From Protein Or Biologically Active Polypeptide Reactant Patents (Class 527/200)
  • Patent number: 4900671
    Abstract: A process for the preparation of a phenolic resin which comprises reacting a phenol with a peroxidase or an oxidase enzyme and a peroxide in an organic solvent containing medium to generate phenolic radicals which react to form a phenolic resin.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: February 13, 1990
    Assignee: The Mead Corporation
    Inventors: Alexander R. Pokora, William L. Cyrus, Jr.
  • Patent number: 4898921
    Abstract: Conducting polymer films comprising a polymer matrix with intercalated, bonded conducting polymers, prepared from a polysaccharide matrix and the monomer of conducting polymer, are useful as anti-static materials, optical filters, solid electrolytes, electrodes and electrochemical sensors. The conducting polymers are polyheterocycles such as polyaniline, polythiophene and their derivatives.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: February 6, 1990
    Assignee: Montclair State College
    Inventors: Brian D. Humphrey, Marc L. Kasner, John L. Isidor
  • Patent number: 4822867
    Abstract: A novel class of materials and processes used in their preparation are described. These materials are comprised of man-made polymers grafted onto protein backbone, specifically onto protein backbone, which has been selectively modified to be used as adhesives, coatings and construction materials. Man-made polymers can be selected from a group including condensation polymers such as phenolics, epoxides, polyamides, thiols, or addition polymers such as acrylics, vinyls and polyolefins. Grafting can be accomplished either stepwise or from already preformed polymers. Grafts can also be formed with more than one polymer either after the first graft is formed or simultaneously. Furthermore grafts can be formed onto a modified or unmodified protein whose backbone has been reduced to a polyamine.
    Type: Grant
    Filed: February 2, 1987
    Date of Patent: April 18, 1989
    Inventor: Semih Erhan
  • Patent number: 4745160
    Abstract: A pharmaceutically or veterinarily acceptable amphipathic, non-cross linked linear, branched or graft block copolymer, which has a minimum weight average molecular-weight of 1000, in which the hydrophobic component is biodegradable or hydrolytically unstable under normal physiological conditions, and the hydrophilic component may or may not be biodegradable or hydrolytically unstable under such conditions, and which copolymer is self-dispersible in water; together with mixtures of such a copolymer and a drug, which may be water-soluble of water-insoluble, which mixtures are self-dispersible in water; and processes for the manufacture of such copolymers and such mixtures.
    Type: Grant
    Filed: June 21, 1985
    Date of Patent: May 17, 1988
    Assignee: Imperial Chemical Industries PLC
    Inventors: Jeffrey R. Churchill, Francis G. Hutchinson
  • Patent number: 4743669
    Abstract: Certain urea-sulfuric acid components, comprised of urea and sulfuric acid in a 1/4 to 7/4 molar ratio, contain a monourea adduct of sulfuric acid, which is catalytically active for promoting organic chemical reactions. The invention provides methods employing such urea-sulfuric acid components for catalyzing organic reactions such as oxidation, oxidative addition, reduction, reductive addition, esterification, transesterification, hydrogenation, isomerization (including racemization of optical isomers), alkylation, polymerization, demetallization of organometallics, nitration, Friedel-Crafts reactions, and hydrolysis. Novel catalysts are disclosed which involve combinations of the urea-sulfuric component with one or more transition metal halides and/or with one or more surfactants. The surfactant-containing compositions are particularly useful for the treatment of materials containing lipophilic substances.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: May 10, 1988
    Assignee: Union Oil Company of California
    Inventor: Donald C. Young
  • Patent number: 4673707
    Abstract: Derivatized polymers containing glycoside side chains linked to the polymer by ether, sulfide, or amine linkages are prepared by reacting a polymer containing alcohol, thiol, and/or amine groups with a glycidyl glycoside having the formula ##STR1## where (SAC).sub.n represents a saccharide residue with n being 1-20. Typical polymers include poly(vinyl) alcohol, poly(ethyleneimine), poly(dimethylaminopropyl methacrylamide), and proteins such as caseinate or gluten. Typical glycosides are glycoside of glucose and maltodextrin-10.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: June 16, 1987
    Assignee: National Starch and Chemical Corporation
    Inventors: John J. Tsai, Martin M. Tessler
  • Patent number: 4569789
    Abstract: Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structures. Finally, a method of characterizing complex multi-chain protein structures is disclosed.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: February 11, 1986
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Walter A. Blattler, John M. Lambert, Peter D. Senter
  • Patent number: 4526938
    Abstract: Pharmaceutical compositions comprising a pharmacologically active polypeptide and a pharmacologically or veterinarily acceptable amphipathic, non-cross-linked linear, branched or graft block copolymer, which has a minimum weight average molecular weight of 5,000, in which the hydrophobic component is biodegradable and the hydrophilic component may or may not be biodegradable, the composition being capable of absorbing water to form a hydrogel when placed in an aqueous, physiological-type environment; copolymers suitable for use in said compositions; and method for the manufacture of such copolymers.
    Type: Grant
    Filed: April 15, 1983
    Date of Patent: July 2, 1985
    Assignee: Imperial Chemical Industries PLC
    Inventors: Jeffrey R. Churchill, Francis G. Hutchinson
  • Patent number: 4478976
    Abstract: A biologically active protein which is bonded to a water-insoluble porous copolymer based on N-vinylimidazole and/or substituted N-vinylimidazoles and monomers which can be copolymerized therewith, its preparation and its use for carrying out enzymatic reactions.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: October 23, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Helmut Goertz, Stefan Marcinowski, Axel Sanner