Capsule (e.g., Gelatin, Etc.) Patents (Class 514/962)
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Patent number: 5466461Abstract: New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.Type: GrantFiled: April 2, 1992Date of Patent: November 14, 1995Assignee: Fidia, S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 5460824Abstract: A tamper-resistant, caplet like medicament that masks the taste of poor tasting drugs and possesses an improved lubricity for easier swallowing is produced by shrinking a gelatin-based capsule about a caplet-shaped tablet of the medicament at specific temperatures, pressure and relative humidity.Type: GrantFiled: June 27, 1990Date of Patent: October 24, 1995Assignee: Warner-Lambert CompanyInventors: Jean C. LeBrun, Jackie L. Massey
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Patent number: 5461042Abstract: The present invention provides an improved compositions and methods for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). The improved means of regulating immune response can be utilized in treating infectious diseases and immune diseases such as diabetes and chronic fatigue syndrome, both diseases now considered to be immune response related syndromes.Type: GrantFiled: January 3, 1994Date of Patent: October 24, 1995Inventor: Roger M. Loria
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Patent number: 5456916Abstract: The present invention provides a resin molding composition for preventing gnawing damage by the animal, a microcapsule filled with a capsaicine compound, and a process for producing the capsaicine compound and the microcapsule.Type: GrantFiled: February 22, 1994Date of Patent: October 10, 1995Assignee: Nippon Kayaku Kabushiki KaishaInventors: Mitsuo Kurata, Yasuhiro Ichikawa, Mika Toya, Iwao Takahashi, Yoshinobu Okui, Shoichi Kato, Takeshi Nishitani
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Patent number: 5453368Abstract: A method for encapsulating a biological substance is biocompatible microcapsules is disclosed, said method comprising:a) maintaining a coating-forming liquid film sheet comprising a solution of a soluble organic polymer in an organic solvent,b) causing droplets comprising biological substance is an aqueous medium to pass through said sheet to form microcapsules comprising cores of said droplets coated by said liquid film, andc) permitting said microcapsules to pass through said sheet so that a portion of said polymer precipitates in the presence of water in said droplets while evaporating a portion of said solvent to form a continuous permeable polymer coating of sufficient structural that said microcapsules are self-supporting.Type: GrantFiled: August 27, 1993Date of Patent: September 26, 1995Assignee: Brown University Research FoundationInventors: Patrick A. Tresco, John F. Mills
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Patent number: 5431917Abstract: A hard capsule for pharmaceutical drugs comprises a water-soluble cellulose derivative as a capsule base, a gelatinizing agent and an auxiliary for gelation. The hard capsule is prepared by preparing an aqueous solution of a capsule base containing a water-soluble cellulose derivative, a gelatinizing agent and an auxiliary for gelation, immersing a capsule molding pin in the aqueous solution of the capsule base, subsequently drawing out the molding pin from the aqueous solution of the capsule base, subjecting the aqueous solution of the capsule base attached to the outer surface of the molding pin to gelate at room temperature, and forming a capsule film on the outer surface of the molding pin.Type: GrantFiled: September 1, 1993Date of Patent: July 11, 1995Assignee: Japan Elanco Company, Ltd.Inventors: Taizo Yamamoto, Kenji Abe, Seinosuke Matsuura
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Patent number: 5419916Abstract: There are disclosed herein a gelatin coating composition which comprises succinated gelatin as the main component and polyethylene glycol, and a hard gelatin capsule formed from said gelatin coating composition. The hard gelatin capsule has sufficient mechanical strength for filling operation. Moreover, it does not become insoluble due to reaction with a special drug having an aldehyde group filled therein. Therefore, it can be used for various drugs, especially macrolide antibiotics for which conventional hard gelatin capsules are inadequate.Type: GrantFiled: July 22, 1993Date of Patent: May 30, 1995Assignee: Japan Elanco Company, LimitedInventors: Taizo Yamamoto, Masato Kobayashi, Seinosuke Matsuura
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Patent number: 5384128Abstract: This invention provides a method and compositions for increasing the permeability of epithelial cells to a chloride ion in a subject comprising administering a permeability enhancing amount of a composition comprising a nontoxic, nonionic surfactant having (1) a critical micelle concentration of less than about 10 mM and a hydrophile-lipophile balance number of from about 10 to 20 and (2) a suitable hydrophobic organic group joined by a linkage to a suitable hydrophilic polyol.Type: GrantFiled: March 2, 1993Date of Patent: January 24, 1995Assignee: University of Alabama Research FoundationInventors: Elias Meezan, Rongxiang Wang
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Patent number: 5382435Abstract: A pharmaceutical composition comprising a shaped enteric material having distributed therethrough preferably substantially uniformly, pharmaceutical loaded particles, said particles having a size no greater than about 10 microns in any dimension and being alkali insoluble and the method of delivering pharmaceuticals to Peyer's glands.Type: GrantFiled: March 24, 1993Date of Patent: January 17, 1995Assignee: Southwest Research InstituteInventors: Richard S. Geary, Herman W. Schlameus
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Patent number: 5376381Abstract: A pharmaceutical dosage form comprising gelatin encapsulating a pharmaceutical composition wherein said composition is at least about 6% (weight %) ethanol and lipid wherein said lipid comprises at least about 60% (weight %) and a method of protecting gelatin from deterioration is disclosed.Type: GrantFiled: January 29, 1991Date of Patent: December 27, 1994Assignee: The Liposome Company, Inc.Inventors: Alan L. Weiner, Joel B. Portnoff, Elaine Chan
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Patent number: 5364646Abstract: Pharmaceutical forms of pimobendan for oral administration comprising citric acid, whereby a constant, satisfactory resorption is ensured even when there are major pH fluctuations in the gastrointestinal tract.Type: GrantFiled: March 16, 1993Date of Patent: November 15, 1994Assignee: Dr. Karl Thomae GmbHInventors: Peter Gruber, Willy Roth, Gottfried Schepky
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Patent number: 5342626Abstract: The present invention relates to a polymer composition comprised of gellan, carrageenan and mannan gums and a process for producing flexible films for encapsulation comprising the gellan, carrageenan and mannan gum composition. The mannan gums include the galactomannans and the glucomannans. Advantageously, soft capsules of the above composition are produced using the novel process. The composition comprises a blend of a gellan gum: (carrageenan/mannan gum) wherein the gellan gum concentration ranges from about 0.1 to 50 weight percent and the ratio of carrageenan/locust bean gum ranges from 3:1 to 1:3. Additional reagents are added to this gum blend to form a film-forming polymer composition useful in the production of gelatin-free capsules or microcapsules.Type: GrantFiled: April 27, 1993Date of Patent: August 30, 1994Assignee: Merck & Co., Inc.Inventors: Philip E. Winston, Jr., Frank J. Miskiel, Raymond C. Valli
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Patent number: 5334374Abstract: Pharmaceutical compositions suitable for administration by inhalation and containing pentamidine, or pharmaceutically acceptable salt thereof, in powder form. Such compositions include pressurized aerosol compositions and nonpressurized power compositions. Also described is finely divided powdered pentamidine with a mass median diameter in the range 0.01 to 10 microns and a method for the prevention or treatment of pneumo-cystis carinii pneumonia which comprises administration by inhalation to a patient having or susceptible to that condition of a therapeutically effective quantity of pentamidine, or a pharmaceutically acceptable salt thereof, in powder form.Type: GrantFiled: November 3, 1992Date of Patent: August 2, 1994Assignee: Fisons plcInventors: Philip S. Hartley, John Stevens
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Patent number: 5320841Abstract: Oral pharmaceutical compositions containing high content anthocyanosides, preferably higher than 80% w/w, suspended in fractionated coconut oil have higher bioavailability than water solutions or suspensions in other lipophilic carriers.Type: GrantFiled: May 3, 1993Date of Patent: June 14, 1994Assignee: IdB Holding S.p.A.Inventors: Robert Seghizzi, Bruno Gabetta, Paolo Morazzoni
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Patent number: 5318798Abstract: When a powdered extract of Kampo medicine is encapsulated as such in hard capsules, the pharmaceutical effects of the Kampo medicine cannot be fully achieved, since the dissolution of the content of the hard capsules requires a long period of time. Therefore, the present invention aims at providing Kampo medicine hard capsules having good dissolution properties.The present invention provides a process for producing Kampo medicine hard capsules which comprises compacting Kampo medicine extract powder, mixing magnesium stearate with the compacted Kampo medicine extract powder and filing the mixture into gelatin hard capsules.It is preferable that the weight ratio of the magnesium stearate to the Kampo medicine powdered extract ranges from 0.5/100 to 3/100. Furthermore, it is preferable that said Kampo medicine is selected from Oren-gedoku-to, Sho-saiko-to, Ninjin-to, San'o-shashin-to, Mao-bushi-saishin-to, Anchu-san, Keishi-bukuryo-gan, Byakko-ka-ninjin-to, Shakuyaku-kanzo-to and Sairei-to.Type: GrantFiled: September 8, 1992Date of Patent: June 7, 1994Assignee: Tsumura & Co.Inventors: Toshihiro Uchida, Shin'ichiro Konishi, Takayoshi Kimura
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Patent number: 5304381Abstract: A polyprenyl compound having formula (1) is stabilized by a tocopherol, an organic acid, a neutral amino acid or a basic amino acid: ##STR1## in which n is an integer of 1 to 3.Type: GrantFiled: March 2, 1990Date of Patent: April 19, 1994Assignee: Eisai Co., Ltd.Inventors: Keizo Uesugi, Nobutaka Noda, Michiru Tanaka, Masanori Kayano
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Patent number: 5286751Abstract: Sustained and enhanced antipyretic response is elicited in a mammalian organism in need of such treatment, i.e., a mammal suffering from elevated body temperature (fever), by administering thereto a unit dosage sustainedly enhancing, antipyretically effective amount of the free acid S(+) flurbiprofen enantiomer, said enantiomer being substantially free of its R(-) flurbiprofen antipode.Type: GrantFiled: May 18, 1990Date of Patent: February 15, 1994Assignee: Analgesic AssociatesInventors: Abraham Sunshine, Eugene M. Laska
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Patent number: 5281420Abstract: The subject invention relates to compositions in dosage form comprising a solid dispersion which is a solidified melt mixture consisting essentially of the following components:(a) from about 15% to about 75% of tebufelone;(b) from about 25% to about 65% of a poloxamer surfactant having a melting point of about 40.degree. C. or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 daltons to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50% to about 90% of the copolymer; and(c) from 0% to about 60% of other components, wherein the other components are miscible with a melt mixture of components (a) and (b).Type: GrantFiled: May 19, 1992Date of Patent: January 25, 1994Assignee: The Procter & Gamble CompanyInventors: Gary R. Kelm, Douglas J. Dobrozsi
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Patent number: 5270054Abstract: A cosmetic product is provided that stores a cosmetic composition in a capsule having a spheroidal body with hollow chamber forming a major portion of the capsule, a tab forming a minor portion of the capsule, and a neck section connecting the tab with the spheroidal body. At least two wings are positioned along opposite sides of the spheroidal body perpendicularly extending outward therefrom. Upon twisting, the neck can be broken to allow release of cosmetic composition from within the chamber.Type: GrantFiled: September 3, 1992Date of Patent: December 14, 1993Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.Inventor: Peter Bertolini
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Patent number: 5213811Abstract: Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.Type: GrantFiled: September 13, 1991Date of Patent: May 25, 1993Assignee: Sterling Drug Inc.Inventors: Steven E. Frisbee, Gregg Stetsko, Margaret A. Lawton
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Patent number: 5211954Abstract: This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia.Type: GrantFiled: April 30, 1992Date of Patent: May 18, 1993Assignee: Sandoz Ltd.Inventor: William R. Sterling
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Patent number: 5209978Abstract: A soft capsule composed of a plurality of cells coalesced to each other and filling substances encapsulated in the individual cells, the wall of at least one of the cells being formed of a material different from a material forming the wall of at least one of the other cells, and said capsule being seamless.Type: GrantFiled: October 10, 1991Date of Patent: May 11, 1993Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Tadashi Kosaka, Kazuki Omata, Tatsuo Hashimoto, Teruaki Yamazaki, Kazuo Hayashi, Tomiya Hosoi, Kenichi Ikuta
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Patent number: 5204113Abstract: Pharmaceutical compositions suitable for administration by inhalation and containing pentamidine, or pharmaceutically acceptable salt thereof, in powder form. Such compositions include pressurized aerosol compositions and non-pressurized powder compositions. Also described is finely divided powdered pentamidine with a mass median diameter in the range 0.01 to 10 microns and a method for the prevention or treatment of pneumacystics carinii pneumonia which comprises administration by inhalation to a patient having or susceptible to that condition of a therapeutically effective quantity of pentamidine, or a pharmaceutically acceptable salt thereof, in powder form.Type: GrantFiled: February 14, 1991Date of Patent: April 20, 1993Assignee: Fisons plcInventors: Philip S. Hartley, John Stevens
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Patent number: 5204111Abstract: A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C., lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M. The alginate capsules are employed in cosmetic compositions.Type: GrantFiled: January 28, 1992Date of Patent: April 20, 1993Assignee: L'OrealInventors: Rose-Marie Handjani, Myriam Kauffmann, Frederic Huguenin
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Patent number: 5178852Abstract: The invention relates to cosmetic and pharmaceutical compositions containing the derivatives of benzylidenecamphor of formula: ##STR1## where R.sub.1 denotes H, OH, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.8 alkoxy, R.sub.3 denotes OH, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.8 alkoxy, or else when R.sub.1 denotes H or OH, R.sub.3 can represent C.sub.1 -C.sub.8 alkyl, R.sub.2 and R.sub.4 denote H or OH, at least one of the radicals R.sub.2 and R.sub.4 representing OH.The compounds (I) are wide-band sunscreens and antioxidants, and are utilized in the treatment of cutaneous inflammations and allergies.Type: GrantFiled: March 29, 1990Date of Patent: January 12, 1993Assignee: L'OrealInventors: Serge Forestier, Alain Lagrange, Gerard Lang, Andre Deflandre, Bernadette Luppi
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Patent number: 5178877Abstract: A pharmaceutical composition comprising a solution of a tenin inhibitor of the formula: ##STR1## wherein R.sub.1 is 4-piperazinyl, 1-methyl-4-piperazinyl, 1-methyl-1-oxo-4-piperazinyl, 2-oxo-4-piperazinyl, 4-morpholinyl, 4-thiomorpholinyl or 1-methyl-4-homopiperazinyl;R.sub.2 is benzyl, p-methoxybenzyl, 2-phenylethyl, 1-naphthylmethyl or 2-naphthylmethyl;R.sub.3 is 4-thiazolyl, 2-amino-4-thiazolyl, 2-thiazolyl, 5-thiazolyl, 1-pyrazolyl, 3-pyrazolyl, 1-imidazolyl, n-propyl, isopropyl, CH.sub.3 S-- or CH.sub.3 SCH.sub.2 --;R.sub.4 is loweralkyl or cyclopropyl;R.sub.5 is hydrogen or loweralkyl; andX is CH.sub.2 or NH; or a pharmaceutically acceptable salt, ester or prodrug thereof in a pharmaceutically acceptable solvent, said solution being encapsulated in a soft elastic gelatin capsule.Type: GrantFiled: July 29, 1991Date of Patent: January 12, 1993Assignee: Abbott LaboratoriesInventors: Kevin G. Garren, Madhu K. Vadnere, John J. Wieland, Mary J. Leveque
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Patent number: 5177208Abstract: A method for preventing the sickling of sickle cells in a patient having sickle cell disease, the method which comprises administering to the patient a therapeutically effective amount of a compound having the formula: ##STR1## wherein X.sup.- is selected from the group consisting of iodide, chloride, bromide, hydroxyl, nitrite, phosphate and acetate.Type: GrantFiled: January 13, 1992Date of Patent: January 5, 1993Inventor: Michael Wilburn
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Patent number: 5169638Abstract: A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20.degree. C. and excipients.Type: GrantFiled: October 23, 1991Date of Patent: December 8, 1992Assignee: E. R. Squibb & Sons, Inc.Inventors: Andrew Dennis, Peter Timmins, Kevin Lee
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Patent number: 5167963Abstract: 8,10-Dideazatetrahydrofolic acid derivatives of the formula: ##STR1## where R.sub.1 and R.sub.2 are selected from hydrogen and alkyl having from one to about eight carbon atoms and the carboxylates and acid addition salts thereof, showing strong inhibition of L1210 murine leukemia cells in culture, modest inhibition of glycinamide ribotide transformylase and aminoimidazole carboxamide ribotide transferase, and insignificant inhibition of dihydrofolate reductase and thymidylate synthase enzymes.Type: GrantFiled: July 27, 1990Date of Patent: December 1, 1992Assignees: SRI International, Sloan-Kettering Institute for Cancer ResearchInventors: Joseph I. DeGraw, William T. Colwell, Francis M. Sirotnak
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Patent number: 5139783Abstract: A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C. lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M.The alginate capsules are employed in cosmetic compositions.Type: GrantFiled: April 9, 1990Date of Patent: August 18, 1992Assignee: L'OrealInventors: Rose-Marie Handjani, Myriam Kauffmann, Frederic Huguenin
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Patent number: 5133974Abstract: An extended release pharmaceutical formulation adapted to approach zero order release of drug over a 12 to at least 24 hour period, comprised of a mixture of 0 to aobut 50% of an immediate release particle containing a drug, inert substrate and binder, coated with talc and up to 100% of an extended release particle comprising the immediate release particle coated with a dissolution modifying system containing plasticizers and a film forming agent.Type: GrantFiled: January 24, 1990Date of Patent: July 28, 1992Assignee: KV Pharmaceutical CompanyInventors: George N. Paradissis, James A. Garegnani, Roy S. Whaley
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Patent number: 5128144Abstract: Pressing having sustained release of active compound for the oral or parenteral administration of medicaments, which contains at least one solid pharmaceutical active compound, polylactic acid and a homo- or copolymer of D(-)-3-hydroxybutyric acid and processes for its production.Type: GrantFiled: September 25, 1990Date of Patent: July 7, 1992Assignee: PCD Polymere Gesellschaft m.b.H.Inventors: Brigitta Korsatko-Wabnegg, Werner Korsatko
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Patent number: 5122384Abstract: A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance.Type: GrantFiled: May 5, 1989Date of Patent: June 16, 1992Assignee: KV Pharmaceutical CompanyInventors: George N. Paradissis, James A. Garegnani, Roy S. Whaley
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Patent number: 5122598Abstract: New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.Type: GrantFiled: May 12, 1989Date of Patent: June 16, 1992Assignee: Fidia S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 5108754Abstract: A method for preventing the sickling of sickle cells in a patient having sickle cell disease, the method which comprises administering to the patient a therapeutically effective amount of a compound having the formula: ##STR1## wherein X.sup.- is selected from the group consisting of iodide, chloride, bromide, hydroxyl, nitrite, phosphate and acetate.Type: GrantFiled: February 8, 1991Date of Patent: April 28, 1992Inventor: Michael Wilburn
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Patent number: 5082661Abstract: A cosmetic product is disclosed in the form of a gelatin walled capsule encompassing a cosmetic composition that includes a carrier which is a silicone polymer and an antioxidant. The antioxidant operates to inhibit degradation of the gelatin wall to prevent malodors from being generated. Retinoic acid derivatives such as retinyl palmitate are especially effective as antioxidants.Type: GrantFiled: September 26, 1990Date of Patent: January 21, 1992Assignee: Elizabeth Arden Co., Division of Conopco, Inc.Inventors: Joseph Melnik, Michael C. Cheney, Anthony Vargas
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Patent number: 5037698Abstract: Capsules containing a hygroscopic or deliquescent component are stabilized by a) forming a mixture of the hydrogscopic or deliquescent compound with a sufficient quantity of water to achieve an equilibrium, b) adding a thickening agent and c) heating the solution or suspension; and introducing the heated composition so formed into the capsule. Preferably an equilibrium-protecting agent, such as glycerin, is also added.Type: GrantFiled: January 19, 1988Date of Patent: August 6, 1991Assignee: Lilly Industries LimitedInventor: Francois Brunel
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Patent number: 5032572Abstract: Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of H, (except that R.sub.1 and R.sub.2 are not both H), Cl, Br, I, NO.sub.2, NH.sub.2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO.sub.3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.Type: GrantFiled: August 12, 1988Date of Patent: July 16, 1991Assignees: Medical College of Ohio, Bowling Green State UniversityInventors: Murray Saffran, Douglas C. Neckers
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Patent number: 5030632Abstract: This invention relates to a hard gelatin capsule containing no more than 5 to 10 milligrams of crystalline temazepam and its use in the treatment of transient insomnia.Type: GrantFiled: August 17, 1990Date of Patent: July 9, 1991Assignee: Sandoz Pharm. Corp.Inventor: William R. Sterling
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Patent number: 5013473Abstract: The use of frangible microcapsules in cleansing creams and cold creams and other cosmetic products improves their cleansing, cleaning, and removal properties without damage to the skin.Type: GrantFiled: February 25, 1988Date of Patent: May 7, 1991Assignee: Minnesota Mining and Manufacturing CompanyInventors: Robert J. Norbury, Robert W. H. Chang, Lowell C. Zeller
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Patent number: 5010061Abstract: The instant invention relates to guar flour formulations, to be ingested, wherein the formulations contain natural guar flour having a particle size diameter or 50 .mu.m to 1500 .mu.m and neither containing nor having been treated with any additive which substantially affects its form or consistency or which substantially delays or reduces the swelling ability of the flour.Type: GrantFiled: August 6, 1990Date of Patent: April 23, 1991Inventors: Ulrich Speck, Panayiotis Roumeliotis
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Patent number: 4981695Abstract: The present invention relates to a multiple-unit-dose comprising L-dopa as pharmaceutically active compound, whereby the composition provides a release of L-dopa in accordance with a test in accordance with U.S. Pharmacopeia Standards in an artificial gastric juice having a pH of at most 1.2 of at most 20% by weight during 1 hr, and in a phosphate buffer according to the same standard a release of at least 35% by weight during 1 hr, and at least 80% by weight during 3 hrs.Type: GrantFiled: July 12, 1989Date of Patent: January 1, 1991Assignee: Lejus Medical AktiebolagInventors: Curt H. Appelgren, Eva C. Eskilsson
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Patent number: 4980375Abstract: Onset-hastened and enhanced antipyretic response is elicited in a mammalian organism in need of such treatment, i.e., a mammal suffering from elevated body temperature (fever), by administering thereto a unit dosage onset-hastening/enhancing antipyretically effective amount of the S(+) ibuprofen enantiomer, said enantiomer being substantially free of its R(-) ibuprofen antipode.Type: GrantFiled: May 25, 1989Date of Patent: December 25, 1990Assignee: Sterling Drug Inc.Inventors: Abraham Sunshine, Eugene M. Laska
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Patent number: 4962124Abstract: Onset-hastened and enhanced antipyretic response is elicited in a human mammal in need of such treatment, i.e., a human mammal suffering from elevated body temperature (fever), by administering thereto a unit dosage onset-hastening/enhancing antipyretically effective amount of the S(+) ketoprofen enantiomer, said enantiomer being substantially free of its R(-) ketoprofen antipode.Type: GrantFiled: August 25, 1989Date of Patent: October 9, 1990Assignee: Analgesic AssociatesInventors: Abraham Sunshine, Eugene M. Laska
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Patent number: 4954346Abstract: A solid dosage form having a fill composition encased in a shell composition; the fill composition comprising(a) 5-60 mg of nifedipine;(b) a 5-7 membered cyclic pharmaceutically acceptable ingestible carbonate of the formula ##STR1## where A is an alpha,omega-C.sub.2 -C.sub.4 alkylene which is unsubstituted or substituted by at least one C.sub.1 -C.sub.4 alkyl; and(c) a pharmaceutically acceptable ingestible surfactant having a total of d ring members and being of the formula ##STR2## wherein B is a C.sub.1-4 -alpha,omega-alkylene;n is an integer from 0 up to d-1;m is an integer from 0 up to (d-n-1);each R is independently H or a C.sub.1-4 alkyl which is unsubstituted or substituted by at least one R';each R' is independently a hydroxy which is free, etherified by R.sup.2, or esterified by R.sup.3 ;each R.sup.2 is a C.sub.2-4 straight or branched oxyalkylene or a poly (C.sub.2-4 straight or branched oxyalkylene), the terminal oxygen of which is bound to hydrogen or R.sup.3 ; and each R.sup.Type: GrantFiled: June 8, 1988Date of Patent: September 4, 1990Assignee: Ciba-Geigy CorporationInventors: Gregory Sparta, Christopher Pelloni, Deborah Winkel
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Patent number: 4948591Abstract: A soft capsular preparation comprising a polyethylene glycol solution of sodium picosulfate. The soft capsular preparation is stable over a prolonged storage time and is convenient to carry around. In addition, an exact dosage of the medicine can be administered.Type: GrantFiled: April 28, 1989Date of Patent: August 14, 1990Assignee: Tokai Capsule Co., Ltd.Inventor: Tohru Yamada
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Patent number: 4931284Abstract: The invention relates to a completely novel type of micro-capsules, viz. such capsules where an encapsulated hydrophobic or lipophilic substance is surrounded by polar solid crystals of polar lipids which expose their hydrophilic face outwards and their hydrophobic face turned inwards towards the hydrophobic or lipophilic substance. These micro-capsules can be utilized to encapsulate for instance tacky substances or substances to be protected against oxidation or influence from light. Moreover, an especially interesting use according to the invention is the use of said micro-capsules in an ointment base, where the active ingredient is well protected within said capsules up to the use but which at the application on the skin directly comes into contact with the skin surface as a consequence of the crystalline structure of the shell.Type: GrantFiled: June 29, 1987Date of Patent: June 5, 1990Assignee: Biogram ABInventors: Bo M. Ekman, Kare V. Larsson, Ake R. Lindahl, Ulf S. E. Rothman
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Patent number: 4927854Abstract: Sustained and enhanced analgesic response is elicited in a mammalian organism in need of such treatment, i.e., a mammal suffering pain, by administering thereto a unit dosage sustainedly enhancing, analgesically effective amount of the free acid S(+) flurbiprofen enantiomer, said enantiomer being substantially free of its R(-) flurbiprofen antipode.Type: GrantFiled: July 21, 1989Date of Patent: May 22, 1990Assignee: Analgesic AssociatesInventors: Abraham Sunshine, Eugene M. Laska
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Patent number: 4927638Abstract: A solution of etoposide in dimethylisosorbide is disclosed. The solution is useful for filling gelatin capsules and may also be formulated into parenteral dosage forms.Type: GrantFiled: September 12, 1988Date of Patent: May 22, 1990Assignee: Bristol-Myers CompanyInventors: Gururaj Bykadi, Murray A. Kaplan, Richard G. Corrao, Edward J. Bara, Ismat Ullah, Shreeram N. Agharkar
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Patent number: 4913901Abstract: An orally administrable and stable solution containing as an active ingredient Methoxasalen (8-methoxyfuro-[3',-2':6,7]-coumarin) of the formula ##STR1## useful in the photochemotherapy of psoriasis, to a process for the preparation thereof and to a process for the use thereof.Type: GrantFiled: March 28, 1984Date of Patent: April 3, 1990Inventor: Ludwig H. Schlager