Nitrogen Bonded Directly To The -c(=x)- Group (e.g., Carboxamide, Etc.) Patents (Class 534/721)
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Patent number: 8974768Abstract: The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.Type: GrantFiled: March 23, 2011Date of Patent: March 10, 2015Assignee: Max-Delbrueck-Centrum fuer Molekulare MedizinInventors: Erich Wanker, Thomas Wiglenda, Julius Tachu Babila, Annett Boeddrich, Michael Schmidt, Franziska Schiele
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Patent number: 6764524Abstract: Asymmetrical 1:2 chromium complex dyes of formula (I), wherein X signifies —SO3M, —SO2NR1R2 or chlorine, Y signifies hydrogen, —SO3M or chlorine, R1 signifies hydrogen, C1-6alkyl, C2-3-hydroxyalkyl or a radical of formulae (a) or (b), R2 signifies hydrogen, C1-6alkyl or C2-3-hydroxyalkyl, or R1 and R2 together with the nitrogen atom to which they are attached, form a 5- or 6-membered saturated heterocycle, R3 signifies hydrogen, C1-2-alkyl, chlorine, —COOM or —SO3M, R4 signifies hydrogen, C1-2-alkyl, C1-2-alkoxy chlorine or —SO3M, n signifies from 0 to 3, M signifies in each case hydrogen or a nonhromophoric cation, and M+signifies hydrogen or a nonchromophoric cation, are useful for dyeing artificially produced oxide layers on aluminium or aluminium alloys, on which they produce grey dyeings in high color yield and hue reproducibilityType: GrantFiled: September 28, 2000Date of Patent: July 20, 2004Assignee: Clariant Finance (BVI) LimitedInventor: Klaus Körte
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Publication number: 20020091241Abstract: This invention provides azo-metal complex dyes for a high-density optical disc recording medium having the following formula (I): 1Type: ApplicationFiled: May 16, 2001Publication date: July 11, 2002Applicant: Industrial Technology Research InstituteInventors: Shin-Shin Wang, Hui-Ping Tsai, Wen-Yih Liao, Chien-Liang Huang, Tzuan-Ren Jeng
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Patent number: 6210448Abstract: 1:2 chromium complex dyes of the formula: in which R signifies C1-9-alkyl or a radical of the formula: R1 signifies C1-4-alkyl, R2 signifies hydrogen or —SO3M, R3 signifies hydrogen, methyl or methoxy, R4 signifies hydrogen, methyl, methoxy or chloro, n signifies from 0 to 3, M signifies hydrogen or a non-chromophoric cation and Kat+signifies hydrogen or a non-chromophoric cation, are suitable for dyeing artificially produced oxide layers on aluminium or aluminium alloys and so give rise to highly lightfast dyeings in yellow shades.Type: GrantFiled: November 24, 1999Date of Patent: April 3, 2001Assignee: Clariant Finance (BVI) LimitedInventor: Klaus Körte
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Patent number: 6153735Abstract: Monoazo metal compound of formula [I] which is excellent in charge control or charge-enhancing property, and toner for developing electrostatic images and powdery paint for electrostatic painting incorporating thereof:D.sub.3 (Met).sub.2 [I]D is a ligand based on a monoazo compound of formula [II] or [III], Met is a metal atom, and the 3 molecules of D are coordinated to the 2 atoms of Met: ##STR1## R.sup.1 -R.sup.10, and R.sup.21 -R.sup.28 are each H, halogen, nitro, alkyl or haloalkyl, aryl, aralkyl, --SO.sub.2 N(R.sup.11).sub.2 (R.sup.11 is H, alkyl, aryl, aralkyl), --N(R.sup.12).sub.2 (R.sup.12 is H, lower alkyl, aryl, aralkyl, acyl), --CONH(R.sup.13) (R.sup.13 is H, a lower alkyl, aryl, aralkyl); 2 or more of R.sup.1 -R.sup.10 and/or R.sup.21 -R.sup.28 may bind together to form an aromatic or aliphatic ring.Type: GrantFiled: April 16, 1998Date of Patent: November 28, 2000Assignee: Orient Chemical Industries, Ltd.Inventors: Kazuaki Sukata, Shuji Sugawara, Shun-ichiro Yamanaka, Tohru Tsuruhara, Masashi Yasumatsu
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Patent number: 5853431Abstract: Compounds of formula (I) ##STR1## wherein R.sub.1 is H or SO.sub.3 M, ##STR2## M is hydrogen or a non-chromophoric cation and X.sup.+ is hydrogen or a non-chromophoric cation, are useful as dyes for oxidized aluminium substrates.Type: GrantFiled: November 6, 1997Date of Patent: December 29, 1998Assignee: Clariant Finance (BVI) LimitedInventor: Klaus Korte
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Patent number: 5401834Abstract: Complexes of the formula ##STR1## which are in free acid or salt form, and mixtures thereof, wherein each ofR.sub.1 and R.sub.3 is independently hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, amino, sulfo or carboxy,each ofR.sub.2 and R.sub.4 is independently hydrogen; C.sub.1-4 alkyl; C.sub.1-4 alkyl monosubstituted by hydroxy, amino, sulfo or carboxy; --COR.sub.5 ; --COOR.sub.6 or --CONHR.sub.7,M is chromium or cobalt, andM.sub.K.sup..sym. is hydrogen or a non-chromophoric cation, useful for dyeing or printing, materials such as natural and synthetic polyamides and particularly artificially produced oxide layers on aluminum and aluminum alloys.Type: GrantFiled: June 22, 1993Date of Patent: March 28, 1995Assignee: Sandoz Ltd.Inventor: Klaus Koerte
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Patent number: 5376151Abstract: Disclosed is an original approach to solving the environmental problem associated with the use of Cr-based metallized azo dyes to deliver black shades on natural and synthetic substrates. This invention affords methods for both the synthesis of metallized dyes and the generation of black dyeings using those dyes without employing metals designated as priority pollutants at any stage in either method. The key element of the disclosure is the use of black 1:2 Fe complexes of azo dyes in lieu of currently used Cr-based complexes which are based on environmentally unfriendly priority pollutant metals without compromising the desirable high fastness properties of the latter complexes, an accomplishment heretofore assumed unachievable.Type: GrantFiled: April 16, 1993Date of Patent: December 27, 1994Assignee: North Carolina State UniversityInventors: Harold S. Freeman, Abraham Reife, Jolanta Sokolawska-Gajda
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Patent number: 5283325Abstract: 1:2 metal complexes of the formula ##STR1## wherein each of R.sub.1 and R.sub.3 is independently hydrogen or nitro, with the proviso that when a ring has two nitro groups, they are meta to each other,each of R.sub.2 and R.sub.4 is independently hydrogen, chloro or --SO.sub.3 M,each of R.sub.5 and R.sub.6 is independently hydrogen, --COR.sub.7, --CONHR.sub.8 or --SO.sub.2 R.sub.9,wherein R.sub.7 is C.sub.1-6 alkyl, C.sub.1-6 alkoxy, phenyl(C.sub.1-4 -alkyl) or phenyl(C.sub.1-4 -alkyl) the phenyl group of which is substituted by 1 or 2 substituents selected from halo, C.sub.1-4 -alkyl, C.sub.1-4 alkoxy, nitro, amino, --COOM, --SO.sub.3 M and acetamido,R.sub.8 is hydrogen, C.sub.1-6 alkyl; phenyl; phenyl substituted by 1 or 2 substituents selected from halo, C.sub.1-4 -alkyl, C.sub.1-4 alkoxy, nitro, amino, --COOM, --SO.sub.3 M and acetamido; naphthyl or naphthyl monosubstituted by chloro, amino, phenylamino, acetamido, benzamido or --SO.sub.3 M, andR.sub.9 is C.sub.Type: GrantFiled: December 2, 1991Date of Patent: February 1, 1994Assignee: Sandoz Ltd.Inventor: Peter Bitterli
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Patent number: 5204453Abstract: The invention relates to a process for the preparation of 1:2 chromium, 1:2 cobalt, 1:2 nickel or 1:2 iron complex azo dyes diazotisation, coupling and metallizing, without isolation of the coupling product, which process comprises diazotizing at least one amine of the benzene or naphthalene series in aqueous solution and coupling the diazonium compound so obtained to at least one coupling component of the benzene or naphthalene series or of the heterocyclic series, such that the azo dye obtained as intermediate contains groups suitable for metal complex formation, and carrying out the diazotization or coupling in the presence of a chromium, cobalt, nickel or iron donor.The dyes obtained by the process of the invention are suitable for dyeing in particular wool or synthetic textile polyamide fibre materials as well as leather, and for use as wood mordant dyes.Type: GrantFiled: December 30, 1991Date of Patent: April 20, 1993Assignee: Ciba-Geigy CorporationInventors: Bernard Chambon, Horst H. Jager, Rudiger Oxenius, Alois Puntener
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Patent number: 5123930Abstract: 1:2 metal complexes of the formula ##STR1## wherein each of R.sub.1 and R.sub.3 is independently hydrogen or nitro, with the proviso that when a ring has two nitro groups, they are meta to each other,each of R.sub.2 and R.sub.4 is independently hydrogen, chloro or --SO.sub.3 M,each of R.sub.5 and R.sub.6 is independently hydrogen, --COR.sub.7, --CONHR.sub.8 or --SO.sub.2 R.sub.9,whereinR.sub.7 is C.sub.1-6 alkyl, C.sub.1-6 alkoxy, phenyl(C.sub.1-4 -alkyl) or phenyl (C.sub.1-4 alkyl) the phenyl group of which is substituted by 1 or 2 substituents selected from halo, C.sub.1-4 -alkyl, C.sub.1-4 alkoxy, nitro, amino, --COOM, --SO.sub.3 M and acetamido,R.sub.8 is hydrogen; C.sub.1-6 alkyl; phenyl; phenyl substituted by 1 or 2 substituents selected from halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, --COOM, --SO.sub.3 M and acetamido; naphthyl or naphthyl monosubstituted by chloro, amino, phenylamino, acetamido, benzamido or --SO.sub.3 M, andR.sub.9 is C.sub.Type: GrantFiled: August 21, 1990Date of Patent: June 23, 1992Assignee: Sandoz Ltd.Inventor: Peter Bitterli
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Patent number: 4977249Abstract: A metal complex compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 which may be the same or different, is a nitro group, a halogen atom, a phenylazo group (inclusive of a substituted phenylazo group) or a naphthylazo group (inclusive of a substituted naphthylazo group), each of n.sub.1 and n.sub.2 which may be the same or different, is an integer of from 1 to 3, each of R.sub.1 and R.sub.2 which may be the same or different, is an amino group, a monoalkylamino group, a dialkylamino group, an acetylamino group and a benzoylamino group (inclusive of a substituted benzoylamino group), M is a chromium atom, an iron atom, a cobalt atom, m is an integer of at least 2, and y.sup.m.sym. is a bivalent or higher polyvalent metal ion. The metal complexes are useful as near infrared absorbers.Type: GrantFiled: December 13, 1989Date of Patent: December 11, 1990Assignee: Hodogaya Chemical Co., Ltd.Inventors: Yuto Matsumoto, Hiroyoshi Yamaga, Noboru Akuzawa, Toshio Obara
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Patent number: 4710198Abstract: A process of dyeing polyamide-containing material is disclosed using dyes of the following formula: ##STR1## wherein Me is cobalt or chromium,Ka.sup..sym. is a cation,p is 0 or 1,R and R' are each independently of the other hydrogen or a group of the formula --CO--(O).sub.n --Y, wheren is 0 or 1, andY is C.sub.1 -C.sub.5 alkyl, or phenyl which may be substituted by nitro, halogen, C.sub.1 -C.sub.5 alkyl or C.sub.1 -C.sub.5 alkoxy,with the proviso that R and R' may not both be hydrogen if p is 1.Novel dyes within this class are also disclosed. The process is especially useful for dyeing leather.Type: GrantFiled: December 9, 1985Date of Patent: December 1, 1987Assignee: Ciba-Geigy CorporationInventors: Fabio Beffa, Hans U. Schutz
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Patent number: 4670486Abstract: High molecular weight organic material is effectively colored by the incorporation therein of a copper or nickel complex of the ligand compound of formula I ##STR1## wherein A is an isocyclic or heterocyclic aromatic moiety, R is H, halogen, lower alkyl or alkoxy, R.sub.1 is H, lower alkyl, phenyl or substituted phenyl, and B is H, lower alkyl, ureido or substituted ureido, guanidino, anilino, benzamido or a heterocyclic aromatic moiety.Type: GrantFiled: June 13, 1985Date of Patent: June 2, 1987Assignee: Ciba-Geigy CorporationInventors: Georg Cseh, Paul Lienhard
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Patent number: 4624907Abstract: An electrophotographic toner capable of being electrified negatively comprising:(a) a binder resin; and(b) a charge-controlling and coloring agent comprising at least one 2:1 type metal complex of the formula (I): ##STR1## where each of X.sub.1 and X.sub.2, which may be the same or different, is a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, a C.sub.1 -C.sub.5 alkoxy group, a nitro group or a halogen atom, each of m and m' is an integer of 1 to 3, each of R.sub.1 and R.sub.2, which may be the same or different, is a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group, a C.sub.1 -C.sub.5 alkoxy group, a halgen atom, a nitro group, a sulfonamide group, a methylsulfonyl group, an ethylsulfonyl group, an acetyl amino group or a benzoyl amino group, each of n and n' is an integer of 1 to 3, Y.sup..sym. is an ammonium ion, an aliphatic ammonium ion, an alicyclic ammonium ion or a heterocyclic ammonium ion, and M is a chromium atom, a cobalt atom or an iron atom.Type: GrantFiled: November 8, 1984Date of Patent: November 25, 1986Assignee: Hodogaya Chemical Co., Ltd.Inventors: Isao Niimura, Katsuichi Motohashi, Hiroyoshi Yamaga, Noboru Akuzawa
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Patent number: 4617382Abstract: The present invention relates to novel chromium complex dyes of the formula ##STR1## wherein Z is hydrogen, chloro, bromo, nitro, lower alkyl or acylamino;L is H.sub.Type: GrantFiled: April 13, 1983Date of Patent: October 14, 1986Assignee: Ciba-Geigy CorporationInventors: Gerhard Back, Fabio Beffa, Arthur Buhler
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Patent number: 4594410Abstract: Azo dyes of the formula ##STR1## and external salts thereof, wherein F is the residue of a monoazo or disazo compound in 1:1 metal complex form or of a trisazo, disazoazoxy or tetrakisazo compound in metal-free or 1:1 metal complex form,each X is independently --NR.sub.2 --Q--NR.sub.3 R.sub.4 or --NR.sub.2 --Q--N.sup..sym. R.sub.5 R.sub.6 R.sub.7,whereinQ is linear or branched C.sub.2-6 alkylene or --NH--CO--CH.sub.2 --,R.sub.2 is hydrogen or C.sub.1-4 alkyl,each of R.sub.3 and R.sub.4 is independently hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkyl monosubstituted by cyano or hydroxy in the 2-, 3-, 4-, 5- or 6-position; phenyl(C.sub.1-3 alkyl); phenyl(C.sub.1-3 alkyl) having, on the phenyl ring, 1, 2 or 3 substituents selected from chloro, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; C.sub.5-6 cycloalkyl or C.sub.5-6 cycloalkyl substituted by 1, 2 or 3 C.sub.1-4 alkyl groups or --NR.sub.3 R.sub.Type: GrantFiled: August 18, 1982Date of Patent: June 10, 1986Assignee: Sandoz Ltd.Inventor: Reinhard Pedrazzi