With Heterocyclic Reactant Other Than Carbohydrate Patents (Class 527/315)
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Publication number: 20130137799Abstract: Anionic graft copolymers and scale inhibition compositions including the anionic graft copolymers in which the anionic graft copolymers include a natural component grafted with an ethylenically unsaturated anionic monomer where the anionic graft copolymer includes 1 or more reacted anhydroglucose units per every 100 anhydroglucose units in the anionic graft copolymer.Type: ApplicationFiled: July 30, 2010Publication date: May 30, 2013Applicant: AKZO NOBEL N.V.Inventors: Klein A. Rodrigues, Matthew M. Vanderhoof, John Ozbek
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Patent number: 8404662Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: August 10, 2012Date of Patent: March 26, 2013Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.Inventors: Jianjun Cheng, Mark Davis, Kay T. Khin
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Patent number: 8399431Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: July 19, 2012Date of Patent: March 19, 2013Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Patent number: 8372933Abstract: Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of ?-, ?-, or ?-cyclodextrins and amines to bisacrylamides.Type: GrantFiled: June 10, 2008Date of Patent: February 12, 2013Assignee: L'Urederra Fundacion Para el Desarrollo Tecnologico y SocialInventors: Paolo Ferruti, Elisabetta Ranucci, Francesco Trotta, Roberta Cavalli, Claudio Fernandez
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Publication number: 20110303611Abstract: Disclosed is a cross-linked molecularly imprinted polymer including cross-linked chitosan having selective binding sites for phosphate ions, phosphate containing molecules, or a combination of both.Type: ApplicationFiled: June 3, 2011Publication date: December 15, 2011Inventors: Tracy J. Terry, Andrew F. Mason, Carl A. Marrese
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Patent number: 7985794Abstract: A starch-polyester graft copolymer and chemically modified starch-polyester graft copolymer composition comprising a chemically modified starch or chemically modified starch-nanoclay product is described. The composition can be produced continuously in a twin-screw co-rotating extruder. The starch-polyester graft copolymer can be solvent cast, melt cast and blown into clear transparent film particularly for use in single use disposable applications and can be biodegradable.Type: GrantFiled: December 7, 2009Date of Patent: July 26, 2011Assignee: Board of Trustees of Michigan State UniversityInventors: Ramani Narayan, Sunder Balakrishnan, Yogaraj Nabar, Jean-Marie Raquez, Philippe Dubois
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Patent number: 7638560Abstract: A foamed starch-polyester graft copolymer and chemically modified starch-polyester graft copolymer composition comprising a chemically modified starch or chemically modified starch-nanoclay product is described. The composition can be produced continuously in a twin-screw co-rotating extruder in the presence of a blowing agent. The foams are biodegradable.Type: GrantFiled: May 18, 2005Date of Patent: December 29, 2009Assignee: Board of Trustees of Michigan State UniversityInventors: Ramani Narayan, Yogaraj Nabar
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Patent number: 7629405Abstract: A starch-polyester graft copolymer and chemically modified starch-polyester graft copolymer composition comprising a chemically modified starch or chemically modified starch-nanoclay product is described. The composition can be produced continuously in a twin-screw co-rotating extruder. The starch-polyester graft copolymer can be solvent cast, melt cast and blown into clear transparent film particularly for use in single use disposable applications and can be biodegradable.Type: GrantFiled: November 19, 2004Date of Patent: December 8, 2009Assignee: Board of Trustees of Michigan State UniversityInventors: Ramani Narayan, Sunder Balakrishnan, Yogaraj Nabar, Jean-Marie Raquez, Philippe Dubois
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Patent number: 7182884Abstract: A bio-liquid crystal polymer is made from a tissue-derived compound or the derivatives. The bio-liquid crystal polymer has a characteristic of liquid crystal under predetermined conditions and is biocompatible.Type: GrantFiled: July 28, 2003Date of Patent: February 27, 2007Assignees: Toyoda Gosei Co., Ltd.Inventors: Tatsuo Kaneko, Michiya Matsusaki, Tran Thi Hang, Mitsuru Akashi, Naoto Kuriyama
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Patent number: 6372813Abstract: The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.Type: GrantFiled: June 25, 1999Date of Patent: April 16, 2002Assignee: MotorolaInventors: Travis Johnson, John McGowen, Allyson Beuhler, Charles Kimball Brush, Robert Emil Lajos
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Patent number: 6342541Abstract: A manufacturing method comprising the steps of forming at first solidified wax layer of a desired shape, depositing onto the first solidified wax layer at least one layer of a liquid resin formulation, solidifying the layer of liquid resin formulation, depositing a second wax layer on to the combination of the first solidified wax layer and the layer of solidified resin formulation, solidifying the second wax layer, and separating the solidified resin formulation from first and second wax layers. Preferably, the resin formulation comprises at least one monofunctional water soluble vinyl or acrylic monomer in combination with a low molecular weight aliphatic polymer having acrylic or methacrylic acid functionality. The solidified wax and resin formulation layers can be machined as may be desired to form mold of a given shape comprising wax layers when the layer of formulation is separated from the wax layers.Type: GrantFiled: December 8, 1999Date of Patent: January 29, 2002Assignee: Advanced Ceramics Research, Inc.Inventors: John Lang Lombardi, Gregory John Artz
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Patent number: 6316505Abstract: Block copolymers containing a fluorinated hydrocarbon unit, a hydrocarbon unit, and a poly(oxyethylene) unit are useful in fluid formulations of pharmaceutical agents. A typical embodiment is: C11H23—CONHC2H4NHCO—C8F16—CONHC2H4NHCOO—(C2H4O)34—H.Type: GrantFiled: August 5, 1999Date of Patent: November 13, 2001Assignee: Supratek Pharma, Inc.Inventors: Alexander V. Kabanov, Serguei V. Vinogradov
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Patent number: 6303670Abstract: Disclosed is an ultraviolet-curable cellulosic coating composition comprising cellulose acetate, diepoxy compound and photo cationic polymerization catalyst. The objective is to provide a novel ultraviolet-curable cellulosic coating composition capable of forming a film excellent in the adherence to polar substrate, solvent resistance, gloss and impact resistance.Type: GrantFiled: February 25, 2000Date of Patent: October 16, 2001Assignee: Nippon Paper Industries Co., Ltd.Inventors: Kenichi Fujino, Shelby F. Thames
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Patent number: 6255385Abstract: A polyhydroxy polymer substituted with covalently linked alkene groups, characterized in that the alkene groups are styryl ether groups. A gel obtained by polymerization of a styryl ether substituted polyhydroxy polymer. A surface that has been hydrophilized by adsorption of a styryl ether polyhydroxy polymer.Type: GrantFiled: May 11, 1999Date of Patent: July 3, 2001Inventors: Jan Ericsson, Charlotta Lindquist
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Patent number: 6201070Abstract: Methods are disclosed for enhancing the toughness, e.g., resistance to cracking upon flexation, of coatings made from cycloaliphatic epoxide derivatives wherein the cycloaliphatic epoxide derivative is a cycloaliphatic epoxide ester of a hydroxy-functional compound containing at least one branched, 1,2-alkylene oxide unit. Processes for making the cycloaliphatic epoxide derivatives and coating formulations comprising the cycloaliphatic epoxide derivatives are also disclosed.Type: GrantFiled: November 20, 1996Date of Patent: March 13, 2001Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Naofumi Kumabe, Thomas Andrew Upshaw, Robert Francis Eaton, Bharat Kanaiyalal Patel, John Kellis Braddock
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Patent number: 6054492Abstract: Block copolymers containing a fluorinated hydrocarbon unit, a hydrocarbon unit, and a poly(oxyethylene) unit are useful in fluid formulations of pharmaceutical agents. A typical embodiment is:C.sub.11 H.sub.23 --CONHC.sub.2 H.sub.4 NHCO--C.sub.8 F.sub.16 --CONHC.sub.2 H.sub.4 NHCOO--(C.sub.2 H.sub.4 O).sub.34 --H.Type: GrantFiled: September 9, 1997Date of Patent: April 25, 2000Assignee: Supratek Pharma Inc.Inventors: Alexander V. Kabanov, Serguei V. Vinogradov
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Patent number: 5932539Abstract: Novel biodegradable amphiphilic polymers are described. Preferred polymers have a lipophilic binding moiety coupled covalently to a hydrophilic tissue adhesion moiety through a divalent linker comprising a natural metabolite or a polymer biodegradable into a natural metabolite. In one embodiment the biodegradable polymers of the invention exhibit the property of self-assembly characteristic of liquid crystals. The present amphiphilic biodegradable polymers can be used alone or in combination with other biocompatible polymers, with cells, growth factors, hormones, and/or other pharmaceutical agents in fabrication of implantable matrices for tissue repair. The polymers are biodegradable into art-recognized biocompatible components, preferably natural metabolites.Type: GrantFiled: October 15, 1997Date of Patent: August 3, 1999Assignee: The Board of Trustees of the University of IllinoisInventors: Samuel I. Stupp, Subramani Iyer
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Patent number: 5914381Abstract: A degradable polymer and a process for preparing the degradable polymer which has a structure resulting from combination of a star-shaped polymer comprising a polyfunctional base compound of polycarboxylic acid having three or more carboxyl groups and/or anhydride of the same or aliphatic polyhydric alcohol having three or more hydroxyl groups and a unit of aliphatic hydroxycarboxylic acid, with aliphatic polyhydric alcohol having two or more hydroxyl groups or polycarboxylic acid having two or more carboxyl groups or anhydrides of the same. The degradable polymer leads to remarkably low coloration as compared with a polymer comprising polysaccharide as a polyfunctional base compound, has high melt tension as compared to common aliphatic polyester is excellent in processability on various molding methods, foam molding and blow molding in particular, and high transparency.Type: GrantFiled: September 8, 1997Date of Patent: June 22, 1999Assignee: Mitsui Chemicals, Inc.Inventors: Yuji Terado, Hiroshi Suizu, Chojiro Higuchi, Masanobu Ajioka
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Patent number: 5886124Abstract: Disclosed are a liquid-absorbent polymer and a substantially clear gelatinoid product. The liquid absorbent polymer comprises a saponified graft copolymer of starch and a polynitrile species, such as polyacrylonitrile. In accordance with the disclosed invention, the liquid-absorbent polymer is prepared from a derivatized starch, the derivatized starch having a degree of substitution sufficient to substantially inhibit starch-starch interactions in the gelatinoid product formed upon mixing of the polymer with liquid. Preferred starches have a degree of substitution (DS) of at least about 0.01. Upon saponification of the liquid-absorbent polymer and placing of the polymer into absorbent contact with a liquid, a gelatinoid product will be formed. The gelatinoid product thus formed will have a substantially homogeneous index of refraction, and thus will be substantially clear.Type: GrantFiled: May 5, 1998Date of Patent: March 23, 1999Assignee: Grain Processing CorporationInventors: Adrian P. Kightlinger, Richard L. Antrim
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Patent number: 5817728Abstract: A preparation process of a degradable copolymer comprising carrying out dehydration polycondensation of polysaccharide (A) with one or more compounds (B) selected from the group consisting of:(b1) hydroxycarboxylic acid,(b2) polyhydroxycarboxylic acid,(b3) aliphatic polyhydric alcohol and aliphatic polybasic acid, and(b4) aliphatic polyester derived from aliphatic polyhydric alcohol and aliphatic polybasic acid.A copolymer having a high molecular weight, excellent toughness, transparency and heat resistance, and additionally having a high melt tension can be obtained with a reaction time less than a half of the conventional process. The copolymer obtained by the invention is a material suited for injection molding, extrusion, calendaring, blow forming, balloon forming, vacuum forming and foaming. Particularly, the copolymer obtained by the invention has a high melt tension and thus the molten copolymer is difficult to sag and flow and can be processed with ease into foams and blow bottles.Type: GrantFiled: March 4, 1996Date of Patent: October 6, 1998Assignee: Mitsui Chemicals, Inc.Inventors: Chojiro Higuchi, Hiroshi Suizu, Masatoshi Takagi, Takeshi Kashima, Yuji Terado, Ikumi Kitada, Masanobu Ajioka, Akihiro Yamaguchi, Taiji Kameoka
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Patent number: 5780568Abstract: The invention relates to a procedure, to a grafted starch derivative produced by this procedure and method of using it. In the procedure a starch or starch derivative is graft-copolymerized with a cyclic ester, producing a starch derivative grafted with an aliphatic polyester. The procedure can be implemented as mass polymerization without the use of a solvent or other medium. The grafted starch derivative produced can be used as a component in hot-melt adhesives and as an impermeable coating for paper and cardboard.Type: GrantFiled: November 27, 1996Date of Patent: July 14, 1998Assignee: Valtion Teknillinen TutkimuskeskusInventors: Jani Vuorenpaa, Soili Peltonen, Jukka Seppala
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Patent number: 5763557Abstract: The invention relates to the chemical bonding of a polymer/or polymers onto non-metallic substrates such as cellophane by ultrasonic techniques. The cellophane film is preactivated by contacting with silver nitrate solution followed by treatment with potassium hydroxide solution whereby particles of silver and silver oxide are uniformly distributed, in situ, over the surface of cellophane film. The pretreated cellophane film when contacted with grafting solution, that contains monomers, prepolymers, catalyst, graft initiator and other ingredients of the composition, which is being agitated with ultrasonic energy results in polymerization of monomer/prepolymer onto the surface of the cellophane film.Type: GrantFiled: September 24, 1996Date of Patent: June 9, 1998Assignee: Polymer Research Corp. of AmericaInventors: Mohan L. Sanduja, Carl Horowitz, Paul Thottathil
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Patent number: 5763504Abstract: Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.Type: GrantFiled: June 7, 1995Date of Patent: June 9, 1998Assignee: Seikagaku Kogyo Kabushiki Kaisha(Seikagaku Corporation)Inventors: Takehisa Matsuda, Minoo J. Moghaddam, Katsukiyo Sakurai
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Patent number: 5760154Abstract: The present invention relates to water-soluble, acid groups-containing graft copolymers which are at least partially biodegradable and are based on polyhydroxy compounds and monoethylenically unsaturated carboxylic acids, sulfonic acids and/or phosphonic acids or the salts of said acids as well as optional further monomers. The present invention further relates to a process for producing said graft copolymers at temperatures of up to 200.degree. C. by means of radical polymerization initiators, in that a total mixture is polymerized which consists of 1-60%-wt. of polyhydroxy compounds, their derivatives or their mixtures, and 95-40%-wt. of a monomer mixture comprising at least one monoethylenically unsaturated carboxylic acid, at least one monoethylenically unsaturated sulfonic acid, one monoethylenically unsaturated sulfuric acid ester and/or vinylphosphonic acid or the salts of said acids with monovalent cations, as well as optional further monomers.Type: GrantFiled: February 28, 1995Date of Patent: June 2, 1998Assignee: Stockhausen GmbH & Co., KGInventors: Frank Krause, Helmut Klimmek
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Patent number: 5583193Abstract: A process for preparing a modified polysaccharide graft copolymer complex which comprises the steps of:i. subjecting polysaccharide to graft copolymerization with a vinyl monomer;ii. treating the polysaccharide graft copolymer with:a. polyethylene glycol to provide a polymer-PEG complex; orb. a silicate compound to provide a silica precipitated polymer; andiii. recovering the polymer-PEG complex or silica precipitated polymer.This modified polysaccharide graft copolymer may be used as a surface sizing agent in the preparation of paper.Type: GrantFiled: May 26, 1995Date of Patent: December 10, 1996Assignee: National Starch and Chemical Investment Holding CorporationInventors: Perincheery Aravindakshan, Velayudhan N. G. Kumar
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Patent number: 5525414Abstract: The present invention provides a method of preparing a sized synthetic fiber comprising the steps of (a) preparing a sizing composition for synthetic materials used in textile manufacturing comprising (i) a lubricant or wetting agent and (ii) a binder composition comprising starch and a reaction product of styrene and 1,3-butadiene wherein said starch is characterized by an intrinsic viscosity of from about 0.07 dl/g to about 0.35 dl/g; (b) sizing synthetic fiber with the sizing composition of step (a); and (c) removing excess sizing composition from the sized fiber.Type: GrantFiled: February 3, 1994Date of Patent: June 11, 1996Assignee: Penford Products Co.Inventors: James A. Wagers, Verne J. Martin
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Patent number: 5462976Abstract: Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.Type: GrantFiled: February 5, 1993Date of Patent: October 31, 1995Assignee: Seikagaku Kogyo Kabushiki KaishaInventors: Takehisa Matsuda, Minoo J. Moghaddam, Katsukiyo Sakurai
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Patent number: 5433876Abstract: Compounds are provided for use in an electrolyte comprising repeating unit selected from the group consisting of cyclic and heterocyclic species having y carbon atoms and z heteroatoms, X, and where y is 4, 5 or 6 and z is 0, 1 or 2. The heteroatom is selected from the group consisting of O, S and N. The repeating unit is further substituted by four to six pendant groups having the formula, (CHR.sub.1).sub.m O(CHR.sub.1 CHR.sub.1 O).sub.n Y, where the majority of pendant groups comprises at least two O and further,in which m is 0 or 1,in which n is in the range of 0 to 25,in which each R.sub.1 is the same or different and R.sub.1 is selected from the group consisting of H, alkyl, allylic and alkenyl radicals having 1 to 18 carbon atoms and Y, andin which each Y is the same or different and Y is a functional group selected from the group consisting of polymerizable functionalities, plasticizing agents and ionic species. Electrolytes, plasticizers and macro-ions prepared from these compounds are described.Type: GrantFiled: June 9, 1993Date of Patent: July 18, 1995Assignee: Arthur D. Little, Inc.Inventors: Denis G. Fauteux, Arthur A. Massucco, John R. Powell, Martin F. van Buren
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Patent number: 5416181Abstract: A dried film reinforced with coalescable water insoluble polymer particles which are substantially noncoalesced is disclosed. Also disclosed are dried films reinforced with noncoalesced water insoluble polymer particles which are readily water dispersible. Also disclosed are stable aqueous dispersions for formation of such films which comprise (a) a water insoluble component comprising coalescable polymer particles which have a T.sub.g less than 55.degree. C. and a majority of which have a particle size of less than 1 micron; and (b) a water soluble component which comprises a water soluble polymer capable of inhibiting coalescence of the polymer particles, or a water soluble polymer and a component capable of inhibiting coalescence of the polymer particles.Type: GrantFiled: December 19, 1991Date of Patent: May 16, 1995Assignee: Penford Products CompanyInventors: Charles C. Nguyen, Verne J. Martin, Edward P. Pauley, Henry L. Buccigross, Stephen Rudolph
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Patent number: 5319048Abstract: A new composition of matter that can be substituted as a bulking agent for sugar or starch to reduce the caloric content of foods comprising the polymeric product of the reaction of a water-soluble polyol with a di- or tri-epoxide, in water containing a water-soluble inorganic base that serves as a catalyst, and the process for making it.Type: GrantFiled: December 30, 1991Date of Patent: June 7, 1994Assignee: Hercules IncorporatedInventors: Lawrence C. Carosino, Anthony B. Clayton
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Patent number: 5274028Abstract: In an improved method for producing a surface graft of a hydrophilic polymer upon a preformed solid or semi-solid polymer substrate having hydroperoxide groups along its surface, n-vinyl pyrrolidone is utilized as the surface-grafting monomer, the substrate is selected to be insoluble in n-vinyl pyrrolidone, and the polymerization is carried out in aqueous alkaline conditions utilizing a combination of metal salts to provide a variable valence metal ion in a reduced state capable of oxidizing to suppress homopolymerization of the monomer in the solution.When the substrate is at least partially soluble in the n-vinyl pyrrolidone, an ethylenically unsaturated monomer having a higher reactivity with the substrate than n-vinyl pyrrolidone is added to the alkaline polymerization solution as a "seeding" monomer. Addition of the "seeding" monomer results in a surface-grafted copolymer effectively externalized from the substrate.Type: GrantFiled: December 6, 1990Date of Patent: December 28, 1993Assignee: Baxter International Inc.Inventors: William J. Bertrand, Stephen L. Coulter, Cary Reich, Paul DeAntonio
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Patent number: 5219971Abstract: Fine-particle, water-swellable polysaccharide graft copolymers by prepared inverse suspension polymerization of 5 to 40 parts of polysaccharide and 95 to 60 parts of an olefinically unsaturated carboxylic acid, in which an aqueous phase which contains the olefinically unsaturated carboxylic acid, polymerization initiator and 100 to 75 wt. % of the polysaccharide is metered into a hydrophobic solvent which contains 0 to 25 wt. % of the polysaccharide at 40.degree. to 100.degree. C., exhibit improved absorptivity properties and particle size distribution.Type: GrantFiled: January 17, 1992Date of Patent: June 15, 1993Assignee: Starchem GmbHInventors: Klaus Heidel, Frank Zimmermann
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Patent number: 5183872Abstract: Polysaccharide graft polymers are prepared by semi-continuous reverse-phase suspension polymerization, partial dewatering and crosslinking, wherein during and after the suspension polymerization, in which an aqueous solution of an at least partially neutralized, olefinically unsaturated carboxylic acid is added to a suspension of a polysaccharide in a nonpolar organic solvent, the viscosity is reduced by adding amphoteric ammonium compounds or quaternary imidazolinium salts to the reaction medium.Type: GrantFiled: October 25, 1991Date of Patent: February 2, 1993Assignee: Starchem GmbHInventors: Klaus Heidel, Sigrid Scholz-Weigl
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Patent number: 5180800Abstract: Finely divided polysaccharide graft polymers having a high absorption capacity for urine and water are prepared by semi-continuous reverse-phase suspension polymerization, in which an aqueous solution of an unsaturated carboxylic acid and an initiator is metered continuously into a suspension of a polysaccharide in an organic solvent and the polymer obtained is subsequently partial dehydrated and the crosslinked.Type: GrantFiled: May 3, 1991Date of Patent: January 19, 1993Assignee: Starchem GmbHInventors: Klaus Heidel, Frank Krause, Peter Hofmann
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Patent number: 5130394Abstract: A stable aqueous polymeric dispersion comprising a graft copolymer of thinned, gelatinized starch and one or more vinyl grafting monomers, the vinyl monomers including at least 10% by weight 1,3-butadiene is disclosed. Also disclosed are paper coating color compositions comprising the polymeric dispersions and pigments and improved high gloss papers coated with the coating color compositions.Type: GrantFiled: February 5, 1991Date of Patent: July 14, 1992Assignee: Penford Products CompanyInventors: Charles C. Nguyen, Verne J. Martin, Edward P. Pauley
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Patent number: 5130395Abstract: An aqueous, salt stable polymeric dispersion comprising the reaction product of a thinned, gelatinized starch and one or more vinyl monomers, said monomer(s) comprising at least 10% 1,3-butadiene by weight is disclosed.Type: GrantFiled: February 5, 1991Date of Patent: July 14, 1992Assignee: Penford Products CompanyInventors: Charles C. Nguyen, Verne J. Martin, Gary R. Luebke, Edward P. Pauley, Duane E. Tupper
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Patent number: 5098977Abstract: Improved articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their preparation and use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extension of 12 to 22 carbon atoms. When exposed to blood, the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation as well as other biocompatibility parameters, such as foreign body immune responses.Type: GrantFiled: December 24, 1990Date of Patent: March 24, 1992Assignee: Board of Regents, The University of Texas SystemInventors: Jack Frautschi, Kevin Tingey
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Patent number: 5086144Abstract: Novel carboxylic acid-functional polymers are obtained by reacting:(a) a hydroxy-functional polymer having an average of at least two hydroxyl groups per molecule; and(b) a cyclic anhydride under reaction conditions to produce acid groups and ester groups; andwherein the hydroxy-functional polymer is obtained by the copolymerization of:(i) 1-95 weight percent of a cellulose ester; and(ii) 5-99 weight percent of at least one ethylenically unsaturated alcohol copolymerizable with the cellulose acetate butyrate; and(iii) 0-94 weight percent of at least one other ethylenically unsaturated monomer copolymerizable with the cellulose ester and the ethylenically unsaturated alcohol.Curable compositions especially useful as coatings are prepared by mixing the novel carboxylic acid-functional polymers with epoxy-functional compounds and, optionally, with anhydridefunctional compounds and, optionally, hydroxy-functional compounds. The coatings are especially useful in clearcoat/basecoat compositions.Type: GrantFiled: August 14, 1989Date of Patent: February 4, 1992Assignee: The Sherwin-Williams CompanyInventors: Mohamad D. Shalati, James A. Marquart, John R. Babjak, Rodney M. Harris
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Patent number: 5075401Abstract: A graft copolymer is made by grafting, by a free radical reaction mechanism in aqueous solution, water soluble ethylenically unsaturated monomeric material on to a water soluble substrate having hydroxyl groups, and the free radicals are formed on the substrate using an oxidizing metal capable of being reduced by the substrate to a lower valency state (for instance cerium) and persulphate or other peroxy compound capable of oxidizing the metal back to a higher valency state. The process is preferably conducted as a reverse phase polymerization process and the invention includes also a novel reverse phase emulsion comprising a dispersion of reverse phase polymer particles of a graft copolymer of carboxymethyl cellulose, dextran or starch with acrylamide and acrylic acid and/or AMPS.Type: GrantFiled: August 25, 1989Date of Patent: December 24, 1991Assignee: Allied Colloids Ltd.Inventor: Lian-Sheng Zhang
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Patent number: 5049634Abstract: A derivatized graft polymer of a polysaccharide, a crosslinked graft polymer of a polysaccharide, and a derivatized and crosslinked graft polymer of a polysaccharide are prepared. The derivatized polymer has the structure Sacch-g-[(M--CH.dbd.N--Y).sub.x -g-[(M).sub.q ]; the crosslinked polymer has the structure Sacch-g-[(M--CH.dbd.N).sub.z -P].sub.w -g-[(M).sub.q ] or Sacch-g-[(M--CH.dbd.C).sub.z -P].sub.w -g-[(M).sub.q ]; the derivatized and crosslinked polymer has the structure Sacch-g-[(M--CH.dbd.N--Y).sub.x ]-g-[(M--CH.dbd.N)-P]-g-[(M).sub.q ] or Sacch-g-[(M--CH.dbd.N--Y).sub.x ]-g-[(M--CH.dbd.C).sub.z -P].sub.w -g-[(M).sub.q ]. Sacch represents a polysaccharide such as starch, gum, or cellulose; g-represents a graft; M represents one or more ethylenically or allylically unsaturated monomers, at least one of which contains an acetal or aldehyde; P represents a multivalen residue from a reagent containing more than one primary amine group or ketone group; --N.dbd.Type: GrantFiled: September 22, 1989Date of Patent: September 17, 1991Assignee: National Starch and Chemical Investment Holding CorporationInventors: John J. Tsai, Patrick G. Jobe, Robert L. Billmers, Rama S. Chandran
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Patent number: 5037930Abstract: In this invention, at least two monomers are grafted onto hydroxy-containing cellulose polymer. The invention thus provides a polymer of a cellulose containing a hydroxy group on which is grafted, by replacement of the hydrogen atom of the hydroxy group, with a copolymer having a polymerized lactam-containing moiety and a polymerized quaternized ammonium-containing moiety. The ratio of the polymerized lactam group of the quaternized ammonium moiety in the grafted copolymer can be predetermined to provide polymers which are particularly useful in the hair treatment industry.Type: GrantFiled: September 22, 1989Date of Patent: August 6, 1991Assignee: GAF Chemicals CorporationInventor: Jenn S. Shih
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Patent number: 5017670Abstract: Improved articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their preparation and use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extension of 12 to 22 carbon atoms. When exposed to blood, the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation as well as other biocompatibility parameters, such as foreign body immune responses.Type: GrantFiled: September 23, 1987Date of Patent: May 21, 1991Assignee: Board of Regents, The University of Texas SystemInventors: Jack Frautschi, Kevin Tingey
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Patent number: 5003022Abstract: A stable aqueous polymeric dispersion comprising a graft copolymer of thinned, gelatinized starch and one or more vinyl grafting monomers, the vinyl monomers including at least 10% by weight 1,3-butadiene is disclosed. Also disclosed are paper coating color compositions comprising the polymeric dispersions and pigments and improved high gloss papers coated with the coating color compositions.Type: GrantFiled: February 5, 1990Date of Patent: March 26, 1991Assignee: Penford Products CompanyInventors: Charles C. Nguyen, Verne J. Martin, Edward P. Pauley
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Patent number: 4898921Abstract: Conducting polymer films comprising a polymer matrix with intercalated, bonded conducting polymers, prepared from a polysaccharide matrix and the monomer of conducting polymer, are useful as anti-static materials, optical filters, solid electrolytes, electrodes and electrochemical sensors. The conducting polymers are polyheterocycles such as polyaniline, polythiophene and their derivatives.Type: GrantFiled: June 3, 1987Date of Patent: February 6, 1990Assignee: Montclair State CollegeInventors: Brian D. Humphrey, Marc L. Kasner, John L. Isidor
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Patent number: 4859758Abstract: Novel carboxylic acid-functional polymers are obtained by reacting:(a) a hydroxy-functional polymer having an average of at least two hydroxyl groups per molecule; and(b) a cyclic anhydride under reaction conditions to produce acid groups and ester groups; andwherein the hydroxy-functional polymer is obtained by the copolymerization of:(i) 1-95 weight percent of a cellulose ester; and(ii) 5-99 weight percent of at least one ethylenically unsaturated alcohol copolymerizable with the cellulose acetate butyrate; and(iii) 0-94 weight percent of at least one other ethylenically unsaturated monomer copolymerizable with the cellulose ester and the ethylenically unsaturated alcohol.Curable compositions especially useful as coatings are prepared by mixing the novel carboxylic acid-functional polymers with epoxy-functional compounds and, optionally, with anhydride-functional compounds and, optionally, hydroxy-functional compounds. The coatings are especially useful in clearcoat/basecoat compositions.Type: GrantFiled: November 16, 1987Date of Patent: August 22, 1989Assignee: The Sherwin-Williams CompanyInventors: Mohamad D. Shalati, James A. Marquart, John R. Babjak, Rodney M. Harris
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Patent number: 4845162Abstract: The present invention relates to a composition comprising a phenolic resin, as for example phenol formaldehyde, an active hydrogen containing polymer as for example a polyamide, and a curing agent, such as a polyepoxide.Type: GrantFiled: June 1, 1987Date of Patent: July 4, 1989Assignee: Allied-Signal Inc.Inventors: George J. Schmitt, Dusan C. Prevorsek, Hong B. Chin, Kwok W. Lem
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Patent number: 4831097Abstract: This invention relates to water soluble heterocyclic cationic graft polymers of cellulose containing units of the structure ##STR1## wherein R is the residue of a cellulosic polymer containing hydroxyl groups; R.sub.1 is hydrogen or methyl; R.sub.2.sup.+ is a quaternized amino amide, a quaternized amino ester or a quaternized 5 or 6 membered heterocyclic ring having up to 2 nitrogen atoms in the ring structure; R.sub.3 is a C.sub.3 to C.sub.8 alkylene group which is optionally substituted with methyl; R.sub.4 is hydrogen or hydroxy; x is an integer having a value of from 1 to 1000 and X is a halide anion.Type: GrantFiled: March 21, 1988Date of Patent: May 16, 1989Assignee: GAF CorporationInventors: Jui-Chang Chuang, Ian W. Cottrell, Stephen C. Johnson
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Patent number: 4816540Abstract: A cationic graft-copolymer comprising a unit derived from a cationic derivative of a water-soluble linear polymers having a hydroxyl groups, namely, a cationic polysaccharide of the following formula (1)[C.sub.6 H.sub.7 O.sub.2 (OH).sub.3-a (OX).sub.a ].sub.x H.sub.2 O (1)and the cationic derivative of polyvinylalcohol of the following formula (2) or the cationic derivative of the partial hydrolyzed polyvinylalcohol of the following formula (3)[CH.sub.2 CH(OH).sub.1-b (OX).sub.b ].sub.n (2)[CH.sub.2 CH(OH).sub.1-b-c (OX).sub.b (OAc).sub.c ].sub.n (3)and a unit derived from a polymerizable olefin compound of the following formula (4) ##STR1## (a, x, b, n, c, Ac, X, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are defined in claim 1-4); a process for preparing the same and a latex reagent made therefrom.Type: GrantFiled: June 12, 1987Date of Patent: March 28, 1989Inventor: Yasuhiko Onishi
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Patent number: 4663163Abstract: A modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly or indirectly to said polysaccharide, and (b) one or more polymerizable compounds containing (i) an ionizable chemcial group, (ii) a chemical group capable of transformation to an ionizable chemical group, (iii) a chemical group capable of causing the covalent coupling of the compound (b) to an affinity ligand or a biologically active molecule or (iv) a hydrophobic compound.Type: GrantFiled: February 2, 1984Date of Patent: May 5, 1987Inventors: Kenneth C. Hou, Tung-Ping D. Liao
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Patent number: H1032Abstract: Processes for manufacturing starch copolymer compositions are provided. In one process, a modified starch is reacted with a hydrophilic vinyl monomer to produce a starch copolymer gel which is, in turn, divided in a plurality of gel fragments. The gel fragments are then dried with a stream of gel to produce a flowable, particulate starch copolymer composition. In another process, water is evaporated from the copolymer gel and further polymerization of vinyl monomers is inhibited during the evaporating by any of a variety of means such as reducing the level of residual vinyl monomer or avoiding conditions which initiate polymerization.Type: GrantFiled: June 27, 1990Date of Patent: March 3, 1992Assignee: A. E. Staley Manufacturing CompanyInventors: John C. Arnold, Robert A. Mooth, Norman A. Portnoy, Keith D. Stanley