Abstract: A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolytic agent, preferably urokinase, tPA, hirudin, or most preferably, ancrod. In the most preferred embodiment, the matrix is extremely thin and is polymerized in situ to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase, tPA, hirudin, or ancrod is effective in preventing surgical adhesions.

Abstract: The present invention is directed to methods that can be used in the treatment of wounds, burns, and photodamaged skin. Methods can be used for both humans and animals and involve the administration of compositions containing selegiline and/or desmethylselegiline.

Abstract: A sheet for whitening cosmetics comprises a sheet-like substrate and an adhesive layer which comprises a wet pressure-sensitive adhesive composition formed on the substrate. The whitening component includes vitamin C or its derivatives such as magnesium L-ascorbyl-2-phosphate, vitamin E nicotinate, kojic acid, hydroquinone, ellagic acid, albumin, galenical extracts, and rice bran extracts. Kojic acid and magnesium L-ascorbyl-2-phosphate are preferred. By contacting the adhesive layer with water and/or a hydrophilic medium such as alcohols, e.g., methanol, ethanol, etc., the wet pressure-sensitive adhesive composition exhibits excellent stickiness and excellent applicability to skin as well as excellent whitening effect with alleviating or eliminating stains, freckles, non-transparency, etc. on the skin.

Abstract: The present invention relates generally to the development of pharmaceutical compositions which provide for sustained release of biologically active polypeptides. More specifically, the invention relates to the use of pH/thermosensitive biodegradable hydrogels, consisting of a A-B di block or A-B-A tri block copolymer of poly(d,l- or l-lactic acid) (PLA) or poly(lactide-co-glycolide) (PLGA) (block A) and polyethylene glycol (PEG) (block B), with ionizable functional groups on one or both ends of the polymer chains, for the sustained delivery of biologically active agents.

Abstract: A method for preparing a gel composition, such as alginate gel beads, using a proper concentration of calcium pantothenate or calcium ascorbate as a gelling agent.

Abstract: The present invention relates to the use in cosmetics of rigid gels containing at least 20% by weight of one or more water-soluble or hydrophilic gelling agent(s) which may be obtained from the said water-soluble or hydrophilic gelling agent in the presence of water by mixing, blending, compression and extrusion in a twin-screw extruder. These gels constitute novel pharmaceutical forms for cosmetic or dermatological use. These gels are generally in the form of sticks, pencils or cakes. They may be aqueous with a matrix consisting of an aqueous gelled network. They may be in anhydrous form with a matrix consisting of a dehydrated gelled network. They may constitute many products in solid form applied to making up, to care of and/or to treatment of the skin, the scalp, the hair or the mucous membranes, or alternatively applied to the hygiene of the body, the skin, the scalp, the hair or the mucous membranes.

Abstract: Particles of a substantially water insoluble biologically active substance, such as Cyclosporin, are loaded with a charged glyceryl ester as an electrostatic stabilizer which imparts to the particles a zeta potential and having an active substance:stabilizer weight ratio of 1:1 to 400:1 and an average particle diameter of 1 nanometer to 10 micrometers. Compositions having such particles are found to be useful delivery systems.

Abstract: A selected thickener-rheology modifier system comprising the combination of a hydrophobically, modified alkali-soluble thickener and a polysaccharide hydrocolloid or gum or polyalkylene glycol, preferably with a surfactant and more preferably with boric acid is especially useful in personal care compositions such as hair care and skin care compositions.

Abstract: The present invention relates to methods for treating protozoan infections comprising administering to a subject suffering from protozoan infection, a bacteriocidal/permeability-inducing (BPI) protein product.

Abstract: A deodorant composition with active antibacterial constituents comprising on a weight basis the plant extracts of Myrtus from about 2% to about 8%, Laurus nobilis, from about 1% to 5% Drosera extract from about 1% to 7%, Myrrhis resin from about 3% to about 6%, and water 74% to 93%. Preferably, the composition is free of alcohol and aluminum.

Abstract: The invention relates to the use, for coating keratin substances, of a crosslinked hybrid polymer material which can be obtained from an aqueous solution containing: (a) at least one water-soluble polymer containing at least functional groups capable of forming hydrogen bonds, and (b) at least one organic or inorganic salt, of ammonium or of a monovalent or polyvalent metal cation; and by physical crosslinking of the said polymer resulting from hydrogen interactions between the functional groups of the said polymer and the water molecules in the hydration sphere of the said hydrated cation, for the preparation of cosmetic or dermatological compositions. The invention relates more particularly to the use of the said coating agent for make-up products, in particular foundations, lipsticks, mascaras, eyeliners and care bases for the nails; for hair formulations, in particular styling products and/or products for holding the hair, or alternatively for skincare products.

Abstract: The present invention relates to a method for obtaining improved photostability of a sunscreen composition that contains at least two sunscreen active ingredients, which are photo-unstable when formulated together, by microencapsulating at least one of said active ingredients in an encapsulating material suitable for holding the encapsulated active ingredient material, thus reducing or preventing its leaching out of the capsules; and adding other acceptable components and additives needed for the preparation of said composition. The sunscreen active ingredients can be selected from UVA and UVB absorbers, preferably a combination thereof. In a preferred embodiment of the present invention said active ingredients are encapsulated in separate sol-gel microcapsules.

Abstract: The mastitis control teat dip composition of the invention provides rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The compositions of the invention are made by combining an aqueous thickened liquid composition containing the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite. The materials can be combined, blended into a smooth viscous material and can be immediately contacted with the target animals. The .compositions of the invention provide rapid initial kill, consistent long term kill and chemical and rheological stability.

Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Abstract: A bandage for treating a bacterial infection of skin is disclosed wherein the bandage contains a composition produced by the method of obtaining an effective amount of at least one lytic enzyme genetically coded for by a specific bacteriophage specific for a bacteria infecting the skin, wherein the bacteria to be treated is selected from the group consisting of Staphylococcus, Pseudomonas, Streptococcus, and combinations thereof. This lytic enzyme is specific for and has the ability to digest a cell wall of one of the bacteria and is coded for by the same bacteriophage capable of infecting the bacteria being digested. The enzyme produced is mixed with a topical carrier.

Abstract: The present invention relates to a cosmetic composition comprising (i) a compound selected from the group consisting of creatine, carnitine, and pyruvic acid, and a cosmetically acceptable salt or ester thereof, (ii) a nutrient, and (iii) a skin-conditioning agent selected from the group consisting of an emollient and a humectant.

Abstract: Cosmetic compositions comprising at least one film-forming polymer, in a cosmetically acceptable medium, wherein said at least one film-forming polymer has, at the polymer concentration of the composition, a mechanical profile, measured in an aqueous-alcoholic medium comprising 20% by volume of ethanol, defined by at least: (i) an attachment angle &agr; of greater than 47°, and (ii) if &agr; is greater than or equal to 90°, a maximum detachment force Fmax<5 newtons.

Abstract: The present invention relates to sustained-release formulations using biodegradable alginate delayed gels or particles and methods thereof.

Abstract: Cosmetic compositions comprising, in a cosmetically acceptable medium: (1) at least one film-forming polymer (A), wherein a film obtained by drying a mixture of said polymer (A) with ethanol or water, at room temperature and at a relative humidity of 50%, has a mechanical profile defined by at least: (i) a degree of elongation at break (&egr;r) of greater than or equal to 300%; (ii) a recovery at 300 seconds (R300) of greater than or equal to 45%; and (iii) if the recovery at 300 seconds (R300) is from 45% to 60%, then the elongation at break is less than or equal to 1300%; and (2) at least one crosslinked thickening polymer (B) comprising at least one (meth)acrylic acid monomeric, wherein said at least one polymer (B) is present in the composition in an amount ranging from at least 0.6% by weight, relative to the total weight of the composition.

Abstract: A local anesthetic for external use is prepared by blending a) an active ingredient selected from lidocaine, prilocaine, and pharmaceutically acceptable salts thereof; b) a percutaneous absorption accelerator, c) ethanol and/or isopropyl alcohol, and d) water, such that the blending ratio of ethanol and/or isopropyl alcohol to water is 0.5 to 1.2 by weight, and the pH is 6.0 to 8.5.

Abstract: The present invention relates to a novel pharmaceutical formulation for the topical application of drugs, particularly non-steroidal anti-inflammatory drugs (NSAID's), comprising a therapeutically effective amount of a drug, sodium phosphate buffer, and, optionally, an alcoholic solvent. It has been found that by the addition of sodium phosphate buffer to such formulations, the permeation of the NSAID can be significantly improved.

Abstract: A method for modifying the surface properties of tissue in vivo is described. The method comprises forming a liquid crystalline matrix on the tissue surface by contacting the surface with a composition comprising a poly(hydroxy substituted amino acid). Compositions comprising a poly(hydroxy substituted amino acid) and synovial fluid are also provided.

Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Abstract: A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Abstract: A moisturizing composition comprising a trihydric or more water soluble polyhydric alcohol, lecithin and 3-methyl-1,3-butylene glycol, wherein lecithin: the trihydric or more water soluble polyhydric alcohol+3-methyl-1,3-butylene glycol=1:1,000 to 1:1 (weight ratio) and the trihydric or more water soluble polyhydric alcohol:3-methyl-1,3-butylene glycol=1:10 to 20:1 (weight ratio), various bases containing the moisturizing composition, and a cosmetic or external preparation containing the moisturizing composition. The moisturizing composition, bases, and cosmetic and external preparation are excellent in moisturizing properties, and have good stability.

Abstract: Formulations have been developed for regional delivery of drugs, for example, into a cavity such as the pelvic region, peritoneal region, or directly on organs of interest. Regional delivery increases comfort and bioavailability of the drug, resulting in rapid and relatively high blood levels in the regions to be treated in the substantial absence of side effects due to the high levels required for efficacy following systemic delivery. In the preferred embodiment, these formulations consist of drug micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or polymeric carrier. The excipient or polymer may be used to manipulate release rates and to increase adhesion to the affected region. The drug formulation can be applied as a dried powder, a liquid suspension or dispersion, or as a topical ointment, creme, lotion, foam or suppository.

Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.

Abstract: This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

Abstract: The present invention relates to a method of exfoliating and moisturizing the skin comprising the steps of topically applying a cosmetic or pharmaceutical composition. The composition comprises an amino sugar, N-acetyl-D-glucosamine and related compounds.

Abstract: This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Abstract: This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

Abstract: Disclosed is a gel sheet for cosmetics, comprising a sheet-like substrate having laminated thereon a hydrous gel sheet, in which the substrate comprises a gel non-impregnating layer and a gel impregnating layer and wherein said hydrous gel layer is provided on the gel non-impregnating layer. In a preferred embodiment, the gel sheet for cosmetics is produced by laminating a hydrous gel layer comprising polyacrylic acid or its salts, water, glycerin, etc. on a substrate comprising a transparent film laminated on a fiber layer, for example, polyethylene film/pulp (paper), polyester film/rayon unwoven fabric, or the like, heating the resulting composite at room temperature or higher temperatures for aging. The gel sheet for cosmetics is excellent in a feeling upon application, interlocking with the substrate, but not causes strike through. The gel sheet in a preferred embodiment gives an impression of transparency and is unattractive when it is applied to the skin.

Abstract: The invention relates to non-emulsion, topical gel compositions which comprise an aliphatic polyhydric alcohol, an alkali salt of a fatty acid ester, a carbohydrate-based or cholesterol-based surfactant/emulsifier, or combination thereof, water, and substantially no oil.

Abstract: There is disclosed a method for producing a system for delivering a drug for the treatment of a condition, comprising immobilizing a drug or other agent in a bio-compatible matrix containing at least one receptor for a physiological substance which will be in the environment of the matrix when administered, said receptor being anchored within the matrix but remaining biologically active being activated in response to the levels of said physiological substance to effect a conformational change in the matrix allowing mobilization and release of the drug only into the environment.

Abstract: A flavonoid-containing sunscreen composition having UV absorbency at 282 nm in water contains at least one flavanone and at least one flavone, the flavanone providing 75 to 98% of the UV absorbency at 282 nm and the flavone providing 2 to 25% of the absorbency at 282 nm. The composition is formed of flavonoids extracted from citrus fruit using water, and separating the extracted flavonoids using a sorbent material, and then recovering the flavonoids from the sorbent material using a solvent.

Abstract: A topical skin protectant formulation containing a barrier cream and a active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Abstract: This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.

Abstract: The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon administration to the eye. The present invention also discloses methods of topical ophthalmic administration of the compositions of the eye.

Abstract: The present invention teaches liquid sunscreen compositions in which level of surfactant is higher than level at which the sunscreen component(s) are still soluble in the surfactant in which they are used; and which comprise minimal levels of cationic polymer. Combination of cationic polymer (especially preferred surfactants and at minimum levels) and minimal levels of sunscreen lead to compositions with minimal levels of deposition and minimal SPF. Further, the compositions also maintain good lather.

Abstract: This invention relates to hydrolytically degradable gels of crosslinked poly(ethylene) glycol (PEG) structures. Addition of water causes these crosslinked structures to swell and become hydrogels. The hydrogels can be prepared by reacting two different PEG derivatives containing functional moieties at the chain ends that react with each other to form new covalent linkages between polymer chains. The PEG derivatives are chosen to provide covalent linkages within the crosslinked structure that are hydrolytically degradable. Hydrolytic degradation can provide for dissolution of the gel components and for controlled release of trapped molecules, including drugs. Reagents other than PEG can be avoided. The hydrolysis rates can be controlled by varying atoms adjacent to the hydrolytically degradable functional groups to provide substantially precise control for drug delivery in vivo.

Abstract: This invention relates to a novel synergistic reversible solid/semi-solid organic composition, said composition comprising (a) at least one saturated long chain fatty acid and/or its glycerol esters and (b) one or more liquid neutral organic compounds, said ingredients (a) and (b) being present in a ratio between 0.1 to 40% by weight, and a process for producing said synergistic reversible solid/semi-solid organic composition by mixing the ingredients (a) and (b) defmed above in a ratio between 0.1 to 40% by weight, at a temperature between 2 to 50° C. and at a pressure in the range of 200 torr to 2500 torr.

Abstract: Pomegranate extracts and methods of use thereof are provided. Particularly, an antioxidative composition comprising an extract from pomegranate is provided. A method of reducing lipid peroxidation, aggregation or retention, HDL oxidation in a sample and a method of alleviating atherosclerosis in a patient are also provided.

Abstract: A cosmetic, dermatological, hygiene and/or pharmaceutical composition comprising a hydrophilic component and a fatty phase which comprises at least one volatile compound and at least one pasty fatty compound. The composition is, in particular, a composition having improved staying power. The use of the combination of a volatile compound and a pasty fatty compound to limit the transfer and/or migration of such a cosmetic, dermatological, hygiene and/or pharmaceutical composition comprising a hydrophilic compound.

Abstract: The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and optionally solubilizers, triglycerides, and neutralizing agents. The invention further relates to a method of preparing such compositions by providing a composition of an ionizable hydrophobic therapeutic agent, an ionizing agent, and a surfactant, and neutralizing a portion of the ionizing agent with a neutralizing agent. The compositions of the invention are particularly suitable for use in oral dosage forms.

Abstract: Cosmetic compositions and methods are provided for revitalizing the skin especially where it is placed in an environment that can cause injury to the skin. The compositions contain an effective amount of cromolyn compounds to provide a prophylactic or repairing effect.

Abstract: A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

Abstract: A dermatologically-compatible composition comprising a hydrophilic gel which comprises a blend of a chitosan and a hydrophilic poly(N-vinyl lactam) having a K value of less than 60.

Abstract: Agrochemical granulated material which is dispersible in water and contains a mixture that is liquid, gel-like, or waxy at +25° C., comprising at least one agrochemical active ingredient and at least one surface-active compound and a thickening agent, and optionally having an outer coating, characterized in that the granulated material has plastic behavior at +25° C.