Rectal Patents (Class 514/966)
  • Patent number: 8952057
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 10, 2015
    Assignee: JR Chem, LLC
    Inventor: José E. Ramirez
  • Patent number: 8748476
    Abstract: The invention provides the use of darifenacin, or a pharmaceutically acceptable derivative thereof, in the manufacture of a medicament for the reduction of urgency in patients suffering from overactive bladder.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: June 10, 2014
    Assignee: Warner Chilcott Company, LLC
    Inventors: Enrico Colli, Paul Quinn, Dzelal Serdarevic, Larence Howard Skillern
  • Patent number: 8388996
    Abstract: A method is provided for manufacturing a medicated tampon assembly having a tampon body, the method including applying a formulation including a therapeutic agent to a substrate to produce a plurality of dosage forms; separating one of the dosage forms from the substrate; and coupling one of the dosage forms to the tampon body. A medicated tampon assembly is provided including a dosage form including a formulation including a therapeutic agent; a substrate portion separated from a substrate, wherein the substrate portion is coupled to the dosage form; and a tampon body having a distal end, wherein the substrate portion is coupled to the distal end of the tampon body.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 5, 2013
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven C. Gehling, Gregory J. Rajala, James D. Milner, Dennis S. Everhart
  • Patent number: 8196745
    Abstract: A suppository delivery device that allows for the insertion of a suppository without having contact with the suppository or rectum. The suppository delivery device includes a stabilizing platform, a stabilizer to which the suppository is mounted, and a package, which protects the user's hands and fingers from the suppository and rectum and prevents germs from contacting the suppository before being inserted into the rectum.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: June 12, 2012
    Assignee: Just Like Sisters, LLC
    Inventors: Karen D. Higgins, Kathleen K. Pieper
  • Patent number: 7993667
    Abstract: A method is provided for manufacturing a medicated tampon assembly having a tampon body, the method including applying a formulation including a therapeutic agent to a substrate to produce a plurality of dosage forms; separating one of the dosage forms from the substrate; and coupling one of the dosage forms to the tampon body. A medicated tampon assembly is provided including a dosage form including a formulation including a therapeutic agent; a substrate portion separated from a substrate, wherein the substrate portion is coupled to the dosage form; and a tampon body having a distal end, wherein the substrate portion is coupled to the distal end of the tampon body.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: August 9, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven C. Gehling, Gregory J. Rajala, James D. Milner, Dennis S. Everhart
  • Patent number: 7731030
    Abstract: A suppository delivery device that allows for the insertion of a suppository without having contact with the suppository or rectum. The suppository delivery device includes a stabilizer to which the suppository is mounted, and a package, which protects the user's hands and fingers from the suppository and rectum and prevents germs from contacting the suppository before being inserted into the rectum.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: June 8, 2010
    Assignee: Just Like Sisters, LLC
    Inventors: Karen D. Higgins, Kathleen K. Pieper
  • Patent number: 7427416
    Abstract: Methods of treating conditions using metal-containing materials are disclosed. Exemplary conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions, fungal conditions, viral conditions, autoimmune conditions, idiopathic conditions, hyperproliferative conditions, noncancerous growths, cancerous conditions and combinations of such conditions. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: September 23, 2008
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Scott H. Gillis, Paul Schechter, James Alexander Robert Stiles
  • Patent number: 7419971
    Abstract: Methods and compositions for enhancing the activity and/or duration of action of soft anti-inflammatory steroids of the haloalkyl 17?-alkoxy-11?-hydroxyandrost-4-en-3-one-17?-carboxylate type and the corresponding ?1,4 compounds and of anti-inflammatory steroids of the hydrocortisone and prednisolone type are described. The enhancing agents have the formula: wherein R is H or C1-C4 alkyl; Z1 is carbonyl or ?-hydroxymethylene; X1 is —O— or —S—; R5 is —OH, —OR6, —OCOOR6 or —OCOR7 wherein R6 is C1-C4 alkyl and R7 is C1-C4 alkyl, fluoromethyl or chloromethyl; and the dotted line in ring A indicates that the 1,2-linkage is saturated or unsaturated; with the proviso that when R is C1-C4 alkyl, then R5 is —OH.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: September 2, 2008
    Inventor: Nicholas S. Bodor
  • Patent number: 7344732
    Abstract: A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body that is manufactured at a first manufacturing facility; and a dosage form coupled to the body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form is manufactured at a second manufacturing facility. Also, a method for producing a medicated tampon including manufacturing a tampon body at a first manufacturing facility; manufacturing a dosage form at a second manufacturing facility, wherein the dosage form includes a formulation including a therapeutic agent; and coupling the dosage form to the tampon body.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: March 18, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Steven Craig Gehling
  • Patent number: 7341737
    Abstract: A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form comprises a plurality of layers. Also, a method for manufacturing a medicated tampon adapted to deliver a therapeutic agent, the method including manufacturing a tampon body having a distal end; producing a dosage form having a plurality of layers, wherein the dosage form includes a formulation including a therapeutic agent; and affixing the dosage form to the distal end of the tampon body.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: March 11, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven Craig Gehling, Donald C. Harrison, James H. Liu, Wolfgang A. Ritschel, Chris Clendening, Giovanni M. Pauletti
  • Patent number: 7255881
    Abstract: Metal-containing materials, as well as their preparation and use are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, anti-proliferative, MMP modulating material, an atomically disordered, crystalline material, and/or a nanocrystalline material. In certain embodiments, the metal-containing material is an atomically disordered, nanocrystalline silver-containing material.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: August 14, 2007
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Scott H. Gillis, Paul Schechter, James Alexander Robert Stiles
  • Patent number: 7226622
    Abstract: Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: June 5, 2007
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Joseph V. DiTrolio
  • Patent number: 7087249
    Abstract: The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and preferably in a nanocrystalline form, for reducing inflammation or infection of the mucosal membrane. The antimicrobial metal may be formulated as, or used in the form of, a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a liquid or solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: August 8, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Antony George Naylor, Peter Howard Moxham
  • Patent number: 7022335
    Abstract: A suppository of retaining in a lower region of rectum, which contains a suppository base containing: (A) a fatty acid triglyceride, (B) one or more C14-18 fatty acid glycerides, and (C) a base ingredient for retaining the suppository in the lower region of rectum, has quite high safety, does not melt by the body temperature when it is held by the fingers before insertion into the rectum so that it is easy to handle, does not deform by elevation of temperature during storage, and prevents stimulation to the rectum mucosa such as congestive hemorrhage and expansion of the rectum mucosa after the insertion.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: April 4, 2006
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Seiichi Hori, Katsuyoshi Aikawa
  • Patent number: 6958159
    Abstract: The present invention relates to an improved pharmaceutical composition useful for the topical treatment of burns, cuts, wounds, abrasions and the like, and to methods of treatment of injured body surfaces such as skin.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: October 25, 2005
    Assignee: Chiltern Pharmaceuticals, Pty Ltd.
    Inventor: Robert Alan Smith
  • Patent number: 6740333
    Abstract: There is provided a suppository comprising at least one biocompatible polymer, wherein the biocompatible polymer is essentially non-biodegradable, and wherein the suppository essentially does not swell when contacted with an aqueous fluid. The suppository may further comprise a plurality of open cells at least partly separated from one another by an interpenetrating matrix comprising at least one biocompatible polymer in branched or crosslinked form. The plurality of interlinked, open cells are capable of containing an aqueous fluid, and the permeability of the suppository ensures that entry of body fluids into the open cells under practical circumstances occurs essentially without dehydration of mucousal membrane tissue contacting the suppository. The suppository furthermore preferably comprises a controlled release formulation.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: May 25, 2004
    Assignee: Anestic ApS
    Inventors: Christian Westy Beckett, Per Robert Topp Eliasen
  • Patent number: 6740338
    Abstract: The present invention relates to a reduced form of Coenzyme Q also known as ubiquinol in oral dosage form such as a gelatin capsule, preferably a soft gelatin capsule. Compositions according to the present invention include storage stable compositions comprising effective amounts of ubiquinol in combination with an amount of a reducing agent effective to maintain ubiquinol in its reduced state when formulated in capsules, tablets and other orally administrable form. Methods of use are also disclosed.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: May 25, 2004
    Inventor: Raj K. Chopra
  • Patent number: 6569883
    Abstract: The invention relates to the use of compounds of the general formula (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-C1-3 alkyl group; and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7cycloalkyl, C2-6 alkenyl or phenyl-C1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: May 27, 2003
    Assignee: Glaxo Group Limited
    Inventors: Michael Brian Tyers, Ian Harold Coates, David Cedric Humber, George Blanch Ewan, James Angus Bell
  • Patent number: 6565850
    Abstract: The present invention is directed to gel compositions useful in the preparation of medicated gel products. Such medicated gel products are suitable for use in the treatment of anorectal disorders such as hemorrhoids. Also disclosed is a method for the treatment of such anorectal disorders using the claimed medicated gel products.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: May 20, 2003
    Inventor: Amparo Blanco
  • Publication number: 20030035850
    Abstract: The present invention is directed to gel compositions useful in the preparation of medicated gel products. Such medicated gel products are suitable for use in the treatment of anorectal disorders such as hemorrhoids. Also disclosed is a method for the treatment of such anorectal disorders using the claimed medicated gel products.
    Type: Application
    Filed: April 5, 1995
    Publication date: February 20, 2003
    Inventor: AMPARO BLANCO
  • Patent number: 6488954
    Abstract: The present invention relates to a liquid suppository composition comprising diclofenac sodium, poloxamer and at least one polymer select from the group consisting of polyethylene oxide and polyvinylpyrrolidone. The composition provides the advantages of. (1) a feel of foreign matter or discomfort does not occur when the composition is rectally administered; and (2) administration is easy and after rectal administration, the composition is neither leaked out from the anus nor shifted into the end of large intestine.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: December 3, 2002
    Assignee: Dong Wha Pharm. Ind. Co., Ltd.
    Inventors: Sung June Yoon, Jei Man Ryu, Jae Hee Jung, Su Jin Cho
  • Patent number: 6462083
    Abstract: This invention provides a suppository base composition of erucic acid and beeswax with improved chemical stability, moldability, and shelf-life. The inventive suppository base also stimulates localized blood flow to the administration site.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: October 8, 2002
    Inventor: Sarfaraz K. Niazi
  • Patent number: 6437006
    Abstract: This invention provides carrier systems useful in preparing pharmaceutical formulations, the systems comprising, by weight percentage, from about 1% to about 20%, preferably from about 5% to about 12%, of a surfactant component; from about 55% to about 93%, preferably from about 60% to about 85%, of a component of one or more polyethylene glycols (PEG); and from about 1% to about 25%, preferably from about 5% to about 15%, of one or more sucrose fatty acid esters or polyvinylpyrrolidone (PVP) with a K value between about 15 and about 90, preferably with a K value of from about 16 to about 18, most preferably about 17, as defined in USP/NF, or a combination of one or more sucrose fatty acid esters or PVP, and, optionally, one or more pharmaceutically acceptable preservatives or antioxidants, such as BHA, BHT, ascorbyl palmitate or benzyl alcohol.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: August 20, 2002
    Assignee: American Cyanamid Company
    Inventors: Joseph K. Yoon, Richard W. Saunders, Mahdi Fawzi
  • Patent number: 6432935
    Abstract: Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and 5-nitro-metronidazol (5-nitro-inidazoles) e.g., (metronidazol or tinidazol or nimorazol) and a pharmaceutically acceptable carrier. The compositions are useful mainly as vaginal suppositories.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: August 13, 2002
    Inventor: Márton Milánkovits
  • Patent number: 6326401
    Abstract: A liquid pharmaceutical formulation for administration by the oro-mucosal route, comprising at least one non-polypeptidic active substance and less than 5% W/W of capryl caproyl macrogol glycerides, process for its preparation and it uses.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: December 4, 2001
    Assignee: Immunotech
    Inventors: Jacques Chauveau, Pascal Meyer, Jacques Barbet, Michel Delaage
  • Patent number: 6326023
    Abstract: The present invention relates to a synergistic formulation comprising pharmaceutically effective amount of &agr;/&bgr; arteether and a neutralized refined vegetable oil suitable for administration by rectal route, method for the treatment of cerebral and comatose malaria and process for the preparation of the said formulation.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: December 4, 2001
    Assignee: Council of Scientific & Industrial Research
    Inventors: Guru Prakash Dutta, Dharam Chand Jain, Ranjendra Singh Bhakuni, Sudhanshu Saxena, Sangeeta Dhawan, Suman Preet Singh Khanuja, Sushil Kumar, Renu Tripathi, Aseem Umesh, Nuzhat Kamal, Anil Kumar Dwivedi, Satyawan Singh
  • Patent number: 6322820
    Abstract: A composition of matter for treating hemorrhoids comprising a pharmaceutically acceptable carrier, between 1% and 10% by weight of zinc oxide, between 0.2% and 5% by weight of resorcinol and between 0.1% and 3% by weight of menthol. A preferred carrier is white petroleum jelly and the composition may further include hydrocortisone as an active ingredient.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: November 27, 2001
    Inventor: Sylvain Simoneau
  • Patent number: 6277396
    Abstract: A dietary supplement system having a daytime component and a nighttime component is provided, wherein the daytime component comprises at least one thermogenic substance and the nighttime component comprises at least one adrenal support substance.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: August 21, 2001
    Assignee: Maximum Human Performance, Inc.
    Inventor: Gerard Dente
  • Patent number: 6270789
    Abstract: The present invention provides a base for suppository comprising oily or fatty base and polyethlene. The suppository prepared by the use of the base of the present invention has superior heat resistance which should not cause quality deterioration such as deformation and cracks, and shows good release, internal absorbability, safety and like compared to those of the suppositories used thus so far in the applied region.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: August 7, 2001
    Assignee: Amato Pharmaceutical Products, Ltd.
    Inventors: Teruyuki Sameshima, Kengo Omachi, Izumi Fukuda
  • Patent number: 6242010
    Abstract: Compositions for remediating ano-rectal inflammatory processes, hemorrhoidal syndromes and ano-rectal wounds. The composition includes the synergistic combination of reduced glutathione and selenium as a selenoamino acid in a suitable carrier for topical applications.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: June 5, 2001
    Assignee: Thione International, Inc.
    Inventor: Theodore Hersh
  • Patent number: 6221401
    Abstract: The present invention provides a bilayer structure for encapsulating multiple containment units. These containment units can attach or contain therapeutic or diagnostic agents that can be released through the bilayer structure. A suitable example of such a containment unit is a unilamellar or multilamellar vesicle.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: April 24, 2001
    Assignee: The Regents of the University of California
    Inventors: Joseph Zasadzinski, Scott Walker, Michael Kennedy
  • Patent number: 6200557
    Abstract: A solution or gel composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for destroying HIV. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH stabilized chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms. Using a lubricant as a vehicle for the chlorine dioxide/phosphate composition; development of vaginal itching due to Candida Albicans will be stopped.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: March 13, 2001
    Inventor: Perry A. Ratcliff
  • Patent number: 6153217
    Abstract: A process for producing a small-sized, lipid-based cochleate is described. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structure by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca.sup.2+ or Zn.sup.2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing pharmaceutical agents or biologically relevant molecules. Small-sized cochleates may be administered orally or through the mucosa to obtain an effective method of treatment.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: November 28, 2000
    Assignees: Biodelivery Sciences, Inc., University of Medicine and Denistry of New Jersey
    Inventors: Tuo Jin, Leila Zarif, Raphael Mannino
  • Patent number: 6136337
    Abstract: There is provided a composition for rectal administration suitable for curing hemorrhoids or the like by which the concentration of a medicine in the affected tissue is increased and the potency of the medicine is expected to continue. The long acting composition for rectal administration includes an acrylic acid polymer, a vasoconstrictor and a rectal tissue-curing agent.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: October 24, 2000
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Osamu Kondo, Tomoko Fujimori, Shigeo Tanaka, Fumio Urushizaki
  • Patent number: 6136334
    Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 24, 2000
    Assignee: MDV Technologies, Inc.
    Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
  • Patent number: 6123961
    Abstract: A method for treating or preventing urinary incontinence and other motility disorders involving the urethrogenital tract, by administering to a mammal an effective amount of the R-isomers of 4-diethylamino-2-butynyl cyclohexylphenylglycolate and 4-ethylamino-2-butynyl cyclohexylphenylglycolate and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: September 26, 2000
    Assignee: Bridge Pharma, Inc.
    Inventor: A. K. Gunnar Aberg
  • Patent number: 6121329
    Abstract: An external preparation for topical administration which aims at inhibiting rejection reactions at organ or bone marrow transplantation or treating autoimmune diseases or allergic diseases and contains as the active ingredient 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: September 19, 2000
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Tsuneo Fujii, Tadashi Mishina, Koji Teshima, Tomonori Imayoshi
  • Patent number: 6106864
    Abstract: There is provided a pharmaceutical dosage form adapted for administration to the gastrointestinal tract of a patient, comprising darifenacin, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adjuvant, diluent or carrier, characterized in that the dosage form is adapted to deliver at least 10% by weight of the darifenacin, or the pharmaceutically acceptable salt thereof, to the lower gastrointestinal tract of the patient. The formulation minimizes unwanted side-effects and increases the bioavailability of darifenacin.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: August 22, 2000
    Assignee: Pfizer Inc.
    Inventors: Thomas Francis Dolan, Michael John Humphrey, Donald John Nichols
  • Patent number: 6060060
    Abstract: This invention relates to analgesic compositions obtained from the fruit of the Capsicum genus, in particular Capsicum annuum and more particularly to purees or extracts of sweet peppers. This invention further relates to therapeutic uses of such analgesic compositions.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: May 9, 2000
    Assignee: BMB Patent Holding Corporation
    Inventor: Barry Miles Belgorod
  • Patent number: 6017554
    Abstract: A stable solution cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices include bacterial infections, such as Actinobacillus actinomycetemcomitans and Porphyromonoas gingivalis, and fungal infections, such as Candida, and leukoplakia. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: January 25, 2000
    Assignee: Micropure, Inc.
    Inventor: Perry A. Ratcliff
  • Patent number: 5994383
    Abstract: Antimicrobial compositions and methods for preparing and using same are provided. The antimicrobial compositions are surfactant-based and contain certain benzalkonium chloride homologs. The compositions are useful in treating infections in animals and humans, and can be applied to areas including the skin, nails, and mouth.
    Type: Grant
    Filed: November 18, 1997
    Date of Patent: November 30, 1999
    Assignee: Woodward Laboratories, Inc.
    Inventors: David L. Dyer, Kenneth B. Gerenraich
  • Patent number: 5958443
    Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: September 28, 1999
    Assignee: MDV Technologies, Inc.
    Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
  • Patent number: 5935592
    Abstract: A stable solution, cream, salve, or spray composition containing activated chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the treatment of vaginitis and endometriosis by reducing any of Candida, Actinobacillus actinomycetemcomitans, Pseudomonades, and Porphyromonas gingivalis present in the vagina or the uterus. The preferred concentration ranges are in the range of about 0.005% to about 2.0% of chlorine dioxide, and in the range of about 0.02% to about 3.0% of phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: August 10, 1999
    Assignee: Micropure, Inc.
    Inventor: Perry A. Ratcliff
  • Patent number: 5902575
    Abstract: A stable solution, cream, salve, or spray composition containing chlorine dioxide and a phosphate, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices brought about by any of leukoplakia, hairy leukoplakia, vaginitis, endometriosis, Candida Albicans, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Pseudomonades, Candida species, and leukoplakia vulvae. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: May 11, 1999
    Assignee: Micropure, Inc.
    Inventor: Perry A. Ratcliff
  • Patent number: 5834003
    Abstract: A method for oxidatively consuming volatile sulfur compounds selected from the group consisting of dimethylsulfide, hydrogen sulfide, and methylmercaptan at the epithelial barrier of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices to maintain the epithelial barrier and reduce penetration of any of Candida, Actinobacillus actinomycetumcomitans, Pseudomonades, and Porphyromonas gingivalis, said method comprising the step of applying to the orifices a composition comprising a topical preparation selected from the group consisting of liquid solutions, suspensions, semi-solids, salves, creams, and suppositories, wherein the topical preparation contains chlorine dioxide in a concentration in the range of about 0.005% to about 2.0% and a phosphate compound selected from the group consisting of disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodiuit phosphate, or sodium monofluorophosphate in a concentration in the range of about 0.02% to about 3.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: November 10, 1998
    Assignee: Micropure, Inc.
    Inventor: Perry A. Ratcliff
  • Patent number: 5811115
    Abstract: A stable solution, cream, salve, or spray composition containing chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices include bacterial infections, such as Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, and fungal infections, such as Candida, and leukoplakia. The preferred concentration ranges are in the range of about 0.005% to about 2.0% chlorine dioxide, and in the range of about 0.02% to about 3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of about 6.0 to about 7.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: September 22, 1998
    Assignee: Micropure, Inc.
    Inventor: Perry A. Ratcliff
  • Patent number: 5719122
    Abstract: Pharmaceutical compositions comprising a calcitonin and a polyglycolysed glyceride and a method of enhancing the transdermal or transmucosal absorption of calcitonin in a mammal are disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: February 17, 1998
    Assignee: SmithKline Beecham Farmaceutici S.p.A.
    Inventors: Laura Chiodini, Teodoro Fonio, Gianfranco Rancati
  • Patent number: 5707645
    Abstract: A small, reusable, previously cooled or frozen bladder that is applied to the anal area of a user. The bladder consists of two two-ply sheets of a flexible, semi-porous material, such as polyethylene, hermetically heat sealed together at the edges to form an internal cavity. The cavity contains a cold-temperature storage means, such as water, glycerol, a combination thereof, or other chemical slurry, and a medicinal agent, such as witchhazel, shark oil, yarrow, other astringents, and lidocaine or other pain relievers.
    Type: Grant
    Filed: September 10, 1996
    Date of Patent: January 13, 1998
    Inventor: Mark Wierson
  • Patent number: 5688528
    Abstract: The invention relates to an oil-in-water emulsion comprising 0.01-50% by weight of the total preparation, preferably 0.1-10%, of a galactolipid material as an emulsifier. The galactolipid material consists of at least 50% digalactosyldiacylglycerols, the remainder being other polar lipids. The said emulsion is suitable as a carrier for one or more active substances in a pharmaceutical composition, but also in nutritional, cosmetical, food and agricultural products.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: November 18, 1997
    Assignee: Scotia LipidTeknik AB
    Inventors: Anders Carlsson, Marina Delogu, Bengt Herslof
  • Patent number: 5679655
    Abstract: This invention includes a pharmaceutical composition including a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically salt thereof. The invention also includes a method of treating disease of the cutis which includes applying to cutis tissues in need of such treatment a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically acceptable salt thereof, said disease having symptoms selected from the group consisting of inflammation, erythema, edema, papules, vesicles, macules, pustules, scaling, cracking, crusting, and lesions.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 21, 1997
    Assignee: Patent Biopharmaceutics, Inc.
    Inventor: Damian J. Gallina