Containing Designated Ingredient To Stabilize An Active Ingredient Patents (Class 514/970)
  • Patent number: 8999400
    Abstract: An aqueous disinfecting solution having a pH of from about 0.5 to about 6 consists essentially of hydrogen peroxide in a concentration of from about 0.05 to about 8 w/w % of the total solution, at least one anionic surfactant in a concentration of from about 0.02 to about 8 w/w % of the total solution, and at least one additional ingredient chosen from benzyl alcohol, an alcohol comprising one to six carbon atoms, and mixtures thereof, in a concentration of from about 0.1 to about 10 w/w % of the total solution.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: April 7, 2015
    Assignee: Virox Technologies Inc.
    Inventors: Jose A. Ramirez, Navid Omidbakhsh
  • Patent number: 8993599
    Abstract: In one general aspect of the present invention, pharmaceutical formulations comprising both a proton pump inhibitor microencapsulated or dry coated with a material that enhances the shelf-life of the pharmaceutical composition and one or more antacid are described. In another general aspect of the present invention, pharmaceutical formulations comprising both a proton pump inhibitor microencapsulated or dry coated with a taste-masking material and one or more antacid are described.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: March 31, 2015
    Assignee: Santarus, Inc.
    Inventors: Warren Hall, Kay Olmstead, Laura Weston
  • Patent number: 8916182
    Abstract: A ‘bioactive’ composition that has one or more oligogalacturonans ((1?4)-?-D-galacturonan) or any other oligosaccharides (oligoguluronans) that may present an ‘egg box’ conformation, this conformation being further stabilized by one or more polycationic saccharide(s), preferably either a chitosan oligosaccharide or a chitosan polysaccharide. A method prepares this composition and it is used, in medical, pharmaceutical, agricultural, nutraceutical, food, feed, textile, cosmetic, industrial and/or environmental applications.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: December 23, 2014
    Assignee: Universite de Namur
    Inventors: Pierre Van Cutsem, Juan Carlos Cabrera Pino
  • Patent number: 8901154
    Abstract: A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: December 2, 2014
    Assignee: Ceva Animal Health LLC
    Inventors: Ian Cottrell, Albert Ahn, Linda Dorneval
  • Patent number: 8815950
    Abstract: The present invention relates to stable dosage forms and compositions of levodopa and carbidopa for the treatment of patients suffering from Parkinson's disease. The dosage forms and compositions comprise both solid and liquid formulations and result in stable pharmaceutical products. Such dosage forms and compositions comprise a metal chelator and a levodopa concentration from about 1 mg/mL to about 30 mg/mL.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: August 26, 2014
    Assignee: Janssen Biotech, Inc.
    Inventors: Julius Remenar, Orn Almarsson, Anthony J. Meehan, Jr., Zhong Zhang
  • Patent number: 8808755
    Abstract: A skin disinfectant in ready-to-use concentrated liquid or dry powdered form. Ready-to-use liquid forms have a pH of from about 2 to about 6 and include: (a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w of the solution; (b) at least one surfactant chosen from imidazoline derivatives, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, alkylsulfo betaines, amine oxides and derivatives thereof in a concentration of from about 0.01 to about 15% w/w of the solution; (c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w of the solution; (d) at least one member chosen from cyclic carboxylic acids and salts thereof in a concentration of from about 0.01 to about 4% w/w of the solution; and (e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w of the solution.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 19, 2014
    Assignee: Virox Technologies Inc.
    Inventor: Navid Omidbakhsh
  • Patent number: 8648175
    Abstract: The present invention provides a new stable pharmaceutical composition of erythropoietin (EPO) that is stabilized with PVP.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: February 11, 2014
    Assignee: Lek Pharmaceuticals d.d.
    Inventors: Andreja Vukmirovic, Tanja Rozman Peterka, Jelka Svetek, Alenka Paris
  • Patent number: 8648108
    Abstract: Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: February 11, 2014
    Assignee: Spectrum Pharmaceuticals, Inc.
    Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijen
  • Patent number: 8637085
    Abstract: An aqueous disinfecting solution having a pH from about 0.5 to about 6 and consisting essentially of hydrogen peroxide in a concentration from about 0.05 to about 8 w/w % of the total solution; at least one anionic surfactant in a concentration from about 0.02 to about 8 w/w % of the total solution, selected from sulfonated C12 to C22 carboxylic acids and alkali metal, ammonium, calcium and magnesium salts thereof; naphthalene sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; C8 to C22 alkyl sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; and alkyl or alkenyl esters or diesters of sulfosuccinic acids in which the alkyl or alkenyl groups independently contain from six to eighteen carbon atoms and alkali metal, ammonium, calcium and magnesium salts thereof; and benzyl alcohol in a concentration from about 0.1 to about 10 w/w % of the solution.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: January 28, 2014
    Assignee: Virox Technologies Inc.
    Inventors: Jose A. Ramirez, Navid Omidbakhsh
  • Patent number: 8614255
    Abstract: The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: December 24, 2013
    Assignee: Civitas Therapeutics, Inc.
    Inventors: Charles D. Blizzard, Michael M. Lipp, Kevin L. Ward, Rachel Ryznal, Daniel Leblanc, Mark Tracy, Rebecca Martin
  • Patent number: 8435942
    Abstract: A method of formulating insulin compositions comprises preparing a carrier having a phosphatidylcholine component which entraps insulin, stabilizing insulin compositions at room temperatures.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: May 7, 2013
    Assignee: Transdermal Biotechnology, Inc.
    Inventors: Nicholas V. Perricone, Chim Potini
  • Patent number: 8334321
    Abstract: A fat emulsion comprises a prostaglandin as an active ingredient, the fat emulsion comprising a phospholipid that comprises phosphatidylcholine (PC) and phosphatidylglycerol (PG) and has a ratio of PC to PG (PC:PG) of 85:15 to 99.7:0.3.
    Type: Grant
    Filed: September 3, 2007
    Date of Patent: December 18, 2012
    Assignee: Q.P. Corporation
    Inventors: Satomi Kamiya, Tomonori Uchida, Hideto Yoshida, Yasutaka Inoue, Noboru Yamada, Kenichi Kajihara
  • Patent number: 8299116
    Abstract: This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) following admixture with a diluent.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: October 30, 2012
    Assignee: Wyeth LLC
    Inventors: Joseph T Rubino, Victoria Siskavich, Maureen M Harrison, Pooja Gandhi
  • Patent number: 8273711
    Abstract: The present invention relates to compositions and methods for transdermal drug delivery comprising formulating a phosphatidylcholine carrier composition containing the drug and applying the composition to the skin.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: September 25, 2012
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 8202548
    Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 19, 2012
    Assignee: Dharma IP, LLC
    Inventors: Sunggyu Lee, Patricia Roberts
  • Patent number: 8138228
    Abstract: A liquid kelp formulation includes an enzyme inactivating component and a preservative to extend the shelf life of the formulation in terms of growth hormones. The formulation can also include a fertilizing additive, and a surfactant. A system is also provided whereby the kelp is maintained in solid form, and dissolved in water just prior to use. The solid form kelp and/or water can include additives, or additives in separate form, if used, can be added to either the kelp or the kelp solution.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: March 20, 2012
    Assignee: Accelegrow Technologies, Inc.
    Inventor: Louis B. Johnson
  • Patent number: 8133920
    Abstract: A growth hormone formulation includes an enzyme inactivating component and a preservative. The formulation can also include a fertilizing additive, and a surfactant. The growth hormone can be a natural one such as that found in kelp or a synthetic one or a combination of both.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: March 13, 2012
    Assignee: Accelegrow Technologies, Inc.
    Inventors: Louis B Johnson, Jeffery L Peel
  • Patent number: 8133919
    Abstract: A growth hormone formulation includes an enzyme inactivating component and a preservative. The formulation can be incorporated into a dry fertilizer for application using the fertilizer itself or a component of the fertilizer such as one or more of the fillers commonly used in fertilizers.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: March 13, 2012
    Assignee: Accelegrow Technologies, Inc.
    Inventors: Louis B. Johnson, Jeffery L. Peel
  • Patent number: 8119168
    Abstract: Disclosed are compositions comprising an effective amount of a zinc containing material having an aqueous solubility within the composition of less than about 25% by weight at 25° C.; from about 5% to about 50% of a surfactant; and from about 40% to about 95% water; wherein the pH of the composition is greater than about 7. Further disclosed are compositions comprising an effective amount of a zinc containing material having an aqueous solubility within the composition of less than about 25% by weight at 25° C.; from about 5% to about 50% of a surfactant; and from about 0.1% to about 5% of a zinc ionophoric material; from about 40% to about 95% water; and wherein the pH of the composition is greater than about 7.
    Type: Grant
    Filed: March 18, 2003
    Date of Patent: February 21, 2012
    Assignee: The Procter & Gamble Company
    Inventors: Eric Scott Johnson, Elizabeth Ann Crane, James Robert Schwartz, Carl Hinz Margraf, III, Gregory V. Tormos, David Thomas Warnke
  • Patent number: 8088417
    Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: January 3, 2012
    Assignee: Dharma IP, LLC
    Inventors: Sunggyu Lee, Patricia Roberts
  • Patent number: 8071619
    Abstract: The invention relates to a novel injectable liquid formulation of paracetamol, comprising an aqueous solvent, a buffer agent with a pKa between 4.5 and 6.5, an isotonic agent and the dimer of paracetamol of formula (I), a method for preparation of said formulation and the use of said dimer for the stabilisation of a liquid paracetamol pharmaceutical formulation.
    Type: Grant
    Filed: February 16, 2004
    Date of Patent: December 6, 2011
    Inventor: Tho Nguyen-Xuan
  • Patent number: 8026276
    Abstract: Parenteral formulations of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl) -2-methylpropionic acid (CCI-779) are provided. One parenteral formulation contains CCI-779, an alcoholic co-solvent, and an antioxidant. Another parenteral formulation contains CCI-779, an alcoholic solvent, an antioxidant, a diluent solvent, and a surfactant. Processes for preparing parenteral CCI-779 formulations using a co-solvent concentrate are also provided.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: September 27, 2011
    Assignee: Wyeth LLC
    Inventors: Joseph T. Rubino, Victoria Siskavich, Maureen M. Harrison, Pooja Gandhi
  • Patent number: 7977369
    Abstract: Methods for treating bladder cancer comprising intravesicular administration of a stabilized pharmaceutical formulation comprising 5-(1-aziridinyl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methyl-1H-indole-4,7-dione (EO9). More specifically, the stabilized pharmaceutical formulation is instilled in the bladder for a time sufficient to treat the cancer.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: July 12, 2011
    Assignee: Spectrum Pharmaceuticals, Inc.
    Inventors: Bastiaan Nuijen, Ernie Pfadenhauer, Jos H. Beijnen
  • Patent number: 7910090
    Abstract: The present invention provides a base composition that allows for the formulation of non-irritating cosmetic and/or dermatological compositions. The base composition includes one or more of electrolyte, buffer, mild preservative, lubricant, or any combinations thereof. It is preferred that one or more of the above components are eye-safe and/or eye-compatible. The present invention also provides photoprotective cosmetic and/or dermatological compositions that include the base composition and one or more sunscreen active components and are non-irritating to mammalian eyes.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: March 22, 2011
    Assignee: Playtex Products, Inc.
    Inventors: Olga V. Dueva-Koganov, James P. SaNogueira
  • Patent number: 7906535
    Abstract: A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: March 15, 2011
    Assignee: Summit VetPharm, LLC
    Inventors: Ian Cottrell, Albert Ahn, Linda Dorneval
  • Patent number: 7842724
    Abstract: Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailability relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the treatment of conditions and diseases in which inhibition of abnormally increased calcium resorption is desired, including cancer, hypercalcemia, osteoporosis, osteopenia and Paget's disease. Methods for preparation and treatment are also provided.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: November 30, 2010
    Assignee: Genta Incorporated
    Inventor: Thomas N. Julian
  • Patent number: 7816332
    Abstract: The present invention provides an aqueous composition comprising—water; —a water miscible solvent; —and a polyene fungicide which is dissolved in the water and water miscible solvent. The present invention further provides a method for the production of the composition of the invention. The composition of the invention may be used as an antifungal treatment for a variety of products including food, feed, agricultural products, growth substrates and in- or outsides of buildings.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: October 19, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Jacobus Stark, Ferdinand Theodorus Jozef Van Rijn
  • Patent number: 7732474
    Abstract: The present invention relates to oral pharmaceutical preparations in the form of pellets in which a benzimidazole compound is stabilized by combining it with microcrystalline cellulose.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: June 8, 2010
    Assignee: Ratiopharm, GmbH
    Inventors: Frank Muskulus, Peter Kraaβ, Andrea Burgenmeister
  • Patent number: 7662855
    Abstract: Compositions for topical application for treating a skin disorder (e.g., acne) include a retinoid, which is solubilized completely in alcohol only with the aid of cosolvents such as esters (e.g., alkyl benzoate, isopropyl palmitate, isopropyl myristate, diisopropyl adipate and their derivatives). This completely solubilized retinoid can be used to formulate an emulsion system or liquid to powder suspension containing a second active, such as an antibiotic (e.g., clindamycin).
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: February 16, 2010
    Assignee: Imaginative Research Associates, Inc.
    Inventors: Mohan Vishnupad, Naomi Vishnupad
  • Patent number: 7632523
    Abstract: An enhanced activity aqueous disinfecting solution having a pH of from about 0.5 to about 6 and consisting essentially of (i) hydrogen peroxide in a concentration of from about 0.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: December 15, 2009
    Assignee: Virox Technologies Inc.
    Inventors: Jose A. Ramirez, Navid Omidbakhsh
  • Patent number: 7585460
    Abstract: The invention relates to a method for inhibiting the biological acidification of water which is in contact with materials containing sulfur in reduced form or with elemental sulfur, susceptible to oxidation on the part of Thiobacilli, comprising putting said materials in contact with soluble inorganic salts at concentrations ranging from 0.4 normal to saturation.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 8, 2009
    Assignees: ENI S.p.A., Enitecnologie S.p.A.
    Inventors: Francesco Crescenzi, Antonella Crisari, Cesare Achille Piatti
  • Patent number: 7544367
    Abstract: A method for producing a suspension, emulsion or dispersion of de-agglomerated particles (advantageously submicron-sized particles) of pyrithione salts comprising contacting agglomerated pyrithione salt particles with a de-agglomerating agent to produce the desired de-agglomerated pyrithione salt particles. Also disclosed is a method for making de-agglomerated submicron-sized particles of pyrithione salts comprision a heating step. Also disclosed are the particles made by the above methods and compositions comprising the particles and a base medium.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: June 9, 2009
    Assignee: Arch Chemicals, Inc.
    Inventors: Saeed M. Mohseni, Charles W. Kaufman, David C. Beaty, John J. Jardas, George Polson
  • Patent number: 7452554
    Abstract: A nanocolloidal platinum dispersion comprising nanocolloidal platinum and a polyacrylic acid salt, the nanocolloidal platinum having an average particle size of 1-5 nm, 90% or more of the nanocolloidal platinum having a particle size in a range of 0.1-10 nm, its production method, and a drink containing such a nanocolloidal platinum dispersion.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: November 18, 2008
    Assignee: APT Co, Ltd.
    Inventors: Yusei Miyamoto, Masashi Kajita, Naoki Toshima
  • Patent number: 7435380
    Abstract: A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from a spray bottle into the ostomy bag and retained on the inner walls thereof without being displaced therefrom by incoming waste during use of the ostomy bag. This allows the composition to continue to deodorize the ostomy bag headspace even after waste material begins to fill the bag.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: October 14, 2008
    Assignee: Church & Dwight Co., Inc.
    Inventor: Anthony E. Winston
  • Patent number: 7378408
    Abstract: Formulations containing an antibacterial alkali metal salt of a cephalosporin compound and methods of treating bacterial infections in dogs and cats.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: May 27, 2008
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Roger N. Kimball, Renuka D. Reddy, Evgenyi Y. Shalaev
  • Patent number: 7368435
    Abstract: A topical formulation having significant parasiticidal activity effective against endoparasites and/or ectoparasites such as heartworms, mites, fleas, ticks, flies is provided, which can be safe to use and avoids the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of a macrocyclic lactone, a neo-nicotinoid and optionally, an insect growth regulator. The topical formulation can be packaged together or packaged so that the macrocyclic lactone and the neo-nicotinoid are stored separately prior to administering the topical insecticide formulation to the animal.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: May 6, 2008
    Assignee: Summit Vetpharm, LLC
    Inventors: Ian W. Cottrell, Albert Ahn, Richard Fisher
  • Patent number: 7368466
    Abstract: A liquid, cold-temperature-stabilized preservative is based on carbendazim or a salt thereof, which includes, as low-temperature stabilizer, at least one aromatic alcohol and/or at least one aromatic glycol ether and/or a pyrrolidone.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: May 6, 2008
    Assignee: Air Liquide Sante (International)
    Inventors: Wolfgang Beilfuss, Ralf Gradtke, Olaf Kramf, Andreas Teevst
  • Patent number: 7345092
    Abstract: A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: March 18, 2008
    Assignee: Summit Vetpharm, LLC
    Inventors: Ian W. Cottrell, Albert Ahn, Richard Fisher, Christine M. Monro, Pierre R. Joseph
  • Patent number: 7306791
    Abstract: The present invention provides methods of preventing and/or treating multiple organ failure comprising the step of administering a therapeutically effective amount of agent comprising tumor cytotoxic factor-II (TCF-II) or hepatocyte growth factor (HGF). Methods of the present invention will be useful for preventing and/or treating the development of multiple organ failure resulting from burn, disseminated intravascular coagulation (DIC), circulatory failure, hemorrhagic shock, infectious disease, acute pancreatitis, ischemic disorder, hepatorenal syndrome, gastrointestinal hemorrhage, nutritional metabolic failure, terminal cancer, acquired immunodeficiency syndrome (AIDS), deterioration of systemic conditions due to radiation affection, and cachexia.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: December 11, 2007
    Assignee: Daiichi Sankyo Co., Ltd.
    Inventors: Hirohiko Arisawa, Hiroaki Masunaga, Hiromi Ogawa, Kanji Higashio
  • Patent number: 7261905
    Abstract: A non-toxic environmentally friendly aqueous disinfectant is disclosed for specific use as prevention against contamination by potentially pathogenic bacteria and virus. The aqueous disinfectant is formulated by electrolytically generating silver ions in water in combination with a citric acid. The aqueous disinfectant may include a suitable alcohol and/or a detergent. The aqueous disinfectant has been shown to be very effective at eliminating standard indicator organisms such as staphylococcus aureus, salmonella cholerasuis and pseudomonas aeruginosa.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: August 28, 2007
    Assignee: Pure Bioscience
    Inventors: Andrew B. Arata, Michael L. Krall
  • Patent number: 7261907
    Abstract: A non-stoichiometric clathrate of lipid and sulfur has been shown to effectively stabilize nerve cell membranes. As such, said compound has proven useful in a variety of neuropsychiatric disorders such as, addiction, depression, autism, Tourette's syndrome, and the like.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: August 28, 2007
    Inventor: Morris Mann
  • Patent number: 7235263
    Abstract: Processes for preparing products comprising an oxygen-generating additive for reducing the amount of skin irritation and inflamation and odor are disclosed. Specifically, products such as training pants and diapers are disclosed which contain a carbohydrate-hydrogen peroxide crystalline powder which, when wetted, produces a stream of oxygen which can be used by various bacteria on and near the wearer's skin during metabolism resulting in a significant decrease in the amount of volatile organic compounds produced by the bacteria during metabolism.
    Type: Grant
    Filed: February 10, 2005
    Date of Patent: June 26, 2007
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: David William Koenig, Bernard J. Minerath, Lindsay M. Gould
  • Patent number: 7229647
    Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: June 12, 2007
    Inventors: Sunggyu Lee, Patricia Roberts
  • Patent number: 7220726
    Abstract: An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal infection in a mammal; a pharmaceutically acceptable dipolar aprotic solvent; and a pharmaceutically acceptable aqueous secondary solvent. The composition can be used in methods of preventing or treating a systemic fungal infection in a mammal. The composition can be prepared by dissolving pimaricin or an antifungal derivative thereof in the pharmaceutically acceptable dipolar aprotic solvent; adding to the solution a pharmaceutically acceptable aqueous secondary solvent; and in a preferred method, by subsequently lypohilizing the composition, whereby a dry, shelf-stable composition is produced. This dry composition can be reconstituted into an aqueous solution suitable for parenteral administration.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: May 22, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Borje S. Andersson, Elias J. Anaissie
  • Patent number: 7205279
    Abstract: This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporin or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: April 17, 2007
    Assignee: Novartis AG
    Inventors: Sylvain Cottens, Barbara Haeberlin, Richard Sedrani, Jacky Vonderscher
  • Patent number: 7202208
    Abstract: The present invention relates to a liquid pharmaceutical composition consisting essentially of an erythropoietin protein, a multiple charged inorganic anion in a pharmaceutically acceptable buffer suitable to keep the solution pH in the range from about 5.5 to about 7.0, and optionally one or more pharmaceutically acceptable excipients. This composition is especially useful for the prophylaxis and treatment of diseases related to erythropoiesis.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: April 10, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventor: Apollon Papadimitriou
  • Patent number: 7182956
    Abstract: A stable composition of a drug comprising a carrier having a phosphatidylcholine component which entraps the drug is applied to the skin for transdermal delivery of the drug.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: February 27, 2007
    Inventors: Nicholas V. Perricone, Chim Potini
  • Patent number: RE39497
    Abstract: A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be stored at ambient temperature. Recovery is by adding aqueous solution to the composition.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: February 27, 2007
    Assignee: Nektar Therapeutics
    Inventors: Felix Franks, Ross H. M. Hatley
  • Patent number: RE41279
    Abstract: The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: April 27, 2010
    Assignee: Ecolab Inc.
    Inventors: David D. McSherry, Francis L. Richter
  • Patent number: RE42377
    Abstract: A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: May 17, 2011
    Assignees: Stryker Corporation, Stryker NV Operations Limited
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox