Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention provides an improved method of producing a stable acid denatured soy/urea adhesive having improved wet and dry strengths, with more efficient production and lower production costs. The method comprises combining urea with soy flour that has been acid treated until denatured and substantially free from urease activity. The soy flour is preferably lowered to a pH of 2.0 to 4.0 for at least 1 minute. Optionally, the method may also include adding a crosslinking agent, diluent or both to the soy flour/urea adhesive and/or adding an emulsified or dispersed polymer. Adhesives and dispersions prepared according to the methods of this invention offer increased stability and strength properties.

Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.

Abstract: The present invention relates to novel amphoteric polysaccharide compounds containing aldehyde function(s) corresponding to the formula (I): P—(O—(Y)p-CAT)m in which: P represents a polysaccharide chain, the said chain hearing one or more aldehyde functions and optionally one or more groups —COOV, this group possibly being obtained during the oxidation of certain carbon atoms of a saccharide unit, Y represents a linear or branched, saturated or unsaturated, optionally hydroxylated divalent C1-C8 divalent hydrocarbon-based group comprising at least one ether and/or amine function in the hydrocarbon-based chain, or a group —Si(R)2—[O—Si(R)2]q-Z-; p is O or 1, and CAT represents an ammonium group or a cationic polymer chain obtained by grafting and polymerization of ethylenic monomers bearing an ammonium function. The invention also relates to their use in cosmetics and to compositions comprising them.

Abstract: The present invention provides an improved method of producing a stable urea-denatured soy flour-based adhesive having improved wet and dry strengths, with more efficient production and lower production costs. The method comprises heating soy flour until denatured and then adding urea to the denatured soy flour. The soy flour may be heated up to 40° C. to 100° C. for at least 15 to 500 minutes. Optionally, the method may also include adding a cross-linking agent to the soy flour/urea mixture and/or adding an emulsified or dispersed polymer. Adhesives prepared according to this invention offer increased stability and strength properties.

Abstract: A method for the production of a cross-linked support matrix that in form of a bed will permit liquid flow velocities above 5 cm/h, preferably above 50 cm/h, to pass through the bed. The method is characterized in that it comprises the steps: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation. The use of a cross-linked support matrix produced by a method comprising the steps of: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation as a support matrix in liquid chromatography, cell culturing, step-wise solid phase synthesis of organic compounds, running catalytic reactions by the use of a solid phase bound catalyst.

Abstract: According to the present disclosure, starch/polymer combinations are provided. The preferred starch/polymer combinations are usable as paper additives, in the wet end of a papermaking process. Typical and preferred starch/polymer combinations of this type, result from combining a starch, having a polymer reactive carbonyl functionality, with a polymer, having a carbonyl reactive functionality, under conditions that allow for covalent interaction between the two. Typically usable components comprise oxidized starch and polymer having reactive primary or reactive secondary amine groups. Also provided are methods of preparing such combinations, methods of use, preferred papers including such combinations, and, analytical techniques usable in preparation of such combinations.

Abstract: The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.

Abstract: Anti-reflective compositions are prepared from cellulosic binders with improved etch rates.

Abstract: An amphoteric polymer dispersion obtained in the presence of at least one of starch or a starch derivative by a two-stage polymerization using anionic and cationic monomers is useful as a sizing agent for paper products, as a coating for various substrates, and as a binder in pigment-free coatings or pigment-containing coatings. The dispersion is exceptionally compatible with widely differing sizing agent systems and coating chemicals.

Abstract: The present invention discloses a process for manufacturing a grafted polyacrylamide flocculant of cationic/ampholytic ions, which is characterized by graft-copolymerizing starch or micro-crystalline cellulose as backbone with acrylamide, while using potassium permanganate as initiator, hydrolyzing and thereafter reacting with alkyl-amino-carbinol. Optionally, the product may also contain additives. It has advantages in readily available raw materials, low cost of production, simple technology and mild reaction conditions. The product has good overall performance, high flocculating ability, wide applicability and is an ideal sludge-dewatering agent and sewage treating agent.

Abstract: A process for producing an amphoteric aqueous polymer dispersion by two-step radical copolymerization includes (a) decomposing a starch by treatment with an enzyme or acid hydrolysis to provide a starch solution composed of decomposed starch and/or derivatives thereof having an average molecular weight ranging from 500 to 2000 g/mole and with the starch solution having an internal viscosity<0.

Abstract: A process for preparing a modified polysaccharide graft copolymer complex which comprises the steps of:i. subjecting polysaccharide to graft copolymerization with a vinyl monomer;ii. treating the polysaccharide graft copolymer with:a. polyethylene glycol to provide a polymer-PEG complex; orb. a silicate compound to provide a silica precipitated polymer; andiii. recovering the polymer-PEG complex or silica precipitated polymer.This modified polysaccharide graft copolymer may be used as a surface sizing agent in the preparation of paper.

Abstract: The present invention provides graft copolymers that are highly absorbent to aqueous electrolyte solutions.

Abstract: The present invention relates to modifying agents for melamine-formaldehyde resins and highly reactive thermosetting resins which are prepared with this agent and consist of 1 mol of melamine, 1.5 to 3.5 mol of formaldehyde, 0.5 to 5% by weight of a polyhydric alcohol, based on the melamine plus formaldehyde, and 0.5 to 10% by weight of the modifying agent, based on the liquid resin. The modifying agent can be added to the melamine-formaldehyde resin as a pulverulent mixture before or during the condensation reaction or in the liquid state in the form of a condensation product prepared in a known manner. The modifying agent consists of 10 to 75% by weight of dicyandiamide, 5 to 70% by weight of cold water-soluble starch (soluble between about 18.degree. and about 25.degree. C.) and 20 to 85% by weight of a guanamine. The highly reactive resins modified in this way are preferably used for coating chipboard and hardboard by a short cycle process.

Abstract: The present invention provides graft copolymers that are highly absorbent to aqueous electrolyte solutions.

Abstract: A method of converting a toxic composition containing an aldehyde to a composition which is substantially non-toxic. The aldehyde is reacted with a compound having protic oxygen or nitrogen atoms and a polyimine or polyimine derivative to absorb or swell the aldehyde-containing composition and preferably to yield a substantially solid reaction product by way of a substantially irreversible reaction.

Abstract: The present invention provides graft copolymers that are highly absorbent to aqueous electrolyte solutions.

Abstract: The present invention provides graft copolymers that are highly absorbent to aqueous electrolyte solutions.

Abstract: The present invention provides graft copolymers that are highly absorbent to aqueous electrolyte solutions.

Abstract: The present invention provides graft copolymers that are highly absorbent to aqueous electrolyte solutions.

Abstract: A thermoplastic resin is formed by imparting thermoplasticity to monosaccharide and/or polysaccharide units to form engineering resin that has excellent mechanical property attributes and excellent biodegradability. A thermoplastic graft copolymer is formed by graft-polymerizing graft to backbone. The copolymer comprises backbone which constitutes the monosaccharide and/or polysaccharide units each having a functional group selected from the group consisting of the hydroxyl group, carboxyl group, amino group and amido group, and graft constituting the polyacetal units consisting of repetitive oxymethylene units --CH.sub.2 O-- that are reaction-bonded with each other through the functional group, the polyacetal units being graft-polymerized to the monosaccharide and/or polysaccharide units. The copolymer has viscosity of 0.1-10 (dl/g) and a melting point of 150.degree.-175.degree. C.

Abstract: Disclosed is a binder insolubilizer for use in binder-containing paper coating compositions, the insolubilizer consisting essentially of an aqueous formulation containing at least about 15 weight percent of titratable glyoxal and at least one polyhydroxy compound.

Abstract: A process for manufacturing thermosetting resins comprises reacting a first compound bearing at least one aldehyde function and a second organic compound bearing at least one hydrogen function. The first chemical is an agricultural by-product containing at least one sugar which can be transformed by hydrolysis into a sugar bearing at least one aldehyde function. Such resins are intended in particular for the manufacture of plywood and particle boards.

Abstract: A coating binder additive is prepared comprising a blocked glyoxal resin mixed with a vinyl or acrylic water soluble polymer which is reactive with free glyoxal.

Abstract: An oxygen permeable, wettable, optically acceptable vision correction lens can be made from homopolymers of aminoglycans, substituted aminoglycans, or crosslinked polymers thereof.

Abstract: A binder for casting sand of the present invention comprises 5-95 wt. % of cellulose acetate and 5-95 wt. % of a thermosetting resin precondensate such as an alkylated methylolmelamine, alkylated methylolurea or a mixture of them, and it is used particularly for the casting carried out at a relatively low casting temperature. Up to about 50% of cellulose acetate may be replaced with an acetate of an aliphatic polyhydric alcohol or an alkyl phthalate. In the resin-coated grains of sand of the present invention, the grains of sand are coated with a binder comprising 5-95 wt. % of cellulose acetate and 5-95 wt. % of a thermosetting resin precondensate.

Abstract: Two types of water soluble complexes of retinoids possessing vitamin A-like biological activity and use but of lower toxicity are disclosed: (A) Cyclodextrin complexes of retinoid-polymers and (B) Complexes of retinoids with ether type derivatives of cyclodextrins.

Abstract: Non-flammable reactive particle compositions useful in forming shaped articles prepared from flammable cellulosic materials and a type of urea/formaldehyde resin. Processes for their preparation and a method of rendering flammable reactive particles substantially inflammable.