Abstract: Disclosed is a compound of the formula wherein Ra and Rb each, independently of the other, are hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, R1 and R2 each, independently of the other, are hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, provided that at least one of R1 and R2 is other than hydrogen, and R3, R4, R5, R6, and R7 each, independently of the others, are alkyl, aryl, arylalkyl, alkylaryl, or a substituent other than hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, wherein in each case alkyl, aryl, arylalkyl, or alkylaryl may or may not be substituted and may or may not have hetero atoms therein, and wherein two or more of R3, R4, R5, R6, and R7 can be joined together to form a ring.

Abstract: The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

Abstract: The present invention relates to new azo dyes, a process for their preparation, and their use for dyeing or printing fibrous materials, to produce materials with brownish shades.

Abstract: Generally regarded as safe (GRAS) dyes can be used as photosensitizing dyes in oral compositions to provide anti-bacterial and anti-inflammatory efficacy. Embodiments include oral care compositions including photosensitizing dyes, methods of making the compositions, methods of using the compositions, and kits containing the compositions and light emitting devices.

Abstract: This invention relates to novel carboxylic acid 4-phenylazo-phenyl ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Abstract: The present invention relates to disperse azo dyes based on a phthalimido-substituted aniline coupling component and an aromatic-carbocyclic or an aromatic-heterocyclic diazo component, to a process for the preparation of such dyes and to their use in the dyeing or printing of semi-synthetic and, especially, synthetic hydrophobic fibre materials, more especially textile materials.

Abstract: A method for preparing essentially pure 3,3?-diamino-4,4?-azoxyfurazan (“DAAF”) that involves reacting an aqueous solution that includes 3,4-diaminofurazan (“DAF”) with OXONE™ (i.e. 2KHSO5.KHSO4.K2SO4) in the presence of a chemical buffer or a material that produces a chemical buffer during the reaction between DAF and the OXONE™. The essentially pure product particles can be used without further purification in preparing pressed articles of that consist of essentially pure DAAF. When sodium hypochlorite is used instead of OXONE, the product is 3,3?-diamino-4,4?-azofurazan (“DAAzF”).

Abstract: The present invention relates to dyes of the general formula (I) where X1 and X2 are both hydrogen or both cyano; R1 is ethyl, straight-chain or branched (C3-C10)-alkyl or —(CH2)nCOO6; R2 is hydrogen, methyl, cyanomethyl, halomethyl, ethyl, cyanoethyl, haloethyl, halogen, —NH—CO—R7 or —NH—SO2—R7; R3 is (C1-C8)-alkyl or hydroxyl-, (C1-C4)-alkoxy-, cyano-, halogen-, R7OCO—, R7OOC—, vinyl- or phenyl-substituted (C1-C8)-alkyl; R4 is hydrogen, (C1-C8)-alkyl or hydroxyl-, (C1-C4)-alkoxy-, cyano-, halogen-, R7OCO—, R7OOC—, vinyl or phenyl-substituted (C1-C8)-alkyl; R5 is hydrogen, halogen, (C1-C4)-alkyl, (C1-C8)-alkoxy or halogen-, cyano- or phenyl-substituted (C1-C8)-alkoxy; R6 is (C1-C4)-alkyl; R7 is (C1-C8)-alkyl or halogen- or cyano-substituted (C1-C8)-alkyl; and n is 1, 2, 3, 4 or 5. The invention also relates to the process of the preparation of the dyes of formula (I) and their use.

Abstract: The invention relates to novel soluble pigment precursors possessing not only higher thermal stability but also improved solubility characteristics and to a process for mass coloration of high temperature polymers that utilizes these novel soluble pigment precursors. The pigment precursors of the invention are essentially of the formula A(B)x  (I) where x is an integer from 1 to 8, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone, isoindolinone, isoindoline, dioxazine, azo, phthalocyanine or diketopyrrolopyrrole series, this radical being linked with xB groups via one or more heteroatoms, these heteroatoms being selected from the group consisting of N, O and S and forming part of the radical A, and B is hydrogen or a group of the formula although at least one B group is not hydrogen and when x is from 2 to 8 the B groups may be identical or different.

Abstract: Compounds of formula A(B)x  (I), wherein x is an integer from 1 to 8, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone, isoindolinone, isoindoline, dioxazine, azo, phthalocyanine or diketopyrrolopyrrole series that is bonded to x groups B via one or more hetero atoms, those hetero atoms being selected from the group consisting of N, O and S and forming part of the radical A, each group B independently of any other(s) is hydrogen or a group of the formula  at least one group B being a group of the formula The compounds according to the invention are used in high-molecular-weight organic materials, thermo-, photo- or chemo-sensitive recording materials, light-sensitive negative or positive resist compositions, ink compositions for ink-jet printing and color tapes for thermal transfer printing.

Abstract: The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.

Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: This invention provides a free-flowing polyester dye powder which has superior stability and transparency for application in electro-photographic imaging systems. In another embodiment this invention provides novel chromophoric diester monomers which are reacted with diol monomers to form an invention polyester dye. A present invention toner composition comprises particulate polyester dye, and one or more optional components such as a charge control agent or a surfactant.

Abstract: Dyes of formula (1) ##STR1## wherein the variables are as defined in the specification and at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 or a substituent on A being --SO.sub.2 F or a substituent to which at least one --SO.sub.2 F group is attached are water-insoluble monoazo dyes useful for coloring synthetic textile materials.

Abstract: Compounds of formulaA(B).sub.x, (I),wherein x is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m and n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: A compound of the formula I ##STR1## in which D is a diazo component,K is an aromatic group of formula a, b or c, ##STR2## Y is C.sub.2-3 alkylene and the remaining symbols are as defined in the specification. These compounds are useful for dyeing or printing textile substrates based on synthetic or semisynthetic, hydrophobic, high molecular weight organic materials. Preferably, the textile substrate is made from a linear aromatic polyester, cellulose 21/2 acetate or cellulose tri-acetate. The dyeings and prints obtained show good all round fastness properties such as good thermomigration properties, lightfastness, thermofixation, blistering properties as well as good wet fastness properties, especially after thermal fixation.

Abstract: Thiazoleazo dyes useful for dyeing or printing textile fibers have the formula ##STR1## where R.sup.1 is hydrogen, substituted or unsubstituted C.sub.1 -.sub.6 -alkyl, halogen, substituted or unsubstituted C.sub.1 -C.sub.6 -alkoxy, substituted or unsubstituted C.sub.1 -C.sub.6 alkythio, substituted or unsubstituted phenylthio, C.sub.1 -C.sub.6 -alkylsulfonyl, substituted or unsubstituted phenylsulfonyl or C.sub.1 -C.sub.4 -alkoxycarbonyl,R.sup.2 is cyano, C.sub.1 -C.sub.4 -alkanoyl, benzoyl, C.sub.1 -C.sub.6 alkylsulfonyl, substituted or unsubstituted phenylsulfonyl or a radical of the formula --CH.dbd.T, where T is the radical of an acidic CH compound,R.sup.3 is hydrogen, substituted or unsubstituted C.sub.1 -.sub.6 -alkoxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, carbamoyl or mono- or di-C.sub.1 -C.sub.4 -alkylcarbamoyl,R.sup.4 is C.sub.1 -C.sub.6 -alkyl, substituted or unsubstituted C.sub.1 -C.sub.6 -alkoxy, substituted or unsubstituted C.sub.1 -C.sub.

Abstract: Certain reducible compounds are useful in analytical compositions, elements and methods, for example for the detection of bacterial cells. These compounds comprise a moiety which provides an aniline dye upon reduction. Structurally, the reducible compounds are quinones having suitable substituents which promote varying amounts of aniline dye release at physiological pH.

Abstract: The new o-aminoazo compounds of the formula ##STR1## in which the substituents D, A, R and R.sub.1 and the index n have the meaning given in the description are valuable intermediates for the preparation of metal complex dyestuffs and are also highly suitable for the dyeing of wool and polyamide.

Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.

Abstract: Disperse dyes, which produce dyeings of excellent thermomigration fastness, consisting of a chromophore and a lactam or oxime radical which detaches on heating to leave an isocyanate or isothiocyanate group, which reacts with a suitable group in the environment. The disclosed dyes are described by the formula ##STR1## where F is the radical of a dye which is free of water-solubilizing groups,B is a bridge member or a direct bond,Z is O or S andV is the radical of a group H--V, where H--V is an oxime of the formula ##STR2## or a lactam of the formula ##STR3## in which R.sup.1 and R.sup.2 are each independently of the other substituted or unsubstituted alkyl or aryl, orR.sup.1 and R.sup.2 together with the carbon atom linking them form a cycloaliphatic ring,R is hydrogen or alkyl andn is an integer from 4 to 11.

Abstract: 2-Hydrazono-4,6-dinitrobenzthiazolones of the formula ##STR1## in which X.sub.1 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -hydroxyalkyl, C.sub.1 -C.sub.4 -sulphoalkyl or C.sub.1 -C.sub.4 -sulphatoalkyl, andX.sub.2 represents hydrogen or --SO.sub.2 X.sub.3, whereX.sub.3 may represent hydrogen, C.sub.1 -C.sub.8 -alkyl or optionally substituted aryl andX.sub.1 also represents a double bond between the cyclic nitrogen atom and the carbon atom 2 according to the formula II below: ##STR2## where X.sub.2 has the meaning specified under the above formula. These hydrazones may be employed in the preparation of azo dyestuffs and as color formers for detecting of biological substances, and in the determination of H.sub.2 O.sub.2.

Abstract: Compounds of the general formula I ##STR1## where R is alkyl or unsubstituted or substituted aryl and K is a radical of the formula ##STR2## B is C.sub.1 -C.sub.4 -alkyl or substituted amino, R.sup.1 is hydrogen, methyl, methoxy or ethoxy, R.sup.2 and R.sup.3 independently of one another are each unsubstituted or substituted alkyl, R.sup.3 may furthermore be hydrogen, R.sup.4 is a radical of the formula --A--OCO--Y--R, Z is hydrogen or methyl, X is hydrogen, methyl, methoxy, chlorine or acylamino, A is C.sub.2 - or C.sub.3 -alkylene and Y is --O-- or --NH--, are very useful for dyeing cellulose esters and synthetic polyesters.

Abstract: The novel dyes of the general formula I ##STR1## where X is hydrogen or C.sub.1 14 C.sub.4 -alkyl or is phenyl which is unsubstituted or substituted by fluorine, chlorine, bromine, methyl, methoxy or nitro, Y is cyano, a carboxylic ester group or nitro, Z is cyano, acetyl, benzoyl or unsubstituted or substituted carbamyl, or X and Z or Y and Z may simultaneously be a carboxylic ester group, and R.sup.1 and R.sup.2 independently of one another are each hydrogen or unsubstituted or substituted alkyl or aryl, are very useful for dyeing polyesters, polyester/cellulose blends or thermoplastics.

Abstract: Azo compounds of the formula I ##STR1## where D=diazo componentR.sub.1 and R.sub.2 =alkyl or aralkylX=H, hydrocarbon radical or acylare useful dyestuffs or dyestuff intermediates.

Abstract: Novel compounds of the general formula I ##STR1## where X is hydrogen, nitro or unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aryl or hetaryl, Y is cyano, nitro, alkanoyl, aroyl, alkylsulfonyl, arylsulfonyl, carboxyl, a carboxylic ester group or unsubstituted or substituted carbamyl, R is unsubstituted or substituted alkyl or aryl, R.sup.1 is hydrogen or R.sup.2, and R.sup.2 is unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aralkyl or aryl, are useful for dyeing textile fibers, in particular polyesters.

Abstract: An azo dyestuff of the formula ##STR1## wherein D=a diazo component,R.sub.1 and R.sub.2 =alkyl or aralkyl,R.sub.3 =H, R or OR.sub.1 andR.sub.4 =a hydrocarbon radical or acyl,which are prepared in a simple manner by aminolysis with ammonia or an amine of the formula ##STR2## of an azo compound of the formula ##STR3## these dyestuffs dye polyester fibres in blue-green to green shades with good fastness to light.

Abstract: An isothiazolylazo dye of the formula I ##STR1## wherein R is an alkyl group or unsubstituted aryl or substituted aryl group selected from the group consisting of ##STR2## and K is a radical of the formula ##STR3## where B is C.sub.1 -C.sub.4 alkyl or a substituted amino radical selected from the group consisting of ##STR4## R.sup.1 is hydrogen, methyl, methoxy or ethoxy, R.sup.2 and R.sup.3 independently of one another are each unsubstituted C.sub.1 -C.sub.4 alkyl or substituted alkyl groups selected from the group of C.sub.1 -C.sub.4 alkyls which are substituted by chlorine, bromine, cyano, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, benzyloxy, phenoxy, phenyl, C.sub.1 -C.sub.4 -alkylcarbonyloxy which is unsubstituted or substituted by C.sub.1 -C.sub.4 -alkoxy, phenoxy or phenyl, phenycarbonyloxy which is unsubstituted or substituted by chlorine, bromine, methoxy, ethoxy, methyl or ethyl, oxycarbonyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.1 -C.sub.

Abstract: This invention relates to novel azo dyes containing a 4-nitropyrazole azo moiety which may be substituted, for example, with an alkyl group which itself may be substituted, and an aniline coupler which may be substituted. The dyes produce bright red shades on hydrophobic textile fiber including polyesters, polyamides, and cellulose esters and show unexpected improvements in one or more of such properties as fastness to light, wash, ozone, gas such as oxides of nitrogen, perspiration, crock and sublimation, dyeability at desirable low energy levels to deep shades, build, pH stability, bloom resistance, leveling, migration, dye bath exhaustion, dye transfer, and the like.

Abstract: Process for the production of triazoles of the formula ##STR1## in which R.sub.1 is hydrogen or an aliphatic or aromatic substituent conventional for diazo components of disperse dyes, which substituent is bound to the N-atom in the 1- or 2-position of the triazole nucleus through a carbon atom, andK is a coupling component radicalcomprising treating a compound of the formula ##STR2## with a dehydrating agent.

Abstract: A compound of the formula: ##STR1## where R is hydrogen, C.sub.1 -C.sub.4 -alkyl, phenyl, chlorophenyl, methylphenyl, methoxyphenyl or nitrophenyl; R.sup.1 is allyl, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkyl substituted by C.sub.1 -C.sub.8 -alkoxy, phenoxy, phenyl or C.sub.1 -C.sub.8 -alkanoyloxy, cyclopentyl, cyclohexyl, methylcyclohexyl, norbornyl, phenyl or phenyl substituted by chlorine, methyl or alkoxy; R.sup.2 is C.sub.1 -C.sub.10 -alkanoyl, C.sub.1 -C.sub.10 -alkanoyl substituted by alkoxy or phenoxy, cyclohexanoyl, benzoyl, benzoyl substituted by chlorine, methyl or methoxy, C.sub.1 -C.sub.8 -alkoxycarbonyl, aminocarbonyl, phenylaminocarbonyl, CH.sub.3 NHCO, C.sub.2 H.sub.5 NHCO, C.sub.3 H.sub.7 NHCO, C.sub.4 H.sub.9 NHCO, (CH.sub.3).sub.2 NCO, CH.sub.3 SO.sub.2, C.sub.6 H.sub.5 SO.sub.2 or p--CH.sub.3 --C.sub.6 H.sub.4 --SO.sub.2 ; or R.sup.1 and R.sup.2, together with the nitrogen atom, form a ring system, and K is a radical of a coupling component.

Abstract: Disclosed are azo dyes containing diazonium moieties from aminothiazoles, aminoisothiazoles, or aminothiadiazoles (1,2,4- or 1,3,4-), and certain coupler moieties from aniline, tetrahydroquinoline, and benzomorpholine type compounds, wherein the diazonium moieties have at least one cinnamoyl group, and wherein a wide variety of groups, e.g., one or more water-solubilizing substituents such as sulfonic acid groups or their metal or amine salts may be present in the dye molecule. These dyes are useful for dyeing materials selected from polyamide, cellulose ester, polyester, wool and other natural and synthetic fibers and generally exhibit improvements in dyeability and fastness properties.

Abstract: Aniline derivatives of the formula ##STR1## wherein X=alkyl,Z=H or alkyl, andY=S-alkyl, SO.sub.2 -alkyl, CO.sub.2 -R (R=alkyl, cycloalkyl, or H) or--if Z=H--Br,are diazo components for preparing valuable azo dyestuffs and starting materials for preparing compounds of the formula ##STR2## and new azo dyestuffs derived therefrom and which--in their nonionic form--are highly suitable for dyeing polyester fibres in blue shades having high tinctorial strength and high fastness levels.

Abstract: A monoazo compound of the formula, ##STR1## wherein X is hydrogen atom or lower alkyl group; Z is hydrogen atom, halogen atom, alkyl group, acylamino group, benzoylamino group or alkylsulfonylamino group; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently are hydrogen atom or alkyl group, provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 cannot simultaneously be hydrogen atoms; and R.sub.5 is hydrogen atom, alkyl group, substituted alkyl group, alkenyl group, cycloalkyl group, aralkyl group or phenyl group.

Abstract: This invention concerns azo dyes having the general formula ##STR1## and their preparations in which X, Y and Z are H or any of a variety of substituents, provided that at least one of X and Y must always be a substituent selected from --CN, --NO.sub.2, --CHO, and other selected groups specified herein, and A is the residue of an aniline, tetrahydroquinoline or benzomorpholine type disperse dye coupling component. These dyes which are unexpectedly non-photochromic produce red to blue shades on polyester fibers and exhibit one or more improved properties such as dyeability, dye exhaustion rate, light fastness, non-blooming, pH stability, build, fastness to ozone and nitrogen oxide, crock and wash fastness, migration, transfer, and pH stability on polyester and other fibers including cellulose ester.