From Protein Or Biologically Active Polypeptide Reactant Patents (Class 527/200)
  • Patent number: 8980295
    Abstract: Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: March 17, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Weiyuan J. Kao, Yao Fu
  • Patent number: 8937025
    Abstract: One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: January 20, 2015
    Assignee: Johns Manville
    Inventors: Mingfu Zhang, Jawed Asrar, Zhihua Guo
  • Patent number: 8916652
    Abstract: The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: December 23, 2014
    Assignee: Kensey Nash Corporation
    Inventors: Jeffrey L. Dalsin, Bruce P. Lee, Laura Vollenweider, Sunil Silvary, John L. Murphy, Fangmin Xu, Amanda Spitz, Arinne Lyman
  • Patent number: 8809477
    Abstract: A wood-containing composite are described that may include a lignocellulosic material, and a formaldehyde-free binder in contact with at least a portion of the lignocellulose material. The binder is formed from a binder composition that includes a soy flour, a polymer, and a crosslinking agent, at least a portion of each of which are covalently crosslinked to each other in the binder. Also described are methods of making wood-containing composites by providing a pre-mixed, one-part binder composition of at least 60 wt. % soy flour, a polymer, and a crosslinking agent. The binder composition is applied to lignocellulosic material, and the combination may be heated at a temperature of about 100° C. or more to cure the binder composition into a binder. The cured binder has the soy protein, polymer, and crosslinking agent covalently bonded to each other.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: August 19, 2014
    Inventors: Mingfu Zhang, Philip Francis Miele, Jawed Asrar
  • Publication number: 20140178695
    Abstract: This invention provides emulsions and adhesives comprising proteins that can be isolated from a variety of sources including renewable plant biomass, and methods of making and using such emulsions and adhesives.
    Type: Application
    Filed: July 26, 2013
    Publication date: June 26, 2014
    Applicant: Biopolymer Technologies, Ltd.
    Inventors: Anthony A. Parker, Joseph J. Marcinko
  • Patent number: 8703893
    Abstract: A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: April 22, 2014
    Assignee: Centro de Ingenienia Genetica y Biotecnologia
    Inventors: José Ángel Ramón Hernández, Fidel Raúl Castro Odio, Vivian-María Sáez Martinez, Rolando Páez Meircles, Eduardo Fernández Sánchez
  • Patent number: 8680224
    Abstract: One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: March 25, 2014
    Assignee: Johns Manville
    Inventors: Mingfu Zhang, Kiarash Alavi Shooshtari, Jawed Asrar
  • Patent number: 8575289
    Abstract: Disclosed is a bio-based and environmentally friendly elastomer product from renewable agricultural substrates. Specifically, glutamine and arginine residues of gliadin are used as synthons to produce novel elastomeric product from the reaction of the oxirane groups of epoxidized vegetable oils under neat reaction conditions with the primary amide functionalities of glutamine and arginine to give the corresponding amidohyroxy gliadinyl triglycerides.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: November 5, 2013
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Rogers E. Harry-O'kuru, Abdellatif Abdelhakim Mohamed, Sherald H. Gordon, Jingyuan Xu
  • Patent number: 8465542
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: June 18, 2013
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Patent number: 8389661
    Abstract: The invention relates to an amphiphilic-BMP polymer complex which is physically and chemically stable and soluble in water, characterized in that: the amphiphilic polymers comprise a hydrophilic polysaccharide skeleton functionalized with hydrophobic substituents and hydrophilic groups the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins), the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to the process for preparing the amphiphilic-BMP polymer complex in an aqueous medium and in the absence of organic solvents likely to denature the protein. The invention also relates to therapeutic compositions of an amphiphilic-BMP polymer complex according to the invention.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: March 5, 2013
    Assignee: ADOCIA
    Inventors: Gerard Soula, Olivier Soula, Remi Soula
  • Patent number: 8283434
    Abstract: Methods for preparing a poly(ether carbonates) of the formula HO—[(CH2CH2—O)n—CO2]m—(CH2CH2—O)n—H are provided. The method comprises polymerizing an activated oligomer of the formula of H—O—(CH2CH2—O)n—CO2—Z, where Z is reactive leaving group.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: October 9, 2012
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Michael David Bentley, Xuan Zhao, Xiaoming Shen
  • Patent number: 8193290
    Abstract: A modified polyurethane including a lipid substituent from at least one urethane nitrogen and/or at least carbon atom of the modified polyurethane.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: June 5, 2012
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Patent number: 8119756
    Abstract: Methods for delivering a biologically active agent into the body of a mammal are provided, the method comprising administering a carbamate-containing conjugate to the mammal.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: February 21, 2012
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Michael D. Bentley, Xuan Zhao, Xiaoming Shen
  • Patent number: 8119742
    Abstract: The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: February 21, 2012
    Assignee: KNC Ner Acquisition Sub, Inc.
    Inventors: Jeffrey L. Dalsin, Bruce P. Lee, Laura Vollenweider, Sunil Silvary, John L. Murphy, Fangmin Xu, Amanda Spitz, Arinne Lyman
  • Publication number: 20110236951
    Abstract: A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide molecule, wherein the particle does not define a dimension greater than about 1 ?m. One example for making the particle includes modifying the polypeptide molecule to provide ?, ?-ethylenically unsaturated terminal functional groups, mixing the modified polypeptide molecule with a silicon-containing polymerizable compound, and subjecting the resulting mixture to conditions sufficient for polymerizing the polymerizable compound to form the particle.
    Type: Application
    Filed: November 9, 2007
    Publication date: September 29, 2011
    Inventors: Jay W. Grate, Jungbae Kim
  • Publication number: 20110189479
    Abstract: One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.
    Type: Application
    Filed: February 1, 2010
    Publication date: August 4, 2011
    Inventors: Mingfu Zhang, Kiarash Alavi Shooshtari, Jawed Asrar
  • Patent number: 7968519
    Abstract: Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: June 28, 2011
    Assignee: The Regents of the University of California
    Inventors: Timothy J. Deming, Miaoer Yu, Scott A. Curtin, Jungyeon Hwang, Michael D. Wyrsta, Andrew Nowak, Scott W. Seidel
  • Publication number: 20110021101
    Abstract: An aqueous binder composition is provided that includes a modified starch and a silane coupling agent, and optionally, a crosslinking agent. The starch from which the modified starch is derived is natural in origin, biorenewable, and is derived from plant sources. The modified starch has been chemically modified from its natural form and may have a degree of polymerization from about 20 to about 4000. Additionally, the modified starches have a low viscosity and cure at moderate temperatures. Advantageously, the modified starches are water dispersible and have excellent resistance to water after curing. In addition, the binder has a light color after being cured. The crosslinking agent may be any compound suitable for crosslinking the starch based compound. In exemplary embodiments, the silane coupling agent is an aminosilane. The environmentally friendly, biorenewable binder may be used in the formation of insulation materials and non-woven chopped strand mats.
    Type: Application
    Filed: June 29, 2010
    Publication date: January 27, 2011
    Inventors: Christopher M. Hawkins, Liang Chen, Jesus M. Hernandez-Torres, William E. Downey
  • Publication number: 20100298525
    Abstract: A polyphosphazene polymer which includes hydrophilic side groups and interacting side groups which are capable of bonding with a biological agent of interest. The bonding may be by non-covalent bonding.
    Type: Application
    Filed: April 26, 2010
    Publication date: November 25, 2010
    Inventor: Alexander K. Andrianov
  • Publication number: 20100093966
    Abstract: Broadly the invention provides for a deinkable toner composition, an image made with the deinkable toner, and a method for making the toner including a coloring agent; a thermoplastic polymer; and a protein. In another embodiment the toner includes a coloring agent and a thermoplastic polymer where the protein has been incorporated into the polymer itself. In typical embodiments the protein is derived from soybeans but may be from other plant or animal sources. Typically the toner has a positive triboelectric charge of between about 10 to about 40 microCoulomb/g, or a negative triboelectric charge of between about 10 to about 40 microCoulomb/g.
    Type: Application
    Filed: November 23, 2009
    Publication date: April 15, 2010
    Applicant: Battelle Memorial Institute
    Inventors: Bhima R. Vijayendran, Herman P. Benecke, Elizabeth Drotleff, Joel D. Elhard, J. David Robbins, Jeffrey Cafmeyer, Joan Muellerleile
  • Patent number: 7683106
    Abstract: A dental material primer and a dentin-regenerating pulp-capping agent which exhibit an excellent dentin-regenerating action, are disclosed. The dental material primer includes a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent includes a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: March 23, 2010
    Assignee: Nippon Synthetic Chemical Industry Co., Ltd.
    Inventors: Masahiro Yoshiyama, Yoshihiro Nishitani, Sadami Tsutsumi, Suong-Hyu Hyon
  • Publication number: 20100063209
    Abstract: A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 11, 2010
    Applicant: The Regents of the University of Colorado, Body Corporate
    Inventors: Christopher Bowman, Kristi Anseth, Bilge Hacioglu, Charlie Nuttleman
  • Publication number: 20100029885
    Abstract: The invention relates to sheet materials comprising crosslinked polymer based layers and production methods thereof. More particularly the invention relates to gelatin based layers that are hardened by an amine-amine crosslinking compound such as triazine type crosslinking compounds. Gelatins solutions used for such materials are buffered to control the hardening speed of the gelatin solutions. This invention also relates to applications of such hardened gelatin layers such as image recording materials but also applications such as test-substrates applicable for pharmaceutical or cosmetic industry.
    Type: Application
    Filed: April 27, 2007
    Publication date: February 4, 2010
    Applicant: FUJIFILM Manufacturing Europe B.V.
    Inventor: Petrus Henricus Maria Van Kessel
  • Publication number: 20090297482
    Abstract: The invention relates to a strain of Enterococcus mundtii having probiotic qualities. The strain of E. mundtii (ST4SA) produces an antimicrobial peptide which exhibits antimicrobial activity against a broad range of bacteria. The invention also provides an isolated nucleotide sequence which codes for the antimicrobial peptide (peptide ST4SA). Another aspect of the invention relates to a process for the production of a peptide of the invention which comprises cultivating Enterococcus mundtii strain ST4SA in a nutrient medium under micro-aerophilic conditions at a temperature of between 100C and 45° C., until a recoverable quantity of said peptide is produced, and recovering said peptide. The isolated peptide of the invention may be used as an antimicrobial agent in a liquid formulation or a gel formulation as a topical treatment and may also be used as an antimicrobial agent following encapsulation in a polymer.
    Type: Application
    Filed: May 25, 2007
    Publication date: December 3, 2009
    Inventors: Leon Milner Theodore Dicks, Svetoslav Dimitrov Todorov, Hendriette Knoetze, Marelize Brink
  • Publication number: 20090214489
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 27, 2009
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, David J. Duffin, Christian M. Gates, Sherril S. Haselden, Larry C. Mattheakis, Peter J. Schatz, Christopher R. Wagstrom, Nicholas C. Wrighton
  • Publication number: 20090168068
    Abstract: A coated metal surface on a solid support, wherein the coating consists of a self-assembled monolayer (SAM) of oligo(ethylene glycol)-terminated amide group-containing alkyl thiols firmly attached to the metal surface via the thiol-end and low molecular weight antigens bound via an amide-group to the SAM-forming OEG molecule, wherein the alkyl portion has 1-20 methylene groups, wherein the oligo(ethylene glycol) portion has 1-15 ethylene oxy units, and wherein the antigens, such as explosives and narcotics, are optionally reversibly bound to antibodies specific for the antigens, is disclosed. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.
    Type: Application
    Filed: October 23, 2008
    Publication date: July 2, 2009
    Applicant: BIOSENSOR APPLICATION SWEDEN AB
    Inventors: Per Mansson, Bo Liedberg
  • Publication number: 20090082537
    Abstract: A polymeric dendrimer-like structure with four branches of monomethoxy-polyethylene glycol that can be represented as: The carboxylic group of the previous structure can be functionalized for the production of conjugates of pharmaceutical interest. The binding of this dendrimer-like polyethylene glycol to therapeutic proteins improves their in vitro and in vivo stability.
    Type: Application
    Filed: November 20, 2006
    Publication date: March 26, 2009
    Inventors: Jose Angel Ramon Hernandez, Fedel Raul Castro Odio, Vivian Maria Saez Martinez, Rolando Paez Meireles, Eduardo Fernandez Sanchez
  • Publication number: 20090076237
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 19, 2009
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Peter Turecek, Juergen Siekmann
  • Publication number: 20090048412
    Abstract: The invention relates to an amphiphilic-BMP polymer complex which is physically and chemically stable and soluble in water, characterised in that: the amphiphilic polymers comprise a hydrophilic polysaccharide skeleton functionalised with hydrophobic substituents and hydrophilic groups the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins), the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to the process for preparing the amphiphilic-BMP polymer complex in an aqueous medium and in the absence of organic solvents likely to denature the protein. The invention also relates to therapeutic compositions of an amphiphilic-BMP polymer complex according to the invention.
    Type: Application
    Filed: July 25, 2008
    Publication date: February 19, 2009
    Applicant: Adocia
    Inventors: Gerard Soula, Olivier Soula, Remi Soula
  • Publication number: 20090042294
    Abstract: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.
    Type: Application
    Filed: September 15, 2008
    Publication date: February 12, 2009
    Applicant: The Cleveland Clinic Foundation
    Inventors: Anthony Calabro, Lee Akst, Daniel Alam, James Chan, Aniq B. Darr, Kiyotaka Fukamachi, Richard A. Gross, David Haynes, Keiji Kamohara, Daniel P. Knott, Hilel Lewis, Alex Melamud, Anthony Miniaci, Marshall Strome
  • Publication number: 20080312134
    Abstract: Vesicles for delivery of active macromolecules, such as oligoaminoacids, oligonucleotides, microRNA, siRNA, dsRNA, single stranded oligonucleotides, DNA, peptide nucleic acids, peptides, proteins, and some synthetic organic drugs which are made from amphiphilic segmented copolymers where one segment contains the active macromolecule. In one preferred embodiment, the active macromolecule is contained in the hydrophilic C segment of an amphiphilic ABC segmented copolymer.
    Type: Application
    Filed: June 6, 2008
    Publication date: December 18, 2008
    Inventors: Thomas Hirt, Zhihua Lu
  • Publication number: 20080287635
    Abstract: Macro hydrophobic clusters and complexes of soybean globular proteins were observed using TEM (Transmission Electron Microscope). Upon unfolding, hydrophobic groups of the proteins became exposed toward the surface of the protein and actively interacted with other hydrophobic groups of other protein molecules, thereby forming hydrophobic bonding. The hydrophobic bonding resulted in hydrophobic protein clusters, the formation of which was affected by the degree of protein unfolding, protein structure, and hydrophobic components. Such hydrophobic clusters followed the global minimum free energy theory and formed spherical like structures with diameters ranging from 100 nm to 3000 nm. Such an understanding lends applicability to many uses in adhesives, molding composites, surfactants for oil-water systems, bio-based interior construction paints and paper coatings, fiber production, and metal powder molding applications.
    Type: Application
    Filed: April 24, 2006
    Publication date: November 20, 2008
    Inventors: Xiuzhui Sun, Li Xhu, Donghai Wang
  • Publication number: 20080281069
    Abstract: The invention relates to a method for producing a polypeptide which is modified with an organic group, wherein a bioactive polypeptide is covalently bound to an organic group that comprises a backbone structure having aromatic side chains, thereby forming a modified polypeptide which is constituted of the bioactive polypeptide and the group having aromatic side chains. At least one of the aromatic side chains of the group is subjected to chemical or enzymatic hydroxylation.
    Type: Application
    Filed: June 29, 2005
    Publication date: November 13, 2008
    Inventor: Herbert P. Jennissen
  • Publication number: 20080248584
    Abstract: Compounds of formula (IIa): are provided where: X is a group capable of being cleaved from the ?-carbon atom to form an ion of formula (I?) C is a carbon atom bearing a single positive charge or a single negative charge; The invention further provides compounds of formula (IIb): where: X is a counter-ion to C. The compounds of formula (IIa) and (IIb) may form ions of formula (I?) by either cleaving the C—X bond between X and the ?-carbon atoms in the case of the compounds of formula (IIa) or dissociating X in the case of compounds of formula (IIb).
    Type: Application
    Filed: August 22, 2007
    Publication date: October 9, 2008
    Inventors: Mikhail Sergeevich SHCHEPINOV, Edwin Mellor SOUTHERN
  • Publication number: 20080233164
    Abstract: A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different, wherein said one or more pendant group segments are the same or different and are selected from: (i) siloxane segments; (ii) segments containing phosphoryl choline or a derivative or analogue thereof; (iii) segments containing a di- or trifluoromethyl group; (iv) heparin-like segments containing a group of formula (XII) D-N?N—Ar—SO3? ??(XII) wherein D is an aliphatic or aromatic group and Ar—SO3? comprises one or more linked aryl and/or heteroaryl groups, at least one of the aryl and/or heteroaryl groups having an SO3? substituent; and (v) segments containing a group of formula (I) [P]n?-[Lys]n-Lys-[Spacer]-Lys-[Al]x ??(I) wherein: [Al] is an inert amino acid; x is 0, 1, 2 or 3; [Spacer] is a fatty acid, amino acid, peptide or PEG; [P]n?-[Lys]n is a dendritic structure formed from n lysine group
    Type: Application
    Filed: January 20, 2005
    Publication date: September 25, 2008
    Applicant: UCL BIOMEDICAL PLC
    Inventors: Alexander Seifalian, Henryk Salacinski, Kaila Srai, Bala Ramesh, Arnold Darbyshire, Steve Hancock
  • Publication number: 20080234193
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Application
    Filed: December 27, 2007
    Publication date: September 25, 2008
    Applicants: Nektar Therapeutics AL, Corporation, Baxter International Inc., Baxter Healthcare SA
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • Publication number: 20080206183
    Abstract: The use of monomers of active a-amino acids for the preparation of hydrophobic polypeptides in the form of precipitates, whereby the polypeptides result from the polymerization of the aforementioned monomers of active a-amino acids in an aqueous solvent and can be resolubilized in the solvent.
    Type: Application
    Filed: April 27, 2006
    Publication date: August 28, 2008
    Applicant: Central national De La Recherche Scientifique
    Inventors: Auguste Commeyras, Helene Collet, Eddy Souaid, Herve Cottet, Bernard Romestand, Odile Yvonne Marie Trambouze
  • Patent number: 7408014
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: August 5, 2008
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Patent number: 7354627
    Abstract: The present invention provides a protein polymer material and a method for preparing the protein polymer material involving applying an energy such as electrical energy or gravitational energy to a protein to cause the protein to assemble in a controlled arrangement. The protein used in this method may be any suitable fibrillar protein capable of self-assembling.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: April 8, 2008
    Assignee: DePuy Products, Inc.
    Inventors: Hugo A. Pedrozo, Mark Shuster
  • Patent number: 7345136
    Abstract: Water-resistant, protein-based adhesive dispersion compositions and methods for preparing them are provided. The adhesive dispersions are prepared by copolymerizing a denatured vegetable protein, such as soy flour, that has been functionalized with methylol groups with one or more reactive comonomers, and preparing an acidic dispersion of the adhesive. The adhesive dispersions exhibit superior water resistance, and can be used to bond wood substrates, such as panels or laminate, or in the preparation of composite materials.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: March 18, 2008
    Assignees: Heartland Resource Technologies LLC, USDA
    Inventors: James M. Wescott, Charles R. Frihart
  • Patent number: 7288532
    Abstract: The present invention is directed to homogeneous phase enzyme-catalyzed processes for producing modified chitosan polymers or oligomers. An enzyme is reacted with a phenolic substrate in the presence of a chitosan polymer or oligomer to produce a modified chitosan polymer or oligomer. The invention also includes modified chitosan polymers or oligomers produced by the novel processes, in particular modified chitosan polymers or oligomers having useful functional properties, such as base solubility and/or high viscosity.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: October 30, 2007
    Assignees: The University of Maryland Biotechnology Institute, The University of Maryland, Baltimore County
    Inventors: Gregory F. Payne, Guneet Kumar
  • Patent number: 7252735
    Abstract: Method for making lignocellulosic composites by adhering lignocellulosic substrates together. A first variant of the method involves using an adhesive composition that comprises a reaction product of (i) first ingredient selected from a soy protein or lignin and (ii) at least one substantially formaldehyde-free curing agent that includes at least one amine, amide, imine, imide, or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the soy protein. A second variant of the method involves using an adhesive composition that comprises a reaction product of (i) a protein or lignin, (ii) a first compound that includes at least one amine, amide, imine, imide or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the protein and (iii) a curing agent.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: August 7, 2007
    Assignee: State of Oregon Acting by and through the Oregon State Board of Higher Education on Behalf of Oregon State University
    Inventor: Kaichang Li
  • Patent number: 7182884
    Abstract: A bio-liquid crystal polymer is made from a tissue-derived compound or the derivatives. The bio-liquid crystal polymer has a characteristic of liquid crystal under predetermined conditions and is biocompatible.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: February 27, 2007
    Assignees: Toyoda Gosei Co., Ltd.
    Inventors: Tatsuo Kaneko, Michiya Matsusaki, Tran Thi Hang, Mitsuru Akashi, Naoto Kuriyama
  • Patent number: 6997960
    Abstract: A first fiber treatment comprising a functional protein prepared by treating proteins such as collagen with a cross-linking agent and a solvent-base resin; a second one comprising the above functional protein and a water-base resin; a third one comprising a water-soluble organic substance having an average molecular weight of 100 to 20000 and a reactive modifier; a fourth one comprising the above functional protein and a reactive modifier; and products such as fibers and textile goods treated with one of the treatments.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: February 14, 2006
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Masahiro Sano, Takaharu Yasue, Fumioki Fukatsu
  • Patent number: 6911227
    Abstract: This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: June 28, 2005
    Assignee: Novocell, Inc.
    Inventors: Jeffrey A. Hubbell, Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Neil P. Desai, Syed F. A. Hossainy
  • Patent number: 6881789
    Abstract: The present invention relates to a novel biopolymer consisting of a three-dimensional cross-linked mixture of (a) a cross-linking agent, activated with an activating agent, dissolved in a aqueous solution, and (b) a recombinant protein, namely polyubiquitin. The novel biopolymer is based on the cross-linking of ubiquitin (monomeric and/or polymeric) with a cross-linking agent, preferably bifunctionalized polyethylene oxides or a polyethylene glycol of various molecular masses (MW 2000 to 35 000 kDa), dissolved in aqueous solution in adequate proportions. The novel biopolymer offers a wide range of formulations since the number of ubiquitin units and cross-linking agent can vary both in length and ratio. The novel hydrogel is also biodegradable by a specific protease and is resistant to a wide range of other proteases.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: April 19, 2005
    Assignee: Viridis Biotech Inc.
    Inventor: Marc Bossé
  • Publication number: 20040082717
    Abstract: Materials comprising proteinaceous prepolymers comprising at least one first reactive group reacted with one or more reactive groups on synthetic prepolymers, and methods of making and using same.
    Type: Application
    Filed: June 24, 2003
    Publication date: April 29, 2004
    Applicants: Southwest Research Institute, Keraplast Technologies, Ltd.
    Inventors: Mark E. Van Dyke, Cheryl R. Blanchard, Robert A. Smith
  • Publication number: 20040037906
    Abstract: An adhesive composition made by reacting a soy protein with at least one compound under conditions sufficient for introducing additional phenolic hydroxyl functional groups, amine functional groups, and/or thiol functional groups into the soy protein structure.
    Type: Application
    Filed: May 13, 2003
    Publication date: February 26, 2004
    Applicants: State of Oregon Acting By and Through the Oregon State, Board of Higher Education on Behalf of Oregon State University
    Inventors: Kaichang Li, Yuan Liu
  • Patent number: 6686161
    Abstract: The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: February 3, 2004
    Assignee: Amersham Biosciences AB
    Inventors: Travis Johnson, John McGowen, Allyson Beuhler, Charles Kimball Brush, Robert Emil Lajos
  • Publication number: 20040019172
    Abstract: The present invention relates to a method for the production of a biodegradable, water absorbable resin, by directly cross-linking of a culture broth with a cross-linker. The cross-linker contains two or more functional groups in the same molecule which can react with the functional groups in the culture broth. The present invention further relates to a biodegradable, water absorbable resin and its uses.
    Type: Application
    Filed: December 12, 2002
    Publication date: January 29, 2004
    Applicant: Tou-Hsiung Yang
    Inventors: Kun-Hsiang Yang, Shih-Ching Yang, Yuan-Chi Su, Toshio Hara