Diazoamino (e.g., Triazenes, Etc.) Patents (Class 534/550)
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Patent number: 9461326Abstract: In a method for making an anion electrolyte membrane, an inorganic nano-powder is uniformly dispersed in an organic solvent to form a mixture. A fluorinated poly(aryl ether) ionomer is dissolved in the mixture to form a first solution. An active component is further dissolved in the first solution to form a second solution. A crosslinking catalyst is added to the second solution to form a membrane casting solution. The membrane casting solution is coated on a substrate to form a membrane, and the coated substrate is heated. Then, the membrane is peeled from the substrate.Type: GrantFiled: September 11, 2013Date of Patent: October 4, 2016Assignees: Tsinghua University, HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD.Inventors: Yu-Ming Shang, Yao-Wu Wang, Xiao-Feng Xie, Min Xu, Jin-Hai Wang, Shu-Bo Wang
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Patent number: 9379406Abstract: In a method for making anion electrolyte membrane a fluorinated poly(aryl ether) ionomer is dissolved in a solvent to form a ionomer solution. A crosslink component is added to the ionomer solution, to achieve a transparent solution. An inorganic component precursor and water are introduced to the transparent solution, to form a sol-gel mixture. A crosslink catalyst is mixed with the sol-gel mixture to form a membrane casting solution. The membrane casting solution is coated on a substrate to form a membrane, and heated. The membrane is removed from the substrate.Type: GrantFiled: July 24, 2013Date of Patent: June 28, 2016Assignees: Tsinghua University, HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD.Inventors: Yu-Ming Shang, Yao-Wu Wang, Shu-Bo Wang, Yong-Gang Liu, Jin-Hai Wang, Xiao-Feng Xie
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Patent number: 8933208Abstract: The purpose of the present invention is to provide novel liquid crystalline compounds that are capable of inducing phase transition by a light stimulus and are useful in the display, optoelectronics, and photonics field. The present invention relates to the liquid crystalline compounds represented by general formula (1): wherein R1, R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, alkoxyl, alkoxycarbonyl, alkoxycarbonyloxy, alkanoyl, alkanoyloxy, alkoxyphenyl, and N-alkylaminocarbonyl, and n is an integer.Type: GrantFiled: May 10, 2011Date of Patent: January 13, 2015Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Yasuo Norikane, Yuki Hirai, Masaru Yoshida
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DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS
Publication number: 20140309240Abstract: The invention provides novel, water-soluble 2-aminoimidazoline derivatives having general Formula (I) as well as some precursors of Formula (I), which are very potent inducers of G2/M cell cycle arrest. In treated tumor cells, compounds of Formula (I) give gene expression profile distinct from known antimitotic agents. The invention also provides methods for preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirably high levels of cell proliferation. The compounds of the invention are also expected to have utility as research tools.Type: ApplicationFiled: April 9, 2014Publication date: October 16, 2014Inventors: Stanislaw Wieslaw Pikul, Wieslaw Marek Cholody -
Patent number: 8834581Abstract: Described are dyes of formula (I) where R1 is hydrogen, alkyl, alkoxy, trifluoromethyl or halogen, M is hydrogen, an alkali metal cation or an optionally substituted ammonium cation, R2 and R3 are each independently hydrogen, alkyl or alkoxy, R4 is alkyl or alkoxy, R5 and R6 are each independently moieties of the formula —(CmH2m)—O—CnH2n+1, m is an integer from 3 to 6, and n is an integer from 0 to 8. These dyes are useful for dyeing and printing materials having polar groups.Type: GrantFiled: December 17, 2011Date of Patent: September 16, 2014Assignee: DyStar Colours Distribution GmbHInventors: Aloysius Engel, Michael Joerss, Clemens Grund, Bernd Hostasch, Gunter Görlitz
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Publication number: 20140243537Abstract: The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (?)-methyl 3-epi-shikimate.Type: ApplicationFiled: October 25, 2012Publication date: August 28, 2014Applicant: Council of Scientific & Industrial ResearchInventors: Varun Rawat, Soumen Dey, Sudalai Arumugam
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Publication number: 20140005149Abstract: Triazene-substituted diphenyl derivatives are suitable as chemotherapeutic agents for treating carcinomas in humans and animals.Type: ApplicationFiled: July 15, 2011Publication date: January 2, 2014Inventor: Heinz Förster
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Publication number: 20130338044Abstract: A bifunctional linker and method of use is provided that has a spacer molecule with a functional group on one end configured to couple to the surface of a substrate and a function group on the other end that is configured couple to a biomolecule and methods of use. The preferred bifunctional linker has a poly(ethylene glycol) spacer ranging from 3 to 20 ethylene glycol units that has a silane functional group to react with a substrate and an azide functional group that can couple to a biomolecule that includes an alkyne group. The preferred linker can produce an azide-derivatized glass surface in one step and the azide functional group of the spacer can in sequence conjugate with a biomolecule using click chemistry, which can be conducted at low temperature and in aqueous solution.Type: ApplicationFiled: June 10, 2013Publication date: December 19, 2013Inventors: Jiayu Liao, Yongfeng Zheng
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Patent number: 8378041Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization CLICK chemistry and a tetrafunctional initiator having terminal halogen groups to form the desired product.Type: GrantFiled: January 30, 2009Date of Patent: February 19, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
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Publication number: 20120052042Abstract: The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.Type: ApplicationFiled: February 22, 2010Publication date: March 1, 2012Inventors: Sébastien Ladet, Philippe Gravagna
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Publication number: 20120028927Abstract: The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.Type: ApplicationFiled: August 9, 2011Publication date: February 2, 2012Applicant: TRIN THERAPEUTICS GMBHInventors: Rudolf Reiter, Jochen Kalbe, Heinz Forster
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Publication number: 20100234327Abstract: The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.Type: ApplicationFiled: July 3, 2008Publication date: September 16, 2010Applicant: TRIN PHARMA GMBHInventors: Rudolf Reiter, Jochen Kalbe, Heinz Forster
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Publication number: 20100210828Abstract: Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. Glycolipids having the formula (I): where R3 indicates a substituted or unsubstituted C1 to C7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R8 indicates a substituted or unsubstituted C1 to C35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.Type: ApplicationFiled: April 15, 2010Publication date: August 19, 2010Applicant: JAPAN AS REPRESENTED BY THE PRESIDENT OF NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRYInventors: Hirokazu ANNOURA, Kenji MURATA, Takashi YAMAMURA
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Publication number: 20100143735Abstract: Provided is a method for modifying a surface of a cyclic olefin copolymer, comprising: coating a compound of the following Chemical Formula 1 on the surface of a cyclic olefin copolymer substrate, irradiating UV light on the cyclic olefin copolymer substrate, and polymerizing a monomer on the cyclic olefin where X is H or F, and n is an integer of 1 to 6.Type: ApplicationFiled: September 9, 2009Publication date: June 10, 2010Applicants: Electronics and Telecommunications Research Institute, Korea Advanced Institute of Science and TechnologyInventors: Dong-Ho Shin, Insung S. Choi, Sung Min Kang, Seung Pyo Jeong, Jinkyu Kim, Bokyung Kong
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Publication number: 20100113551Abstract: The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.Type: ApplicationFiled: March 14, 2008Publication date: May 6, 2010Applicants: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Steven John Woodhead, David Charles Rees, Martyn Frederickson, Kyla Merriom Grimshaw
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Publication number: 20100009380Abstract: The present invention relates to compositions and methods for characterization of cysteine oxidative states. In particular, the present invention provides cysteine-oxidative-state-specific labeling agents and uses thereof.Type: ApplicationFiled: July 2, 2009Publication date: January 14, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventor: Kate S. Carroll
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Publication number: 20090259016Abstract: The present invention relates to methods for preparing degradable model networks from any monomer functionality with any degradation methodology. It is based on the use of Atom-Transfer Radical Polymerization and CLICK chemistry to form the desired product.Type: ApplicationFiled: January 30, 2009Publication date: October 15, 2009Inventors: Jeremiah Johnson, Jeffrey T. Koberstein, Nicholas J. Turro
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Publication number: 20090155241Abstract: A compound or its salt that inhibits the activity of a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1; a compound or its salt that inhibits the expression of a gene for the protein; an antisense polynucleotide comprising a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding the protein or a partial peptide thereof or a part of the nucleotide sequence; an antibody against the protein; etc. are useful as preventive/therapeutic agents for cancer, apoptosis promoters for cancer cells, or the like.Type: ApplicationFiled: July 22, 2005Publication date: June 18, 2009Inventors: Tetsuo Mashima, Takashi Tsuruo
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Patent number: 7517369Abstract: The present invention relates to dyes of formula (1) that are soluble in organic solvents, wherein Cat+ is an organic cation, to a process for their preparation and to their use in the production of colored plastics or polymeric color particles, printing colorants, printing pastes and printing inks.Type: GrantFiled: December 19, 2005Date of Patent: April 14, 2009Assignee: Ciba Specialty Chemicals CorporationInventors: Thomas Ruch, Ursula Luterbacher
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Patent number: 7348319Abstract: The present invention relates to nitric oxide-releasing amidine diazeniundiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines.Type: GrantFiled: August 19, 2005Date of Patent: March 25, 2008Assignee: United States of America as represented by the Department of Health and Human ServicesInventors: Joseph A Hrabie, Larry K Keefer, Ernst V Arnold
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Patent number: 7105502Abstract: The invention provides NO- or NO?-releasing imidate; and thioimidate, diazeniumdiolates, in which the N2O2? functional group is bonded to a carbon atom. The imidate and thioimidate diazeniumdiolates are bound to a polymer or a substrate.Type: GrantFiled: November 6, 2003Date of Patent: September 12, 2006Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Ernst V Arnold, Larry K Keefer, Joseph A Hrabie
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Patent number: 6949530Abstract: The present invention relates to nitric oxide-releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines.Type: GrantFiled: July 18, 2002Date of Patent: September 27, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joseph A. Hrabie, Larry K. Keefer, Ernst V. Arnold
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Patent number: 6911433Abstract: Provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) having the formula: in which R is a saccharide, which is attached to the O2 of the compound by the anomeric carbon of a pyranose ring or a furanose ring.Type: GrantFiled: January 7, 2003Date of Patent: June 28, 2005Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joseph E. Saavedra, Larry K. Keefer, Aloka Srinivasan, Christian Bogdan, William G. Rice, Xinhua Ji
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Patent number: 6504045Abstract: The invention relates to six new crystal polymorphs, &agr; (alpha), &bgr; (beta), &ggr; (gamma), &dgr; (delta), &zgr; (zeta), and &eegr; (eta), of the disazo colorant of the formula I, having characteristic reflections in the X-ray diffraction spectrum. The novel crystal polymorphs are prepared by treatment in organic solvents.Type: GrantFiled: September 13, 2001Date of Patent: January 7, 2003Assignee: Clariant GmbHInventors: Ruediger Jung, Hans-Joachim Metz, Joachim Weber, Martin U. Schmidt, Olaf Schupp, Andreas Wacker
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Patent number: 6417178Abstract: Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.Type: GrantFiled: November 6, 1997Date of Patent: July 9, 2002Assignee: University of PittsburghInventors: William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
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Patent number: 6168776Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.Type: GrantFiled: April 18, 1997Date of Patent: January 2, 2001Assignee: University of PittsburghInventors: William E. Klunk, Jay W. Pettegrew, Chester A. Mathis, Jr.
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Patent number: 5861138Abstract: Novel ligands for use in MRI contrast agents and which have the formula ##STR1## wherein R.sub.1 -R.sub.14, M", l, m, and n are defined herein.Type: GrantFiled: November 20, 1996Date of Patent: January 19, 1999Assignee: Hoechst Celanese Corp.Inventors: Wei-Jun Peng, Daniel A. Aguilar
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Patent number: 5808038Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: September 12, 1994Date of Patent: September 15, 1998Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
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Patent number: 5731301Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: May 31, 1995Date of Patent: March 24, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
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Patent number: 5672593Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: June 28, 1993Date of Patent: September 30, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
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Patent number: 5548070Abstract: The organosilicon compounds have at least one Si--C-bonded organic radical which contains at least one triazene group. The organosilicon compounds can be employed as heat- and light-unstable free radical initiators for the preparation of homo-, graft co- and block copolymers from olefinically unsaturated compounds and for crosslinking organosilicon compounds and organic compounds which can be polymerized by free radical polymerization.Type: GrantFiled: July 19, 1994Date of Patent: August 20, 1996Assignee: Wacker-Chemie GmbHInventors: Jochen Dauth, Bernward Deubzer, Elfriede Mayer, Oskar Nuyken, Brigitte Voit, Ralf Kollefrath
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Patent number: 5420254Abstract: A compound of the formula I ##STR1## in which D is a diazo component,K is an aromatic group of formula a, b or c, ##STR2## Y is C.sub.2-3 alkylene and the remaining symbols are as defined in the specification. These compounds are useful for dyeing or printing textile substrates based on synthetic or semisynthetic, hydrophobic, high molecular weight organic materials. Preferably, the textile substrate is made from a linear aromatic polyester, cellulose 21/2 acetate or cellulose tri-acetate. The dyeings and prints obtained show good all round fastness properties such as good thermomigration properties, lightfastness, thermofixation, blistering properties as well as good wet fastness properties, especially after thermal fixation.Type: GrantFiled: October 19, 1993Date of Patent: May 30, 1995Assignee: Sandoz Ltd.Inventors: Ruedi Altermatt, Robert Egli, Beat Henzi
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Patent number: 5270453Abstract: Aromatic bistriazene compounds of the formula ##STR1## wherein --R.sub.1, --R.sub.2, --R.sub.3, and --R.sub.4 are independently --H, --C.sub.6 H.sub.5, --C.sub.6 H.sub.4 Y, or C.sub.1 -C.sub.4 alkyl; --R.sub.5 -- is ##STR2## --R.sub.6 is --F, --Cl, --Br, --CH.sub.3, or --CF.sub.3 ; r is 0, 1, 2, 3, or 4; and --Y is halogen, --NO.sub.2, --C.sub.6 H.sub.5, or C.sub.1 -C.sub.4 alkyl. These bistriazene compounds are useful for cross-linking polymers such as poly(imides), poly(aryl ether ketones), poly(aryl ether sulfones), poly(quinolines), poly(quinoxalines), and nonaromatic fluoropolymers having aliphatic C--H groups.Type: GrantFiled: November 17, 1992Date of Patent: December 14, 1993Assignee: Raychem CorporationInventors: Aldrich N. K. Lau, Lanchi P. Vo, Frank W. Mercer
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Patent number: 5250667Abstract: Compounds of the structure ##STR1## where --R' is --F, --CF.sub.3, --CN, or --Cl; each --R", which may be the same or different, is independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl or hydroxyalkyl moieties and aryl moieties; and n is 0 or 1. Such compounds are useful as derivatizing and crosslinking agents for polymers, especially fluorinated poly(arylene ethers).Type: GrantFiled: September 9, 1992Date of Patent: October 5, 1993Assignee: Raychem CorporationInventors: Aldrich N. K. Lau, Lanchi P. Vo
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Patent number: 5235044Abstract: A composition having the structure ##STR1## wherein --R' is --F or --Cl, each --R", which may be the same or different, is independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl or hydroxyalkyl moieties and aryl moieties, and n is 1 or 2. These compositions are useful as co-monomers or end-cappers for the introduction of thermally reactive cross-linking sites into polymers.Type: GrantFiled: September 9, 1992Date of Patent: August 10, 1993Assignee: Raychem CorporationInventors: Frank W. Mercer, Aldrich N. K. Lau, Lanchi P. Vo
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Patent number: 4923970Abstract: A substituted 1-(2-chloroethyl)-3-acyl-3-alkyltriazene of the formula: ##STR1## in which R.sub.1 is 1-oxoalkyl containing from two to eight carbon atoms, fluorinated 1-oxoalkyls containing from two to eight carbon atoms and substituted with up to three fluorine atoms, benzoyl, phenylacetyl, carboalkoxy containing from two to eight carbon atoms, fluorinated carboalkyl containing from two to eight carbon atoms and up to three fluorine atoms, carbophenoxy, N-phenyl aminocarbonyl, N-alkyl aminocarbonyl containing from two to eight carbon atoms, thiocarbamoyl, N-alkylthiocarbamoyls with from two to eight carbon atoms, N-phenylthiocarbamoyl, dialkylphosphonates in which the alkyl groups can be the same or different and each contains from one to seven carbon atoms, phenylsulfonyl, and meta or para-substituted phenylsulfonyl in which the meta or para substituent is methyl, ethyl, methoxy, ethoxy, fluoro and chloro; and R.sub.Type: GrantFiled: March 28, 1988Date of Patent: May 8, 1990Assignee: Bionetics Research, Inc.Inventors: Christopher J. Michejda, Richard H. Smith, Jr.
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Patent number: 4601969Abstract: A lithographic resin for use with deep ultraviolet radiation comprises a weakly acidic resin and an alpha phosphoryl substituted diazo carbonyl compound as a sensitizer.Type: GrantFiled: March 28, 1985Date of Patent: July 22, 1986Assignee: International Business Machines CorporationInventors: Nicholas J. Clecak, Barbara D. Grant, Robert D. Miller, Terry C. Tompkins, Carlton G. Willson