Noncarbon Atom Double Or Triple Bonded And The Diazoamino Group Bonded Directly To The Same Acyclic Carbon Patents (Class 534/553)
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Patent number: 8871916Abstract: A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diazo-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compounds and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.Type: GrantFiled: December 14, 2012Date of Patent: October 28, 2014Assignee: Wisconsin Alumni Research FoundationInventors: Ronald Thaddeus Raines, Eddie Leonard Myers
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Patent number: 8592565Abstract: The invention relates to carbon surfaces modified with one or more azide groups. The invention also relates to methods of modifying carbon surfaces with one or more azide groups.Type: GrantFiled: January 10, 2008Date of Patent: November 26, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Christopher E. D. Chidsey, Anando Devadoss, Neal K. Devaraj
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Publication number: 20130203974Abstract: A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.Type: ApplicationFiled: December 14, 2012Publication date: August 8, 2013Inventors: Ronald Thaddeus RAINES, Eddie Leonard MYERS
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Patent number: 8217022Abstract: The present invention refers to analogues of 1,3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for the treatment of different types of tumors. Said compounds show cytotoxicity at very low concentrations (IC50 0.22 to 12.8 ?M), and good solubility. These compounds can be used in the treatment of tumor patients as single drugs or in combination with other cytostatics.Type: GrantFiled: April 20, 2011Date of Patent: July 10, 2012Assignee: Rudjer Boskovic InstituteInventors: Maja Osmak, Slovenko Polanc, Tamara Cimbora Zovko, Anamaria Brozovic, Marijan Kocevar, Vita Majce, Branko Alic
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Publication number: 20110097735Abstract: The present invention relates to fluorescent pyrene dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.Type: ApplicationFiled: October 28, 2009Publication date: April 28, 2011Applicant: Biotium, Inc.Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung
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Patent number: 6435240Abstract: A method for producing by electrochemical reduction a carbon-containing material with its surface modified by organic groups, in particular functionalized organic groups, contacting the carbon-containing material with an organic diazonium salt in solvent, optionally in the presence of an electrolyte; negative polarisation of the carbon-containing material relative to an anode also in contact with an electrolyte solution separate from the diazonium salt solution. The electrochemical reduction is carried out on an organic diazonium salt in protic solvent in an acid medium.Type: GrantFiled: August 27, 1999Date of Patent: August 20, 2002Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Olivier Fagebaume, Jean Pinson, Jean-Michel Saveant
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Patent number: 5808038Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: September 12, 1994Date of Patent: September 15, 1998Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
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Patent number: 5731301Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: May 31, 1995Date of Patent: March 24, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
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Patent number: 5672593Abstract: The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.Type: GrantFiled: June 28, 1993Date of Patent: September 30, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christopher J. Michejda, Jeffrey J. Blumenstein
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Patent number: 5554739Abstract: Processes for preparing a carbon product having an organic group attached to a carbon material. The carbon material is selected from graphite powder, a graphite fiber, a carbon fiber, a carbon cloth, a vitreous carbon product, and an activated carbon product. In one process at least one diazonium salt reacts with a carbon material in the absence of an externally applied electric current sufficient to reduce the diazonium salt. In another process at least one diazonium salt reacts with a carbon material in a protic reaction medium.Type: GrantFiled: December 15, 1994Date of Patent: September 10, 1996Assignee: Cabot CorporationInventor: James A. Belmont
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Patent number: 4923970Abstract: A substituted 1-(2-chloroethyl)-3-acyl-3-alkyltriazene of the formula: ##STR1## in which R.sub.1 is 1-oxoalkyl containing from two to eight carbon atoms, fluorinated 1-oxoalkyls containing from two to eight carbon atoms and substituted with up to three fluorine atoms, benzoyl, phenylacetyl, carboalkoxy containing from two to eight carbon atoms, fluorinated carboalkyl containing from two to eight carbon atoms and up to three fluorine atoms, carbophenoxy, N-phenyl aminocarbonyl, N-alkyl aminocarbonyl containing from two to eight carbon atoms, thiocarbamoyl, N-alkylthiocarbamoyls with from two to eight carbon atoms, N-phenylthiocarbamoyl, dialkylphosphonates in which the alkyl groups can be the same or different and each contains from one to seven carbon atoms, phenylsulfonyl, and meta or para-substituted phenylsulfonyl in which the meta or para substituent is methyl, ethyl, methoxy, ethoxy, fluoro and chloro; and R.sub.Type: GrantFiled: March 28, 1988Date of Patent: May 8, 1990Assignee: Bionetics Research, Inc.Inventors: Christopher J. Michejda, Richard H. Smith, Jr.
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Patent number: 4678497Abstract: Triazine-substituted azobenzenesulfonamides useful as preemergent and postemergent herbicides, selected from compounds of Formulae I or II ##STR1## or agriculturally suitable salts thereof, wherein R, R.sub.1, R.sub.2, R.sub.3 and A are as defined herein.Type: GrantFiled: January 13, 1986Date of Patent: July 7, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Wallace C. Petersen