Gelatin Patents (Class 530/354)
  • Patent number: 9157078
    Abstract: It is an object of the present invention to provide a protein having high cellular adhesiveness that is useful as a cell adhesion support. The present invention provides a cell-adhesive protein comprising methionine, wherein at least a portion of the methionine residues is oxidized.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: October 13, 2015
    Assignee: FUJIFILM Corporation
    Inventor: Kazutaka Ogiwara
  • Patent number: 8981058
    Abstract: The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: March 17, 2015
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Israel Nur, Liliana Bar, Guy Tomer, Eyal Sheetrit
  • Patent number: 8962131
    Abstract: Transparent conductive films comprising silver nanowires dispersed in polyvinyl alcohol or gelatin can be prepared by coating from aqueous solvent using common aqueous solvent coating techniques. These films have good transparency, conductivity, and stability. Coating on a flexible support allows the manufacture of flexible conductive materials.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: February 24, 2015
    Assignee: Carestream Health Inc.
    Inventors: Choufeng Zou, Karissa Eckert
  • Publication number: 20140378662
    Abstract: A method of producing a tissue repair material, the method including: (a) obtaining a gelatin-containing intermediate that contains a gelatin and has a mesh structure, using a gelatin solution in which the gelatin is dissolved in an aqueous medium; (b) drying the gelatin-containing intermediate; and (c) cross-linking the gelatin before or after the drying of the gelatin-containing intermediate.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Applicant: FUJIFILM CORPORATION
    Inventors: Shoji OYA, Hidekazu SAKAI, Ai KAWAKAMI, Takahiro HIRATSUKA, Hideo FUSHIMI, Kazuhiro YAMAGUCHI, Ichiro NISHIMURA, Yoshitaka OONO, Izumi OGURA
  • Publication number: 20140370500
    Abstract: The embodiments herein provide a nanoparticle system for targeted gene delivery or a drug delivery and a method of synthesising the same. The nanoparticle composition for targeted gene transfer and drug delivery comprises a protein, a chitosan and a lipid. A method of synthesizing the nanoparticles involves preparing a gelatine and chitosan gel. A milky colloid solution is prepared with the gelatine, chitosan solution and a phosphatidylcholine. The milky colloid is homogenized for the self assembly of the nanoparticles. The milky colloid is subjected to high speed and high pressure homogenizer. The CHO cells are transfected with nanoparticles and lipofectamine 2000 for comparing the transfection efficiency. The nanoparticles deliver DNA, RNA, ribozyme and nucleotide sequences. The nanoparticles deliver lipophylic and hydrophilic drugs. The transfection efficiency of gene and drug is higher when the target cells are transferred with nanoparticles, compared to the cells transferred with lipofectamine 2000.
    Type: Application
    Filed: September 3, 2014
    Publication date: December 18, 2014
    Inventors: Jalaledin Ghanavi, Poopak Farnia
  • Patent number: 8906679
    Abstract: A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: December 9, 2014
    Assignee: Taipei Veterans General Hospital
    Inventors: Shih-Hwa Chiou, Cherng-Kang Perng, Han-Tzo Lin, Yi-Ping Yang
  • Patent number: 8901017
    Abstract: Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more primary amine groups. The first and second crosslinking compounds may be individually crosslinkable with each other and with the protein. Also described are fiber products that may include inorganic or organic fibers and a cured thermoset binder prepared from a protein and at least two crosslinking compounds. Additionally, methods of making fiber products are described that include providing inorganic or organic fibers, and applying a liquid binder composition to the fibers to form a fiber-binder amalgam. The liquid binder composition may include a protein and at least two crosslinking compounds that include a carbohydrate and an organic amine with two or more primary amines. The amalgam may be heated to a curing temperature to form the fiber product.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: December 2, 2014
    Assignee: Johns Manville
    Inventors: Mingfu Zhang, Jawed Asrar, Uranchimeg Lester
  • Publication number: 20140329992
    Abstract: A method for forming a porous tissue material.
    Type: Application
    Filed: May 6, 2014
    Publication date: November 6, 2014
    Applicant: FUJIFILM Corporation
    Inventor: Huibert VAN BOXTEL
  • Publication number: 20140329267
    Abstract: It is provided a self-healing polymer network comprising transition metal thiolates, particularly thiolates of a transition metal that is able to self-assemble by metallophilic attractions, and more particularly Au(1), Ag(1), Cu(1) thiolates, or a mixture thereof, and, optionally, disulfide bonds, thiol and other thiolate groups. It is also provided several processes for the preparation of the self-healing polymer networks of the invention, as well as uses thereof.
    Type: Application
    Filed: November 27, 2012
    Publication date: November 6, 2014
    Inventors: Ibón Odriozola, Pablo Casuso, Natividad Díaz, Iraida Loinaz, Germán Cabañero, Hans-jürgen Grande
  • Publication number: 20140316013
    Abstract: The present invention relates to a crosslinked gelatin support, in which a surface of a crosslinked gelatin is negatively charged and has a zeta potential in ethanol of from ?3 to ?50 mV, and a support for controlled release of a physiologically active substance, including: the crosslinked gelatin support; and a physiologically active substance adsorbed and retained on and/or inside the crosslinked gelatin support.
    Type: Application
    Filed: April 18, 2014
    Publication date: October 23, 2014
    Applicant: NITTO DENKO CORPORATION
    Inventors: Shinji SUGAWARA, Chieko MIURA, Tomoko SUDO, Masao NAKAGAWA, Toshiyuki YOSHIKAWA
  • Patent number: 8859735
    Abstract: Polypeptides are provided, where the polypeptides include one or more groups of formula —R1—C(O)R2, where R1 is an amino acid side chain, R2 is a C8-C24 polyunsaturated alkenyl group, and the polypeptide is a gelatin.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: October 14, 2014
    Assignee: Empire Technology Development LLC
    Inventors: William B. Carlson, Vincenzo Casasanta, III, Gregory David Phelan
  • Publication number: 20140227195
    Abstract: There is provided a gelatin-ICG complex that can suppress leakage of ICG included therein. The complex has a gelatin derivative including at least one of a phospholipid covalently bonded to a gelatin or a cholesterol covalently bonded to a gelatin, and indocyanine green.
    Type: Application
    Filed: April 17, 2014
    Publication date: August 14, 2014
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Yasuhiko Tabata, Masato Minami, Yoshinori Tomida, Satoshi Yuasa, Tetsuya Yano, Jun-ichiro Jo, Mie Morita
  • Patent number: 8785598
    Abstract: Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 22, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Jung Hyun Han
  • Patent number: 8779097
    Abstract: The invention discloses a process for the acceleration of gelling time of regenerated silk fibroin using gelling agent, preferably silica to create a porous structure, devoid of microbial growth.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: July 15, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Shailesh Prakash Nagarkar, Ashish Kishore Lele
  • Patent number: 8703117
    Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: April 22, 2014
    Assignee: Lifebond Ltd.
    Inventors: Orahn Preiss Bloom, Ishay Attar, Natalie Iram, Chagai Komlos, Meir Haber
  • Publication number: 20140094590
    Abstract: It is an object of the present invention to provide a protein having high cellular adhesiveness that is useful as a cell adhesion support. The present invention provides a cell-adhesive protein comprising methionine, wherein at least a portion of the methionine residues is oxidized.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 3, 2014
    Applicant: Fujifilm Corporation
    Inventor: Kazutaka OGIWARA
  • Publication number: 20140057053
    Abstract: Polypeptides are provided, where the polypeptides include one or more groups of formula —R1—C(O)R2, where R1 is an amino acid side chain, R2 is a C8-C24 polyunsaturated alkenyl group, and the polypeptide is a gelatin.
    Type: Application
    Filed: August 27, 2012
    Publication date: February 27, 2014
    Inventors: William B. Carlson, Vincenzo Casasanta, III, Gregory David Phelan
  • Patent number: 8632785
    Abstract: A botulinum toxin pharmaceutical formulation comprising a botulinum toxin and a low molecular weight recombinant or native gelatin fragment suitable for administration to a human patient, and methods for treating patients with various diseases and afflictions using the formulation.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: January 21, 2014
    Assignee: Allergan, Inc.
    Inventor: Terrence J. Hunt
  • Publication number: 20130274190
    Abstract: The present invention provides a biomaterial comprising a scaffold consisting of collagen, hyaluronic acid, and gelatin, which are cross-linked via ethyl-3-[3-dimethylaminopropyl]carbodiimide (EDC) between any two of collagen, hyaluronic acid, and gelatin. The present invention further provides a method for preparing the biomaterial and a method for enhancing wound healing with the biomaterial.
    Type: Application
    Filed: April 11, 2012
    Publication date: October 17, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Min WANG, Mei-Ling HO, Gwo-Jaw WANG, Je-Ken CHANG, Yi-Ting CHOU, Ching-Ying WU, Su-Shin LEE
  • Publication number: 20130266664
    Abstract: Electrospun scaffolds crosslinked with acrylates and methods of making the same are provided. Because the cross-linking linking is carried out under mild conditions, biologically active agents are incorporated into the scaffolds in a facile manner.
    Type: Application
    Filed: December 20, 2011
    Publication date: October 10, 2013
    Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Hu Yang, Gary L. Bowlin, Alpana Dongargaonkar
  • Publication number: 20130253074
    Abstract: Disclosed herein is a hyaluronic acid epoxide derivative film comprises a polymer containing a hydroxyl (—OH) terminal group. The film is prepared by allowing an epoxy crosslinker to react with a mixture of hyaluronic acid and a polymer containing a hydroxyl (—OH) terminal group and has improved physical strength, in vivo stability, flexibility, adhesiveness to biological tissue, and biocompatibility.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Applicant: GENEWEL CO., LTD
    Inventors: Young Woo Lee, Wan Jin Cho, Ji Yeon Jang
  • Publication number: 20130231023
    Abstract: Binder compositions are described, where the compositions include a protein, a first crosslinking compound that includes a carbohydrate, and a second crosslinking compound that includes two or more primary amine groups. The first and second crosslinking compounds may be individually crosslinkable with each other and with the protein. Also described are fiber products that may include inorganic or organic fibers and a cured thermoset binder prepared from a protein and at least two crosslinking compounds. Additionally, methods of making fiber products are described that include providing inorganic or organic fibers, and applying a liquid binder composition to the fibers to form a fiber-binder amalgam. The liquid binder composition may include a protein and at least two crosslinking compounds that include a carbohydrate and an organic amine with two or more primary amines. The amalgam may be heated to a curing temperature to form the fiber product.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 5, 2013
    Inventors: Mingfu Zhang, Jawed Asrar, Uranchimeg Lester
  • Publication number: 20130211048
    Abstract: The present invention addresses the problem of providing: a tissue adhesive film having high adhesive strength and high biocompatibility; and a method for producing the tissue adhesive film. This problem can be solved by using a tissue adhesive film comprising an integration of gelatin and cross-linking reagents, wherein the gelatin is provided with an amino group on the side chain thereof and has a molecular weight of 50,000 or higher and 100,000 or lower, and the cross-linking reagents have two or more active ester groups or an anhydride.
    Type: Application
    Filed: October 5, 2011
    Publication date: August 15, 2013
    Applicant: National Institute for Materials Science
    Inventor: Tetsushi Taguchi
  • Patent number: 8507659
    Abstract: It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a chemically modified biopolymer or polypeptide, wherein a biopolymer or polypeptide is chemically modified in a reaction solution containing an organic fluorine compound.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: August 13, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Shouji Ooya, Tetsuo Hiratou, Kentaro Nakamura
  • Patent number: 8501196
    Abstract: This invention relates to the use of a composition comprising a polysaccharide and a botulinum toxin for reducing a skin wrinkle. In some embodiments, the polysaccharide comprises disaccharides. In some embodiments, the average molecular weight of a disaccharide unit of the polysaccharide is between about 345 D and about 1,000 D.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: August 6, 2013
    Assignee: Allergan, Inc.
    Inventor: Terrence J. Hunt
  • Publication number: 20130178426
    Abstract: The invention has as its object the provision of a medicine capable of reducing a volume of emphysema-suffering pulmonary alveoli or alveolar sacs by means of a respiratory region volume inhibitor containing a coating film formation as a main component and capable of forming a coating film in a respiratory region, characterized by being used in such a way that the coating film-forming component is administered to an emphysema-suffering pulmonary alveolar parenchyma in a human-respiratory region in an amount of 0.004 to 200 g/application, preferably 0.07 to 20 g/application and more preferably 0.5 to 5 g/application on each occasion.
    Type: Application
    Filed: August 10, 2011
    Publication date: July 11, 2013
    Applicant: Terumo Kabushiki Kaisha
    Inventors: Takao Anzai, Atsuhiko Nogawa, Yuichi Tada
  • Publication number: 20130172985
    Abstract: Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 4, 2013
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Glenn D. Prestwich, Aleksander Skardal, Jianxing Zhang
  • Patent number: 8475812
    Abstract: The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: July 2, 2013
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Israel Nur, Eyal Sheetrit, Liliana Bar, Guy Tomer
  • Patent number: 8470597
    Abstract: A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: June 25, 2013
    Assignee: Taipei Veterans General Hospital
    Inventors: Shih-Hwa Chiou, Cherng-Kang Perng, Han-Tzo Lin, Yi-Ping Yang
  • Publication number: 20130157992
    Abstract: The present invention relates to improved methods of making compositions and compositions made by these methods having improved stability and/or extended release of an active agent or drug upon administration. These compositions may generally comprise an active agent or drug non-covalently immobilized or bound to an excipient substrate. The active agent or drug may include a wide variety of drugs. Binding of the active agent or drug to the substrate may be achieved by evaporating a solvent containing the active agent dissolved therein or by triggering co-precipitation by addition of a precipitating solvent. Additional steps of vacuum removal of surrounding atmosphere and replacement with inert gas may provide additional stability. Present methods and compositions also facilitate manufacturing of drug products and may make these processes safer in some cases.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 20, 2013
    Inventor: Keith R. Latham
  • Publication number: 20130157261
    Abstract: Disclosed are compositions and methods for quantitation and calibration of images in fluorescence microscopy. Also provided are tissue phantoms that contain known amount(s) of fluorophore standard(s), as well as components and diagnostic kits containing the same for use in various histological analyses. In certain embodiments, three distinct nucleic-acid based assays provide improvements over conventional TUNEL methods to facilitate precise quantitation of a variety of nucleic acids obtained from a biological sample.
    Type: Application
    Filed: June 1, 2012
    Publication date: June 20, 2013
    Applicant: The Methodist Hospital Research Institute
    Inventors: Martyn Alun Sharpe, David S. Baskin
  • Publication number: 20130129710
    Abstract: The invention discloses a method for producing a hemostatic composition comprising mixing a biocompatible polymer suitable for use in hemostasis and a genipin-type crosslinker, crosslinking said polymer by said genipin-type crosslinker to obtain a crosslinked biocompatible polymer, and finishing said crosslinks polymer to a pharmaceutically acceptable hemostatic composition, new hemostatic compositions and methods for using such compositions.
    Type: Application
    Filed: October 25, 2012
    Publication date: May 23, 2013
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Baxter International Inc., Baxter Healthcare S.A.
  • Publication number: 20130115252
    Abstract: A method of preparing genipin-rich materials from the fruit of Genipa americana fruit for their use as a cross-linking agent and as a raw material to produce colors is disclosed. The genipin-rich materials can be used in a broad range of applications including personal care, cosmetics, dietary supplements, packaging, textiles, beverages, foodstuffs, drugs, and animal feeds.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 9, 2013
    Applicant: Wild Flavors, Inc.
    Inventor: Wild Flavors, Inc.
  • Patent number: 8435953
    Abstract: An object of the present invention is to provide a sustained release composition containing SDF-1. The present invention provides a sustained release composition containing (1) SDF-1 and (2) a hydrogel containing modified gelatin having a carboxyl group and/or a sulfo group. Since the composition can release SDF-1, a chemokine which is a capable of promoting accumulation of vascular progenitor cells in vivo, in the sustained manner, it can be useful for treatment and/or suppression of symptom progression of ischemic disease or bone disease, as pharmaceutical preparations in various formulations.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: May 7, 2013
    Assignees: Ono Pharmaceutical Co., Ltd.
    Inventor: Yasuhiko Tabata
  • Publication number: 20130066049
    Abstract: A cross linked recombinant gelatin composition for the induction of blood coagulation and hemostasis.
    Type: Application
    Filed: April 7, 2011
    Publication date: March 14, 2013
    Applicant: FUJIFILM MANUFACTURING EUROPE B.V.
    Inventor: Elisabeth Marianna Wilhelmina Maria Van Dongen
  • Patent number: 8367388
    Abstract: Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and preferably prepared in a non-phosphate buffer solvent. Optionally and preferably, the cross-linkable protein includes gelatin and any gelatin variant or variant protein as described herein. Optionally and preferably, the non-toxic material comprises transglutaminase (TG), which may optionally comprise any type of calcium dependent or independent transglutaminase, which may for example optionally be a microbial transglutaminase (mTG).
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: February 5, 2013
    Assignee: Lifebond Ltd.
    Inventors: Orahn Preiss Bloom, Ishay Attar, Natalie Iram, Chagai Komlos, Meir Haber
  • Patent number: 8318903
    Abstract: A benign solvent for dissolving proteins comprises alcohol, salt and water. The ratio by volume of water to alcohol is between about ninety-nine-to-one and about one-to-ninety-nine. A salt concentration is between near zero moles per liter and the maximum salt concentration soluble in water. The amount of protein by weight as compared to the mixture of water and alcohol is between near zero percent and about 25 percent. A method for forming a protein structure from a benign solvent comprises forming a benign solvent from water, alcohol, and salt; and dissolving a protein in the benign solvent to form a protein solution. The method further comprises extracting the protein from the protein solution; and arranging the protein into a protein structure.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: November 27, 2012
    Assignee: Case Western Reserve University
    Inventors: Bin Dong, Olivier Arnoult, Gary Wnek, Lingui Meng
  • Publication number: 20120295287
    Abstract: This document provides methods and materials related to detecting neurotransmitters and other biologically active small molecules. For example, methods for detecting and measuring hapten levels in a biological sample using antibodies specific for conjugated haptens are provided.
    Type: Application
    Filed: November 8, 2010
    Publication date: November 22, 2012
    Applicant: Pharmasan Labs, Inc.
    Inventors: Gottfried H. Kellermann, Han J.G. Huisman
  • Publication number: 20120282211
    Abstract: We provide methods and compositions for the treatment of dysregulation of blood vessel growth by regulation of neovascularization. Embodiments accomplish this by restricting the diffusion and transport of therapeutic agents through conjugating them to polymers or polymer constructs while retaining the binding affinities and functions of the therapeutic agents.
    Type: Application
    Filed: November 24, 2010
    Publication date: November 8, 2012
    Applicant: CARNEGIE MELLON UNIVERSITY
    Inventors: Newell R. Washburn, Liang Tso Sun
  • Publication number: 20120270810
    Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.
    Type: Application
    Filed: December 22, 2010
    Publication date: October 25, 2012
    Inventors: Orahn Preiss-Bloom, Guy Tomer
  • Patent number: 8293873
    Abstract: The invention relates to a combination of a solution of a gelatin derivative and at least one amino acid, if desired in the form of a pharmaceutically acceptable salt or carboxylic acid derivative, for inhibiting renal uptake of substances, that are potentially damaging for the kidneys, in a living being.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: October 23, 2012
    Assignee: BioSynthema Inc.
    Inventors: Marion De Jong, Eric P. Krenning, Edgar Rolleman
  • Patent number: 8268968
    Abstract: It is an object of the present invention to provide a method wherein a structure which was prepared with a biopolymer such as gelatin is chemically modified with the use of a low-volatile chemical substance without dissolution of gelatin, and a biopolymer crosslinking method for producing a biopolymer having high strength (a high degree of crosslinking). The present invention provides a method for producing a modified biopolymer, which comprises reacting a structure prepared with a biopolymer with a solid-state compound having a melting point of 50° C. or more at a humidity of 50% or more, and a method for crosslinking biopolymer which comprises treating a biopolymer with a crosslinking agent, wherein the crosslinking agent concentration in a reaction mixture is 1.0% to 10% by weight and crosslinking is carried out in the presence of an organic fluorine compound.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: September 18, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Shouji Ooya, Tetsuo Hiratou
  • Publication number: 20120225101
    Abstract: Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 6, 2012
    Inventors: Weiyuan J. KAO, Yao Fu
  • Patent number: 8252747
    Abstract: A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: August 28, 2012
    Inventors: Johan Lowinger, Bruno Lowinger, Frank DeLustro, David Cox, David A. Browdie
  • Publication number: 20120195828
    Abstract: An object of the present invention is to provide a kidney-imaging agent which is composed of bioabsorbable materials, transiently accumulates in a kidney for a short period of time, and does not remain in the kidney for a prolonged time after accumulation. The present invention provides a kidney-imaging agent which comprises a gelatin-like protein.
    Type: Application
    Filed: July 30, 2010
    Publication date: August 2, 2012
    Applicant: FUJIFILM CORPORATION
    Inventors: Kentaro Nakamura, Yasuhiko Tabata
  • Patent number: 8221783
    Abstract: Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: July 17, 2012
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Michael N. Helmus, Yixin Xu, Barron W. Tenney, Paul L. Valint, Shrirang V. Ranade
  • Publication number: 20120178907
    Abstract: Process for producing instantaneous cold soluble gelatin in form of agglomerates of gelatin granules carried out in a fluid bed under controlled temperature, which comprises soaking the gelatin granules through atomising a granulating liquid in the fluid bed, where the granulating liquid is made up of water.
    Type: Application
    Filed: August 13, 2009
    Publication date: July 12, 2012
    Inventors: Enrico Maini, Michele Maini
  • Publication number: 20120141590
    Abstract: Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
    Type: Application
    Filed: September 30, 2011
    Publication date: June 7, 2012
    Inventors: Michael Malakhov, Fang Fang
  • Publication number: 20120142598
    Abstract: The present invention provides compositions comprising hydrolyzed gelatin or a mixture of hydrolyzed gelatin and gelatin, and the same compositions for use in methods comprising administering a low dose of the compositions useful in prophylaxis and treatment of hair loss in humans and shedding in animals. The compositions provide a palatable, malleable and well-tolerated product.
    Type: Application
    Filed: December 3, 2007
    Publication date: June 7, 2012
    Inventor: Zeev Pam
  • Publication number: 20120135448
    Abstract: The present invention provides methods and devices for the fabrication of 3D polymeric fibers having micron, sub-micron, and nanometer dimensions, as well as methods of use of these polymeric fibers.
    Type: Application
    Filed: May 13, 2010
    Publication date: May 31, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Mohammad Reza Badrossamay, Josue Adrian Goss