Abstract: A composition for the treatment of skin includes an alpha amino acid, which is most preferably an alpha amino dicarboxylic acid such as aspartic acid or glutamic acid. The composition has a pH in the range of 0.5 to 5. Also disclosed is a method for preparing the compositions wherein the amino acid is first solubilized in a strong acid, and the resultant solution then neutralized with a base to the therapeutic pH range. Also disclosed is a carrier for dermatological compositions comprising a solution of ascorbic acid and mineral salts.

Abstract: Composition comprising an oil phase, an aqueous phase, at least one emulsifier of water-in-oil (W/O) type, at least one emulsifier of oil-in-water (O/W) type, characterized in that the composition is an inverted latex comprising from 20% to 60% by weight, and preferably from 25% to 45% by weight, of a branched or crosslinked anionic polyelectrolyte based on at least one monomer possessing a strongly acidic function, copolymerized either with at least one monomer possessing a weakly acidic function or with at least one neutral monomer. The compositions have cosmetic applications.

Abstract: The present invention relates to gel compositions comprising alkyl amides of tri-basic carboxylic acids and methods of making gel compositions.

Abstract: A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one &agr;-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-&ggr;-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, &agr;-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component.

Abstract: There is described a foamable formulation comprising a foamable carrier and an active ingredient which may be admixed with the carrier or packaged separately and dispersed into the carrier during the foaming process. Alginate gel is a preferred foamable carrier. The foam produced from such a formulation, and a foam sheet produced by drying the foam, also form part of the invention. The formulation, foam and foam sheet are especially useful for medical applications, for example in treating burns. As apparatus to store the components of the formulation and to generate the foam is also described.

Abstract: A skin absorbent cream including the ingredients MSM, urea, propylene glycol and a large molecular medication. This combination of ingredients softens the skin to allow penetration of the medication through the skin and into the underlying blood vessels. The large molecular medication dissolves in the propylene glycol between as low as 25° C. to 150° C. and becomes the transporter through the outer skin layer and into the blood stream.

Abstract: The present invention relates to compositions for sanitizing and moisturizing skin surfaces. Such compositions an effective amount of sanitizing agent to kill or reduce the growth of microorganisms; a lipophilic skin moisturizing agent; an effective amount of a degreasing agent selected from the group consisting of: silicones, wax materials, powders, fluorochemicals and mixtures thereof; optionally a thickener, a humectant, a perfume; and water. The skin sanitizing compositions of the present invention are suitable for use in leave-on or rinse-off products.

Abstract: Compositions and methods of applying the compositions to plants are disclosed. The compositions include a polymer component that releases heat over a range of dropping ambient temperatures beginning at about 32° F. By exhibiting a broad freezing temperature transition range, the compositions, when applied to plants, effectively reduce the threshold temperature at which substantial frost and/or freeze damage to plants will occur.

Abstract: A cosmetic or dermatological composition for treating keratinous material, particularly hair, including a cosmetically or dermatologically acceptable medium containing at least one silicone-grafted polymer with a polysiloxane backbone grafted by non-silicone organic monomers and at least one silicone selected from silicones which comprise at least one optionally quaternary amine function, silicone resins, and silicone gums, is disclosed. Such compositions are particularly suitable for use as rinsable or non-rinsable products for washing and conditioning hair, hair setting, or hair styling.

Abstract: Topically applicable UVA photoprotective cosmetic/dermatological compositions comprise an effective photoprotecting amount of at least one UVA screening agent substituted by at least one optionally neutralized sulfo functional group, and an effective UVA photoprotecting-enhancing amount of at least one otherwise non-UVA photoprotecting iron chelating agent, thereby imparting a synergistic protection factor (PF) effect thereto, in a cosmetically/dermatologically acceptable topical vehicle, carrier or diluent therefor.

Abstract: A water and oil emulsion solid antiperspirant or deodorant composition comprising, by weight of the total composition: 0.1-30% of a silicone elastomer, 0.05-30% of a gellant, 1-25% of an antiperspirant or deodorant active, 1-90% water, and 1-75% oil.

Abstract: A stable emulsion composition is disclosed which comprises: (A) a metal overbased gelled composition, prepared by forming a mixture of (i) a carbonated overbased material in an oleophilic medium, which material contains a metal salt of at least one organic acid material containing at least 8 carbon atoms, and (ii) an alcohol or an alcohol-water mixture; (B) a surfactant; and (C) an aqueous liquid. The stable emulsion composition may further comprise at least one of a solute, a suspended solid or an oxidation inhibitor.

Abstract: A process for the preparation of biologically active silicon compounds by hydrolysis of a precursor which produces a compound which prevents the formation of polymers from the silicon hydrolyzed bonds.

Abstract: The stable multiple emulsion of the X/O/Y type contains at least one X/O phase in which X is an oil-immiscible component and O an oil phase. The X/O phase can contains an active substance, possibly in solid form, for example for medical, cosmetic or technical applications. The Y phase can be an aqueous phase, an aqueous liquid, preferably liquid-crystalline, gel or a W/O/W emulsion and serves as carrier for the at least one X/O phase. The X/O phase is produced using an emulsifier that has an HLB value equal to or less than 6 and/or is a W/O emulsifier. The preparation of the X/O phase itself and its diffusion in the Y phase are done with standard stirring tools. The drops of the X/O phase have long-term stability and, even when greatly diluted, do not interact with the Y phase or the drops or other X/O phases dispersed therein.

Abstract: An improved self-foaming shaving gel is provided which includes water, a water-soluble soap component, and a self-foaming agent, plus a hydrogenated polyisobutene in combination with a fluorosurfactant.

Abstract: Disclosed is a cosmetic soap-gelled solid stick composition, which maintains its shape and aesthetic properties even when stored at high temperatures for long periods of time. The composition includes at least one alcohol (monohydric and/or polyhydric), water, and a soap gelling agent, the alcohol being a solvent for the soap gelling agent, the soap gelling agent being alkali metal (e.g., sodium) salts of fatty acids having C.sub.12 -C.sub.22 carbon chain length. At least 65% by weight, of the total weight of the soap gelling agent, are alkali metal salts of fatty acids having C.sub.20 -C.sub.22 carbon chain length.

Abstract: The use of at least one homogeneous polyholoside in a cleansing and/or makeup remover composition for the skin and/or mucosae and/or eyes, comprising a cosmetically or dermatologically acceptable vehicle is disclosed, as is a composition for cleansing and/or removing makeup from the skin and/or mucosae and/or eyes, which comprises at least one homogeneous polyholoside.

Abstract: The present invention relates to the use of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, and their derivatives ("APC compounds"). More specifically, the present invention relates to use of APC compounds to improve the appearance and health of skin, hair, lips and nails. The present invention also relates to methods of topically administering APC compounds to cleanse skin and remove make-up, moisturize skin, enhance the shine and wear of nail coating compositions, and to improve compositions having pigments and/or iron oxides.

Abstract: A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

Abstract: The present invention relates to preparations alleviating the symptoms caused by drying of the mucous membranes of the body. The preparations contain trimethylglycine as an active agent. The invention also relates to the use of trimethylglycine as an agent alleviating the symptoms of dry mucous membranes in different preparations intended for the body care and hygiene, and to a method of alleviating the symptoms, caused by drying, appearing on the mucous membranes of the body.

Abstract: Cosmetic or pharmaceutical preparations, characterized in that they comprise an effective concentration of hydrophilic starch esterified with one or more n-octenylsuccinate radicals.

Abstract: An O/W/O type multiple emulsion in which an O/W type emulsion is dispersed in the outer phase oil wherein the O/W type emulsion in the inner phase contains water, an oil based ingredient, a surfactant and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-surfactant-oil-water system or N-long chain acyl acidic amino acid monosalt and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-N-long chain acyl acidic amino acid monosalt-oil-water system, said outer phase oil contains organophilic modified clay minerals and an emulsifying agent with a HLB of 7 or lower, and the weight ratio of the O/W type emulsion and the outer phase oil is 2:3-19:1. An O/W/O type multiple emulsion with superior stability over time and good usability.

Abstract: The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity.

Abstract: Sympathetically maintained peripheral neuropathic pain syndromes are relieved by topically applying, to the affected region of a patient suffering from such pain, a pain relieving amount of an aqueous gel comprising clonidine, a water-gelling amount of a pharmaceutically acceptable gelling agent and having a physiologically tolerable pH value. Pain relief was achieved with applied amounts of clonidine in the range of about 2 milligrams per day to about 6 mg per day.

Abstract: Cosmetic compositions in the form of a transparent foaming gel comprising:(i) at least one alkyl ether carboxylic acid with a fatty chain,(ii) at least one diol with a fatty chain, and(iii) water.

Abstract: The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical administration of an opioid analgesic agent, e.g., morphine sulfate, in admixture with a skin- or mucosal-specific penetration enhancer, to produce a localized analgesic effect in inflamed or non-inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of opioid agent, e.g., into the systemic circulation.

Abstract: A stable personal lubricant composition containing at least one water soluble polyhydric alcohol, a water soluble polymer derived from cellulose, tocopherol or a tocopherol derivative, an emulsifier and water.

Abstract: A single phase aqueous gel composition comprising 0.0-50% of a polysaccharide gellant, and 1-30% of an antiperspirant active ingredient solubilized in the aqueous single phase.A water and oil emulsion comprising a gelled aqueous phase comprising a polysaccharide gellant and an antiperspirant active ingredient solubilized in the aqueous single phase; and an oil phase,A method for preparing an emulsion antiperspirant or deodorant composition comprising preparing a first aqueous solution of antiperspirant or deodorant active, preparing a second aqueous solution of polysaccharide gellant, emulsifying the second aqueous solution in an oily phase to form an emulsion, combining the first aqueous solution and the emulsion so that the first and second aqueous solutions form a single homogeneous phase in the emulsion; and pouring the mixture into containers.

Abstract: Vaginal pharmaceutical compositions administrable through the topical route, particularly in the form of foams and creams containing a therapeutically effective amount of rifaximin (Common International Denomination) are useful in the treatment of vaginal infections, particularly bacterial vaginosis.

Abstract: The present invention concerns a formulation for an oral veterinary composition containing a fluoroquinolone antimicrobial agent or a pharmaceutically acceptable salt thereof, and a method of treating a microbial infection in a ruminant. The present veterinary composition, when administered orally to a ruminating animal (e.g., a cow or a feedlot calf), allows the fluoroquinolone to be readily and extensively absorbed from the rumen into the circulating blood and provides an unexpectedly extended duration of therapeutic antimicrobial blood level.

Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.

Abstract: An aerosol preparation which when sprayed forms a sherbet-like solid, which comprises a concentrate containing a lower alcohol having 1 to 3 carbon atoms and a higher alcohol having at least 12 carbon atoms and a propellant containing a liquefied gas. Said aerosol preparation does not require any complicated emulsifying procedure for the production, can contain components labile in water and have a durable cooling effect, and therefore, it is quickly calmative on the pain caused by contusion, sprain, muscular fatigue, etc. and the itch caused by athlete's foot, insect bite, etc.

Abstract: Pesticides for the extermination of terrestrial arthropods are disclosed which comprise formulations of a combination of terpenes in aqueous solutions which may be used together with citral. No resistance to the formulations of the invention has been seen. When used on the scalp or body for lice infestation no extended dwell time is required. The formulations do not have unpleasant odors. The formulations are directed towards providing topical preparations which may be used on the skin, scalp and hairy body parts of humans and animals, sprays for use directly against terrestrial arthropods, a dipping solution for combs and a laundry additive, amongst others.

Abstract: An inhibitor of cholesterol synthesis is used for the treatment, alleviation or prevention of skin disorders.

Abstract: The present invention relates, in general, to methods of treating disorders of the eye, and, in particular, to methods of preventing or treating elevated eye pressure and glaucoma. The invention further relates to compounds and compositions suitable for use in such methods.

Abstract: The use of alkane-1,2-diols for inactivating skin microorganisms by topical application includes 1,2-Octanediol used against the germs that cause acne and dandruff, as well as those that cause mastitis in dairy animals, and its activity strengthened by a synergistic interaction with gels such as glycerol poly(meth)acrylate.

Abstract: A stabilized two-part disinfecting system comprising a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition. The first part contains a non-esterifying acid and an alcohol-containing humectant or antifreeze, while the second part contains a salt of an organic acid and an optional metal chlorite. Methods for making a disinfecting composition by mixing the two-part disinfecting system, as well as for disinfecting substrates by contact therewith, are also disclosed.

Abstract: This invention relates to gelled compositions formed through the introduction of specific solvents to compositions comprising 2,4-O-(3,4-dimethylbenzylidene)-D-sorbitol. Such compositions provide excellent gelling for any number of potential applications, particularly where translucent gels are desired. In general, these compositions are formed by introducing heated solvents to the specific monobenzylidene sorbitol present in its solid form. The monobenzylidene sorbitol is preferably added in very low amounts to the target solvents in order to generate the desired gelling effect. A method of producing such gelled compositions is also provided.

Abstract: Non-greasy topical solutions, emulsion gels or lotions comprising as the active agent a compound of formula I ##STR1## and a lower alkanol, and if desired together with a solubilizing agent or an oil phase such as isopropyl myristate are useful delivery systems.

Abstract: The present application relates to the use, as a cosmetic product, of crosslinked and at least 90% neutralized poly(2-acrylamido-2-methylpropanesulphonic acid) polymers. They generally comprise, distributed randomly:a) from 90 to 99.9% by weight of units of general formula (1) below: ##STR1## in which X.sup.+ denotes a cation or a mixture of cations, not more than 10 mol % of the cations X.sup.+ being able to be protons H.sup.+ ;b) from 0.01 to 10% by weight of crosslinking units derived from at least one monomer having at least two olefinic double bonds; the weight proportions being defined relative to the total weight of the polymer.The present application relates in particular to their use as thickener and/or gelling agent in cosmetic and/or dermatological compositions.

Abstract: A moisturizing composition comprising a trihydric or more water soluble polyhydric alcohol, lecithin and 3-methyl-1,3-butylene glycol, wherein lecithin:the trihydric or more water soluble polyhydric alcohol+3-methyl-1,3-butylene glycol=1:1,000 to 1:1 (weight ratio) and the trihydric or more water soluble polyhydric alcohol:3-methyl-1,3-butylene glycol=1:10 to 20:1 (weight ratio), various bases containing the moisturizing composition, and a cosmetic or external preparation containing the moisturizing composition. The moisturizing composition, bases, and cosmetic and external preparation are excellent in moisturizing properties, and have good stability.

Abstract: The invention relates to fly attractant compositions that comprise at least one volatile short chain carboxylic acid, at least one organic sulfide and at least one nitrogen heterocycle. In a preferred embodiment the composition additionally comprises at least one ammonia-releasing compound. In a particularly preferred example, the composition is preparable by combining, for example, the carboxylic acid, the organic sulfide and the nitrogen heterocycle. The invention also relates to an insect trap comprising a means for retaining flies and an insect attractant composition of this invention. The trap is useful in commercial, residential and livestock facilities.

Abstract: The present invention relates to the use of at least one thermal spring water from the Vichy basin as substance P antagonist in a cosmetic composition or for the preparation of a pharmaceutical composition. The invention also relates to the use of at least one thermal spring water from the Vichy basin in a cosmetic composition or for the preparation of a pharmaceutical composition, more especially a dermatological composition, intended for treating disorders associated with excessive synthesis and/or release of substance P.

Abstract: Topically applicable UVA photoprotective cosmetic/dermatological compositions comprise an effective photoprotecting amount of at least one UVA screening agent substituted by at least one optionally neutralized sulfo functional group, and an effective UVA photoprotecting-enhancing amount of at least one otherwise non-UVA photoprotecting iron chelating agent, thereby imparting a synergistic protection factor (PF) effect thereto, in a cosmetically/dermatologically acceptable topical vehicle, carrier or diluent therefor.

Abstract: A composition and delivery system are disclosed that will allow feverfew to be administered to a person in form in which an active ingredient of feverfew, particularly parthenolide can be readily and quickly assimilated by the person's body, particularly the central nervous system, and the therapeutic effects of the feverfew be rapidly imparted to the person. Feverfew is administered in the form of aqueous nasal spray composition, to provide therapeutic moisturization of nasal mucous membranes, relief of migraine headaches and antispasmodic effect, such as to relieve menstrual cramping or aid digestion. The effect is enhanced when the composition also contains nanoclustered resonant water. Vitamins, vitamin derivatives, surfactants, wetting agents, preservatives and emulsifiers may also be present.

Abstract: Cosmetic and/or dermatological compositions containing a non-photocatalytic metal oxide and tocopherol and, optionally, a metal-inactivating complexing agent are effective for inhibiting the light-induced peroxidation of lipids, and in particular lipids of sebaceous origin such as squalene.

Abstract: The invention relates to the use of aminoalcohol derivatives containing a urea functional group corresponding to the following formula: ##STR1## in which: R.sub.1 represents a linear or branched, saturated or unsaturated alkyl radical having from 8 to 22 carbon atoms;R.sub.2 represents a hydrogen atom or a linear or branched, saturated alkyl radical having from 1 to 6 carbon atoms;R.sub.3 represents a linear or branched, monohydroxylated or polyhydroxylated, saturated alkyl group having from 1 to 10 carbon atoms, in and for the preparation of cosmetic or dermatological compositions. These compounds are used in particular as moisturizing agents in care products for the skin or as conditioning agents in hair products.

Abstract: The present invention discloses high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent the desired tooth surfaces is preferably used in combination with the sustained release dental composition. The sustained release dental compositions include a high carboxypolymethylene concentration which results in very high viscosity. The high level of carboxypolymethylene makes dilution of the dental compositions from saliva difficult and time consuming so that the compositions stay within the tray reservoirs, thereby providing sustained release. The concentrated carboxypolymethylene adds a unique tackiness to the dental composition which helps retain and seal the soft tray material against the patient's teeth.

Abstract: The present invention relates to a mixture of a silicone wax, a silicone fluid and two long chain lactate molecules which is effective in reducing the tacky feel of compositions. The present invention is suitable for use in creams, gels, lotions and salves that are applied to the skin.

Abstract: A viscous gel for delivering minor effective homeopathic amount of zinc or another metal to the nasal membrane.