Containing Chemically Combined Protein Or Biologically Active Polypeptide Patents (Class 525/54.1)
-
Patent number: 7163677Abstract: A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a second degradable unit (preferably hydrolyzable). A carrier composition comprising the synthetic polymer and a bioactive agent is useful for the delivery of the bioactive agent into the nuclei of the cells.Type: GrantFiled: October 24, 2003Date of Patent: January 16, 2007Assignee: Nitto Denko CorporationInventors: Sheng Li, Chris Castell, Sang Van
-
Patent number: 7160924Abstract: The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods of making and using the same.Type: GrantFiled: July 18, 2003Date of Patent: January 9, 2007Assignees: The General Hospital Corporation, Amgen, Inc.Inventors: Olaf B. Kinstler, David L. Ladd, Mikahil I. Papisov
-
Patent number: 7153896Abstract: An element for the attachment of protein arrays, the element comprising a surface to which are attached a plurality of piperazine functional groups wherein the piperazine functional groups are represented by Formula I: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, are hydrogen, alkyl, alkenyl, alkynyl, alkylhalo, cycloalkyl, cycloalkenyl, alkylthio, alkoxy, with the proviso that at least one of R1 to R10 be a non-labile chemical unit that attaches the piperazine functional group to the surface of the element.Type: GrantFiled: November 14, 2003Date of Patent: December 26, 2006Assignee: Eastman Kodak CompanyInventors: Kevin P. Dockery, David M. Teegarden, Tiecheng A. Qiao, Brian J. Antalek, Susan Power
-
Patent number: 7151135Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.Type: GrantFiled: March 10, 2005Date of Patent: December 19, 2006Assignee: Angiotech Pharmaceuticals (US), Inc.Inventors: Woonza M. Rhee, Frank A. DeLustro, Richard A. Berg
-
Patent number: 7125960Abstract: A crosslinked elastin, a water-soluble crosslinking agent to be used for crosslinking, molded elastin articles, medical instruments and regeneration tissues using the crosslinked elastin, and a surgical therapy method and regeneration treatment wherein the medical instruments are employed. There is provided a biocompatible functional material having elasticity suitable for transplantation into the body without causing detachment of cell adhesion proteins.Type: GrantFiled: May 30, 2002Date of Patent: October 24, 2006Assignee: Chisso CorporationInventor: Miyamoto Keiichi
-
Patent number: 7112629Abstract: Ink-receiving print media products capable of producing high quality printed images which are light-fast, humid-fast, have low coalescence (graininess) levels, and are characterized by other beneficial attributes. The print media products have at least one ink-receiving layer supported by a substrate. The ink-receiving layer includes a binder blend designed to achieve the aforementioned goals, namely, gelatin, a poly(vinyl alcohol-polyethylene oxide) copolymer, and a poly((styrene)-(n-butyl acrylate)-(methyl methacrylate)-(2-(tert-butylamino) ethyl methacrylate)) copolymer. One or more optional pigments and/or additional binders can also be included within the ink-receiving layer. The ink-receiving layer may optionally be employed in combination with one or more additional material layers thereover or thereunder which can contain, for example, one or more pigments and/or binders.Type: GrantFiled: December 7, 2004Date of Patent: September 26, 2006Assignee: Hewlett-Packard Development Company, L.P.Inventors: Bor-Jiunn Niu, Stefan Schuttel, Meinrad Schaer
-
Patent number: 7109166Abstract: This invention is directed to a sustained release composition comprised of Compound (A) having the formula or a pharmaceutically acceptable salt thereof, and a copolymer comprised of poly-(I)-lactic-glycolic-tartaric acid wherein the amino group of Compound (A) is ionically bound to a carboxyl group of the copolymer and wherein further the composition may be made into a sustained release pharmaceutical composition with pharmaceutically acceptable carrier(s).Type: GrantFiled: August 16, 2000Date of Patent: September 19, 2006Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SASInventor: Jacques-Pierre Moreau
-
Patent number: 7094871Abstract: The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.Type: GrantFiled: November 15, 2001Date of Patent: August 22, 2006Assignee: Gryphon TherapeuticsInventors: Lynne Canne, Stephen B. H. Kent, Reyna Simon
-
Patent number: 7087247Abstract: The invention relates to novel absorbable polyesters, produced by ring-opening polymerisation of hydroxycarboxylic acids in the presence of a polyol containing an electrolyte, in an extruder. In particular, the invention relates to novel polylactide glycolide polyesters which are essentially free of dextran sulphate and which are produced by ring-opening polymerisation of lactide and glycolide in the presence of dextran sulphate in the extruder; to the production of the same and to their use in depot medicaments.Type: GrantFiled: November 8, 2001Date of Patent: August 8, 2006Assignee: Creative Peptide Sweden ABInventors: Youxin Li, Detlef Mohr, Tim Seiffert
-
Patent number: 7081495Abstract: Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing ?-amino acyl groups, preferably joined to the focal group, are used to assist transfection of cells in vitro and in vivo by DNA. The complex of dendrimer and DNA may be used in gene therapy, for instance to delivery clotting factor genes to cells.Type: GrantFiled: September 23, 1999Date of Patent: July 25, 2006Assignee: School of Pharmacy, University of LondonInventors: Alexander T Florence, Andrew F Wilderspin, Istvan Toth, Henry K Bayele, Thiagarajan Sakthivel
-
Patent number: 7078496Abstract: The invention provides reagents and methods for conjugating a polymer specifically to the ?-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the ?-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.Type: GrantFiled: October 9, 2002Date of Patent: July 18, 2006Assignee: Nektar Therapeutics AL, CorporationInventors: Michael J. Roberts, Zhihao Fang
-
Patent number: 7057019Abstract: Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments include a cross-linking agent having a polyalkylene oxide member. Other embodiments include a system for administering an albumin material, the system having albumin and a crosslinking agent that reacts with the albumin to form a crosslinked material made of crosslinked albumin. Another embodiment is a method of making a biocompatible material that includes a step of mixing albumin with an n-functional crosslinking agent wherein n is at least 3.Type: GrantFiled: February 11, 2003Date of Patent: June 6, 2006Assignee: Incept LLCInventor: Chandrashekhar P. Pathak
-
Patent number: 7053150Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.Type: GrantFiled: December 11, 2003Date of Patent: May 30, 2006Assignee: Nektar Therapeutics AL, CorporationInventors: Antoni Kozlowski, Xiaoming Shen, Michael D. Bentley, Zhihao Fang, Tony L. Sander
-
Patent number: 7052686Abstract: Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.Type: GrantFiled: September 28, 2001Date of Patent: May 30, 2006Assignee: Schering CorporationInventors: Seoju Lee, David C. Wylie, Susan V. Cannon-Carlson
-
Patent number: 7041855Abstract: The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.Type: GrantFiled: November 18, 2003Date of Patent: May 9, 2006Assignee: Sun Bio, Inc.Inventors: Perry Rosen, Kwang Nho
-
Patent number: 7038016Abstract: The present invention employs a dissolved activated polyethylene glycol (aPEG) or related molecule that has been passed through a filtration means for the substantial reduction of bioburden or endotoxin levels in the aPEG solution. The resulting filtered aPEG solution can be used for the preparation of a PEGylated hemoglobin solution containing substantially reduced levels of bioburden or endotoxin.Type: GrantFiled: August 21, 2001Date of Patent: May 2, 2006Assignee: Apex Bioscience, Inc.Inventors: Todd Lewis Talarico, Cyrus John Stacey
-
Patent number: 7034127Abstract: Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also disclosed are stable intermediates formed by partially reacting a hyaluronan with divinyl sulfone and stopping the reaction before completion to leave free, or reactive vinyl groups on the hyaluronan molecule available for conjugation with the biologically active substance.Type: GrantFiled: July 1, 2003Date of Patent: April 25, 2006Assignee: Genzyme CorporationInventors: Edward G. Parent, Nancy E. Larsen
-
Patent number: 7022214Abstract: Carboxylic acid-substituted polyalkylene polyamines in which amine nitrogen atoms on the polyamine backbone structure are replaced by guanidine groups provide a pH range extending into high pH values. These substances are useful as carrier ampholytes in isoelectric focusing.Type: GrantFiled: January 21, 2004Date of Patent: April 4, 2006Assignee: Bio-Rad Laboratories, Inc.Inventor: Lee Olech
-
Patent number: 7018624Abstract: A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application.Type: GrantFiled: March 14, 2003Date of Patent: March 28, 2006Assignee: Debio Recherche Pharmaceutique S.A.Inventor: J. Milton Harris
-
Patent number: 7015340Abstract: The invention relates to a heat-sensitive compound having the property of being soluble in water below a critical temperature Tc and insoluble in water above this temperature Tc, this property being thermally reversible, characterized in that it comprises a first amphiphilic and thermally reversible part corresponding to one of the following formulae (I) and (II): in which i is an integer ranging from 1 to 20 and j is an integer ranging from 3 to 30. This compound can be used to extract a chemical entity, such as uranium.Type: GrantFiled: September 6, 2002Date of Patent: March 21, 2006Assignee: Commissariat a L'Energie AtomiqueInventors: Charles Madic, Laurence Berthon, Nicole Zorz, Hélène Coulombeau, Fabienne Testard, Thomas Zemb, Sébastien Gibanel, Chantal Larpent, Krystyna Baczko
-
Patent number: 7009034Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.Type: GrantFiled: November 9, 2001Date of Patent: March 7, 2006Assignee: Incept, LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
-
Patent number: 6992161Abstract: Cationic polyurethanes and polyureas formed from (a) at least one diisocyanate or reaction product thereof with one or more compounds containing two or more active hydrogen atoms per molecule, and (b) at least one diol, primary or secondary amino alcohol, primary or secondary diamine or primary or secondary triamine each with one or more tertiary, quaternary or protonated tertiary amine nitrogen atoms and having a glass transition temperature of at least 25° C. and an amine number of from 50 to 200, based on the non-quaternized or -protonated compounds, or other salts of these polyurethanes and polyureas, are useful as ingredients of cosmetic and pharmaceutical preparations.Type: GrantFiled: November 4, 1996Date of Patent: January 31, 2006Assignee: BASF AktiengesellschaftInventors: Son Nguyen Kim, Axel Sanner, Peter Hössel
-
Patent number: 6982298Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule (having a plurality of amine or carboxylic acid groups respectively attached along the length of the molecule), reacting this macromolecule with a hydroxyphenyl compound having a free carboxylic acid group in the case of a polyamine or a free primary amine group in the case of a polycarboxylate, and substituting the hydroxyphenyl compound onto the macromolecule via a carbodiimide-mediated reaction pathway to provide a hydroxyphenyl-substituted macromolecule. This macromolecule is then linked to other such macromolecules via an enzyme catalyzed dimerization reaction between two hydroxyphenyl groups attached respectively to different macromolecules under metabolic conditions of temperature and pH.Type: GrantFiled: January 8, 2004Date of Patent: January 3, 2006Assignee: The Cleveland Clinic FoundationInventors: Anthony Calabro, Richard A. Gross, Aniq B. Darr
-
Patent number: 6979464Abstract: The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.Type: GrantFiled: December 11, 1998Date of Patent: December 27, 2005Assignee: Battelle Memorial InstituteInventor: Anna Gutowska
-
Patent number: 6967107Abstract: The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.Type: GrantFiled: March 14, 2005Date of Patent: November 22, 2005Assignee: Biosite, Inc.Inventors: Kenneth F. Buechler, Mariusz G. Banaszczyk, Joseph Barry Noar
-
Patent number: 6962903Abstract: A modified annexin protein, preferably annexin V, is used to prevent thrombosis without increasing hemorrhage. Annexin binds to phosphatidylserine on the outer surface of cell membranes, thereby preventing binding of the prothrombinase complex necessary for thrombus formation. It does not, however, affect platelet aggregation necessary for hemostasis. The modified annexin molecule can be a homodimer of annexin, an annexin molecule coupled to one or more polyethylene glycol chains, or an annexin molecule coupled to another protein. By increasing the molecular weight of annexin, the modified annexin is made to remain in circulation for sufficient time to provide a sustained therapeutic effect.Type: GrantFiled: February 21, 2002Date of Patent: November 8, 2005Assignee: Alavita, Inc.Inventor: Anthony Allison
-
Patent number: 6962954Abstract: Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins.Type: GrantFiled: December 19, 2003Date of Patent: November 8, 2005Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventor: Paul K. Smith
-
Patent number: 6956135Abstract: The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.Type: GrantFiled: September 12, 2003Date of Patent: October 18, 2005Assignee: Sun Bio, Inc.Inventors: Perry Rosen, Kwang H. Nho
-
Patent number: 6916962Abstract: The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.Type: GrantFiled: May 7, 2003Date of Patent: July 12, 2005Assignee: Sun Bio, Inc.Inventors: Perry Rosen, Kwang Nho
-
Patent number: 6916900Abstract: A method of making polyaniline grafted lignosulfonic acid is disclosed. The method comprises mixing of aniline and a lignosulfonate in the presence of a transition metal salt.Type: GrantFiled: April 5, 2004Date of Patent: July 12, 2005Assignee: GeoTech Chemical Company, LLCInventor: Tito Viswanathan
-
Patent number: 6911496Abstract: Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents.Type: GrantFiled: January 27, 2004Date of Patent: June 28, 2005Assignee: Cohesion Technologies, Inc.Inventors: Woonza M. Rhee, Frank A. DeLustro, Richard A. Berg
-
Patent number: 6908963Abstract: The invention provides reagents and methods for conjugating polymers specifically to the ?-amine of polypeptides in high yield. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a thioester moiety capable of specifically conjugating to the ?-amine of a polypeptide having a cysteine or histidine at the N-terminus. The invention provides active thioester derivatives of PEG that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG and polypeptide. Use of these active esters to prepare PEG-proteins and PEG-peptides is described.Type: GrantFiled: October 9, 2001Date of Patent: June 21, 2005Assignee: Nektar Therapeutics AL, CorporationInventors: Michael J. Roberts, Zhihao Fang
-
Patent number: 6906132Abstract: Disclosed is a low formaldehyde emission coating from formaldehyde-based resins that can be applied to a panel for reducing sag and enhancing the strength of the panel. Formaldehyde emissions are reduced by the inclusion of polymeric formaldehyde reactive materials comprising a polyamide scavenger into the coating formula. These formulations are useful as coatings or binders.Type: GrantFiled: December 27, 2001Date of Patent: June 14, 2005Assignee: AWI Licensing CompanyInventors: Hector Belmares, Kenneth G. Caldwell
-
Patent number: 6899889Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: March 7, 2000Date of Patent: May 31, 2005Assignee: NeoMend, Inc.Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
-
Patent number: 6887952Abstract: The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.Type: GrantFiled: February 12, 2004Date of Patent: May 3, 2005Assignee: Biosite, Inc.Inventors: Kenneth F. Buechler, Mariusz G. Banaszczyk, Joseph Barry Noar
-
Patent number: 6887974Abstract: Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be flanked at each end with a biodegradable component which is flanked at each end with a protein reactive functional component. A polymeric crosslinking agent is disclosed having a biodegradable component, polyalkylene oxide, and at least three reactive functional groups that are each capable of forming a covalent bond in water with at least one functional group such as an amine, thiol, or carboxylic acid.Type: GrantFiled: February 5, 2002Date of Patent: May 3, 2005Assignee: Incept LLCInventor: Chandrashekhar P. Pathak
-
Patent number: 6884842Abstract: Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.Type: GrantFiled: October 26, 2001Date of Patent: April 26, 2005Assignee: Alnis BioSciences, Inc.Inventors: David S. Soane, Stephen E. Barry, Andrew Goodwin, David A. Offord, Michael G. Perrott
-
Patent number: 6881789Abstract: The present invention relates to a novel biopolymer consisting of a three-dimensional cross-linked mixture of (a) a cross-linking agent, activated with an activating agent, dissolved in a aqueous solution, and (b) a recombinant protein, namely polyubiquitin. The novel biopolymer is based on the cross-linking of ubiquitin (monomeric and/or polymeric) with a cross-linking agent, preferably bifunctionalized polyethylene oxides or a polyethylene glycol of various molecular masses (MW 2000 to 35 000 kDa), dissolved in aqueous solution in adequate proportions. The novel biopolymer offers a wide range of formulations since the number of ubiquitin units and cross-linking agent can vary both in length and ratio. The novel hydrogel is also biodegradable by a specific protease and is resistant to a wide range of other proteases.Type: GrantFiled: May 29, 2001Date of Patent: April 19, 2005Assignee: Viridis Biotech Inc.Inventor: Marc Bossé
-
Patent number: 6872576Abstract: The invention relates to an immunoassays, binding assays, solid phase substrates (12) and other devices with an antigen or antibody or ligand or receptor (11) embedded into a solid phase substrate (12). The antigen or antibody is mixed with a molten thermoplastic and formed into the solid phase substrate (12).Type: GrantFiled: March 17, 2000Date of Patent: March 29, 2005Assignee: Embedded Concepts, LLCInventor: John A. McIntyre
-
Patent number: 6867181Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.Type: GrantFiled: January 26, 2000Date of Patent: March 15, 2005Assignees: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S., Poly-Med, IncorporatedInventors: Shalaby Wahba Shalaby, Steven A. Jackson, Jacques-Pierre Moreau
-
Publication number: 20040265927Abstract: Synthetic bodies having a thee-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and comprising phospho-amino acid-side group carrying entities such as beads, are provided. They can be administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions), inflammatory disorders neurodegenerative disorders and endothelial dysfunction disorders.Type: ApplicationFiled: August 23, 2004Publication date: December 30, 2004Inventors: Anthony E. Bolton, Arkady Mandel, Stephen J. Houldsworth, Natalie J. Lazarowych
-
Publication number: 20040260019Abstract: The invention relates to a method of cross-linking poly(amino acid) compounds (e.g. proteins, polypeptides, protein polymers, etc.) to each other or attaching such compounds to polyamino or polycarboxyl compounds. The method involves lyophilizing a solution of at least one poly(amino acid) compound, or at least one poly(amino acid) compound and a polyamino or polycarboxyl compound, maintaining the lyophilized solid under vacuum, heating the lyophilized solid under vacuum to an elevated temperature effective to cause cross-linking without denaturing of the poly(amino acid) compounds, and cooling the product and releasing the vacuum. The method produces cross-linking without the use of activating compounds or cross-linking molecules. The invention also relates to novel cross-linked products.Type: ApplicationFiled: August 13, 2004Publication date: December 23, 2004Inventors: Harvey Kaplan, Mary Alice Hefford, Brigitte Leanne Simons
-
Patent number: 6833488Abstract: A bio-compatible, biodegradable macromolecular water-absorbent polymeric material having a three-dimensional configuration with intermolecular covalent bonds and containing free functional groups selected from OH, SH, NH2, and COOH. The polymer is formed by polymer-polymer inter-coupling interaction between a natural water-soluble polymer A or its derivatives having a molecular weight between 20,000 and 500,000 Da, and a synthetic polymer B in a ratio of A:B of 15:85 to 85:15.Type: GrantFiled: March 30, 2001Date of Patent: December 21, 2004Assignee: Exotech Bio Solution Ltd.Inventors: Mircea Dan Bucevschi, Monica Colt
-
Patent number: 6833408Abstract: A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.Type: GrantFiled: September 30, 2002Date of Patent: December 21, 2004Assignee: Cohesion Technologies, Inc.Inventors: Louis C. Sehl, Olof Mikael Trollsas, Donald G. Wallace, David Toman, Frank A. DeLustro, Jacqueline A. Schroeder, George H. Chu
-
Publication number: 20040253206Abstract: Drug-oligomer conjugates and pharmaceutical compositions prepared therefrom. Methods of making and using the drug-oligomer conjugates and pharmaceutical compositions.Type: ApplicationFiled: March 29, 2004Publication date: December 16, 2004Inventors: Nnochiri N. Ekwuribe, Tatyana Dyakonov, Christopher H. Price
-
Publication number: 20040249065Abstract: A method for producing biodegradable plastic from natural materials containing polysaccharides and oligosaccharides by treating the polysaccharide-containing or oligosaccharide-containing materials with a basic aqueous solution, subsequently treating the mixture with a modifying material to create an anionic product, and then contacting the anionic product with proteins to produce the biodegradable plastic material. The process provides relatively inexpensive methods for preparing biodegradable plastics that are useful for manufacturing various articles and also to provide an environmental solution that will reduce the amount of natural wastes that could be practically utilized for the benefit of mankind.Type: ApplicationFiled: June 9, 2003Publication date: December 9, 2004Inventors: Christopher H. Schilling, David S. Karpovich, Piotr Tomasik
-
Publication number: 20040248776Abstract: More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for synthesizing intermediates useful in synthesizing these oxytocin analogs are also provided.Type: ApplicationFiled: July 8, 2004Publication date: December 9, 2004Applicant: Ferring B.V.Inventors: Kazimierz Wisniewski, Jacek Stalewski, Guangcheng Jiang
-
Patent number: 6828412Abstract: A polymer comprising: a polymeric backbone comprising at least one unit having the structure (I), wherein R-R4 comprise groups selected from the group consisting of H, C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl or any of the group consisting of C1-C12 alkyl, C6-C18 aryl, C7-C18 aralkyl, C6-C18 cycloalkyl substituted, within the carbon chain or appended thereto, with one or more heteroatoms; R and R2 or R and R4 or R and R1 or R2 and R3 may be joined so that with the carbon atom(s) to which they are attached they together form a saturated, partially unsaturated or unsaturated ring system respectively, may have a pendent group which may incorporate a linker unit, (for example a peptide linkage) or a unit having the structure (I); A comprises a proton donating moiety selected from the group consisting of formula (1).Type: GrantFiled: July 19, 2002Date of Patent: December 7, 2004Assignee: School of Pharmacy, University of LondonInventors: Stephen James Brocchini, Marie-Claude Dubois Clochard
-
Publication number: 20040242855Abstract: The present invention relates to the separation of protein from a solution wherein the separation process is carried out in a vessel, the interior surface of which comprises fluoropolymer.Type: ApplicationFiled: April 29, 2004Publication date: December 2, 2004Inventors: Sharon Ann Libert, Victor Sisto Lusvardi, Timothy Tucker Norton
-
Patent number: RE38827Abstract: This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.Type: GrantFiled: November 14, 2002Date of Patent: October 11, 2005Assignee: 3M Innovative Properties CompanyInventors: Thomas H. Barrows, Terry W. Lewis, Myhanh T. Truong, Matthew T. Scholz