Abstract: The present invention provides antibacterial zeolite exhibiting a less discoloring action, obtained by treating the surface of zeolite supporting an antibacterial metal with 0.5 to 20% by weight, based on said zeolite, of a composition comprising (A) 100 parts by weight of a hydrolyzable silane and/or oligomer thereof which comprises 10 to 100% by weight of a hydrolyzable silane and/or oligomer thereof having an aryl group; (B) 1 to 1000 parts by weight of an organopolysiloxane having a basic nitrogen atom; and (C) 0.2 to 250 parts by weight of an acid which is soluble in water and which can form a salt with the aforesaid (B). The present antibacterial zeolite exhibits a remarkably less action of discoloring an organic polymer which contains the antibacterial zeolite when the polymer blend is placed under the influence of heat or the sunshine.

Abstract: The present invention relates to a microemulsion preconcentrate composition comprising (1) cyclosporin as an active component; (2) alkyl ester of polycarboxylic acid and/or carboxylic acid ester of polyols as a lipophilic solvent; (3) oil; and (4) surfactant. The composition according to the present invention is characterized in that it dissolves in an external phase such as water, artificial gastric fluid and artificial intestinal fluid by controlling the mixing ratio of the components thereby to get the microemulsion form of inner phase diameter of 100 nm or below. The composition according to the present invention can be formulated as the dosage form of a soft capsule, a hard capsule sealed with a gelatin banding at the conjugated portion, or an oral liquid preparation for oral administration.

Abstract: For the oral administration of the anti-depressant mirtazapine an aqueous solution or suspension is found which is preferably stabilized by methionine, is thickened, and which has a pH of from 2.5 to 3. By the formulation according to the invention, an undesirable local anesthetic effect of mirtazapine is avoided.

Abstract: A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.

Abstract: Disclosed are compositions comprising paclitaxel; and a pharmaceutically-acceptable, water-miscible, non-aqueous solvent, together with kits comprising the composition and methods of using the composition.

Abstract: A composition for local anesthesia which comprises (A) lidocaine, (B) a catecholamine such as epinephrine in an amount of, for example, 1/200,000 (g/ml) based on the volume of the composition, and (C) one or more amino acids such as glycine, glutamic acid, and L-glutamic acid-L-lysine or one or more hydroxycarboxylic acids such as lactic acid, glycolic acid, and citric acid, which has a duration suitable for short-time dental operations such as tooth extraction and excellent storage stability.

Abstract: Disclosed is a stable dilute solution composition of a 3-isothiazolone compound selected from the group consisting of 5-chloro-2-methyl-3-isothiazolone, 2-methyl-3-isothiazolone, 5-chloro-2-ethyl-3-isothiazolone, 2-ethyl-3-isothiazolone, 4,5-dichloro-2-methyl-3-isothiazolone, and mixtures thereof in water having extremely low levels of copper ion and an oxidant.

Abstract: Disclosed are pharmaceutical compositions containing solid dispersions in the form of co-precipitates, which solid dispersions contain rapamycin and a carrier medium, and methods of treatment utilizing such pharmaceutical compositions.

Abstract: Oil-in-water type emulsions having a pH below or equal to 3.5, especially a pH below or equal to 3, and comprising as a stabilizing agent a substantially water-soluble crosslinked anionic copolymer consisting of units derived from the reaction between (i) acrylamide, (ii) 2-acrylamido-2-methylpropanesulfonic acid and (iii) at least one compound possessing multiple olefinic unsaturation (crosslinking agent), in which the compound possessing multiple olefinic unsaturation is present in the copolymer at a concentration of between 0.06 and 1 mmol per mole of the collective monomer units, are stable.

Abstract: A sprayable or solid biodegradable wax carrier for insect pheromones and a method for constant release rate of the pheromone from the biodegradable wax. A composition comprising a pheromone and paraffin wax formulated as an aqueous emulsion or a solid suitable for application to a surface of a tree or crop for mating disruption of insect pests. Pheromone is released by diffusion or by partitioning from the biodegradable wax carrier or by pheromone exposure due to the biodegradable wax carrier degradation.

Abstract: The present invention relates to a novel structuring system comprising both xanthan gum and cross-linked polyacrylic acid polymer which combination unexpectedly has been found to provide enhanced stability for large size benefit agent droplets in an amphoteric/anionic surfactant system relative to use of either structurant alone.

Abstract: A pharmaceutical composition in the form of a microemulsion preconcentrate comprising a cyclosporin dissolved in a solvent system further comprising a hydrophobic component, a hydrophilic component, and a surfactant, wherein either the hydrophobic component is selected from tocol, tocopherols, tocotrienols, and derivatives thereof, or the hydrophilic component is selected from propylene carbonate or polyethylene glycol having an average molecular weight of less than 1000.

Abstract: Methods are provided to prepare a variety of tissues in a pathology-stable form keyed to the use of an aqueous solution of C.sub.2-6 dialdehyde and/or dialdehyde addition products, including the group consisting of glyoxal and/or glutaraldehyde in an amount sufficient to prevent autolysis and other degradative changes in various tissues. The said solution is capable of treating a tissue so as to maintain the tissue in a condition suitable for pathology and/or other experimental observation. The stabilizing solution is also useful to prepare parts or whole animals and plants in an anatomically preserved state for a prolonged period of time, and compositions useful in that method.

Abstract: A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can accept an electron, and a chelating agent, which can contribute its available electrons to the accepting orbital of the chlorine dioxide molecule. Both active and passive methods of releasing the chlorine dioxide from such chelates by competitive displacement with selected metal cations are presented. In this manner a stabilized solution of molecular chlorine dioxide can be stored until needed and the chlorine dioxide released at time of use for cleaning, disinfection or other uses.

Abstract: New microbicidal, optionally solvent- and emulsifier-free microbicidal active compound combinations and agents comprising known azole fungicides and quaternary ammonium compounds and their use in the preservation of materials.

Abstract: A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enhancer. Methods of enhancing transdermal electrotransport delivery and of forming a composition for the enhancement of transdermal electrotransport drug delivery, and a transdermal electrotransport delivery device (10) utilizing the compositions of the invention are disclosed.

Abstract: Gel for local treatment of skin diseases and for prophylaxis, characterised by containing more than 90% of a drying and/or protein coagulating, short-chained alcohol or alcohol mixture, primarily ethanol, and possibly adjuvants or additives and by containing a gelling agent, that possesses good skin-adhesive properties, that gives a matrix formation of alcohol or alcohol mixtures, that creates an evaporation-inhibiting effect, gives a prolonged effect, and forms a protective plaster when the gel has dried.

Abstract: A composition, suitable for stabilizing a polymeric composition against the effects of light, comprisinga) an N-acylated 2,2,6,6-tetraalkylpiperidinyl group (hereinafter N-acylated HALS) containing compound; andb) an N-oxy-subst. 2,2,6,6-tetraalkylpiperidinyl group (hereinafter N-oxy-substituted HALS) containing compound.A further aspect of the invention relates to a composition, suitable for stabilizing a polymeric composition against the effects of light, comprisinga) an N-acylated 2,2,6,6-tetraalkylpiperidinyl-group-containing compound in which a spiro group is attached in the 4-position (hereinafter defined as component i); andb) an N-acylated 2,2,6,6-tetraalkylpiperidinyl-group-containing compound in which in the 4-position no spiro group is present (hereinafter defined as component ii).These compounds are suitable as light stabilizers in acid catalyzed lacquer system.

Abstract: Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group capable of forming hydrogen and Van der Waal bonds with the reactive moieties of the aldehydes and antimicrobial agents in the preservative and embalming compositions. The amount of polar chemical(s) necessary to stabilize the reactive aldehydes and antimicrobial compounds/agents is based on a molar ratio of (i) polar groups in the stabilizing chemicals to (ii) reactive groups in the active preservative ingredient of at least 0.8.

Abstract: Solid and liquid pharmaceutical preparations containing cilansetron or its acid addition salts as active substance which include an amount sufficient to stabilize cilansetron against racemization, of a physiologically compatible water-soluble acid additive selected from monobasic or multibasic organic acids having 2 to 12 carbon atoms with a first p.sub.s value between 1.1 and 4.8, acid salts of the aforementioned multibasic organic acids, and acid salts of multibasic mineral acids having a first available pK.sub.s value between 1.5 and 7.5, as well as the use of such acid additives for stabilizing cilansetron against racemization in pharmaceutical preparations.

Abstract: Novel, stable formulations of bupropion hydrochloride are provided which will maintain at least 80% of initial bupropion hydrochloride potency after one year. Methods of inhibiting degradation of bupropion hydrochloride are also provided.

Abstract: This invention discloses organoleptically acceptable formulations containing non-solubilized S(+) 1,8-diethyl-1,3,4,9-tetrahydropyrano?3,4-b!indole-1-acetic acid, preferably with an acidic component, also known as S(+)etodolic acid or S(+)etodolac.

Abstract: Stable microbicidal compositions containing a 3-isothiazolone compound, chlorate or perchlorate salts, copper salts and water are disclosed. Also disclosed are methods of preventing or reducing precipitate formation in 3-isothiazolone compositions.

Abstract: A composition for oral administration which contains a pyridazinone compound of the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each independently a hydrogen atom or a lower alkyl, X is a halogen atom, a cyano or a hydrogen atom, Y is a halogen atom, a trifluoromethyl or a hydrogen atom, and A is a C.sub.1 -C.sub.8 alkylene optionally substituted by hydroxy, or a pharmacologically acceptable salt thereof, and an organic acid. According to the present invention, a composition for oral administration which is stable to heat, light, moisture and the like and which shows improved dissolution and absorption of a pyridazinone compound can be provided.

Abstract: The present invention provides aqueous low (70 weight percent or less) VOC hair styling compositions. More particuarly, the present invention provides a low VOC hair styling composition containing at least one acrylic hair fixative resin and one or more plasticizing compounds selected from polycarboxylic acid esters and dimehiconecoporyols. The present invention also provides a low beading, low VOC hair styling composition comprising at least one surface tension reducing compound, at least one acrylic hair fixative resin, and at least one simeticone. The present invention also provides an aqueous hair resin composition which inhibits microbial growth. The aqueous hair resin composition contains at least one acrylic hair fixative resin and iodopropynylbutylcarbamate.

Abstract: The present invention provides for stabilization of misoprostol in solid dispersions using amorphous excipients or excipients which have been converted to an amorphous state such as hydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, cellulose acetate phthalate, cellulose acetate butyrate, hydroxyethyl cellulose, ethyl cellulose, polyvinyl alcohol, polyethylene glycol, starch, polypropylene, dextrans, dextrins, hydroxypropyl .beta.-cyclodextrin chitosan, co-(lactic/glycolic)copolymers, poly(orthoester), polyvinyl chloride, polyvinyl acetate, ethylene vinyl acetate, lectins, carbopols, silicon elastomers, cyclodextrins, polyacrylic polymers, maltodextrins, lactose, fructose, inositol, trehalose, maltose, and raffinose, (and other mono-, di- and tri- saccharides) and .alpha.-, .beta.- and .gamma.-cyclodextrins, and more preferably the excipients which are used are dextran, maltodextrin, hydroxypropyl .beta.-cyclodextrin and maltose.

Abstract: A liquid bait for target insects and methods of attracting or controlling insects by means of its use. Sorbitol is dissolved in an amount of water sufficient to form an aqueous carrier. The dissolved sorbitol is in a concentration great enough to be effective as a humectant to retard drying of the liquid carrier. The liquid bait further includes at least one insect attractant that is dissolved, dispersed, suspended, or emulsified in the liquid carrier in an amount effective to attract the target insects. The insect attractant may include, in combination, sucrose, fructose, d-maltose, the lithium salt of saccharin, lithium chloride, and vitamins. The liquid bait also may include an effective amount of an insect control active ingredient selected from the group consisting of insecticides, insect growth regulators, chitin inhibitors, insect pathogens, insect-controlling materials derived from insect pathogens, and combinations thereof.

Abstract: Concentrated aqueous liquid disinfectant compositions which exhibit a blooming effect when diluted in a larger volume of water are provided. The concentrate compositions include non-phenolic constituents to provide a disinfecting effect, and are non pine-oil containing. Working strength dilutions of the concentrated aqueous liquid disinfectant compositions are effective against gram positive type pathogenic bacteria such as Staphylococcus aureus, as well as gram negative type pathogenic bacteria such as Salmonella choleraesuis.

Abstract: A preparation comprising ortho silicic acid which is stabilized with a stabilizing agent and is substantially free of organic silicon compounds, preferably a nitrogen-containing stabilizing agent such as choline, to a method for preparing such a preparation, comprising: i) providing a solution containing a stabilizing agent; ii) dissolving an inorganic silicon compound in the solution containing the stabilizing agent; and iii) hydrolyzing the silicon compound to ortho silicic acid, and to the obtained biological preparation.

Abstract: The present invention relates to the use of orange extract for the preparation of pharmaceutical, cosmetic, food or agricultural compositions with an anti-radical activity. The orange extract is substantially free from ascorbic acid.

Abstract: The subject of the invention is an aqueous suspension containing: 0.1-20% by mass beta-cypermethrin, 0-40% by mass other pesticide substance, 1-10% by mass surface active substances in total and within this, 1-5% by mass ethoxylated polyaryl-phenol-phosphate or sulfate, 0.1-25% by mass mineral and/or synthetic silicates, 0.1-1% by mass synthetic silicic acid and up to 100% by mass other auxiliary materials and water as dispersant.

Abstract: The invention relates to a tablet or capsule that is characterised by a powder mixture having a content of stable ranitidine hydrochloride Form 1 together with a carrier and/or diluent, and to manufacturing processes for the tablet.

Abstract: Stable topical emulsions for cosmetic/pharmaceutical purposes can be made from a two component system of a powdered ascorbic acid phase and a liquid phase, the liquid phase containing an emulsion stabilizingly effective amount of an organoclay material.

Abstract: An aqueous acidic disinfecting and sterilizing composition for medical instruments, which may include brass, copper, aluminum, stainless steel, plastic and ceramic components. The composition contains hydrogen peroxide, peracetic acid, a corrosion inhibitor system, a surfactant and a stabilizer. These compositions have in use stability and are effective as a disinfectant and/or sterilant either at room or when heated. For other applications, surfactants, sequestering agents and stabilizers may be optional.

Abstract: Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

Abstract: Invented are stabilized tablet formulations of substituted 3,5-diene steroidal compounds. Also invented are methods of preparing stabilized tablet formulations of substituted 3,5-diene steroidal compounds.

Abstract: Oil-in-water type emulsions having a pH below or equal to 3.5, especially a pH below or equal to 3, and comprising as a stabilizing agent a substantially water-soluble crosslinked anionic copolymer consisting of units derived from the reaction between (i) acrylamide, (ii) 2-acrylamido-2-methylpropanesulfonic acid and (iii) at least one compound possessing multiple olefinic unsaturation (crosslinking agent), in which the compound possessing multiple olefinic unsaturation is present in the copolymer at a concentration of between 0.06 and 1 mmol per mole of the collective monomer units, are stable.

Abstract: A cockroach repellent comprising a non-toxic, non-noxious, non-corrosive compound that is substantially odorless to humans and organisms except to cockroaches, wherein the present invention provides an environmentally safe cockroach repellent that consists of various compositions of matter that includes a mixture of selective amounts of linoleic acid together with a suitable antioxidant preservative which creates a non-noxious vaporous pheromic substance that is repellent to cockroach presence and prevents subsequent infestation in a given area, the compound being synergistic in prolonging over time the desirable action of the invention, and whose vapors do not form a flammable mixture with air.

Abstract: The invention relates to the use of a dispersion of surface-stabilized polymer particles in a non-aqueous medium, in a cosmetic, hygiene or pharmaceutical composition. Moreover, the invention also relates to compositions comprising the above-mentioned dispersion of polymer particles.

Abstract: An oral composition, particularly a gel, is provided which includes at least 2%, preferably 6% or higher of hydrogen peroxide in a carrier stabilized by a triphenylmethane dye. Particularly useful as the dye are FD&C Blue 1 and FD&C Green 3 at levels ranging from 0.006 to 1 %. Further stability can also be achieved through use of a chelating acid, particularly phosphoric acid.

Abstract: The present invention relates to water-emulsifiable liquid formulations of insecticidal active compounds, characterized in that they containa) 2.5 to 30% of active compound,b) 5 to 77.5% of a mixture of benzyl acetate and an alcohol in the ratio 25-95% to 5-75%,c) 2.5 to 20% of formulation auxiliary.

Abstract: The present invention provides improved methods for manufacturing solutions including medical solutions. To this end, in an embodiment, a method for preparing a medical solution is provided comprising the steps of: placing a solution in a gas permeable container; and allowing carbon dioxide to permeate through the container until a desired pH is achieved.

Abstract: A syrup containing N-acetyl-cysteine, stable for at least two years, having pleasant taste and smell, consists of an aqueous solution of NAC, a sweetening agent and a thickening agent. The solution can also contain a flavoring agent and a preservative. The pH is between 5 and 8.

Abstract: Disclosed are compositions and methods for preventing or substantially inhibiting the hemolytic activity of hemolysis inducing agents. The methods and compositions are based on the use of an anionic oligosaccharide, such as polysulfated cyclodextrin, to achieve the desired reduction in hemolytic active inducing agents.

Abstract: A retinal-containing cosmetic skin-care composition comprising an oil-in-water emulsion stabilized by BHT and a method for preparing same.

Abstract: A stable, freeze-dried, and pharmaceutically acceptable formulation includes a protein, a buffer, alanine, and mannitol, at a mass ratio of mannitol/alanine being 0.1-1, wherein the formulation being useful in an assay kit.

Abstract: Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nasal mucosa. The compositions are suitably adapted for administration in the form of a nasal spray.

Abstract: Method of preserving mineral slurries from microbiological attack comprising introducing a nitrite or TBIP followed by sufficient 3-isothiazolone biocide to protect the slurry from attack. Mineral slurries which are so protected are also disclosed.

Abstract: Gelatin coated pharmaceutical dosage units containing, for example, analgesic compounds, such as aspirin, stabilized with a proteolytic enzyme, such as pepsin, are described.

Abstract: Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nasal mucosa. The compositions are suitably adapted for administration in the form of a nasal spray.