From N-c-(c=o)-oh Containing Reactant Or Acid Derivative Thereof, E.g., Alpha Amino Acid, Etc. Patents (Class 528/328)
  • Patent number: 10370620
    Abstract: Provided herein is a method for producing polyaspartic acid under reflux cooling. Further provided herein are compositions including polyaspartic acid obtainable through the method. Also provided herein is a use of polyaspartic acids obtainable through the method in dishwashing agents, detergents, and cleaning agents.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: August 6, 2019
    Assignee: BASF SE
    Inventors: Gazi Tuerkoglu, Juergen Detering, Dietrich Fehringer, Christian Benz
  • Patent number: 10233286
    Abstract: The present invention relates to methods for producing polyaspartic acids with a weight-average molecular weight (Mw) of from 6,000 to 15,000 g/mol. The invention also relates to polyaspartic acids which can be obtained by the method according to the invention, to a composition containing the polyaspartic acids, and to the use thereof as scale inhibitors, dispersants and as an additive in dishwashing agents, detergents or cleaning agents.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: March 19, 2019
    Assignee: BASF SE
    Inventors: Jürgen Detering, Gazi Türkoglu, Dietrich Fehringer
  • Patent number: 10092500
    Abstract: The application relates to oral care compositions comprising substantive polyesteramides formed from polyols, polycarboxylic acids (or esters, anhydrides or halides thereof) and arginine. The formed polyesteramides are active in biofilm inhibition, biofilm dissolution and retarding or preventing acid production from oral bacteria.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: October 9, 2018
    Assignee: BASF SE
    Inventors: Ted Deisenroth, Glen Thomas Cunkle, Lauren Junker, Michael Kuepfert, Paul Odorisio, Steven N. Saunders, Vishal Ramnarine, Neethu Abraham
  • Patent number: 9636411
    Abstract: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-?-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: May 2, 2017
    Assignee: Nitto Denko Corporation
    Inventors: Hao Bai, Kwok Yin Tsang, Yi Jin, Lei Yu
  • Patent number: 9359408
    Abstract: A biologically derived polymer that facilitates the solubilization and protection of small molecules for use in drug delivery, in which the polymer is a protein polymer. A biologically derived polymer that facilitates the solubilization and protection of small molecules for use in drug delivery, incorporating fluorinated amino acids into the protein polymer for visualization and detection by 19F NMR, 19F MRS, and 19F MRI.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: June 7, 2016
    Assignee: New York University
    Inventors: Jin Kim Montclare, Carlo Yuvienco
  • Patent number: 9273180
    Abstract: Polyol compositions containing methane linkages derived from amino acids. The polyols are obtained from the reaction of the carbonate with the cadres in the amino acids. Individual amino acids or mixtures of amino acids that are prepared from the hydrolysis of the proteins can be used.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: March 1, 2016
    Assignee: Board of Trustees of Michigan State University and Vahid Sendijarevice, joint ownership
    Inventors: Ramani Narayan, Daniel Graiver, Elodie Hablot, Vahid Sendijarevic, Siva Rama Krishna Chalasani
  • Patent number: 8993686
    Abstract: Biodegradable saturated and unsaturated polyester amides (PEA)s made from multiamino acid monomers and methods of making biodegradable saturated and unsaturated PEAs.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 31, 2015
    Assignee: Cornell University
    Inventors: Chih-Chang Chu, Mingxiao Deng
  • Publication number: 20150064788
    Abstract: The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
    Type: Application
    Filed: February 28, 2013
    Publication date: March 5, 2015
    Inventors: Natasa Anastasov, Ines Höfig, Christian Thirion
  • Patent number: 8952106
    Abstract: The present invention is directed to linear, biodegradable polyesteramide (PEA) polymers synthesized with repeating units derived from aminophenol esters and diacids. These PEAs have a monomer repeat represented by as well as a variety of uses to coat, form or comprise medical devices, combination medical devices and pharmaceutical compositions, including sustained release formulations.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: February 10, 2015
    Assignee: TYRX, Inc.
    Inventors: Arthur Schwartz, Satish Pulapura, Sarita Nethula, Archana Rajaram, Arikha Moses
  • Patent number: 8927682
    Abstract: Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: January 6, 2015
    Assignee: Board of Trustees of Michigan State University
    Inventors: Gregory L. Baker, Milton R. Smith, III, Xuwei Jiang, Erin B. Vogel
  • Patent number: 8920788
    Abstract: Disclosed is a water-soluble high-molecular weight conjugate of physiologically active substances which enable medicament to release without depending on the enzymes in a living body and which is expected to have a useful therapeutic effect. A high-molecular weight conjugate of a physiologically active substance has a substituent group represented by a general formula (1) bonded to a side-chain carboxy group of a block copolymer which has a polyethylene glycol moiety and either a polyaspartic acid moiety or a polyglutamic acid moiety.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: December 30, 2014
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Masayuki Kitagawa, Chieko Seno
  • Patent number: 8907045
    Abstract: Block co-polymers including a hydrophilic block and a hydrophobic poly(amino acid) block which further includes dihydroxyphenyl moieties are provided, as well as methods of making and using the same. Such block copolymers may be used to prepare biocompatible adhesives which display good adhesives properties in aqueous environments, including in in vivo applications.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: December 9, 2014
    Assignee: Empire Technology Development LLC
    Inventors: Josef Peter Klein, Floyd Brian Karp, Yansong Gu, Roger A. Sahm
  • Patent number: 8889821
    Abstract: A polyester amide compound having a polycarboxylic acid unit in an amount of 25 to 50 mol %, the polycarboxylic acid unit containing an aromatic dicarboxylic acid unit represented by the following formula (I) in an amount of 70 mol % or more; a polyhydric alcohol unit in an amount of 25 to 50 mol %, the polyhydric alcohol unit containing an aliphatic diol unit represented by the following formula (II) in an amount of 70 mol % or more; and a structural unit represented by the following formula (III) in an amount of 0.1 to 50 mol %: wherein, in formula (I), Ar represents an arylene group; in formula (II), X represents a C2 to C20 alkylene group; and in formula (III), R represents a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: November 18, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Ryoji Otaki, Tsuneaki Masuda, Takafumi Oda
  • Patent number: 8841382
    Abstract: The present invention provides an amphiphile of the formula (I) as described hereinafter. The invention further relates to a process for preparing the amphiphile and to a composition comprising the amphiphile and a sparingly water-soluble active ingredient. It further relates to a process for producing the composition by contacting the amphiphile and the active ingredient, and to the use of the amphiphile for solubilizing a sparingly water-soluble active ingredient in aqueous solutions. The invention also relates to the use of the amphiphile in an agrochemical formulation comprising the amphiphile and a pesticide for controlling phytopathogenic fungi and/or unwanted vegetation and/or unwanted insect or mite infestation and/or for regulating the growth of plants, and finally to plant propagation material comprising the amphiphile.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: September 23, 2014
    Assignee: BASF SE
    Inventors: Anna Cristadoro, Holger Türk, Michael Ishaque, Rabie Al-Hellani
  • Patent number: 8835595
    Abstract: A polyamide compound containing: from 25 to 50 mol % of a diamine unit, which contains an aromatic diamine unit represented by the following formula (I), in an amount of 50 mol % or more; from 25 to 50 mol % of a dicarboxylic acid unit, which contains a linear aliphatic dicarboxylic acid unit represented by the following formula (II-1) and/or an aromatic dicarboxylic acid unit represented by the following formula (II-2), in an amount in total of 50 mol % or more; and from 0.1 to 50 mol % of a constitutional unit represented by the following formula (III): wherein n represents an integer of from 2 to 18, Ar represents an arylene group, and R represents a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group.
    Type: Grant
    Filed: December 24, 2010
    Date of Patent: September 16, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Takafumi Oda, Ryoji Otaki, Shota Arakawa, Tsuneaki Masuda, Hiroyuki Matsushita, Ryuji Hasemi
  • Patent number: 8791226
    Abstract: The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 29, 2014
    Assignee: Sigma-Aldrich Co. LLC
    Inventor: Ettigounder Ponnusamy
  • Patent number: 8779085
    Abstract: The present invention discloses a method of producing a modified polyimide comprising a polycarbonate, which modified polyimide has excellent electric properties and adhesion as well as excellent heat resistance, flexibility, bending property, low warping, chemical resistance and storage stability; and the modified polyimide. Also disclosed are a composition comprising the modified polyimide and used thereof.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: July 15, 2014
    Assignee: PI R&D Co., Ltd.
    Inventors: Toshiyuki Goshima, Maw Soe Win, Eika Kyo
  • Patent number: 8772438
    Abstract: A process for making a polyamide polymer, said process comprising heating, in one or more ionic liquid(s), one or more polyamide precursor(s) selected from: (i) one or more free dicarboxylic acid(s) or ester(s) thereof, with one or more diamine(s); or (ii) one or more salt(s) of a dicarboxylic acid with a diamine; or (iii) one or more lactam(s); or (iv) mixtures of any of the foregoing precursors (i) to (iii).
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: July 8, 2014
    Assignee: Invista North America S.är.l.
    Inventors: Keith Whiston, Charles Richard Langrick, Kenneth Richard Seddon, Alberto V. Puga
  • Patent number: 8759475
    Abstract: Polyamides, e.g., polyhexamethylene adipamide, are continuously produced via the following stages: Stage 1: into and through a reactor, polycondensing a liquid stream which contain the polyamide monomer(s) at a pressure P1 greater than atmospheric pressure, the stream of material at the outlet of the reactor including a vapor phase which contains steam and a liquid phase which at least contains the product of polycondensation; Stage 2: feeding the outlet stream of material into a chamber, evacuating at least a portion of the vapor phase therefrom and recovering at least the liquid phase which at least contains the product of polycondensation, the pressure P2 in the chamber being regulated at a set value such that it is greater than atmospheric pressure and the residence time of said liquid phase in the chamber being less than 5 minutes; and Stage 3: pressure reducing at least the liquid phase which at least contains the stream of polycondensation product recovered during Stage 2.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: June 24, 2014
    Assignee: Rhodia Operations
    Inventors: Jean-Francois Thierry, Sébastien Lomel, Vincent Mollet, Matthieu Helft, Cédric Fillon
  • Publication number: 20140171535
    Abstract: Polyol compositions containing methane linkages derived from amino acids. The polyols are obtained from the reaction of the carbonate with the cadres in the amino acids. Individual amino acids or mixtures of amino acids that are prepared from the hydrolysis of the proteins can be used.
    Type: Application
    Filed: September 24, 2013
    Publication date: June 19, 2014
    Applicant: BioPlastic Polymers and Composites, LLC.
    Inventors: Ramani Narayan, Daniel Graiver, Elodie Hablot, Vahid Sendijarevic, Siva Rama Krishna Chalasani
  • Publication number: 20140166586
    Abstract: Lysine-based polymers, particularly copolymers of lysine and maleic acid, are useful as coagulants for clarification of wastewaters, including produced waters from oils sands mining operations. They can be advantageously used in combination with commercial coagulants, and in combination with flocculants. Such combinations may include dry blends. Also described are methods of preparation of lysine homopolymers and copolymers.
    Type: Application
    Filed: April 28, 2011
    Publication date: June 19, 2014
    Inventor: C. Steven Sikes
  • Publication number: 20140138654
    Abstract: Ferroelectric memory elements which contain a poly ?-amino acid which is a copolymer containing a glutamic acid-?-ester unit represented by the formula (I), defined herein, and a glutamic acid-?-ester unit represented by the formula (II), defined herein, in a molar ratio of units of formula (I) to units of formula (II) of 10/90-90/10 are useful as recording elements such as RFID and the like.
    Type: Application
    Filed: November 11, 2013
    Publication date: May 22, 2014
    Applicant: Ajinomoto Co., Inc.
    Inventors: Satoru OHASHI, Sei UEMURA, Manabu KITAZAWA, Toshihide KAMATA
  • Patent number: 8722848
    Abstract: A polyamide compound containing from 0.1 to 50 mol % of a diamine unit that contains at least 50 mol % of a linear aliphatic diamine unit represented by the following general formula (I), from 0.1 to 50 mol % of a dicarboxylic acid unit that contains a linear aliphatic dicarboxylic acid unit represented by the following general formula (II-1) and/or an aromatic dicarboxylic acid unit represented by the following general formula (II-2) in an amount of at least 50 mol % in total, and from 0.1 to 50 mol % of a constituent unit represented by the following general formula (III): [In the above-mentioned general formulae (I) and (II-1), m and n each independently indicate an integer of from 2 to 18. In the general formula (II-2), Ar represents an arylene group. In the general formula (III), R represents a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: May 13, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Takafumi Oda, Ryoji Otaki, Tsuneaki Masuda
  • Patent number: 8664426
    Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: March 4, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Patent number: 8658702
    Abstract: Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve their binding capacity or selectivity with particular water contaminants such as bromide, nitrate, and sulfate. The macromolecules may be either recyclable or non-recyclable, and may be recovered or separated from water using means such as ultrafiltration, flocculation, or immobilization on a substrate.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 25, 2014
    Inventors: Mamadou Diallo, Changjun Yu
  • Patent number: 8653225
    Abstract: A polyamide compound containing from 25 to 50 mol % of a diamine unit that contains at least 50 mol % of an alicyclic diamine unit represented by the following general formula (I); from 25 to 50 mol % of a dicarboxylic acid unit that contains a linear aliphatic dicarboxylic acid unit represented by the following general formula (II-1) and/or an aromatic dicarboxylic acid unit represented by the following general formula (II-2) in an amount of at least 50 mol % in total; and from 0.1 to 50 mol % of a constituent unit represented by the following general formula (III): wherein, in the formulae, n indicates an integer of from 2 to 18; Ar represents an arylene group; and R represents a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: February 18, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Takafumi Oda, Ryoji Otaki, Tsuneaki Masuda
  • Publication number: 20130338310
    Abstract: Disclosed are an ink jet recording water-based ink having excellent long-term storage stability and ejection stability at a pigment concentration greater than or equal to a certain level and a simple and efficient method for producing such a water-based ink. The present invention provides an ink jet recording water-based ink in which the total content of polyvalent metals as impurities in the water-based ink is not more than 1.2 ppm in terms of 1 mass % of a pigment concentration. Furthermore, the present invention provides a method for producing an ink jet recording water-based ink; the method enables efficient production of the above-mentioned ink jet recording water-based ink through a contact treatment with a particulate chelating resin in which each resin particle contains both an alkali metal-bonded chelating group and a hydrogen-bonded chelating group.
    Type: Application
    Filed: December 22, 2011
    Publication date: December 19, 2013
    Applicant: DIC CORPORATION
    Inventors: Yoshinosuke Shimamura, Hiroyuki Buei, Yukihiko Kawaharada, Shinichi Okada, Soetrisno Misawa
  • Patent number: 8592549
    Abstract: A method of forming a polyamide composition includes melt blending specific amounts of a poly(phenylene ether) masterbatch, a first polyamide, glass fibers, and a flame retardant that includes a metal dialkylphosphinate. The poly(phenylene ether) masterbatch is prepared by melt blending specific amounts of a poly(phenylene ether) and a second polyamide. The method provides a polyamide composition with a desirable balance of flame retardancy, melt flow, heat resistance, and mechanical properties, while reducing the amount of metal dialkylphosphinate required by corresponding compositions without the poly(phenylene ether) masterbatch. A corresponding polyamide composition is described, as are the poly(phenylene ether) masterbatch, and a method of reducing the metal dialkylphosphinate content of a flame retardant polyamide composition.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: November 26, 2013
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Snezana Grcev, Johannes E. Fortuijn
  • Publication number: 20130303723
    Abstract: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
    Type: Application
    Filed: December 28, 2012
    Publication date: November 14, 2013
    Inventors: Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya
  • Publication number: 20130261256
    Abstract: An object of the present invention is to provide a copolymer polyamide which has excellent strength, high-temperature strength, low water absorbance, low blocking properties, releasability and plasticizing time stability, and a copolymer polyamide composition which has excellent vibration fatigue characteristics, surface appearance and continuous productivity. A copolymer polyamide of the present invention is obtained by polymerizing (a) at least one alicyclic dicarboxylic acid, (b) one diamine having 8 or more carbon atoms, and (c) at least one copolymer component selected from the group consisting of the following (c-1) to (c-3): a (c-1) dicarboxylic acid other than the alicyclic dicarboxylic acid; a (c-2) diamine having fewer carbon atoms than the (b) diamine; and a (c-3) lactam and/or aminocarboxylic acid, and the copolymer polyamide satisfies specific conditions.
    Type: Application
    Filed: January 6, 2012
    Publication date: October 3, 2013
    Applicant: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Shinji Ieda, Kazunori Terada, Yu Nitto
  • Publication number: 20130230467
    Abstract: The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.
    Type: Application
    Filed: July 7, 2011
    Publication date: September 5, 2013
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Eric Doris, Frédéric Duconge, Edmond Gravel, Nicolas MacKiewicz, Bertrand Tavitian
  • Patent number: 8519175
    Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: August 27, 2013
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20130172517
    Abstract: The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons.
    Type: Application
    Filed: February 5, 2013
    Publication date: July 4, 2013
    Applicant: Sigma-Aldrich Co. LLC
    Inventor: Ettigounder Ponnusamy
  • Publication number: 20130156725
    Abstract: The present invention relates to a synthetic polypeptide which is a random linear pentapolymer comprising alanine, glutamic acid, lysine, tyrosine and phenylalanine and use thereof in treating autoimmune diseases, in particular multiple sclerosis.
    Type: Application
    Filed: February 11, 2013
    Publication date: June 20, 2013
    Applicant: MAPI PHARMA LTD.
    Inventor: MAPI PHARMA LTD.
  • Patent number: 8445603
    Abstract: The present invention is directed to linear, biodegradable polyesteramide (PEA) polymers synthesized with repeating units derived from aminophenol esters and diacids. These PEAs have a monomer repeat represented by as well as a variety of uses to coat, form or comprise medical devices, combination medical devices and pharmaceutical compositions, including sustained release formulations.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: May 21, 2013
    Assignee: TYRX, Inc.
    Inventors: Arthur Schwartz, Satish Pulapura, Sarita Nethula, Archana Rajaram, Arikha Moses
  • Publication number: 20130115457
    Abstract: Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.
    Type: Application
    Filed: June 21, 2011
    Publication date: May 9, 2013
    Applicants: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC., UNIVERSITY OF SOUTH FLORIDA
    Inventors: Donald T. Haynie, Lei Zhai
  • Patent number: 8436201
    Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: May 7, 2013
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20130109832
    Abstract: A polyamide compound containing from 0.1 to 50 mol % of a diamine unit that contains at least 50 mol % of a linear aliphatic diamine unit represented by the following general formula (I), from 0.1 to 50 mol % of a dicarboxylic acid unit that contains a linear aliphatic dicarboxylic acid unit represented by the following general formula (II-1) and/or an aromatic dicarboxylic acid unit represented by the following general formula (II-2) in an amount of at least 50 mol % in total, and from 0.1 to 50 mol % of a constituent unit represented by the following general formula (III): [In the above-mentioned general formulae (I) and (II-1), m and n each independently indicate an integer of from 2 to 18. In the general formula (II-2), Ar represents an arylene group. In the general formula (III), R represents a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group.
    Type: Application
    Filed: February 23, 2011
    Publication date: May 2, 2013
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY INC.
    Inventors: Takafumi Oda, Ryoji Otaki, Tsuneaki Masuda
  • Patent number: 8399600
    Abstract: The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons. In preferred embodiments, the polymer is a homopolymer of poly-L-lysine.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: March 19, 2013
    Assignee: Sigma-Aldrich Co. LLC
    Inventor: Ettigounder Ponnusamy
  • Patent number: 8378058
    Abstract: A conducting polymer including a conducting linker to connect a probe to the polymer, the linker including an unsaturated organic chain.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: February 19, 2013
    Assignee: Auckland Uniservices Limited
    Inventors: Jadranka Travas-Sejdic, Christian Soeller, Hui Peng, Vittorio Capno, Ralph Cooney
  • Publication number: 20130030061
    Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: BEZWADA BIOMEDICAL, LLC
  • Publication number: 20130023642
    Abstract: A polyesteramide compound containing from 50 to 99.9 mol % of an ester unit represented by the following general formula (I), and from 0.1 to 50 mol % of a constituent unit represented by the following general formula (II): wherein, in the above-mentioned general formula (I), X represents an alkylene group; in the above-mentioned general formula (II), R represents a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group.
    Type: Application
    Filed: February 23, 2011
    Publication date: January 24, 2013
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY INC
    Inventors: Takafumi Oda, Ryoji Otaki
  • Patent number: 8329853
    Abstract: The invention relates to an improved process for the preparation of poly-?-glutamic acids which comprises the polymerization of tertiary ?-esters of ?-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-?-glutamic acid-?-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-?-glutamic acid. The invention also relates to poly-?-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: December 11, 2012
    Assignee: Cell Therapeutics, Inc.
    Inventors: Marc McKennon, Giovanni Da Re, Luca Feliciotti, Marco Artico, Gianluca Pardi, Mario Grugni
  • Publication number: 20120302723
    Abstract: A polyamide compound containing: from 25 to 50 mol % of a diamine unit, which contains an aromatic diamine unit represented by the following formula (I), in an amount of 50 mol % or more; from 25 to 50 mol % of a dicarboxylic acid unit, which contains a linear aliphatic dicarboxylic acid unit represented by the following formula (II-1) and/or an aromatic dicarboxylic acid unit represented by the following formula (II-2), in an amount in total of 50 mol % or more; and from 0.1 to 50 mol % of a constitutional unit represented by the following formula (III): wherein n represents an integer of from 2 to 18, Ar represents an arylene group, and R represents a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group.
    Type: Application
    Filed: December 24, 2010
    Publication date: November 29, 2012
    Inventors: Takafumi Oda, Ryoji Otaki, Shota Arakawa, Tsuneaki Masuda, Hiroyuki Matsushita, Ryuji Hasemi
  • Patent number: 8288505
    Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: October 16, 2012
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Patent number: 8202946
    Abstract: A variety of graft copolymers can be formed sodium poly(aspartate) with a wide variety of monomers in an aqueous medium by the use of grafting method in the presence of radical initiator at a temperature of from about five degrees Centigrade to about 100 degrees Centigrade. Graft copolymers at high conversion with molecular weight up to millions can be prepared using this method.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: June 19, 2012
    Assignee: NanoChem Solutions, Inc.
    Inventors: Damodar R. Patil, Laiduien G. Fan, Joseph C. Fan, Jiangping Yu
  • Patent number: 8178641
    Abstract: A method for producing an amino group-containing conjugated diene polymer includes polymerizing a conjugated diene compound in the presence of a reaction product of 1,3-bis(diphenylethenyl)benzene or a derivative thereof and an organolithium compound to obtain a conjugated diene polymer, and reacting the conjugated diene polymer with a modifier.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: May 15, 2012
    Assignee: JSR Corporation
    Inventors: Satoshi Kura, Toshiyuki Hayakawa, Kazuhiro Iso, Susumu Komiyama
  • Publication number: 20120094994
    Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: December 24, 2011
    Publication date: April 19, 2012
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20120088888
    Abstract: To provide a novel polyimide precursor or polyimide which can provide a liquid crystal alignment film having a low volume resistivity, a liquid crystal aligning agent containing these polymers, a liquid crystal alignment film and a novel diamine which is useful as the starting material of these polymers.
    Type: Application
    Filed: March 9, 2010
    Publication date: April 12, 2012
    Applicant: Nissan Chemical Industries, Ltd.
    Inventor: Masato Nagao
  • Publication number: 20120082837
    Abstract: A polyglutamic acid (?-PGA) fiber having antibacterial property and high water absorptivity is provided. A main component of the ?-PGA fiber includes a modified ?-PGA, and the modified ?-PGA is a polymer consisting of a ?-glutamic acid segment and a ?-modified glutamic acid segment, in which the modified glutamic acid segment has a formula as shown below: wherein X is H or Na, and Y is Cl, Br or I, and wherein a molar ratio of the modified ?-glutamic acid segment to the ?-glutamic acid segment is not lower than 0.05.
    Type: Application
    Filed: March 18, 2011
    Publication date: April 5, 2012
    Applicant: FAR EASTERN NEW CENTURY CORPORATION
    Inventors: Jo-Wei Huang, Chun-Yi Li, Mei-Ting Fan Chiang