body.

Abstract: A multiple emulsion to administer at least one water-soluble or liposoluble active ingredient in the form of a water/oil/water emulsion comprising a dispersed phase of a water/oil type and an aqueous dispersion medium which is a gelled aqueous phase useful as cosmetic compositions for external skin application.

Abstract: Cosmetic/pharmaceutical compositions, well suited for the treatment of a variety of mammalian disorders of, for example, the skin, hair and/or mucous membranes, a manifestation of which is an excess in the synthesis and/or in the release of substance P, e.g., for the treatment of cutaneous disorders and sensitive skin, comprise an effective substance P antagonist amount of at least one .beta.-adrenergic agonist, e.g., salbutamol, in a cosmetically/pharmaceutically acceptable medium therefor.

Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.

Abstract: The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across the epithelial monolayer of the mucous membrane. The NO donor compounds include polyalkyleneamine NO donors as well as tertiary and quaternary amino aliphatic NO donor compounds. The compounds and compositions of the invention are useful in any situation in which it is desirable to deliver NO across a mucosal surface. For example, the compounds and compositions of the invention are particularly useful in treating pulmonary hypertension, male impotence, and several other specific conditions.

Abstract: The invention provides a composition for treating seborrheic dermatitis on the scalp, a method for treating seborrheic dermatitis and a method for making the composition of the invention. The composition of the invention, which is not a shampoo and does not contain any soap or detergent for cleaning hair, is a unique scalp medicament blend of ingredients. The composition comprises from about 0.5 to about 2.5 weight percent, based upon the weight of the composition, hydrocortisone; from about 2.5 to about 7.5 weight percent elemental sulfur; and from about 90 to about 97 weight percent of an active vehicle comprising a generally neutral hydrocarbon jelly, such as petrolatum or petroleum jelly, and gelled aqueous carboxypolymethylene.

Abstract: A composition is disclosed which is useful in alleviating, at least in part, symptoms of acne vulgaris, psoriasis or seborrhea, which includes a potassium-based compound a dermatologically acceptable base for the potassium-based compound, which is preferably a potassium salt, and which include potassium acetate, potassium aluminate, potassium arsenite solution, potassium bicarbonate, potassium bisulfate potassium bitartararte, potassium bromide, potassium carbonate, potassium chloride, potassium citrate, potassium gluconate, potassium glycerophosphate, potasium iodate, potassium iodide, potassium manganate, potassium permanganate, potassium phosphate monobasic potassium phosphate dibasic, potassium phosphate tribasic, potassium phosphite or a combination thereof. The composition is topically applied to the areas of a patient's skin which are afflicted with any of acne vulgaris, psoriasis or seborrhea.

Abstract: Disclosed is a composition including a lower alcohol and water in a weight ratio of about 35:65 to 100:0, between at least 0.5% and 8.0% by weight thickener system comprised of at least two emulsifiers, each emulsifier present in at least 0.05% by weight wherein the composition free of auxiliary thickeners has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein each emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The composition is useful as a presurgical scrub replacement, a lotion or other hand preparation.

Abstract: A coating of a liquid, non-stinging, water-based skin treatment composition is applied to skin adjacent a wound and allowed to form a dry film prior to applying a pressure sensitive dressing over the wound. The aqueous composition includes a water dispersible film forming polyester resin and may be formulated with no volatile organic solvents for the resin. The dried film bonds strongly to the pressure sensitive adhesive of the dressing but is relatively easily removed from the skin and thus serves to reduce the force needed to remove the dressing from the skin.

Abstract: Substantially clear gelled compositions suitable for use in cosmetics or pharmaceutical compositions and containing cationic polymer are formed by solvating a reverse phase emulsion of water soluble or water swellable cationic polymer in a liquid hydrophobic ester of a polyol with a polyol mixture which contains propylene glycol and/or butylene glycol together with glycerine in proportions which result in a composition having a clarity of below 30 NTU.

Abstract: The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.

Abstract: The invention discloses a cosmetic product for topical administration in disturbed subcutaneous connective fatty tissue, in particular cellulite, where one or more substance(s) present in the product locally inhibit(s) the formation and/or action of estrogens in the subcutaneous fatty tissue. Suitable substances are, in particular, aromatase inhibitors and/or anti-estrogens. The cosmetic is effective in the cosmetic treatment of cellulite.

Abstract: The present invention comprises methods and compositions for topically treating and moisturizing keratinous structures of humans and animals including skin, hair, fingernails, toenails, hooves, and horns.

Abstract: Various preparations for treating or relieving pain in a patient are disclosed wherein preparations containing caesium ions, preferably in the form of caesium chloride, and preferably also magnesium ions in the form of magnesium sulphate, are administered externally or internally to the patient. In one preferred embodiment a topical preparation is provided which consists of strips of microporous material (A) on each side of a plastics backing layer (B) impregnated with an aqueous solution containing caesium chloride and magnesium sulphate. In an alternative embodiment a cream preparation containing caesium chloride and magnesium sulphate is provided for external application to the patient.

Abstract: The present application relates to a composition, in particular a cosmetic, dermatological, hygiene or pharmaceutical composition, to care for and/or make up the skin, which composition may be in the form of a compact powder or a cast product, comprising a dispersion of polymer particles in a fatty substance. Furthermore, the invention relates to the use of this dispersion in such a composition.

Abstract: Improved aqueous gliadin-containing cosmetic formulations are provided which include form about 0.5-10% by weight gliadin dispersed in an aqueous solvent system together with additional ingredients giving desired end properties. The formulations are preferably selected from the group consisting of hairsprays, hair shampoos and shampoo conditioners, hair styling gels, hair conditioners, instant conditioners, and hair reparatives, as well as sunscreens, shaving creams and bath and shower gels.

Abstract: Stable, recrystallization-resistant dermatological/cosmetic compositions, well suited for preventing/treating oxidative stress of the skin, comprise a substantially ethanol-free aqueous phase, the aqueous phase containing an active amount of solubilized melatonin values and an amount of at least one glycol effective to dissolve such melatonin values.

Abstract: Disclosed are skin smoothing compositions containing hydroxyacids or hydroxyacid derivatives, a polymeric film-forming agent, a physical exfoliant, and a pharmaceutically acceptable carrier. Also disclosed are methods for using the skin smoothing compositions to improve the smoothness of human skin.

Abstract: In a food-like medicine comprising a seamless capsule enclosing effective ingredients and at least one of a gel and a high viscous liquid, the seamless capsule has: a diameter (d) within a range of 0.5-5 mm, a relation of a membrane thickness (.theta.) of the seamless capsule to the diameter (d) being 0.01 d.ltoreq..theta..ltoreq.0.05 d, and a ratio (.rho.) of a major axis to a minor axis of the seamless capsule not more than 1.3.

Abstract: Pharmaceutical gel formulations for topical drug delivery include drug, colloidal silicon dioxide, triacetin and, preferably, propylene glycol. The gel formulations are well suited for topical delivery of the drug 4-amino-2-ethoxymethyl-.alpha.,.alpha.-dimethyl-1H-imidazo?4,5-c!quinoline -1-ethanol, which when applied topically induces cytokines, such as interferon and tumor necrosis factor, locally in the skin or mucous membranes of a mammal. The gel formulations are also well-suited for topical delivery of drugs for treatment of diseases involving skin and/or mucosal lesions because the gel formulations do not need to include irritating components.

Abstract: A wrinkle-care product, an aging-preventive cosmetic and a skin cosmetic each comprising a guanidine derivative of formula (I) or an acid addition salt thereof: ##STR1## wherein R1 represents a hydrogen atom, a lower alkyl group or --(AO).sub.m --(BO).sub.n --D--E ?wherein A and B may be the same or different and each represents an alkylene group having 2 to 8 carbon atoms; D represents a binding hand, --CO--, or an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms; E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an unsubstituted or substituted aryl group; m is a number of from 1 to 6; and n is a number of from 0 to 6!; k is a number of from 1 to 10; and G represents a hydrogen atom, a hydroxyl group, a carboxyl group, a sulfonate group or a phosphate group. These products are excellent in the effects of inhibiting wrinkling and smoothing wrinkles without damaging the physiological conditions of the skin.

Abstract: Nongreasy, nonsticky cosmetic and/or dermatological compositions for topical application to human skin and/or hair, characteristically without imparting a shiny appearance thereto, contain at least one fatty substance and an amount of deformable hollow particulates effective to avoid the greasy and/or sticky feel otherwise attributable to the at least one fatty substance, said deformable hollow particulates comprising a copolymer of vinylidene chloride, acrylonitrile and a (meth)acrylic comonomer and having a particle size ranging from 1 .mu.m to 250 .mu.m.

Abstract: A stable solution, cream, salve, or spray composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the treatment of vaginitis and endometriosis by reducing any of Candida, Actinobacillus actinomycetemcomitans, Pseudomonades, and Porphyromonas gingivalis present in the vagina or the uterus. The preferred concentration ranges are in the range of about 0.005% to about 2.0% of chlorine dioxide, and in the range of about 0.02% to about 3.0% of phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.

Abstract: The inventive compositions contain an oil-in-water and a water-in-oil emulsion, each buffered to a specific pH, so that the difference in pH values of the two emulsions is at least two units. The molecular mixing is minimized by selecting suitable oil and oil phase in a water-in-oil emulsion. The change in pH is further minimized by buffering each emulsion. The particular advantage of the inventive compositions is the ability to separate within a single composition, with minimal intermixing, active compounds which require different pH environments for stability and/or optimum efficacy.

Abstract: Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin conditions using these compounds and compositions. ##STR1## wherein R.sub.4 is (CR.sub.5 R.sub.6 --CR.sub.7 R.sub.8 --X.sub.1).sub.n --CR.sub.9 R.sub.10 --C(.dbd.X.sub.2)X.sub.3 R.sub.11, n is an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, are independently, hydrogen or non-hydrogen substituents; and X, X.sub.1, X.sub.2, X.sub.3, Y and Z are independently, O, NH, or S.

Abstract: Compositions suitable for cosmetic and/or dermatological use which contain a cosmetic and/or dermatological active agent, at least 20% of a fatty phase, a fatty acid ester of a C.sub.5 -C.sub.7 carbohydrate and polyol.

Abstract: Topically applicable dermocosmetic compositions for whitening/depigmenting human skin, comprise a skin-whitening/depigmenting effective amount of at least one melatonin derivative having the structural formula (I): in which R.sub.1 is a lower alkyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, and R.sub.3 is a hydrogen atom or a lower acyl radical, with the proviso that the hydroxyl radical is in the 4-, 6- or 7-position on the indole ring system, or a physiologically acceptable salt, solvate or bioprecursor/prodrug thereof, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, carrier or diluent therefor.

Abstract: The present invention relates to compositions for treating acne and other skin lesions and also to methods of treatment utilizing these compositions. These compositions and methods of treatment employ benzoyl peroxide, a compound for reducing the skin irritation associated therewith, and a topical carrier.

Abstract: A cosmetic composition consisting essentially of (i) a fatty phase, (ii) at least one fatty acid ester of a C.sub.5 -C.sub.7 carbohydrate, and (iii) at least one polyol.

Abstract: A compact solid gel is described containing water, that consists of water in a concentration ranging from 15% to 90%, thermoreversible polysaccharides in a concentration ranging from 0.3% to 4%, humectant compounds in a concentration ranging from 4% to 40%, and powder phase in a concentration ranging from 2% to 35%.