Capsule (e.g., Gelatin, Etc.) Patents (Class 514/962)
  • Patent number: 8968872
    Abstract: Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: March 3, 2015
    Assignee: DSM Nutritional Products AG
    Inventor: Nianxi Yan
  • Patent number: 8877239
    Abstract: Nutritional supplement formulations suitable for specific enhancement of cell and mitochondrial function comprise enriched formulations of phospholipids and chemical precursors containing specifically identified concentrations of phosphatidylglycerol, phosphatidic acid and phosphatidylcholine, and mitochondrial and cell membrane phospholipid molecules as well as other desirable constituents. Methods of enriching extracted sources of cell and mitochondrial membrane molecules and precursors from microbes, plants and other sources are also set forth. The formulae can be combined with nutritional, prebiotic, and probiotic (microbial) factors that increase bioavailability through the digestive tract and increase absorption at the cellular and subcellular levels. These lipid combinations can be used to treat mitochondrial disorders associated with medical pathologies, chronic illnesses and syndromes, or to maintain lipid balance for normal mitochondrial function, and can be administered in many different forms.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: November 4, 2014
    Assignee: Nutritional Therapeutics, Inc.
    Inventors: Robert Settineri, James F. Palmer
  • Patent number: 8815916
    Abstract: The present invention relates to pharmaceutical formulations comprising at least one acid-labile proton pump inhibiting agent and at least one antacid, which have improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, safety, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to, a gastrointestinal disorder or disease in a subject in need thereof.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: August 26, 2014
    Assignee: Santarus, Inc.
    Inventors: Kay Olmstead, Warren Hall, Gerald T. Proehl
  • Patent number: 8557294
    Abstract: The present invention relates to novel coating compositions for application to solid dosage forms such as tablets or caplets, solid dosage forms coated with the composition, and methods of preparing said coating compositions.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: October 15, 2013
    Assignee: Capsugel Belgium NV
    Inventors: Robert Anthony Scott, Dominique Cade, Frederic Hoehn, Ewart Thomas Cole
  • Patent number: 8535695
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: September 17, 2013
    Assignee: Chiasma Inc.
    Inventors: Paul Salama, Roni Mamluk, Karen Marom, Irina Weinstein, Moshe Tzabari
  • Patent number: 8263119
    Abstract: The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or lanthanum hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The capsules of the present invention dissolve at a similar rate before and after storage. The oral pharmaceutical capsules of the present invention can be administered to treat a patient at risk for or suffering from hyperphosphatemia, at risk for or suffering from chronic kidney disease (CKD), at risk for or suffering from soft tissue calcification associated with CKD, or at risk for or suffering from secondary hyperparathyroidism.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: September 11, 2012
    Assignee: Shire LLC
    Inventor: Roger Withington
  • Patent number: 8236345
    Abstract: A pharmaceutical composition, comprising a thiazolidinedione, such as Compound (I), metformin hydrochloride and a pharmaceutically acceptable carrier, wherein the thiazolidinedione and metformin hydrochloride are each dispersed within its own pharmaceutically acceptable carrier in the pharmaceutical composition and the use of such a composition in medicine.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: August 7, 2012
    Assignee: SmithKline Beecham Limited
    Inventors: Karen Lewis, Nicola Jayne Lilliott, Donald Colin MacKenzie
  • Patent number: 8088403
    Abstract: The present invention relates to a method for preparing microcapsules by coacervation, and to the use of transglutaminase for cross-linking in complex coacervation. The present invention relates further to coacervation processes in general in which a material to be encapsulated is added to a solution comprising at least one colloid below the gelling temperature of the colloid. According to a method of the present invention, an emulsion or suspension of hydrophobic material is prepared after cooling a solution that includes hydrocolloids below the critical gelling temperature of a coacervate phase.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: January 3, 2012
    Assignee: Firmenich SA
    Inventors: Grégory Dardelle, Valéry Normand
  • Patent number: 8034450
    Abstract: Described herein are microcapsules and emulsions prepared from low Bloom gelatin and methods of making and using thereof.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: October 11, 2011
    Assignee: Ocean Nutrition Canada Limited
    Inventors: Jonathan Michael Curtis, Wei Zhang, Yulai Jin, Colin James Barrow
  • Patent number: 7727629
    Abstract: Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: June 1, 2010
    Assignee: Ocean Nutrition Canada Limited
    Inventor: Nianxi Yan
  • Patent number: 7566704
    Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble ?-glucan composition comprising ?-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: July 28, 2009
    Assignee: Biopolymer Engineering, Inc.
    Inventors: Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff
  • Patent number: 7323452
    Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 29, 2008
    Assignee: Wardan, L.L.C.
    Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
  • Patent number: 7265151
    Abstract: Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder and social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder and panic attacks.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: September 4, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Connie Sanchez, Sandra Hogg
  • Patent number: 7264824
    Abstract: Oral dosage form for food and food supplement as well as dietetics comprising polyunsaturated acids in a xylose-hardened gelatine capsule with a retarded release time.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: September 4, 2007
    Assignee: Meduna Arzneimittel GmbH
    Inventor: Friedel Frauendorfer
  • Patent number: 7189412
    Abstract: A novel fenofibrate-containing composition having equivalent bioavailability, when compared to conventional capsules, is effective in reducing the size of the conventional capsule preparations. The fenofibrate-containing composition comprises the following formula: (a) fenofibrate 100 parts by weight, (b) a solid surfactant 3 to 4 parts by weight, (c) lactose 1 to 2 parts by weight, and (d) magnesium stearate 1 to 2 parts by weight, in admixture with a binder and a disintegrator, wherein the sum of said binder and said disintegrator is 17 to 20 parts by weight, and the fenofibrate and the solid surfactant are co-micronizates.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: March 13, 2007
    Assignee: ASKA Pharmaceutical Co., Ltd.
    Inventor: Masaru Okamoto
  • Patent number: 7144585
    Abstract: Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: December 5, 2006
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Tadashi Mukai, Yuso Tomohira, Masafumi Toda, Keigo Yamada, Yoshikazu Oka
  • Patent number: 7128933
    Abstract: An orally ingestible composition for the treatment of external personal odors can include about 35% w/w to about 50% w/w of the essential oil of lavender, about 1% w/w to about 10% w/w of the essential oil of rosemary, about 1% w/w to about 10% w/w of the essential oil of sage, and sufficient carrier medium to make up to 100% by weight.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: October 31, 2006
    Inventors: Mitchell Kurk, Odilza Vital
  • Patent number: 7060263
    Abstract: An improved soft gelatin formulation and process methodology that increases single Coenzyme Q10 molecules presented to the absorption channels of the small intestines by providing medium chain triglycerides, Vitamin E and natural beta carotene to Coenzyme Q10 in a soft gel capsule to increase the absorption thereof.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: June 13, 2006
    Inventors: Ronald G. Udell, Siva P. Hari
  • Patent number: 7041316
    Abstract: The present invention relates to new stable enteric coated pharmaceutical dosage forms for oral use containing Omeprazole or Lansoprazole, to a formulation and a method for the manufacture of such a dosage forms, and to a method of gastric acid pump inhibition and providing gastrointestinal cytoprotective benefit by using them.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: May 9, 2006
    Assignee: Sage Pharmaceuticals, Inc.
    Inventor: Jivn-Ren Chen
  • Patent number: 7022685
    Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble ?-glucan composition comprising ?-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: April 4, 2006
    Assignee: Biopolymer Engineering, Inc.
    Inventors: Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff
  • Patent number: 6998421
    Abstract: The present invention comprises a group of related lipid molecules, and methods for their use, that maybe used to treat inflammation and certain inflammation related diseases. The group of related lipid molecules are capable of inhibiting certain enzyme systems including phospholipase A2, and cyclooxygenase-2. The group of related lipid molecules of the invention may be characterized by specific structural characteristics, or by specific biological activity, including inhibition of the previously listed enzymes.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: February 14, 2006
    Assignee: Biozone Laboratories, Inc.
    Inventor: Brian Keller
  • Patent number: 6967026
    Abstract: A hard capsule which is made mainly of a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer in the presence of polyvinyl alcohol and/or a derivative thereof. Unlike conventional hard capsules, this hard capsule can be filled with a solvent (e.g., polyethylene glycol) for a sparingly soluble drug ingredient.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: November 22, 2005
    Assignees: Nisshin Kasel Co., Ltd., Daido Chemical Corporation
    Inventors: Noboru Hoshi, Toshio Shimamoto, Shigeru Sugiyama
  • Patent number: 6964958
    Abstract: Schizophrenia and bipolar disorders with mania may be treated by imidazenil or other benzodiazepine-3-carboxamide derviatives.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: November 15, 2005
    Inventors: James Auta, Erminio Costa, John M. Davis, Alessandro Guidotti, Patricia Tueting
  • Patent number: 6960613
    Abstract: Use of escitalopram (the S-(+)-enantiomer of citalopram) or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment of neurotic disorders is provided, including anxiety states, in particular generalised anxiety disorder and social anxiety disorder, post traumatic stress disorder, obsessive compulsive disorder and panic attacks.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: November 1, 2005
    Assignee: H. Lundbeck A/S
    Inventors: Connie Sanchez, Sandra Hogg
  • Patent number: 6893658
    Abstract: An object of the present invention is to provide soft capsule formulations of active vitamins D, well-suited to practical production with easy discrimination of active ingredient levels, in which stability of the active vitamins D3 to light and heat is ensured, and which material is highly safe to the human body. According to the present invention, soft capsule formulations of active vitamins D3 can be obtained-wherein the capsule shell contains a white pigment and yellow iron oxide and/or red iron oxide, or titanium oxide and caramel, or yellow iron oxide.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: May 17, 2005
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshimitsu Iida, Yutaka Ogawa
  • Patent number: 6855733
    Abstract: A soft gelatine capsule formulation for improved manufacturing of Coenzyme Q10, comprising Coenzyme Q10 in a thixatropic gelatine carrier capable of admixing without heating with Coenzyme Q10, and capable of keeping Coenzyme Q10 in suspension at ambient temperature.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: February 15, 2005
    Assignee: Soft Gel Technologies, Inc.
    Inventors: Ronald G. Udell, Yousry M. A. Naguib, Siva P. Hari
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Patent number: 6827930
    Abstract: A sport fishing system having: a rod and reel, including fishing line; at least one fishing lure or natural bait; and a controlled released fish attractant for applying to the fishing lure or natural bait. The system may further include an applicator for applying the controlled released fish attractant to the fishing lure or natural bait. In the preferred embodiment, the controlled release fish attractant includes: an attractant and a substantially hydrophobic, film forming release agent.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: December 7, 2004
    Assignee: Carolina Lunker Sauce, L.L.C.
    Inventors: Stephen Russell Cobb, Michael D. Jacobson, Joseph A. Lupia
  • Patent number: 6790495
    Abstract: The invention relates to a method for manufacturing a starch-containing shape body and a homogenised, starch-containing mass and shape bodies manufactured therefrom. The method is carried out in a manner such that the value of the limiting viscosity index of the mass manufactured therewith is at least 40 ml/g. Such a valve of the limiting viscosity index ensures an elongation at rupture of the extruded material of at least 150%, by which means soft capsules with a one-part capsule casing may be manufactured with the rotary die process.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: September 14, 2004
    Assignee: Peter Greither
    Inventors: Ivan Tomka, Dieter Engel, Erich Brocker, Rico Ménard
  • Patent number: 6726927
    Abstract: The present invention relates to new stable enteric coated pharmaceutical dosage forms for oral use containing Omeprazole or Lansoprazole, to a formulation and a method for the manufacture of such a dosage forms, and to a method of gastric acid pump inhibition and providing gastrointestinal cytoprotective benefit by using them.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: April 27, 2004
    Assignee: Sage Pharmaceuticals, Inc.
    Inventor: Jivn-Ren Chen
  • Patent number: 6723339
    Abstract: The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol present is present in less than 12% of the total weight of the composition absent the hard gelatine capsule.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: April 20, 2004
    Assignee: Novartis AG
    Inventors: Armin Meinzer, Barbara Haeberlin
  • Patent number: 6710083
    Abstract: A method of treating palmar and plantar fibromatosis is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a patient of an initial dosage of a composition comprising 13-cis-retinoic acid for an initial treatment period, and thereafter administering a maintenance dosage of the composition.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: March 23, 2004
    Inventor: L. Dean Parks
  • Patent number: 6706281
    Abstract: A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: March 16, 2004
    Assignee: Euro-Celtique, S.A.
    Inventors: Benjamin Oshlack, Mark Chasin, Hua-Pin Huang
  • Patent number: 6696584
    Abstract: Compositions and methods of using conjugated linoleic acid preparations enriched for the t10,c12 and c9,t11 isomers are disclosed. It is found that preparations of conjugated linoleic acid containing a ratio of t10,c12 to c9,t11 of about greater than 1.2:1 are desirable for a wide variety of nutritional, therapeutic and pharmacologic uses.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: February 24, 2004
    Assignee: Natural ASA
    Inventors: Daria Jerome, Carl Skarie
  • Patent number: 6653339
    Abstract: The present invention is directed to a a method for the treatment of irritable bowel syndrome comprising the multiple daily pulse dosing of an immediate release formulation of the anti-muscarinic darifenacin. Dosing two or three times a day is particularly preferred.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: November 25, 2003
    Assignee: Pfizer Inc.
    Inventors: Peter James Dunn, Michael John Humphrey, Paul Quinn
  • Patent number: 6623734
    Abstract: A new soft gelatine formulation and process methodology is disclosed herein that increases single Coenzyme Q10 molecules presented to the absorption channels of the small intestines by providing medium chain triglycerides, Vitamin E, and natural beta carotene to Coenzyme Q10 in a soft gel capsule to increase the absorption thereof.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: September 23, 2003
    Assignee: Soft Gel Technologies, Inc.
    Inventors: Ronald G. Udell, Siva P. Hari
  • Patent number: 6610673
    Abstract: A swallowable, solid dose form composition for treating upper gastrointestinal tract distress containing bismuth subsalicylate, carbonate or bicarbonate salt, disintegrating agent, anionic or nonionic surfactant, and microcrystalline cellulose is described.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: August 26, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Francis Bernard Chapura, Daniel Louis Barone, Michael Gerard Colacino
  • Patent number: 6592844
    Abstract: A process is described for preparing microspheres, films and coatings from protein or modified protein in which the protein product is stabilized by carrying out the preparation in the presence of an aqueous solution of at least one &agr;-hydroxy acid. The microspheres, films and coatings so produced have improved stability in aqueous solution.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: July 15, 2003
    Assignees: Chiron Corporation, University of Nottingham
    Inventors: Allan G. A. Coombes, Wu Lin, Derek T. O'Hagen, Stanley S. Davis
  • Patent number: 6569460
    Abstract: A novel oral dosage to be delivered to the stomach comprising a safe and effective amount of an active ingredient selected from the group consisting of emepronium bromidebromide, doxycycline, and other tetracyclines/antibiotics, iron preparations, quinidine, nonsteroidal anti-inflammatory drugs, alprenolol, ascorbic acid, captopril, theophylline, zidovoudine (AZT), bisphosphonates and mixtures thereof and pharmaceutically-acceptable excipients, wherein said oral dosage form is a generally oval form and film coated to facilitate rapid esophageal transit and avoid irritation in the mouth, buccal cavity, pharynx, and esophagus.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: May 27, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Richard John Dansereau, Petrus Jakobus Bekker
  • Patent number: 6569452
    Abstract: An oral pharmaceutical formulation, which comprises, in a hydroxypropylmethylcellulose capsule, a camptothecin analogue dispersed or solubilized in a semi-solid matrix of a polyethyleneglycol with a molecular weight ranging from 400 to 20000.
    Type: Grant
    Filed: June 20, 2001
    Date of Patent: May 27, 2003
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Paola Civaroli, Lorena Muggetti, Alessandro Martini
  • Patent number: 6555581
    Abstract: The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized pharmaceutical compositions that include pharmaceutically active ingredients such as levothyroxine (T4) sodium and liothyronine (T3) sodium (thyroid hormone drugs), preferably in an immediate release solid dosage form. Also provided are methods for making and using such immediate release and stabilized compositions.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: April 29, 2003
    Assignee: Jones Pharma, Inc.
    Inventors: G. Andrew Franz, Elaine A. Strauss, Philip A. DiMenna, Rocco L. Gemma
  • Patent number: 6544533
    Abstract: 10-Hydroxy-2-decenoic acid compounds, particularly the 10-hydroxydec-2-enoates, are well suited for promoting desquamation of human skin and/or stimulating epidermal renewal and thus combating intrinsic and/or extrinsic cutaneous aging.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: April 8, 2003
    Assignee: Societe L'Oreal S.A.
    Inventors: Lionel Breton, Nathalie Pineau, Emile Benechie, Martine Li, Françoise Picot, Pierre Potier
  • Patent number: 6509035
    Abstract: A coenzyme A oral preparation, a producing method and a use for treating hyperlipemia thereof are disclosed. The coenzyme A oral preparation of the present invention is tablet, capsule, powder, granule or microcapsule, which is consisted of coenzyme A, an antioxidant, an acidic buffer or acidifier and one or more pharmaceutically acceptable excipient(s).
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: January 21, 2003
    Assignee: Shanghai Materia Medica Bioengineering Institute
    Inventors: Genfu Ren, Guijun Fei
  • Patent number: 6495596
    Abstract: The present invention comprises a group of related lipid molecules, and methods for their use, that maybe used to treat inflammation and certain inflammation related diseases. The group of related lipid molecules are capable of inhibiting certain enzyme systems including phospholipase A2, and cyclooxygenase-2. The group of related lipid molecules of the invention may be characterized by specific structural characteristics, or by specific biological activity, including inhibition of the previously listed enzymes.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 17, 2002
    Assignee: Biozibe Laboratories, Inc.
    Inventor: Brian Keller
  • Patent number: 6475519
    Abstract: The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value of at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol, if present, is present in less than 12% of the total weight of the composition absent the hard gelatine capsule.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: November 5, 2002
    Assignee: Novartis AG
    Inventors: Armin Meinzer, Barbara Haeberlin
  • Patent number: 6468559
    Abstract: Oral dosage forms are provided for the administration of a bisphosphonic acid compound in the prevention and treatment of conditions involving calcium or phosphate metabolism, i.e., conditions associated with bone resorption such as osteoporosis, Paget's disease, periprosthetic bone loss, osteolysis, malignant hypercalcemia, metastatic bone disease, multiple myeloma, and periodontal disease. The dosage forms are either enterically coated capsules housing the drug in a liquid or semi-solid carrier, or enterically coated osmotically activated drug delivery devices.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: October 22, 2002
    Assignee: Lipocine, Inc.
    Inventors: Feng-Jing Chen, Mahesh V. Patel
  • Patent number: 6468509
    Abstract: The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: October 22, 2002
    Assignee: Sol-Gel Technologies Ltd.
    Inventors: Noa Lapidot, Shlomo Magdassi, David Avnir, Claudio Rottman, Orit Gans, Alon Seri-Levy
  • Patent number: 6465018
    Abstract: A dietary supplement is provided that comprises creatine combined with ginseng and astragalus and, optionally, glutamine. The dietary supplement enhances the general energy boost and muscular strength increase achieved from the consumption of creatine alone, while also increasing immune function.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: October 15, 2002
    Inventor: B. David Tuttle
  • Patent number: 6413494
    Abstract: A colonic drug delivery composition contains a first polysaccharide and a second polysaccharide wherein both polysaccharide are degradable by colonic enzymes and are mixed at a environmental pH of about 7 or above, without use of a cross-linking agent. A colon selective pharmaceutical composition and dosage form for oral delivery of a drug, diagnostic reagent, or mixture thereof includes the drug, diagnostic reagent, or mixture thereof in contact with the polysaccharide composition. A method of preparing such a colonic drug delivery composition and the colon selective pharmaceutical composition and dosage from are also disclosed.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: July 2, 2002
    Assignee: Samyang Corporation
    Inventors: Seung Seo Lee, Chang Baeg Lim, Chaul Min Pai, Sujung Lee, In Park, Moon Gun Seo, Heenam Park
  • Patent number: 6410050
    Abstract: The present invention provides a cellulose capsule comprising the steps of: i) preparing a mixed solution of pectin and glycerin, ii) adding said mixed solution to solubilized cellulose aqueous solution, iii) adding a small amount of glacial acetic acid, calcium gluconate, sucrose fatty acid ester to said mixture, and iv) standing by adjusting viscosity and forming a capsule.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: June 25, 2002
    Assignee: Suheung Capsule Co., Ltd.
    Inventor: Joo Hwan Yang