Glycoprotein, E.g., Mucins, Proteoglycans, Etc. Patents (Class 530/395)
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Patent number: 11744876Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.Type: GrantFiled: June 10, 2020Date of Patent: September 5, 2023Assignee: SUTRO BIOPHARMA, INC.Inventors: Alice Yam, Andreas Maderna, Cristina Abrahams, Willy Solis, Xiaofan Li, Ryan Stafford, Gang Yin, Venita De Almeida, Krishna Bajjuri, Adam A. Galan
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Patent number: 11655451Abstract: The present disclosure relates to methods for culturing human epidermal keratinocytes. When keratinocytes are cultured on plates coated with a laminin containing an alpha-4 chain or an alpha-5 chain, in a xeno-free, chemically defined cell culture medium, they expand efficiently in vitro. Useful cell culture kits for culturing keratinocytes are also described herein, as are methods of using such cells for treatment of burns or chronic wounds.Type: GrantFiled: May 4, 2018Date of Patent: May 23, 2023Assignees: NATIONAL UNIVERSITY OF SINGAPORE, SINGAPORE HEALTH SERVICES PTE LTDInventors: Karl Tryggvason, Monica Suryana Tjin, Alvin Wen Choong Chua
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Patent number: 11649446Abstract: Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided.Type: GrantFiled: October 23, 2019Date of Patent: May 16, 2023Assignee: YALE UNIVERSITYInventors: Farren Isaacs, Miriam Amiram, Adrian Haimovich, Dieter Soil
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Patent number: 11639929Abstract: This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.Type: GrantFiled: February 6, 2020Date of Patent: May 2, 2023Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: David Margulies, Leila Motiei, Naama Lahav
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Patent number: 11285200Abstract: Provided herein are host cells capable of producing hybrid oligosaccharides and polysaccharides, wherein said hybrid oligosaccharides and polysaccharides do not comprise a hexose at the reducing end of their first repeat unit. Also provided herein are hybrid oligosaccharides or polysaccharides and bioconjugates which can be produced by the host cells described herein, wherein said bioconjugates comprise a carrier protein linked to a hybrid oligosaccharide or polysaccharide that does not comprise a hexose at the reducing end of its first repeat unit.Type: GrantFiled: April 16, 2019Date of Patent: March 29, 2022Inventor: Amirreza Faridmoayer
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Patent number: 11208462Abstract: Provided are agents that specifically bind a ligand of ciliary neurotrophic factor receptor (CNTFR). In certain aspects, an agent of the present disclosure is a soluble CNTFR polypeptide. The soluble CNTFR polypeptide may have an altered (e.g., reduced) binding affinity for one or more ligand-CNTFR complex subunits, an altered (e.g., increased) binding affinity for one or more CNTFR ligands, or any combination thereof. Compositions that include the agents of the present disclosure are also provided, as are methods of using the agents (e.g., for treating a cell proliferative disorder) and methods of identifying an individual as having a cell proliferative disorder associated with CNTFR signaling.Type: GrantFiled: December 6, 2017Date of Patent: December 28, 2021Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jun Woo Kim, Jennifer R. Cochran, Eric Alejandro Sweet
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Patent number: 11208655Abstract: Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3? and/or 5?-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.Type: GrantFiled: May 20, 2019Date of Patent: December 28, 2021Assignee: Sarepta Therapeutics, Inc.Inventors: Gunnar J. Hanson, Dwight D. Weller, Bao Zhong Cai, Ming Zhou
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Patent number: 11154577Abstract: This document provides methods and materials for treating a mammal (e.g., a human) having one or more tumors. For example, embolic agents including an amnion tissue preparation (e.g., amnion coated embolic agents) that can be used in arterial embolization to reduce or eliminate blood flow in a blood vessel that supplies a tumor are provided.Type: GrantFiled: April 8, 2019Date of Patent: October 26, 2021Inventor: Gary M. Petrucci
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Patent number: 10662235Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.Type: GrantFiled: June 21, 2017Date of Patent: May 26, 2020Assignee: Janssen Biotech, Inc.Inventors: Mark Anderson, Ricardo Attar, Michael Diem, Linus Hyun, Alastair King, Steven Jacobs, Shalom Goldberg, Donna Klein, Sheri Moores, Karyn O'Neil, Kristen Picha
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Patent number: 10603356Abstract: A method is provided for treating bowel disease related to the activity of TNF-?, through the administration of a ?-defensin, analog, or derivative. Such a ?-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The ?-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.Type: GrantFiled: April 21, 2016Date of Patent: March 31, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Michael E. Selsted, Dat Q. Tran
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Patent number: 10557852Abstract: This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.Type: GrantFiled: April 28, 2015Date of Patent: February 11, 2020Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: David Margulies, Leila Motiei, Naama Mankovski, Yael Nissinkorn
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Patent number: 10449249Abstract: Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.Type: GrantFiled: August 3, 2018Date of Patent: October 22, 2019Assignee: NUTRILEADS B.V.Inventors: Ruud Albers, Jari Helin, Werner Klaffke, Jean Hypolites Koek, Petronella Anna Kreijveld, Jari Natunen, Erwin Werner Tareilus, Richardus Paulus Anton Oranje
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Patent number: 10098948Abstract: Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.Type: GrantFiled: February 8, 2016Date of Patent: October 16, 2018Assignee: NUTRILEADS B.V.Inventors: Ruud Albers, Jari Helin, Werner Klaffke, Jean Hypolites Koek, Petronella Anna Kreijveld, Jari Natunen, Erwin Werner Tareilus, Richardus Paulus Anton Oranje
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Patent number: 9952203Abstract: The present invention relates to a new binder molecule useful e.g. as an immune suppressor. In particular, it has been recognized that the UL11 protein of human the cytomegalovirus, binds to the CD45 molecule, potentially altering the immune system of an individual. In addition, the present invention relates to binder molecules, in particular, fusion molecules containing the CD45 binding domain of the UL11 protein in combination with a second molecule of interest for delivery of said molecule to cells expressing the CD45 molecule. Moreover, the present invention relates to pharmaceutical compositions comprising the UL11 protein of human cytomegalovirus, or derivatives or homologs thereof, or a nucleic acid sequence encoding the same.Type: GrantFiled: March 21, 2012Date of Patent: April 24, 2018Assignee: Medizinische Hochschule HannoverInventors: Penelope Kay-Fedorov, Martin Messerle, Thomas F. Schulz, Lars Steinbrück, Ildar Gabaev
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Patent number: 9931392Abstract: The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated.Type: GrantFiled: January 17, 2014Date of Patent: April 3, 2018Assignee: London School of Hygiene and Tropical MedicineInventors: Brendan Wren, Jon Cuccui, Sherif Abouelhadid
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Patent number: 9808417Abstract: Disclosed is a method of treating skin in need thereof, the method comprising topically applying to the skin a composition comprising an effective amount of an ethanolic or a butanolic extract from the leaf and stem of Docynia delavajy, wherein the composition reduces oxidation in the skin, reduces tumor necrosis factor-alpha (TNF-?) in the skin, or reduces metalloprotease-1 (MMP-1) activity in the skin.Type: GrantFiled: October 19, 2016Date of Patent: November 7, 2017Assignee: Mary Kay Inc.Inventors: Tiffany Florence, Michelle Hines
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Patent number: 9624470Abstract: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to produce differentiated cells of the lymphoid lineages.Type: GrantFiled: July 29, 2011Date of Patent: April 18, 2017Assignee: Wisconsin Alumni Research FoundationInventors: Igor I. Slukvin, Maksym A. Vodyanyk, James A. Thomson
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Patent number: 9498427Abstract: Disclosed are compositions that include Docynia delavajy extract, Elaeagnus lanceolatus extract, or a combination of such extracts.Type: GrantFiled: April 22, 2015Date of Patent: November 22, 2016Assignee: MARY KAY INC.Inventors: Tiffany Florence, Michelle Hines
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Patent number: 9499602Abstract: The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.Type: GrantFiled: February 12, 2014Date of Patent: November 22, 2016Assignees: ADVAXIS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Yvonne Paterson, Paulo MaCiag
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Patent number: 9416173Abstract: Several new peptides have been developed that show effectiveness as vaccines against candidiasis and other fungal diseases. A new conjugate vaccine of a ?-mannotriose linked to a fungal peptide linked to tetanus toxin has been shown to be effective as a vaccine with or without use of an adjuvant. In addition, a monoclonal antibody has been identified that offers protection from a Candida infection.Type: GrantFiled: April 20, 2012Date of Patent: August 16, 2016Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Hong Xin, Jim E. Cutler
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Patent number: 9383352Abstract: Disclosed herein are methods and tests for diagnosing and/or monitoring a metabolic condition such as diabetes in a subject, wherein the methods and tests measure salivary glycoproteins. Some of the methods are based on the oxidation of glycoproteins in a sample from the subject, such as saliva or urine, for example using sodium metaperiodate, and then detecting the aldehydes generated during oxidation using a chemical detection method. Also disclosed are kits and lateral flow devices for detecting glycoproteins in a saliva sample.Type: GrantFiled: March 26, 2014Date of Patent: July 5, 2016Assignee: Diabetomics, Inc.Inventors: Srinivasa R. Nagalla, Eric S. Bean
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Patent number: 9260507Abstract: A peptide is provided with a defined sequence present in the alpha3 chain of the LG4 globule of laminin 332 (laminin 5), and peptides with sequences homologous to the peptide with the defined sequence capable of binding to the syndecan-1 receptor. Pharmaceutical or cosmetic compositions containing the peptide are provided. The peptide is used in the area of tissue healing and regeneration or as an adjuvant in culture media intended for epidermal or epithelial reconstruction. The synthetic peptide comprises the sequence KKLRIKSKEK (SEQ ID NO: 1) or a sequence of identical size, in which the K residue (in position 1) and the R residue (in position 4) are conserved, the sequence being able to bind to the syndecan-1 receptor.Type: GrantFiled: March 15, 2010Date of Patent: February 16, 2016Assignees: Symatese, Centre National De La Recherche Scientifique, Universite Claude Bernard Lyon IInventor: Patricia Rousselle
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Patent number: 9260535Abstract: Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.Type: GrantFiled: November 16, 2010Date of Patent: February 16, 2016Assignee: NutriLeads B.V.Inventors: Ruud Albers, Jari Helin, Werner Klaffke, Jean Hypolites Koek, Petronella Anna Kreijveld, Jari Natunen, Erwin Werner Tareilus, Richardus Paulus Anton Oranje
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Patent number: 9234895Abstract: The present invention relates generally to methods for identifying organ-specific secreted proteins and for identifying organ-specific molecular blood fingerprints therefrom. As such, the present invention provides compositions comprising such proteins, detection reagents for detecting such proteins, and panels, and arrays for determining organ-specific molecular blood fingerprints.Type: GrantFiled: August 8, 2012Date of Patent: January 12, 2016Assignee: Institute for Systems BiologyInventors: Leroy Hood, Biaoyang Lin
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Patent number: 9216220Abstract: Provided herein are systems, methods, and compositions for polymer nanoparticles and polymer magnetic nanoparticles. More particularly, the polymer nanoparticles and polymer magnetic nanoparticles are temperature sensitive and responsive to a first temperature.Type: GrantFiled: March 25, 2009Date of Patent: December 22, 2015Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Kytai T. Nguyen, Maham Rahimi, Soujanya Kona, Arthur H. Lin
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Patent number: 9192593Abstract: An amino-acid containing composition for inhibiting accumulation of fat, containing leucine in an amount of 33 to 67% by weight and threonine in an amount of 33 to 67% by weight, in terms of free amino acids thereof, based on whole amino acids.Type: GrantFiled: August 30, 2007Date of Patent: November 24, 2015Assignee: Ajinomoto Co., Inc.Inventors: Yuri Hirabayashi, Hitoshi Murakami, Hisamine Kobayashi
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Patent number: 9095600Abstract: The present invention relates to a novel preventive and/or therapeutic drug for myocardial infarction. The present invention provides a preventive and/or therapeutic drug for myocardial infarction or myocardial ischemia-reperfusion injury, the drug containing a lipid membrane structure retaining adenosine.Type: GrantFiled: September 18, 2009Date of Patent: August 4, 2015Assignees: OSAKA UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, DAIICHI SANKYO COMPANY, LIMITEDInventors: Tetsuo Minamino, Masafumi Kitakaze, Masatsugu Hori, Hiroyuki Takahama, Hiroshi Kikuchi, Kouichi Hashimoto, Hideo Kobayashi, Ayako Iijima, Daigo Asano
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Patent number: 9068001Abstract: Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.Type: GrantFiled: August 5, 2011Date of Patent: June 30, 2015Assignees: Selexys Pharmaceuticals, Oklahoma Medical Research FoundationInventors: Scott Rollins, Richard Alvarez, Russell Rother, Rodger P. McEver, Ziad S. Kawar
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Patent number: 9040020Abstract: The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.Type: GrantFiled: April 9, 2013Date of Patent: May 26, 2015Assignee: Technische Universitaet MuenchenInventors: Arne Skerra, Andreas Eichinger, Hyun-Jin Kim
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Patent number: 9040478Abstract: The present invention relates to a compound which is a polysaccharide derivative of GCSF, or of a GCSF like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.Type: GrantFiled: October 5, 2012Date of Patent: May 26, 2015Assignee: Lipoxen Technologies LimitedInventors: Sanjay Jain, Peter Laing, Gregory Gregoriadis
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Publication number: 20150140005Abstract: There is provided a method of treating an inflammatory response to infection and complications associated therewith, by administering a proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor to a subject, in need thereof. There is also provided a method of treating or preventing treating or preventing renal failure; renal dysfunction; respiratory failure; respiratory dysfunction; or acute lung injury. Provided herein are uses, pharmaceutical compositions, and commercial packages associated therewith.Type: ApplicationFiled: May 17, 2013Publication date: May 21, 2015Inventors: Keith R. Walley, John H. Boyd, James A. Russell
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Publication number: 20150141626Abstract: Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy.Type: ApplicationFiled: January 2, 2015Publication date: May 21, 2015Inventors: Stephen D. Gillies, Jeffrey Way, Anita A. Hamilton
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Publication number: 20150139904Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.Type: ApplicationFiled: May 21, 2013Publication date: May 21, 2015Applicant: University of MiamiInventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Liu Zhao-Jun, Sapna Deo
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Publication number: 20150133363Abstract: The present application relates to polypeptides derived from the soluble part of the glycoprotein of the enveloped virus of Primate T-cell leukemia virus (PTLV), or fragments or variants thereof named receptor binding domain ligands (RBD) selected for their ability to bind specifically to the nutrient transporter GLUT1.Type: ApplicationFiled: December 18, 2014Publication date: May 14, 2015Inventors: Jean-Luc BATTINI, Nicolas MANEL, Felix KIM, Sandrina KINET, Naomi TAYLOR, Marc SITBON
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Publication number: 20150133528Abstract: Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of hemoglobin genes (HBB, HBD, HBE1, HBG1 or HBG2). Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of hemoglobin genes. Methods for modulating expression of hemoglobin genes using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of hemoglobin genes.Type: ApplicationFiled: May 16, 2013Publication date: May 14, 2015Applicants: RaNA Therapeutics, Inc., The General Hospital Corporation d/b/a Massachusetts General HospitalInventors: Arthur M. Krieg, Romesh Subramanian, James McSwiggen, Jeannie T. Lee
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Patent number: 9029506Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.Type: GrantFiled: August 25, 2011Date of Patent: May 12, 2015Assignees: aTyr Pharma, Inc., Pangn Biopharma LimitedInventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain Philippe Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
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Patent number: 9024110Abstract: This invention discloses the development of a novel platform for recombinant production of bioactive glycoproteins and cancer specific vaccines in plants. Plants and plant cell cultures have been humanized with respect to human mucin-type protein O-glycosylation. A panel of plant cell factories for production of recombinant glycoproteins with designed human O-glycosylation, including an improved cancer vaccine candidate, has been developed. The platform provides basis for i) production of an essentially unlimited array of O-glycosylated human glycoprotein therapeutics, such as human interferon ?2B and podoplanin, and ii) for further engineering of additional cancer specific O-glycans on glycoproteins of therapeutical value. Currently, mammalian cells are required for human O-glycosylation, but plants offer a unique cell platform for engineering O-glycosylation since they do not perform human type O-glycosylation.Type: GrantFiled: March 23, 2011Date of Patent: May 5, 2015Inventors: Zhang Yang, Damian Paul Drew, Emma Adhiambo Arigi, Peter Ulvskov, Steven B. Levery, Eric Bennett, Henrik Clausen, Brent Larsen Petersen
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Publication number: 20150118155Abstract: The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.Type: ApplicationFiled: June 14, 2012Publication date: April 30, 2015Applicant: Hill's Pet Nutrition, Inc.Inventors: Samer Al-Murrani, Xiangming Gao
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Publication number: 20150119558Abstract: The present invention provides modified cells for producing proteins with modified glycosylation patterns. Proteins produced in such cells, and the use of such proteins in medicine, and particularly in the treatment of cancer, is also provided.Type: ApplicationFiled: January 18, 2013Publication date: April 30, 2015Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventor: Zhiwei Song
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Publication number: 20150112022Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.Type: ApplicationFiled: December 16, 2014Publication date: April 23, 2015Inventors: Ashutosh Chilkoti, Felipe Garcia Quiroz, Miriam Amiram
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Publication number: 20150110829Abstract: Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.Type: ApplicationFiled: May 23, 2013Publication date: April 23, 2015Inventors: Che-Hung Robert Lee, Valerian B. Pinto
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Publication number: 20150112047Abstract: Disclosed is a bifunctional adapter molecule comprising two binding moieties A and B, the adapter molecule being capable of reversibly equipping a fusion protein carrying an oligohistidine affinity tag with a further affinity tag, wherein the binding moiety A comprises at least two chelating groups K, wherein each chelating group is capable of binding to a transition metal ion, thereby rendering moiety A capable of binding to an oligohistidine affinity tag, and the binding moiety B is an affinity tag other than an oligohistidine tag.Type: ApplicationFiled: October 27, 2014Publication date: April 23, 2015Inventor: Thomas SCHMIDT
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Publication number: 20150110826Abstract: The present invention relates to recombinant microalgal cells and their use in heterologous protein production, methods of production of heterologous polypeptides in microalgal extracellular bodies, microalgal extracellular bodies comprising heterologous polypeptides, and compositions comprising the same.Type: ApplicationFiled: October 17, 2014Publication date: April 23, 2015Applicant: SANOFI VACCINE TECHNOLOGIES, S.A.S.Inventors: Anne-Cecile V. BAYNE, James Casey LIPPMEIER, Kirk Emil APT, Ross Eric ZIRKLE
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Publication number: 20150104479Abstract: The invention provides a conjugate of a Neisseria meningitidis serogroup X capsular polysaccharide and a carrier molecule. The conjugate is typically made by (a) oxidising a primary hydroxyl group in the capsular polysaccharide, to give an oxidised polysaccharide with an aldehyde group; and (b) coupling the oxidised polysaccharide to a carrier molecule via the aldehyde group, thereby giving the conjugate. The conjugate may be part of an immunogenic composition. This composition may comprise one or more further antigens, particularly capsular polysaccharides from serogroups A, W135, C and Y and conjugated forms thereof. The composition may be in an aqueous formulation. The composition is useful as a vaccine, e.g. for raising an immune response in a mammal. The invention also provides processes for making the conjugate.Type: ApplicationFiled: May 22, 2013Publication date: April 16, 2015Applicant: NOVARTIS AGInventors: Maria Rosaria Romano, Francesca Micoli, Francesco Berti, Roberto Adamo, Paolo Costantino
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Publication number: 20150104816Abstract: A marker for detecting pancreatic cancer, said marker comprising a glycoprotein C4BPA or PIGR, whereby a pancreatic cancer patient can be distinguished from a chronic pancreatitis patient or a normal subject and thus specifically diagnosed. Also, the marker is usable in monitoring the postoperative prognosis of a pancreatic cancer patient. When the aforesaid marker is used in combination with another pancreatic cancer marker such as CA19-9, furthermore, a pancreatic cancer patient can be distinguished from a chronic pancreatitis patient or a normal subject and diagnosed more specifically.Type: ApplicationFiled: April 1, 2013Publication date: April 16, 2015Applicant: NITTO BOSEKI CO., LTD.Inventors: Kenta Noda, Toshihide Miura, Humio Nomura, Kazuyuki Sogawa, Mamoru Sato, Hideyuki Yoshitomi, Masaru Miyazaki
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Publication number: 20150105325Abstract: Disclosed are pharmaceutical and synergistic compositions comprising human recombination alpha-fetoprotein expressed in eukaryotic cells for preparation of therapeutic agents for use in oncology, immunotherapy, stem cell therapy and cosmetology and also for the diagnosis of cancer and embryonic pathologies.Type: ApplicationFiled: December 5, 2014Publication date: April 16, 2015Inventors: Igor Dudich, Lydia Semenkova, Igor Dudich, Eduard Tatulov
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Publication number: 20150098955Abstract: The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.Type: ApplicationFiled: October 10, 2012Publication date: April 9, 2015Inventors: Anthony Coyle, Manuel Baca, Thomas Thisted, Stacey Drabic, Luba Grinberg, Shabazz Novarra, Vaheh Oganesyan, Ronald Herbst, David Kenneth Spencer
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Publication number: 20150093331Abstract: The present invention relates to biomarkers, methods and assay kits for the identification, monitoring and treatment of breast cancer.Type: ApplicationFiled: September 3, 2014Publication date: April 2, 2015Applicant: OncoLock Co., Ltd.Inventor: Yeou-Guang Tsay
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Publication number: 20150093401Abstract: The present invention provides a polypeptide having the formula: St-R1-S1-Q-S2-R2 wherein St is a stalk sequence which, when the polypeptide is expressed at the surface of a target cell, causes the R and Q epitopes to be projected from the cell surface; R1 and R2 are a Rituximab-binding epitopes each having the an amino acid sequence selected from the group consisting of SEQ ID No. 1, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 and 16 or a variant thereof which retains Rituximab-binding activity; S1 and S2 are optional spacer sequences, which may be the same or different; and Q is a QBEnd1O-binding epitope having the amino acid sequence shown as SEQ ID No. 2 or a variant thereof which QBEnd1O-binding activity. The invention also provides a nucleic acid sequence encoding such a polypeptide and uses thereof in adoptive cell transfer.Type: ApplicationFiled: April 11, 2013Publication date: April 2, 2015Applicant: UCL BUSINESS PLCInventors: Martin Pulé, Brain Phillip
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Publication number: 20150086580Abstract: Compositions and methods are provided relating to HCV E2 protein and modifications thereto which enhance the immunogenicity of the protein for vaccine development with respect to the generation of a neutralizing immune response.Type: ApplicationFiled: September 22, 2014Publication date: March 26, 2015Inventors: Steven Foung, Zhen-Yong Keck, Thomas R. Fuerst