Containing Chemically Combined Protein Or Biologically Active Polypeptide Patents (Class 525/54.1)
Solid polymer treated by stepwise reaction with naturally occurring alpha or beta amino acid or a material which contains a residue of said amino acid, e.g., a functionally protected amino acid, etc. (Class 525/54.11)
  • Fluorogenic materials and uses thereof
    Patent number: 7629437
    Abstract: A method is presented for the preparation and use of fluorogenic peptide substrates that allows for the configuration of general substrate libraries to rapidly identify the primary and extended specificity of enzymes, such as proteases. The substrates contain a fluorogenic-leaving group, such as 7-amino-4-carbamoylmethyl-coumarin (ACC). Substrates incorporating the ACC leaving group show comparable kinetic profiles as those with the traditionally used 7-amino-4-methyl-coumarin (AMC) leaving group. The bifunctional nature of ACC allows for the efficient production of single substrates and substrate libraries using solid-phase synthesis techniques.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: December 8, 2009
    Assignee: The Regents of the University of California
    Inventors: Jennifer L. Harris, Bradley J. Backes, Jonathan A. Ellman, Charles S. Craik
  • Biopolymer and methods of making it
    Patent number: 7625961
    Abstract: The present invention relates to a composition, which can be referred to as a biopolymer, including fermentation solid and thermoactive material. The present invention also includes methods of making the biopolymer, which can include compounding fermentation solid and thermoactive material. The present biopolymer can be formed into an article of manufacture.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: December 1, 2009
    Assignee: POET Research, Inc.
    Inventor: Michael J. Riebel
  • Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces
    Patent number: 7625552
    Abstract: According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: December 1, 2009
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Michael N. Helmus, Paul Valint, Shrirang V. Ranade
  • Bifunctional-modified hydrogels
    Patent number: 7615593
    Abstract: Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: November 10, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Weiyun John Kao, Jing Li, David Lok, Rathna Gundloori
  • Bioabsorbable Surgical Composition
    Publication number: 20090266467
    Abstract: Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses.
    Type: Application
    Filed: March 24, 2009
    Publication date: October 29, 2009
    Inventors: Joshua B. Stopek, Ahmad Robert Hadba
  • Hydrogels for protein concentration
    Patent number: 7605232
    Abstract: A method of concentrating proteins from whole blood comprising exposing whole blood to covalently crosslinked hydrogel to remove water from the blood into the hydrogel to thereby concentrate the proteins in the whole blood. The hydrogel may absorb, for example, 50% or 90% of the water from the blood while excluding proteins with a weight of more than about 15,000 Daltons. In some embodiment, the hydrogels are dry, sterile, and spherical.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: October 20, 2009
    Assignee: Incept LLC
    Inventor: Chandrashekhar P. Pathak
  • Methods of preparing polymers having terminal amine groups using protected amine salts
    Patent number: 7601798
    Abstract: The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: October 13, 2009
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Belen Rubio
  • ASYMMETRIC FLUORO-SUBSTITUTED POLYMETHINE DYES
    Publication number: 20090252687
    Abstract: The present invention relates to improved conjugates of biological molecules with an improved class of water-soluble, green to near infra-red (NIR) cyanine labelling dyes. The dyes are asymmetric fluoro-substituted polymethines, and exhibit a high degree of photostability and reduced dye-dye quenching, as well as a high fluorescence quantum yield. The conjugates are useful for in vivo optical imaging, as well as fluorescence detection methods. Also disclosed are pharmaceutical compositions containing the conjugates, kits for the preparation of such compositions, and methods of in vivo imaging using the conjugates.
    Type: Application
    Filed: July 31, 2007
    Publication date: October 8, 2009
    Inventor: Michael Edward Cooper
  • IL-21 Derivatives and Variants
    Publication number: 20090253864
    Abstract: The invention provides derivatives of IL-21 or variants thereof, methods of producing such variants, new variants of IL-21, and various methods of using such molecules.
    Type: Application
    Filed: August 12, 2008
    Publication date: October 8, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Bernd Peschke, Christine Bruun Schiodt, Helle Woldike, Florencio Zaragoza Dorwald, Anne Worsaae
  • Composition, method and use of bi-functional biomaterials
    Patent number: 7598344
    Abstract: The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: October 6, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: Angela M. Belcher, Christine J. Schmidt, Kiley P. H. Miller, Archit Sanghvi
  • Protein crosslinkers, crosslinking methods and applications thereof
    Patent number: 7597882
    Abstract: Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: October 6, 2009
    Assignee: Incept LLC
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, James H. Dreher
  • Thermosensitive and biocompatible amphiphilic poly(organophosphazenes) and preparation method thereof
    Patent number: 7598318
    Abstract: The present invention relates to a thermosensitive and biocompatible poly(organophosphazenes) represented by Formula 1, and a preparation method thereof: wherein R is a methyl or ethyl group; R? is selected from the group consisting of COOR, CH2COOR, CH2CH2COOR, CH2CH(CH3)2, CH2C6H5, CH(CH3)CH2CH3 and CH3; R? is selected from the group consisting of CH2COOR, CH2CH2COOR, CH2CH(CH3)2, CH2C6H5, CH(CH3)CH2CH3 and CH3; R?? is a group selected from the group consisting of CH2COOR, CH2CH2COOR and H, wherein R is the same as defined above; n is a number between from 30 to 100; x is a number selected from the integers of 3, 4, 7, 12 and 16; y is a number between from 0.5 to 1.5; a equals to 1; and b and c equal to 0 or 1.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: October 6, 2009
    Assignee: EWHA University - Industry Collaboration Foundation
    Inventors: Youn Soo Sohn, Ji Yeon Seong, Yong Joo Jun, Joo Ik Kim
  • MODIFIED RECOMBINANT FACTOR VIII AND VON WILLEBRAND FACTOR AND METHODS OF USE
    Publication number: 20090247459
    Abstract: The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.
    Type: Application
    Filed: November 7, 2008
    Publication date: October 1, 2009
    Inventors: Hans-Peter Schwarz, Peter Turecek
  • Biocompatible crosslinked polymers with visualization agents
    Patent number: 7592418
    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: September 22, 2009
    Assignee: Incept LLC
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
  • Water-Soluble Polymer Alkanals
    Publication number: 20090234070
    Abstract: The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.
    Type: Application
    Filed: January 28, 2009
    Publication date: September 17, 2009
    Applicant: Nektar Therapeutics Al, Corporation
    Inventor: Antoni Kozlowski
  • Collagen Powder and Collagen-Based Thermoplastic Composition For Preparing Conformed Articles
    Publication number: 20090226557
    Abstract: The invention provides a new collagen based technology. The invention provides a dry collagen powder as a pre-cursor for the preparation of an homogeneous thermoplastic collagen-based composition, which may further comprise additives. The present invention relates also the use of said composition in the manufacturing of solid articles conformed according to plastic technology, and to the articles.
    Type: Application
    Filed: March 13, 2006
    Publication date: September 10, 2009
    Inventors: Vicente Etayo Garralda, Oliver Kotlarski, Franz Maser, Michael Meyer
  • NOVEL ANTITHROMBOTIC AGENT
    Publication number: 20090221496
    Abstract: The present invention provides: a pharmaceutical composition comprising an albumin conjugated with polyethylene glycol; and a method of treating a human thrombosis or a human ischemic disease, comprising intravenously administering an albumin conjugated with polyethylene glycol to a patient.
    Type: Application
    Filed: March 1, 2007
    Publication date: September 3, 2009
    Applicant: KEIO UNIVERSITY
    Inventors: Makoto Suematsu, Shintaro Mandai
  • Method Of Producing A Modified (POLY) Peptide
    Publication number: 20090220452
    Abstract: This invention relates to a method of producing a modified (poly)peptide, said method comprising the step of modifying in an organic solvent a crown ether-bound (poly)peptide at one or more carboxylic groups by esterification or thioesterification and/or at the amino group of the N-terminal amino acid by amidation or alkylation. Furthermore provided are (poly)peptides and antibodies obtainable with the method of the invention as well as medical uses thereof.
    Type: Application
    Filed: September 28, 2006
    Publication date: September 3, 2009
    Applicant: UNIVERSITY OF GENEVA
    Inventor: Paolo Botti
  • SMALL PEPTIDIC AND PEPTIDO-MIMETIC AFFINITY LIGANDS FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
    Publication number: 20090215025
    Abstract: The present invention pertains to compounds that show a high affinity to Factor VIII and Factor VIII-like proteins, and their uses. The compounds are characterized by the general Formula B-Q-X, wherein B represents a dipeptide, tripeptide, or a peptidomimetic; Q represents a spacer and X represents an anchoring molecule; Q and X are optional. These compounds can be used for coating a solid support material. The resulting coated solid support material can be used for purifying Factor VIII by means of affinity chromatography methods. In addition, the compounds of the present invention may be used for stabilizing Factor VIII and for enhancing its activity. The present invention thus pertains also to methods for manufacturing a stabilized Factor VIII containing medicament of increased activity. The inventive compounds can furthermore be used in diagnostic kits and as research tools.
    Type: Application
    Filed: December 7, 2006
    Publication date: August 27, 2009
    Applicant: TECHNISCHE UNIVERSITAT MUNCHEN
    Inventors: Sebastian Knor, Horst Kessler, Charlotte Hauser, Alexey Khrenov, Evgueni Saenko
  • Macromolecular Conjugates And Processes For Preparing The Same
    Publication number: 20090203842
    Abstract: Making a suspended or soluble macromolecular conjugate comprising binding a first macromolecule to a solid via a stable, disruptable bond, stably linking additional macromolecules, and releasing the macromolecular conjugate, as well as macromolecular conjugates prepared by the method.
    Type: Application
    Filed: April 8, 2009
    Publication date: August 13, 2009
    Applicant: ABBOTT LABORATORIES
    Inventor: John C. Russell
  • Methods of preparing polymers having terminal amine groups using protected amine salts
    Patent number: 7569657
    Abstract: The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: August 4, 2009
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Belen Rubio
  • BIOMIMETIC MODELLING SYSTEMS FOR REPRODUCING SPREADING PHENOMENA OF COSMETIC AND PHARMACEUTICAL FORMULATIONS ON HUMAN SKIN
    Publication number: 20090189986
    Abstract: The invention relates to a skin substitute for investigating the behavior of cosmetic and pharmaceutical compositions to be applied topically, where the skin substitute is a three-dimensionally crosslinked polyacrylamide matrix and water and at least one polypeptide is bonded in
    Type: Application
    Filed: January 21, 2009
    Publication date: July 30, 2009
    Applicant: EVONIK GOLDSCHMIDT GMBH
    Inventors: Ralph Scheuermann, Christian Frech, Jurgen Meyer
  • Imprinted polymer for binding of organic molecules or metal ions
    Publication number: 20090191644
    Abstract: The invention relates to an imprinted polymer imprinted with an organic molecule or a metal ion wherein the matrix of the polymer has been prepared from one or more monomers including bilirubin or an analogue thereof. The imprinted polymers may be prepared by polymerising one or more monomers including bilirubin or an analogue or derivative thereof in the presence of the molecule or metal ion to be imprinted or an analogue or derivative thereof, and subsequently at least partly removing the molecule or ion to be imprinted or its analogue or derivative. The polymers may be used in a method for detection and/or assay of the imprinting molecule or metal ion.
    Type: Application
    Filed: June 29, 2005
    Publication date: July 30, 2009
    Inventor: Miruna Petcu
  • Poly(Ethylene Glycol) Derivatives with Proximal Reactive Groups
    Publication number: 20090186984
    Abstract: An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated (polyethylene glycol) and the biologically active agent.
    Type: Application
    Filed: March 24, 2009
    Publication date: July 23, 2009
    Applicant: Nektar Therapeutics AL, Corporation
    Inventors: J. Milton Harris, Antoni Kozlowski
  • COVALENT ASSEMBLY OF ULTRATHIN POLYMERIC FILMS
    Publication number: 20090170179
    Abstract: In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films.
    Type: Application
    Filed: October 9, 2008
    Publication date: July 2, 2009
    Inventors: David M. Lynn, Maren E. Buck, Jingtao Zhang
  • Branched polyalkylene glycols
    Patent number: 7547765
    Abstract: The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity are bound; and a physiologically active polypeptide modified with the branched polyalkylene glycol.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: June 16, 2009
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Tatsuya Murakami, Noriko Sukurai, Kinya Yamashita, Mayumi Mukai, Takashi Kuwabara
  • CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY
    Publication number: 20090142842
    Abstract: Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
    Type: Application
    Filed: November 7, 2008
    Publication date: June 4, 2009
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: James W. Yockman, Jonathan Brumbach, Lane V. Christensen, Sung Wan Kim
  • LIGAND MOLECULE-IMMOBILIZED POLYMER, LIGAND MOLECULE-IMMOBILIZED PARTICLE, METHOD OF DETECTING TARGET SUBSTANCE, AND METHOD OF SEPARATING TARGET SUBSTANCE
    Publication number: 20090137064
    Abstract: A ligand molecule-immobilized polymer has a structure represented by the following general formula (1). In the general formula (1), R1 represents a ligand molecule-containing group, R2 represents a hydrophobic group, R3 represents a spacer site, R4 represents a hydrophilic group, R5 represents a group having charge, a to d specify a composition ratio and each represent an integer of 1 or more, and n and m specify chain lengths and represent integers satisfying the relationships of 1?n(a+b+c+d)?10,000 and 1?m?350.
    Type: Application
    Filed: November 24, 2008
    Publication date: May 28, 2009
    Applicant: CANON KABUSHIKI KAISHA
    Inventor: Kousuke Mukumoto
  • Drug Carrier
    Publication number: 20090136443
    Abstract: The present invention has an object of providing a drug carrier capable of controlling in vivo pharmacokinetics. The present invention is directed to a drug carrier comprising a molecular assembly having a drug incorporated therein, and the above object can be achieved by a part of the amphiphilic molecules included in the molecular assembly being released from the molecular assembly by an external environmental change. The present invention utilizes a phenomenon that the hydrophilic-hydrophobic balance of the amphiphilic molecules is shifted toward hydrophilicity by an external environmental change and thus the amphiphilic molecules are freed from the molecular assembly.
    Type: Application
    Filed: March 10, 2006
    Publication date: May 28, 2009
    Applicants: Oxgenix Co., Ltd., WASEDA UNIVERSITY
    Inventors: Shinji Takeoka, Yosuke Okamura, Hideo Kanazawa, Shuji Hisamoto, Kohei Kubota, Yosuke Obata
  • TRIGGERABLY DISSOLVABLE HOLLOW FIBERS FOR CONTROLLED DELIVERY
    Publication number: 20090136553
    Abstract: Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue structures because nutrients, cytokines or other cell growth and/or differentiation compounds, as well as drugs, such as antibiotics and steroids, can be administered over time, and the tubular structures can be dissolved non-invasively.
    Type: Application
    Filed: September 25, 2008
    Publication date: May 28, 2009
    Inventors: Jorg C. Gerlach, Jianjun Guan, Steven R. Little, Alan J. Russell, Jillian Tengood, William R. Wagner
  • Organic compounds
    Publication number: 20090137737
    Abstract: The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical moldings, for example ophthalmic moldings such as in particular contact lenses.
    Type: Application
    Filed: January 21, 2009
    Publication date: May 28, 2009
    Inventors: Thomas Hirt, Jacalyn Marie Schremmer, Troy Vernon Holland, Dieter Lohmann
  • Accelerants for the Modification of Non-Natural Amino Acids and Non-Natural Amino Acid Polypeptides
    Publication number: 20090137736
    Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
    Type: Application
    Filed: November 8, 2006
    Publication date: May 28, 2009
    Applicant: AMBRX, INC.
    Inventors: Feng Tian, Zhenwei Miao
  • CONTROLLED MOLECULAR WEIGHT AMINO ACID POLYMERS HAVING FUNCTIONALIZABLE BACKBONES AND END GROUPS AND PROCESSES FOR PREPARING THE SAME
    Publication number: 20090131589
    Abstract: The present disclosure relates to processes for preparing metal-free, mono-dispersed polymers of amino acids. The polymers include homopolymers, random copolypeptides, block copolypeptides, block copolymers with at least one peptidyl block, grafted copolypeptides, and polypetidyl dendrimers. The disclosed process does not make use of a heavy metal catalyst, inter alia, copper or nickel containing reagents. The disclosed process encompasses a “living polymerization” such that the growth of each polymer chain is not truncated or otherwise halted by undesirable side reactions or limitations due to the length or size of the growing polymer chain, provides amino acid comprising polymers having a narrow polydispersity, is conducted at lower temperatures, and avoids the premature secondary folding that inhibits the formation of polymers having a low polydispersity index.
    Type: Application
    Filed: October 29, 2008
    Publication date: May 21, 2009
    Inventors: Carmen Scholz, Willy Vayaboury
  • Modular Bioresorbable or Biomedical, Biologically Active Supramolecular Materials
    Publication number: 20090130172
    Abstract: The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or bio medical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.
    Type: Application
    Filed: May 3, 2006
    Publication date: May 21, 2009
    Inventors: Patricia Yvonne Wilhelmina Dankers, Gaby Maria Hoorne-Van Gemert, Henricus Marie Janssen, Egbert Willem Meijer, Anton Willem Bosman
  • Solid Support for Fmoc-Solid Phase Synthesis of Peptides
    Publication number: 20090131587
    Abstract: The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.
    Type: Application
    Filed: November 5, 2008
    Publication date: May 21, 2009
    Applicant: MALLINCKRODT INC.
    Inventors: KRIPA S. SRIVASTAVA, MATTHEW R. DAVIS
  • Absorbable ?-cyanoacrylate compositions
    Patent number: 7534907
    Abstract: A monomer composition comprising at least one polymerizable alkyl ester ?-cyanoacrylate monomer. Specifically, the ?-cyanoacrylate monomer is an alkyl ester ?-cyanoacrylate monomer of the general formula having a spacer R1: n is from 2 to 12; R3 and R4 are each an alkyl group or a hydrogen, and at least one of R3 or R4 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 carbon atoms; R2 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 carbon atoms; and the combined number of carbon atoms (N) in the spacer R1 is at least n+1.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: May 19, 2009
    Assignee: Ethichon, Inc.
    Inventor: Hongbo Liu
  • Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof
    Publication number: 20090123365
    Abstract: A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a capping ligand, an amphiphilic copolymer, and combinations thereof, wherein the hydrophobic protection structure encapsulates the nanospecies, and at least one histidine-tagged peptide or protein conjugated to the hydrophobic protection structure, wherein the at least one histidine-tagged peptide or protein has at least one binding site.
    Type: Application
    Filed: May 2, 2006
    Publication date: May 14, 2009
    Applicant: EMORY UNIVERSITY
    Inventors: Lily Yang, Shuming Nie, Xiaohu Gao, Xiang Hong Peng
  • Polymer nanoparticles coated by magnetic metal oxide and uses thereof
    Publication number: 20090110644
    Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.
    Type: Application
    Filed: September 24, 2008
    Publication date: April 30, 2009
    Inventors: Shlomo Margel, Benny Perlstein, Chaya Brodie, Tom Mikkelsen
  • Supramolecular Ionomers
    Publication number: 20090111930
    Abstract: The invention relates to supramolecular ionomers. i.e. polymers having quadruple hydrogen bonding units (4H-units) and ionic groups or ionogenic groups within their structure. The supramolecular ionomers can be dispersed or solubilized in water at high solids contents while maintaining low viscosities, facilitating easy use and processing of the resulting aqueous formulations. The aqueous supramolecular ionomer compositions have excellent film-forming properties. Moreover, the polymer materials have good mechanical properties after drying, as they are not tacky, show high elasticity and low or no creep.
    Type: Application
    Filed: July 11, 2005
    Publication date: April 30, 2009
    Inventors: Gaby Maria Leonarda van Gemert, Ronny Mathieu Versteegen, Henricus Marie Janssen, Egbert Willem Meijer, Anton Willem Bosman
  • Dendrimer Based Compositions And Methods Of Using The Same
    Publication number: 20090104119
    Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based multifunctional compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).
    Type: Application
    Filed: August 25, 2005
    Publication date: April 23, 2009
    Inventors: Istvan J. Majoros, Thommey P. Thomas, James R. Baker, Zhengyi Cao, Jolanta F. Kukowska-Latallo
  • Polymer conjugates of interferon Beta-1a and uses
    Publication number: 20090104150
    Abstract: An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
    Type: Application
    Filed: March 20, 2008
    Publication date: April 23, 2009
    Inventors: Blake Pepinsky, Laura Runkel, Margot Brickelmaier, Adrian Whitty, Paula Hochman
  • CONJUGATE ADDITION REACTIONS FOR THE CONTROLLED DELIVERY OF PHARMACEUTICALLY ACTIVE COMPOUNDS
    Publication number: 20090098083
    Abstract: The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
    Type: Application
    Filed: August 15, 2008
    Publication date: April 16, 2009
    Inventors: Jeffrey A. Hubbell, Donald Elbert, Ronald Schoenmakers
  • Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
    Patent number: 7511095
    Abstract: The invention provides reagents and methods for conjugating a polymer specifically to the ?-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the ?-amine of a polypeptide having a cytokine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: March 31, 2009
    Assignee: Nektar Therapeutics AL, Corporation
    Inventors: Michael J. Roberts, Zhihao Fang
  • REACTIVE SURFACE ON A POLYMERIC SUBSTRATE
    Publication number: 20090081797
    Abstract: Plasma treated cyclic polyolefin copolymer surfaces having enhanced binding density for binding biologically active agents and cells are provided. These plasma treated cyclic polyolefin copolymer surfaces may be further enhanced for binding biologically active agents or cells by the application of conjugates. Methods of making and characterizing treated polymer surfaces are also provided.
    Type: Application
    Filed: August 29, 2008
    Publication date: March 26, 2009
    Inventors: ANDREI G FADEEV, Santona Pal, David Michael Weber
  • Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules
    Publication number: 20090054590
    Abstract: Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P and Q represent linkage fragments that join polymer arms polya and polyb, respectively, to central carbon atom, C, by hydrolytically stable linkages in the absence of aromatic rings in the linkage fragments. R typically is hydrogen or methyl, but can be a linkage fragment that includes another polymer arm. A specific example is an mPEG disubstituted lysine having the structure where mPEGa and mPEGb have the structure CH3O—(CH2CH2O)nCH2CH2— wherein n may be the same or different for polya- and polyb- and can be from 1 to about 1,150 to provide molecular weights of from about 100 to 100,000.
    Type: Application
    Filed: September 20, 2008
    Publication date: February 26, 2009
    Applicant: Nektar Therapeutics AL, Corporation
    Inventors: J. Milton Harris, Francesco Maria Veronese, Paolo Caliceti, Oddone Schiavon
  • Compositions comprising polyphenol
    Publication number: 20090035440
    Abstract: The present invention provides a composition comprising polyphenol and polymer comprising amine groups, wherein at least 0.1% polyphenol by weight of the composition is present as part of a complex with the polymer, and wherein the complex is in the form of particles. Also provided are uses of polymers comprising amine groups for controlling the properties of polyphenol and a method of manufacturing a composition comprising a complex of polyphenol and polymer.
    Type: Application
    Filed: July 30, 2008
    Publication date: February 5, 2009
    Inventor: Krassimir Petkov Velikov
  • POLYOXYALKYLENE DERIVATIVE
    Publication number: 20090023859
    Abstract: A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided.
    Type: Application
    Filed: February 17, 2006
    Publication date: January 22, 2009
    Applicant: NOF CORPORATION
    Inventors: Kenji Sakanoue, Kenichiro Nakamoto, Yuji Yamamoto, Hiroki Yoshioka
  • ANTIMICROBIAL CONSTRUCTS
    Publication number: 20090022888
    Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
    Type: Application
    Filed: July 11, 2008
    Publication date: January 22, 2009
    Applicants: ALLVIVO VASCULAR, INC., State Univ.
    Inventors: Jennifer A. Neff, Joseph McGuire, Pranav R. Joshi
  • Therapeutic Drug-Eluting Endoluminal Covering
    Publication number: 20090012595
    Abstract: The present invention is of methods of preventing restenosis and promoting vascular re-healing. Specifically, the present invention is of a method of exposing the luminal wall of a blood vessel to a substance by deploying a drug-eluting polymer film inside the lumen of a blood vessel during or following angioplasty.
    Type: Application
    Filed: December 15, 2004
    Publication date: January 8, 2009
    Inventors: Dror Seliktar, Rafael Beyar
  • IMPROVED CARRIERS FOR DELIVERY OF NUCLEIC ACID AGENTS TO CELLS AND TISSUES
    Publication number: 20090011004
    Abstract: This invention relates to drug delivery and specifically to the preparation and use of functionalized carriers such as nanopolymers and nanovesicles for improved delivery of nucleic acid agents (NAA) to tissues and cells. These compounds have broad applicability for treating numerous diseases and disorders, including neurodegenerative and neuromuscular disorders. The concept encompasses preferably polymeric carriers for delivery of a class of oligonucleotides that modulate RNA splicing.
    Type: Application
    Filed: January 2, 2007
    Publication date: January 8, 2009
    Applicant: Philadelphia Health & Education Corp., D/B/A/ Drexel University of College of Medicine
    Inventors: Gordon John Lutz, Margaret Alison Wheatley