Ointment Or Salve Base Patents (Class 514/969)
  • Patent number: 8529970
    Abstract: Materials with high levels of unsaponifiable matter, such as extracts from plants, produce hydrolysates with unique properties. Properties that are sought in traditional saponification of natural oils are a result of low levels of unsaponifiables. These properties include high levels of aqueous surfactant activity, water-solubility or ready water-dispersability, activity as foaming agents, and the like. An objective of traditional saponification processes is to increase the water-solubility and surfactant activity of naturally occurring materials. It has been found that the application of a hydrolysis process to materials, particularly materials with a high level of unsaponifiables (e.g., at least 6 weight percent of the material), produces a product with properties significantly different from those products resulting from the conventional saponification of materials with less than 6 weight percent of unsaponifiables.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 10, 2013
    Assignee: International Flora Technologies, Ltd.
    Inventors: James H. Brown, Lee Roy Copeland, Robert Kleiman, Melanie K. Cummings, Sambasivarao Koritala
  • Patent number: 8425954
    Abstract: A THC composition comprises cannabis leaves simmered in butter, which is then filtered and cooled, and then mixed with shea butter. The resulting compound is used for topical skin relief, sun protection for skin and other uses. The butter used for simmering the cannabis leaves may be cow butter, sheep butter, olive oil, cooking oil, and other compositions.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: April 23, 2013
    Inventor: Sonya Stone
  • Patent number: 8388978
    Abstract: A topical skin care composition and method for its use comprising water, Chlorella vulgaris extract, an algae extract, a phospholipid or lecithin, glycerin, retinyl palmitate, tocopheryl acetate, and magnesium ascorbyl phosphate.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: March 5, 2013
    Assignee: Mary Kay Inc.
    Inventor: Gopa Majmudar
  • Patent number: 8329147
    Abstract: The invention relates to alkyl benzoate mixtures, the sum of the C12- and C14-alkyl benzoates being greater than or equal to 85%, in relation to the total sum of the alkyl benzoates. The invention also relates to the use of said alkyl benzoate mixtures in cosmetic and/or pharmaceutical preparations, in particular as oil components.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: December 11, 2012
    Assignee: Cognis IP Management GmbH
    Inventors: Achim Ansmann, Rolf Kawa, Hans-Dieter Clages, Lars Zander
  • Patent number: 8221802
    Abstract: A unique, synergistic formulation for the treatment of first-degree skin burns is provided for topical use and alleviates the full spectrum of symptoms and concerns associated with epidermal burns, including pain, blistering, redness, swelling, compromised skin integrity, risk of infection and scarring. The formulation contains natural homeopathic extracts combined with a pharmaceutically acceptable carrier suitable for topical administration. The formulation may include three or more of the following homeopathic extracts: Cantharis Vesicatoria, Echinacea Angustifolia, Calendula Officinalis and Hypericum Perforatum.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: July 17, 2012
    Assignee: The Akshay Wellness Group, Inc.
    Inventor: Sai S. Manickam
  • Patent number: 8021700
    Abstract: A general healing ointment for use on cracked lips, rashes, burns and the like is herein disclosed. The ointment is manufactured from an all natural blend of petroleum jelly, vitamin E cream and oil, cocoa butter, and pine pitch. It provides relief for a variety of ailments such as cracked skin, cold sores, rashes, acne, boils, and the like. It is readily absorbed by the skin and not visible to others, but won't dry out the skin afterwards.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: September 20, 2011
    Inventor: Wayne Johnson
  • Patent number: 7959955
    Abstract: A unique, synergistic formulation for the treatment of first-degree skin burns is provided for topical use and alleviates the full spectrum of symptoms and concerns associated with epidermal burns, including pain, blistering, redness, swelling, compromised skin integrity, risk of infection and scarring. The formulation contains natural homeopathic extracts combined with a pharmaceutically acceptable carrier suitable for topical administration. The formulation includes the following homeopathic extracts: Cantharis vesicatoria, Echinacea anqustifolia, Calendula officinalis and Hypericum perforatum.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: June 14, 2011
    Assignee: The Akshay Wellness Group, Inc.
    Inventor: Sai S. Manickam
  • Patent number: 7858662
    Abstract: The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkynyl group, preferably a C11-C15 alkyl, alkylene or alkynyl group, particularly a C11-C13 alkyl, alkylene or alkynyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkynyl group, preferably a C1-C6 alkyl, alkylene or alkynyl group, in particular a C2-C4 alkyl, alkylene or alkynyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m—O]nH group with n=1 to 10, preferably n=1 to 5, m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—(R3)]— group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tu
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: December 28, 2010
    Assignee: MediGene AG
    Inventors: Yunik Chang, Robert Lathrop, Erwin Böhm, Irene Gander-Meisterernst, Regina Greger, Johanna Holldack, Ulrich Moebius
  • Patent number: 7824713
    Abstract: A method for treating diaper rash, leg ulcers and bed sores using super hydrated bacteriostatic topical preparation with a stable acid pH 5.82, by applying this topical application, which is a mixture of anhydrous lanolin (USP), water, boric acid powder (USP), edible corn starch, white petrolatum, cosmetic grade, and zinc oxide ointment (USP 20% zinc oxide) mixed in a paddle mixer at a temperature of about 100° F. to 107° F. then applying topically, the super hydrated bacteriostatic preparation, at room temperature, on the rash, leg ulcers, or bed sores.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: November 2, 2010
    Inventor: Wallace W. Shong
  • Patent number: 7605173
    Abstract: A pharmaceutical liquid composition containing the Pirfenidone in a very high concentration of more or less 25% by weight can be obtained by dissolving the Pirfenidone in diethylene glycol monoethyl ether. Even when the liquid medicinal compositions are stored for a long period of time, the Pirfenidone will not be recrystallized with a good chemical and physical stability. Furthermore, the liquid compositions are little irritating to the wounds on the mucous membrane of the skin and suitable for the manufacture of pharmaceutical formulations to be administered either via the oral, percutaneous, nasal or vaginal routes or by means of spray, patch, inhalation, injection or intravenous drip.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: October 20, 2009
    Assignee: KDL, Inc.
    Inventor: Pyare L. Seth
  • Patent number: 7556818
    Abstract: A composition and method of applying to skin which has psoriasis a gel that contains curcumin and/or curcuminoids. Prior to applying of the gel to the skin, the affected layer is soaked in one-hundred percent alcohol. The alcohol functions to dissolve the curcumin and/or curcuminoids with the alcohol not only comprising a solvent but functions as a carrier to cause the freshly dissolved (nascent) curcumin to penetrate through the stratum corneum layer of the skin and into the epithelial layer of the skin.
    Type: Grant
    Filed: July 3, 2004
    Date of Patent: July 7, 2009
    Inventor: Madalene C. Y. Heng
  • Patent number: 7462369
    Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: December 9, 2008
    Inventor: Jeffrey B. Smith
  • Patent number: 7374770
    Abstract: Polyethylene glycol ethers of alkyl alcohols having the general formula CH3(CH2)xCH2(OCH2CH2)nOH wherein x is 8 to 20 (of which ceteareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2(difluoromethyl)-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: May 20, 2008
    Assignee: SkinMedica, Inc.
    Inventors: Joyce T. Chou, Prakash Parab
  • Patent number: 7357923
    Abstract: A topical product for the application to the skin or mucosal surfaces comprises yellow beeswax in an oleaginous base of, e.g., olive oil, sunflower oil, almond oil, cod liver oil, castor oil, along with an excipient vehicle. The product is useful in connection with a variety of conditions and ailments of the skin (including burns and abrasions) and mucosal surfaces of, for example, the vaginal and anal areas.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: April 15, 2008
    Assignee: CAC Pharmaceuticals
    Inventor: Ramon Efrain Vasquez Lipi
  • Patent number: 7223724
    Abstract: The present invention is directed to VEGF-2 polynucleotides and polypeptides and methods of using such polynucleotides and polypeptides. In particular, provided are methods of treating retinal disorders with VEGF-2 polynucleotides and polypeptides.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: May 29, 2007
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ralph Alderson, Robert Melder, Viktor Roschke, Steven M. Ruben, Craig A. Rosen
  • Patent number: 7214381
    Abstract: The present invention refers to a pharmaceutical composition suitable for the transdermal or transmucosal administration of one or more active agents, in form of a gel or a solution, comprising as a permeation enhancers a combination of: a) saturated fatty alcohol of formula CH3—(CH2)n—CH2OH or saturated fatty acid CH3—(CH2)n—CH2COOH wherein n is an integer number 8÷22, preferably 8÷12, most preferably 10, or unsaturated fatty alcohol or fatty acid of formula: CH3(CnH2(n-1))—OH or CH3(CnH2(n-1))—COOH wherein n is an integer number 8÷22, b) a ternary vehicle or carrier consisting of a C1÷C4 alkanol, a polyalcohol in particular propylenglycol and water, c) optionally also a monoalkylether of diethylenglycol.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: May 8, 2007
    Assignee: Antares Pharma IPL AG
    Inventors: Dario Carrara, Gabriel Porto, Jorge Rodriguez
  • Patent number: 7199159
    Abstract: The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C1–C7, alkyl group, a cycloalkyl group, a heterocycle, a C2–C7 alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group, or R1 and R2, taken together, represent a C2–C7 alkylene which may contain one or more hetero atoms, and the group R3 represents a primary, secondary or tertiary amine, or pharmaceutically acceptable salts thereof, to manufacture a medicinal product with cicatrizing action, the said medicinal product being in a pharmaceutical form for topical use.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: April 3, 2007
    Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)
    Inventors: Pierre Jean-Paul Potier, Nobumichi-André Sasaki, Maria Conception Achab, Gisèle Franck, Claude Thal, Joanna Bakala
  • Patent number: 7175836
    Abstract: A cosmetic water-in-oil composition is provided which includes a water-in-oil emulsifying silicone surfactant, crosslinked silicone elastomer and conjugated linoleic acid. The conjugated linoleic acid functions to improve radiance on facial surfaces to which the composition is topically applied.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: February 13, 2007
    Assignee: Conopco, Inc.
    Inventors: Kelly Denise Hart, Marcina Siciliano, Jeffrey William Rosevear, Brian John Dobkowski
  • Patent number: 7175835
    Abstract: A cosmetic water-in-oil composition is provided which includes a water-in-oil emulsifying silicone surfactant, an ultrafine titanium dioxide and conjugated linoleic acid. The presence of conjugated linoleic acid stabilizes the composition against color degradation and also maintains an approximately steady viscosity.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: February 13, 2007
    Assignee: Conopco, Inc.
    Inventors: Sofia Simoulidis, Jeffrey William Rosevear, Brian John Dobkowski
  • Patent number: 7172754
    Abstract: A cosmetic water-in-oil composition is provided which includes a water-in-oil emulsifying silicone surfactant, organic sunscreen agent and conjugated linoleic acid. The conjugated linoleic acid functions to moderate shine on facial surfaces to which the organic sunscreen agent formulated composition is topically applied.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: February 6, 2007
    Assignee: Conopco, Inc.
    Inventors: Jeffrey William Rosevear, Marcina Siciliano, Brian John Dobkowski, Bivash Ranjan Dasgupta, Lei Huang
  • Patent number: 7087249
    Abstract: The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and preferably in a nanocrystalline form, for reducing inflammation or infection of the mucosal membrane. The antimicrobial metal may be formulated as, or used in the form of, a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a liquid or solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: August 8, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Antony George Naylor, Peter Howard Moxham
  • Patent number: 7045496
    Abstract: The present invention is directed to VEGF-2 polynucleotides and polypeptides and methods of using such polynucleotides and polypeptides. In particular, provided are methods of treating retinal disorders with VEGF-2 polynucleotides and polypeptides.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: May 16, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventors: Ralph Alderson, Robert Melder, Viktor Roschke, Steven M. Ruben, Craig A. Rosen
  • Patent number: 6989163
    Abstract: A treatment to induce urothelial sensory nerve re-growth in the female vulvae, comprising a compound of menthol, L-arginine and a phytoestrogen.
    Type: Grant
    Filed: August 30, 2003
    Date of Patent: January 24, 2006
    Assignee: 40 J's LLC
    Inventors: Ronald James Thompson, Rhett Larck Frye
  • Patent number: 6919320
    Abstract: The invention relates to compositions comprising 2?-deoxyribonucleosides. The invention also relates to methods of accelerating the healing of wounds, abrasions, cuts, incisions, and superficial burns induced by heat, sunlight, chemical agents, or infections, and methods for ameliorating the effects of aging of the epidermal tissues comprising administering the compositions of the present invention to an animal.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 19, 2005
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Reid Warren von Borstel, Michael Kevin Bamat
  • Patent number: 6881756
    Abstract: The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol or a pharmaceutically-acceptable ester thereof.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: April 19, 2005
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventor: Gerard J. Gendimenico
  • Patent number: 6846837
    Abstract: Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: January 25, 2005
    Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
  • Patent number: 6797260
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: September 28, 2004
    Inventor: Terence Prevendar
  • Patent number: 6733794
    Abstract: A composition for topical analgesic and antiseptic use which consists essentially of a approximately equal proportions of alcohol, turpentine, and eucalyptus oil.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: May 11, 2004
    Inventors: Edward L. Ingram, Mary Scott
  • Patent number: 6730329
    Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: May 4, 2004
    Inventor: Jeffrey B. Smith
  • Patent number: 6723349
    Abstract: The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a modified polyoxometalate, wherein the modified polyoxometalate comprises the admixture of (1) a polyoxometalate and (2) a cerium compound, a silver compound, a gold compound, a platinum compound, or a combination thereof.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: April 20, 2004
    Assignee: Emory University
    Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
  • Patent number: 6720012
    Abstract: An analgesic composition that can be applied topically comprises boric acid and a suitable carrier. The inventive analgesic composition can be used to provide pain relief to a person suffering from arthritis and any general pain associated with muscles or joints.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: April 13, 2004
    Assignee: A & L of Michigan, Inc.
    Inventor: Annie L. Jones
  • Patent number: 6660776
    Abstract: A composition and method for lubricating and protecting the oral cavity generally and specifically the teeth, gums and tongue using a flavored petrolatum. In the preferred embodiment, the composition contains about 96%-98% (w/w) of petrolatum and about 2%-4% (w/w) of flavoring. The composition is liberally applied to the affected areas of the oral cavity to lubricate and protect those areas during dental or medical procedures having an aesthetically pleasing flavor without leaving an undesirable aftertaste.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: December 9, 2003
    Inventor: Pellom McDaniels, III
  • Patent number: 6660283
    Abstract: The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: December 9, 2003
    Assignee: Societe L'Oreal S.A.
    Inventors: Lionel Breton, Florence Girerd, Béatrice Renault
  • Patent number: 6652874
    Abstract: Formulations have been developed for regional delivery of drugs, for example, into a cavity such as the pelvic region, peritoneal region, or directly on organs of interest. Regional delivery increases comfort and bioavailability of the drug, resulting in rapid and relatively high blood levels in the regions to be treated in the substantial absence of side effects due to the high levels required for efficacy following systemic delivery. In the preferred embodiment, these formulations consist of drug micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or polymeric carrier. The excipient or polymer may be used to manipulate release rates and to increase adhesion to the affected region. The drug formulation can be applied as a dried powder, a liquid suspension or dispersion, or as a topical ointment, creme, lotion, foam or suppository.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: November 25, 2003
    Assignee: FemmePharma
    Inventors: Vanaja V. Ragavan, Gerianne M. DiPiano
  • Patent number: 6627603
    Abstract: A method for the controlled release of an active principle contained in a multiple water-in-oil-in-water emulsion characterized in that the multiple emulsion comprises an invert emulsion Ei with an aqueous phase A1 containing at least a hydrophilic active principle. The emulsion Ei is dispersed in the form of direct emulsion droplets Ed, in a continuous aqueous phase A2, with the two emulsions Ed and Ei stabilized by at least a surfactant, present in their respective continuous phases. The multiple emulsion is brought in the presence of an effective amount of an agent for transforming it into a direct emulsion and induce the release of the active principle, contained in the aqueous phase A1 of emulsion Ei, in the aqueous phase A2.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: September 30, 2003
    Assignee: Centre National de la Recherche Scientifiquue (C.N.R.S.)
    Inventors: Jérôme Bibette, Marie-Françoise Ficheux, Fernando Leal Calderon, Lida Bonnakdar
  • Patent number: 6617356
    Abstract: Suspensions, emulsions or dispersions of therapeutically active agents which are water insoluble or water intolerant such as nutritional supplements, herbal products, drugs, bacteria, yeast, vitamins and minerals are prepared as suspensions in edible vegetable oils such as orange, lemon, soybean, cotton seed, peanut, canola corn oil, sunflower, safflower, palm kernel, palm and coconut. The active therapeutic agent may be in crystalline or amorphous form, it may be a liquid as for example an oil such as vitamin B or beta carotene, or a preparation of a comminuted plant structure such as flower, parts, leaf; stern, root or tree bark, or an extract of a dried plant structure or a freeze dried preparation of a vital bacteria or yeast. The suspension is formed by active mixing of the active agent and oil.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: September 9, 2003
    Inventors: Louis P. Goodman, Dennis Bizub
  • Patent number: 6579541
    Abstract: The invention relates to a method and composition for destroying or inhibiting proliferation of microbes using oxidative fluorinator compounds. Fluoride salts that do not dissociate completely in aqueous solutions, such as tri- or tetravalent transition metal fluorides, inert gas fluorides, or tri- or tetravalent rare earth fluorides, are effective antimicrobial agents even at levels up to about 20 ppm, when used alone or in conjunction with a strong oxidizer.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 17, 2003
    Assignee: Marantech Holding, LLC
    Inventor: Marvin S. Antelman
  • Patent number: 6551619
    Abstract: The invention relates to solid, particulate lipid-based excipients which are loaded with cyclosporine. Said excipients have improved biopharmaceutical properties for cyclosporines in vivo, are of a better quality (in terms of fineness, homogeneity of the particles, inclusion of the medicament) and are more physically stable in the particulate formulation (no aggregation or gel formation). The invention also relates to a therapeutic treatment with cyclosporine formulations which produce an average blood level concentration in the steady state range of 300 ng/ml to over 1000 ng/ml, preferably over 800 ng/ml, especially up to 900 ng/ml, preferably 400 ng/ml to 800 ng/ml in the absence of high initial blood level concentrations essentially over 1500 ng/ml, especially over 1200 ng/ml. This blood level concentration is preferably maintained for an extended period of at least 5 hours, preferably at least 7 hours.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: April 22, 2003
    Assignee: Pharmatec International S.R.L.
    Inventors: Lawrence John Penkler, Rainer Helmut Müller, Stephan Anton Runge, Vittorino Ravelli
  • Patent number: 6515029
    Abstract: An absorbent article having a bodyside liner includes a hydrophilic lotion formulation on the outer bodyfacing surface thereof. The hydrophilic lotion formulation comprises from about 10 to about 90 weight percent of a hydrophilic solvent, from about 5 to about 90 weight percent of a high molecular weight polyethylene glycol, and from about 0 to about 60 weight percent of a fatty alcohol. The hydrophilic lotion formulation has a reduced adverse effect on the absorbent and liquid uptake properties of the liner and the absorbent body when compared to conventional lipophilic or hydrophobic lotion formulations. The hydrophilic lotion formulation acts as a lubricant to reduce the abrasion of the skin caused by the liner and also transfers to the skin to provide improved skin health.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: February 4, 2003
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Duane Gerard Krzysik, David Charles Musil, Frank Andrew Rosch, III, Gordon Allen Shaw, Diane Michele Underhill, Jeffrey Michael Hockersmith
  • Patent number: 6497895
    Abstract: Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: December 24, 2002
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Kathryn E. Uhrich
  • Patent number: 6488965
    Abstract: Antimicrobial/pharmaceutical preparations (e.g., solutions, gels, ointments, creams, sustained release preparations, etc.) which comprise chlorite (e.g., a metal salt of a chlorite) in combination with a peroxy compound (e.g., hydrogen peroxide), and methods for using such preparations for disinfection of articles or surfaces (e.g., contact lenses, counter tops, etc.), antisepsis of skin or other body parts, prevention or deterrence of scar formation and/or treatment and prophylaxis of dermal (i.e., skin or mucous membrane) disorders (e.g., wounds, burns, infections, cold sores, ulcerations, psoriasis, acne, or other scar-forming lesions).
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: December 3, 2002
    Inventor: Hampar L. Karageozian
  • Patent number: 6475526
    Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: November 5, 2002
    Inventor: Jeffrey B. Smith
  • Patent number: 6471973
    Abstract: The invention relates to a flavonoid ester. This flavonoid ester results from the reaction product of at least one flavonoid selected from the group consisting of a flavonoid with a ketone group in the 4-position, a salt, ester or ether of such a flavonoid, and a C-heteroside and/or O-heteroside derivative of such a flavonoid, with the proviso that this flavonoid contains at least one free alcohol group, with an organic monoacid having from 3 to 30 carbon atoms. These flavonoid esters constitute useful active principles for the manufacture of cosmetic, dermopharmaceutical, pharmaceutical, dietetic or agri-foodstuff compositions.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: October 29, 2002
    Assignee: Coletica
    Inventors: Eric Perrier, Anne-Marie Mariotte, Ahcène Boumendjel, Delphine Bresson-Rival
  • Patent number: 6465442
    Abstract: The present invention relates to a compositions and methods for treating tinnitus. In preferred embodiments of the invention, muscurinic and/or opioid agents are administered to the affected ear in amount effective to relieve one or more tinnitus symptoms. A preferred agent is an anticholinesterase inhibitor, such as neoostigmine.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: October 15, 2002
    Inventor: George F. El Khoury
  • Patent number: 6465440
    Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: October 15, 2002
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Reid W. von Borstel, Fedor Romantsev
  • Patent number: 6447806
    Abstract: Particles of a substantially water insoluble biologically active substance, such as Cyclosporin, are loaded with a charged glyceryl ester as an electrostatic stabilizer which imparts to the particles a zeta potential and having an active substance:stabilizer weight ratio of 1:1 to 400:1 and an average particle diameter of 1 nanometer to 10 micrometers. Compositions having such particles are found to be useful delivery systems.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: September 10, 2002
    Assignee: Novartis AG
    Inventors: Peter Gassmann, Heinz Sucker
  • Patent number: 6440428
    Abstract: The invention refers to new pharmaceutical preparations for the treatment of psoriasis and condyloma acuminata, and containing podophyllotoxin in combination with a liquid triglyceride.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: August 27, 2002
    Assignee: Analytecon SA
    Inventors: Kurt Leander, Jan Gunzinger, Börje Rosen
  • Patent number: 6433003
    Abstract: This invention is directed to methods for treating hyperhidrosis in mammals. Specifically, the methods of this invention involve the topical administration of glycopyrrolate compounds to humans.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: August 13, 2002
    Inventors: Arthur M. Bobrove, Jeffrey D. Urman
  • Patent number: 6416778
    Abstract: Formulations have been developed for regional delivery of drugs, for example, into a cavity such as the pelvic region, peritoneal region, or directly on organs of interest. Regional delivery increases comfort and bioavailability of the drug, resulting in rapid and relatively high blood levels in the regions to be treated in the substantial absence of side effects due to the high levels required for efficacy following systemic delivery. In the preferred embodiment, these formulations consist of drug micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or polymeric carrier. The excipient or polymer may be used to manipulate release rates and to increase adhesion to the affected region. The drug formulation can be applied as a dried powder, a liquid suspension or dispersion, or as a topical ointment, creme, lotion, foam or suppository.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: July 9, 2002
    Assignee: FemmePharma
    Inventors: Vanaja V. Ragavan, Gerianne M. DiPiano
  • Patent number: RE39573
    Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: April 17, 2007
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Reid W. von Borstel, Fedor Romantsev