Abstract: A polymerizable yellow dye which is used to block or lower the intensity of blue light transmitted through ophthalmic lenses and is represented by the following formula (I): wherein R1 is hydrogen or —NHCOCH3; R2 is hydrogen or C1-C3 alkyl groups; R3 and R4 are independently hydrogen or —OCO—R5, wherein R5 is isopropenyl group or a substituted isopropenyl group represented as —R6—(R7O)n—COC(CH3)CH2, R6 is NH or R7 is C1-C5 alkylene groups and n is an integer of 1-40.

Abstract: Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts. Multiple types of quenching moieties can be employed to increase the absorption range and a multiple number of each type of quenching moiety can be used to increase the total absorptivity within the absorption range. The multi-chromophoric quenchers can be tethered to probes for biomolecules, insoluble supports and/or fluorescent dyes for use in a wide variety of biomolecular assays.

Abstract: The present invention relates to new azo dyes, a process for their preparation, and their use for dyeing or printing fibrous materials, to produce materials with brownish shades.

Abstract: A linker system is provided where a small molecule reactive group, e.g., an activity based probe which binds to certain enzymes at the active site, is linked through an aryl diazo linker to an affinity molecule such as biotin. The reactive group may comprise a number of functionalities known to react with a specific target to be studied. This enables the probe to be exposed to analytes, such as proteins and bind specifically to them to form a complex having an affinity molecule allowing immobilization of the bound analyte on an affinity column or other support, e.g. with streptavidin. Then, the linker is cleaved without causing removal of the affinity group or dissociation of the probe from the analyte. The linker is cleaved under mild reducing conditions, e.g., dithionite. The probe is synthesized along with the linker on a solid support.

Abstract: The present invention relates to a method of making asymmetrical bis(thiosemicarbazones), compounds useful as synthetic intermediates in the method, new bis(thiosemicarbazones) that can be readily accessed by use of the method and methods of treatment and imaging utilising some of the new bis(thiosemicarbazones).

Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

Abstract: The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.

Abstract: A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the following structure, wherein R1 and R2 are defined herein, using N-trifluoroacetylmorpholine. The sulfonamide compounds that may be prepared as described herein include 5-chloro-thiophene-2-sulfonic acid [(1S,2R)-2-(3,5-difluoro-phenyl)-3,3,3-trifluoro-1-hydroxymethyl-propyl]-amide using N-trifluoroacetylmorpholine.

Abstract: An azo dye represented by formula (I): A-N?N—B??formula (I) wherein, A represents a group having a substituent required for inducing an intramolecular nucleophilic substitution reaction with a nitrogen atom of a reduced azo group as a nucleophilic species when the azo group is reductively decomposed, the group forming a compound containing the nitrogen atom in a ring structure, and B represents an aromatic or hetero ring which is bound to the azo group through a carbon atom.

Abstract: A compound represented by the general formula (I) below: In the formula, A is as defined in the specification and B denotes where n is an integer of 1 to 4, and a process for producing the above compound includes a reaction between an activated ester and a t-butoxycarbonylaminoethylamine or an ?-amino acid derivative.

Abstract: The invention provides an optical method which permits, with the aid of 6 simple measurements, a conclusion regarding the suitability of antennas (groups which can absorb electromagnetic radiation) for incorporation into photoaddressable polymers.

Abstract: Novel addition products of hydroxyl-protecting groups (such as isocyanates) with oxyalkylene-substituted intermediates, such as poly(oxyalkylenated) aniline compounds, for the eventual production of substituted, and substantially pure, colorants, particularly diazo and triphenylmethane derivatives, through the reaction of such intermediates with certain reactants are provided. These new colorants exhibit improved wax and/or oil solubility and high purity, particularly due to the inability of certain impurities to deleteriously react with the protected hydroxyl groups of either the intermediate or the colorant during and/or after formation thereof. A method for producing such novel colorants through utilization of these novel substantially pure colorant intermediates is also provided.

Abstract: This invention relates to colorants comprising a chromophore having two azo acetoacetanilide moieties, wherein said moieties each have at least one poly(oxyalkylene) chain, preferably at least two such chains. Such colorants exhibit extremely good base stability and lightfastness, particularly when incorporated within certain media and/or on the surface of certain substrates. These poly(oxyalkylene) chains provide solubility in different solvents or resins thereby permitting the introduction of such excellent coloring chromophores within diverse media and/or or diverse substrates. Compositions and articles comprising such colorants are provided as are methods for producing such inventive colorants.

Abstract: Specific novel compounds of aromatic bis-acetoamide structures are provided as intermediate compounds to forming different types of coloring agents, at least. Such compounds are useful as intermediates in the production of certain bis-acetoanilide azo dyes, pigments, and polymeric colorants. Such compounds facilitate production of such coloring agents that exhibit favorable tinctorial strength and intense color from orange to greenish yellow within and on different substrates and media. Coloring agents and methods of making such agents are encompassed within this invention as well.

Abstract: The invention relates to a method for preparing a compound of the formula A(D)x(E)y (I) by reaction of a compound of the formula A(H)x(H)y with a pyrocarbonic acid diester of the formula wherein x and y are each independently of the other an integer from 0 to 6, but x and y are not simultaneously the number 0, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone, isoindolinone, isoindoline, dioxazine, azo, phthalocyanine or diketopyrrolopyrrole series, which radical is bonded via one or more nitrogen atoms to x groups D and via one or more oxygen atoms to y groups E, the nitrogen atoms and oxygen atoms forming part of the radical A, each group D or E independently of any other(s) is hydrogen or a group of the formula wherein at least one group D or E is not hydrogen, and L is any desired group suitable solubilization, in the presence of a base as catalyst, in which method the reaction takes place in an aroma

Abstract: The invention relates to novel soluble pigment precursors possessing not only higher thermal stability but also improved solubility characteristics and to a process for mass coloration of high temperature polymers that utilizes these novel soluble pigment precursors. The pigment precursors of the invention are essentially of the formula A(B)x  (I) where x is an integer from 1 to 8, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone, isoindolinone, isoindoline, dioxazine, azo, phthalocyanine or diketopyrrolopyrrole series, this radical being linked with xB groups via one or more heteroatoms, these heteroatoms being selected from the group consisting of N, O and S and forming part of the radical A, and B is hydrogen or a group of the formula although at least one B group is not hydrogen and when x is from 2 to 8 the B groups may be identical or different.

Abstract: Compounds of formula A(B)x  (I), wherein x is an integer from 1 to 8, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone, isoindolinone, isoindoline, dioxazine, azo, phthalocyanine or diketopyrrolopyrrole series that is bonded to x groups B via one or more hetero atoms, those hetero atoms being selected from the group consisting of N, O and S and forming part of the radical A, each group B independently of any other(s) is hydrogen or a group of the formula  at least one group B being a group of the formula The compounds according to the invention are used in high-molecular-weight organic materials, thermo-, photo- or chemo-sensitive recording materials, light-sensitive negative or positive resist compositions, ink compositions for ink-jet printing and color tapes for thermal transfer printing.

Abstract: The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.

Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: A fluorine-containing macroazo compound having a fluorine segment in the molecule is useful as a polymerization initiator for producing, for example, fluorine-containing block polymers.

Abstract: Dyes of formula (1) ##STR1## wherein the variables are as defined in the specification and at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 or a substituent on A being --SO.sub.2 F or a substituent to which at least one --SO.sub.2 F group is attached are water-insoluble monoazo dyes useful for coloring synthetic textile materials.

Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: New azodicarboxylic acid derivatives of formula I ##STR1## where R.sub.1 is hydrogen, oxyl, hydroxyl, alkyl, allyl, benzyl, alkoxy or acyl, and X is --O-- or --NR-- where R is hydrogen or alkyl, are useful for the stabilization of polymers, particularly unsaturated elastomers, by being grafted thereon.

Abstract: Disperse dyes of formula ##STR1## wherein D is the radical of a diazo component of formula ##STR2## Z.sub.1 is a radical of formula ##STR3## Z.sub.2 is hydrogen or a radical of formula (4), X is hydrogen, halogen, CF.sub.3, R.sub.3, OR.sub.3, NH--CO--R.sub.7, NH--CO--OR.sub.8, NH--SO.sub.2 --R.sub.7 or ##STR4## wherein R.sub.3 is C.sub.1 -C.sub.6 alkyl; R.sub.4 and R.sub.5 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl; R.sub.7 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkyl or phenyl; and R.sub.8 is C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.4 alkoxy-C.sub.2 -C.sub.4 alkyl; A.sub.1 is hydrogen, halogen, SO.sub.2 R.sub.3, CF.sub.3, NO.sub.2 or CN; A.sub.2 is hydrogen, halogen or CN; A.sub.3 is hydrogen or halogen, with the proviso that at least one of the substituents X, A.sub.1, A.sub.2 and A.sub.3 may not be hydrogen, and A.sub.4 is hydrogen, halogen, nitro, R.sub.3, NHCOR.sub.3 or OR.sub.3.

Abstract: Azo dyes of formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, unsubstituted C.sub.2 -C.sub.4 alkanoylamino or C.sub.2 -C.sub.4 alkanoylamino which is substituted by hydroxy, sulfo or sulfato, or are halogen or sulfo,R.sub.3, R.sub.4 and R.sub.5 are each independently of one another hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen or sulfo,R.sub.6 is hydrogen, C.sub.1 -C.sub.4 alkyl, halogen, sulfo, unsubstituted C.sub.2 -C.sub.4 alkanoylamino or C.sub.2 -C.sub.4 alkanoylamino which is substituted by hydroxy, sulfo or sulfato, or is a radical of formula --O--Y, wherein Y is hydrogen, C.sub.1 -C.sub.8 alkyl or C.sub.1 -C.sub.8 alkyl which is substituted by hydroxy, C.sub.1 -C.sub.4 alkoxy, sulfo or sulfato,R.sub.7 is hydrogen, C.sub.1 -C.sub.8 alkyl or hydroxy-substituted C.sub.1 -C.sub.8 alkyl, or C.sub.2 -C.sub.8 alkyl which is interrupted in the chain by the group --O-- or ##STR2## and X is C.sub.1 -C.

Abstract: Disclosed is a liquid crystal monomer compound represented by formula (1): ##STR1## wherein n is an integer of from 2 to 18, X is direct bond, --(C.dbd.O)--O--, --(C.dbd.O)--NH-- or --N.dbd.N--, R.sup.1 is hydrogen or a lower alkyl group, and R.sup.2 is hydrogen, a cyano group or a methoxy group, as well as a liquid crystal polymer derived therefrom.

Abstract: The compounds of the formula (1) indicated in claim 1 are suitable for use as direct dyes for dyeing and printing a wide range of materials, in particular cellulose-containing fibre materials, producing dyeings and prints having good fastness properties.

Abstract: Certain reducible compounds are useful in analytical compositions, elements and methods, for example for the detection of bacterial cells. These compounds comprise a moiety which provides an aniline dye upon reduction. Structurally, the reducible compounds are quinones having suitable substituents which promote varying amounts of aniline dye release at physiological pH.

Abstract: The new o-aminoazo compounds of the formula ##STR1## in which the substituents D, A, R and R.sub.1 and the index n have the meaning given in the description are valuable intermediates for the preparation of metal complex dyestuffs and are also highly suitable for the dyeing of wool and polyamide.

Abstract: Disperse dyes, which produce dyeings of excellent thermomigration fastness, consisting of a chromophore and a lactam or oxime radical which detaches on heating to leave an isocyanate or isothiocyanate group, which reacts with a suitable group in the environment. The disclosed dyes are described by the formula ##STR1## where F is the radical of a dye which is free of water-solubilizing groups,B is a bridge member or a direct bond,Z is O or S andV is the radical of a group H--V, where H--V is an oxime of the formula ##STR2## or a lactam of the formula ##STR3## in which R.sup.1 and R.sup.2 are each independently of the other substituted or unsubstituted alkyl or aryl, orR.sup.1 and R.sup.2 together with the carbon atom linking them form a cycloaliphatic ring,R is hydrogen or alkyl andn is an integer from 4 to 11.

Abstract: A macromolecular azo compound is produced by the reaction of a compound having at least 1 diazo linkage and at least 2 hydroxyl groups in a molecule, a compound having at least 2 isocyanate groups in a molecule and a compound having at least 2 hydroxyl groups in a molecule. A resin useful as a paint can be obtained by polymerizing a polymerizable unsaturated bond-containing monomer in the presence of this compound.

Abstract: A monoazo dyestuff of the formula: ##STR1## wherein D represents substituted or unsubstituted phenyl, imidazolyl, pyridyl, thiazolyl, thiadiazolyl, thienyl, benzoisothiazolyl, pyridinoisothiazolyl, thienoisothiazolyl, thienothiazolyl or benzothiazolyl, R.sup.1 represents substituted or unsubstituted alkyl, cyclohexyl, alkenyl, aralkyl or aryl, R.sup.2 and R.sup.3 each represents hydrogen, alkyl optionally substituted by cyano, hydroxy, alkoxy or alkoxyalkoxy, alkenyl, cyclohexyl, aryl or aralkyl, or together represent a 5- or 6-membered nitrogen-containing heterocyclic ring formed by combining R.sup.2 and R.sup.3, A represents ##STR2## X represents fluorine or chlorine, and Y.sup.1 represents hydrogen, chlorine, methyl or acylamino. The monoazo dyestuff is especially useful in the dyeing of cellulose-containing fibers and exhibits good fastness properties including good wet color fastness and good light fastness.

Abstract: Azo compounds of the formula I ##STR1## where D=diazo componentR.sub.1 and R.sub.2 =alkyl or aralkylX=H, hydrocarbon radical or acylare useful dyestuffs or dyestuff intermediates.

Abstract: An azo dyestuff of the formula ##STR1## wherein D=a diazo component,R.sub.1 and R.sub.2 =alkyl or aralkyl,R.sub.3 =H, R or OR.sub.1 andR.sub.4 =a hydrocarbon radical or acyl,which are prepared in a simple manner by aminolysis with ammonia or an amine of the formula ##STR2## of an azo compound of the formula ##STR3## these dyestuffs dye polyester fibres in blue-green to green shades with good fastness to light.

Abstract: Monoazo compounds of the formula ##STR1## wherein R.sub.1 is chloro, bromo nitro, C.sub.1-4 alkylsulfonyl, phenylsulfonyl, (C.sub.1-4 alkyl)carbonyl or benzoyl,each of R.sub.2 and R.sub.3, independently, is hydrogen, chloro or bromo, with the proviso that at least one of R.sub.2 and R.sub.3 is hydrogen,each of R.sub.4 and R.sub.5, independently, is C.sub.1-4 alkyl, ##STR2## or in which each of R.sub.10, R.sub.11 and R.sub.12, independently, is hydrogen, chloro, bromo, methyl, methoxy or ethoxy, andR.sub.6 is C.sub.1-4 alkyl, (C.sub.1-4 alkoxy)C.sub.2-4 alkyl, phenyl or phenyl substituted by up to three substituents selected from the group consisting of choro, bromo, methyl, methoxy and ethoxy,which compounds are useful as disperse dyes for substrates consisting of or comprising hydrophobic, high molecular weight synthetic or semi-synthetic organic fibers such as polyesters, synthetic polyamides and cellulose 21/2 acetate and triacetate.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is nitro or cyano;R.sub.2 is cyano or halo;R.sub.3 is C.sub.1-4 alkyl;R.sub.4 is methyl or ethyl;R.sub.5 is C.sub.1-8 alkyl; andR.sub.6 is --CH.sub.2 CHOHCH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.a R.sub.7, --CH.sub.2 CHOHC.sub.6 H.sub.5, --CH(C.sub.6 H.sub.5)CH.sub.2 OH; --(CH.sub.2).sub.n O--CO--NHR.sub.3, --CH.sub.2 CH(R.sub.4)--O--CO--NHR.sub.3 ; --(CH.sub.2).sub.n --O--CO--R.sub.3, --CH.sub.2 CH(R.sub.4)--O--CO--R.sub.3 or C.sub.2-4 hydroxyalkyl, with the provisos that R.sub.6 may be any of the last three groups only when R.sub.1 and R.sub.2 are both cyano and that R.sub.6 may be C.sub.2-4 hydroxyalkyl also when R.sub.5 is C.sub.1-2 alkyl,whereinR.sub.7 is phenyl; phenyl substituted by 1 or 2 substituents independently selected from hydroxy, chloro, bromo, methyl and C.sub.1-4 alkoxy; benzyl; benzyl substituted by 1 or 2 substituents independently selected from hydroxy, chloro, bromo, methyl and C.sub.