The Hetero Ring Is Six-membered And Consists Of One Nitrogen And Five Carbons (e.g., Pyridine, Etc.) Patents (Class 534/770)
  • Publication number: 20140335019
    Abstract: Provided herein are compositions and methods for the treatment and analysis of neurological disorders. In particular, provided herein are small molecules targeted to amyloid-? (A?) or metal-A? species for the treatment, diagnosis, or study of neurological conditions such as Alzheimer's disease (AD) and other diseases and conditions.
    Type: Application
    Filed: November 30, 2012
    Publication date: November 13, 2014
    Inventors: Mi Hee Lim, Katayoun Saatchi, Urs Hafeli, Joo-Yong Lee
  • Publication number: 20140148416
    Abstract: The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.
    Type: Application
    Filed: September 30, 2011
    Publication date: May 29, 2014
    Applicants: KYOTO UNIVERSITY, DAITO CHEMIX CORPORATION
    Inventors: Akira Kakizuka, Seiji Hori, Hanako Ikeda, Nagahisa Yoshimura, Noriko Nakano, Toshiyuki Shudo, Tomohiro Fuchigami
  • Publication number: 20140128350
    Abstract: The present invention describes compounds of formula (I) Wherein: R1 is selected from C1-C6 alkyl, CF3, Phenyl & 2-thienyl R2 is selected from C1-C6 alkyl, phenyl & CF3 R3 is selected from H, C1-C6 alkyl, halo, NO2, NH2, haloalkyl R4 is selected from H, C1-C6 alkyl, halo, NO2, NH2, haloalkyl R5 is selected from H, C1-C6 alkyl, halo, NO2, NH2, haloalkyl R6 is selected from H, —(CH2)nC(O)OR7 & C(O)C6H4—R7 R7 is selected from C1-C6 alkyl, phenyl optionally substituted by 1-3 substituents selected from CF3, NO2 and halo. n is 0-6 These compounds have been identified as novel anticancer agents.
    Type: Application
    Filed: November 8, 2013
    Publication date: May 8, 2014
    Inventors: Ibrahim Mahmoud Abdou, Alaa EIDin Abdel Aziz Salem, Abdu Adem, Hussein F. Zhodi, Hany Abdel Aziz Al Deab
  • Publication number: 20130184241
    Abstract: The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.
    Type: Application
    Filed: July 28, 2011
    Publication date: July 18, 2013
    Applicant: KYOTO UNIVERSITY
    Inventors: Akira Kakizuka, Seiji Hori, Toshiyuki Shudo, Tomohiro Fuchigami
  • Publication number: 20130078186
    Abstract: The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.
    Type: Application
    Filed: March 23, 2011
    Publication date: March 28, 2013
    Applicant: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN
    Inventors: Erich Wanker, Thomas Wiglenda, Julius Tachu Babila, Annett Boeddrich, Michael Schmidt, Franziska Schiele
  • Publication number: 20110092621
    Abstract: The invention relates to a dye of formula (1) The also relates to the preparation of the dye and its uses.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 21, 2011
    Applicant: DyStar Colours Deutschland GmbH
    Inventors: Gunter Görlitz, Carsten Harfmann
  • Publication number: 20100011518
    Abstract: Disclosed are compounds of formula D is an aromatic or a cationic heteroaromatic group, which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, hydroxy-C1-C14alkyl, C3-C8cycloalkyl, —CN, NO2, —NR3R4, halogen, C6-C10aryl, which is optionally substituted or C1-C14alkyl, or by one or more groups Z; E1 and E2 independently from each other are ?CH; or ?N—; K is an aromatic or heteroaromatic group which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, C3-C8cycloalkyl, C6-C10aryl, halogen, hydroxy, NO2, —NR3R4, —N(R3)(CO)R4, —SO2NR1R2, —SONR1R2 or by one or more Z; or a radical of formula —NR1R2; R1 and R2 independently from each other are hydrogen; C1-C14alkyl; cyclo-C1-C14alkyl; C6-C10aryl; an aromatic or heteroaromatic group which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, C3-C8cycloalkyl, C6-C10aryl, halogen, hydroxy, —NR5R6, —N(R5)—(CO)R5 or by Z; Z is a group of the formula (1a) *—X1—Y1—W1, wherein X1 is the direct bond; —NR7—; —O—; —NR7(C?O)—; —(CO)NR7—; —O(C?O)—; —(CO)O—; or —
    Type: Application
    Filed: June 4, 2007
    Publication date: January 21, 2010
    Inventors: Christian Cremer, Olof Wallquist, Victor Paul Eliu, Kishor Ramachandra Nivalkar
  • Patent number: 7648943
    Abstract: An azo dye represented by formula (II) as defined in the specification, a process of producing the same and a coloring composition containing the azo dye.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: January 19, 2010
    Assignee: Fujifilm Corporation
    Inventors: Toshiki Fujiwara, Yoshihiko Fujie, Yoshiharu Yabuki, Masaru Takasaki
  • Patent number: 7569516
    Abstract: The present invention relates to a new class of plant growth regulators. In particular, the invention relates to 5-substituted-1-arylpyrazole-3-carboxylic acid derivative of general formula (I) and a method for treatment of plants with such compounds in order to induce growth regulating responses.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: August 4, 2009
    Assignee: Bayer CropScience AG
    Inventors: Henricus Bastiaans, Gunter Donn, Nathalie Knittel, Arianna Martelletti, Richard Rees, Michael Schwall
  • Patent number: 7405280
    Abstract: The invention relates to chromogenic compounds and the use thereof for the determination of enzymes of the family of carboxypeptidases N and carboxypeptidases U. The above is more specifically a compound of formula (I) in which A=(1), (2), (3), (4) or (5), R1, R2=H, —CH3, —CH(CH3)2, —OCH3, —Cl,—CF3,—OCF3,—SCH3, R3=an amino acid group which may be hydrolysed by a carboxypeptidase A and R4=a basic amino acid group.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: July 29, 2008
    Assignee: Diagnostica Stago
    Inventor: Gérard Quentin
  • Publication number: 20080119643
    Abstract: The present invention provides 4,4?-diazobenzanilide derivatives, a process for their preparation, their use as dyes, dyed paper, formulations comprising them and also precursors thereof and their processes of preparation.
    Type: Application
    Filed: October 10, 2005
    Publication date: May 22, 2008
    Inventors: Michael Lennartz, Holger Lautenbach
  • Patent number: 7029502
    Abstract: The present invention relates to an azo dye of formula wherein D is the radical of a diazo component of the benzene, naphthalene, diphenyl, thiophene, benzothiazole, benzisothiazole, thiadiazole, indazole, benzotriazole, pyrazole, anthraquinone, naphthalic acid imide, chromone, phthalimide or diphenylene oxide series, R1 is an unsubstituted or substituted aryl radical and R2 is an unsubstituted or substituted aryl radical, with the exception of the compounds of formulae (1a) and (1b) to a process for its preparation and to its use in a process for the production of mass-colored plastics or polymeric color particles, and in the dyeing or printing of semi-synthetic or synthetic hydrophobic fiber materials.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: April 18, 2006
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Antoine Clément, Anton Andreoli, Urs Lauk, Athanassios Tzikas
  • Publication number: 20040089200
    Abstract: A coloring composition for image formation comprising an azo dye having an aromatic nitrogen-containing 6-membered heterocyclic ring as a coupling component, a coloring composition which comprises an azo compound having an oxidation potential nobler than 1.0 V vs. SCE and comprising at least two substituents having a pKa value of −10 to 5 in water, and a method for improving ozone resistance of a color image, the method comprising using a compound having an oxidation potential nobler than 1.0 V vs. SCE and showing a maximum absorption at a wavelength between 500 nm and 580 nm with a half-value width of 150 nm or narrower.
    Type: Application
    Filed: September 12, 2003
    Publication date: May 13, 2004
    Inventors: Toshiki Fujiwara, Naoyuki Hanaki, Shigeaki Tanaka, Tadashi Omatsu, Yoshiharu Yabuki
  • Publication number: 20030186947
    Abstract: Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
    Type: Application
    Filed: February 11, 2003
    Publication date: October 2, 2003
    Inventors: Jayasree Vasudevan, Alan T. Johnson, Liming Wang, Roshantha A. Chandraratna
  • Publication number: 20030109687
    Abstract: Compounds of the formula
    Type: Application
    Filed: August 5, 2002
    Publication date: June 12, 2003
    Inventors: Tae K. Song, Min Teng, Roshantha A. Chandraratna
  • Patent number: 6506431
    Abstract: The spore germination inhibitor of the invention is 6-carbamoyl-2-pyridine carboxylic acid which is produced by a microorganism of genus Bacillus, such as Bacillus subtilis, and can inhibit germination of sporogenous bacteria resulting in the prevention of spoilage and putrefaction of foods, particularly in combination with D-alanine.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: January 14, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Katsunori Kobayashi, Shigeru Yamanaka, Tomomi Kuwahara, Hiroshi Miyano, Kohki Ishikawa, Ryosuke Fudou
  • Patent number: 6492502
    Abstract: Azo compounds of the 2-(4-amino)phenyldiazinecarboximidamide type and 2-(4-amino)phenylhydrazinecarboximidamide type, a process for their synthesis, their use for dyeing keratin fibers, dye compositions containing them, and dyeing processes.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: December 10, 2002
    Assignee: L'Oreal, S.A.
    Inventors: Jean-Christophe Henrion, Michel Philippe
  • Publication number: 20020183285
    Abstract: Compounds having Formulas 5 and 6 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
    Type: Application
    Filed: March 14, 2002
    Publication date: December 5, 2002
    Inventors: Jayasree Vasudevan, Alan T. Johnson, Liming Wang, Dehua Huang, Roshantha A. Chandraratna
  • Patent number: 6162417
    Abstract: Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I, .sup.75 Br, .sup.76 Br, .sup.77 Br, .sup.82 Br, .sup.18 F, or .sup.210 At; small alkyl, small alkenyl, or small alkynyl, any of which contains from one to about six carbon atoms and optionally having a carbon atom replaced by an O or S; or halogen substituted-small alkyl, halogen substituted-small alkenyl, or halogen substituted-small alkynyl wherein said compound contains at least one radioacitve halogen.The compounds bind to the serotonin transporter. Depending upon the choice of halogen substituent, the compounds are useful for PET or SPECT imaging, diagnosis and treatment of psychiatric disorders such as depression, anxiety, obsessive-compulsive disorder, and other conditions associated with defects of serotonin transporter function.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: December 19, 2000
    Assignee: Emory University
    Inventors: Mark M. Goodman, Bing Z. Shi
  • Patent number: 6133432
    Abstract: A process for preparing a compound of the formula ##STR1## wherein R is C.sub.1 -C.sub.18 alkyl by reacting a compound of the formulaRO.sub.2 C--CH.sub.2 CN (II)with a cyanide salt and formaldehyde or source thereof. Compounds of formula (I) are useful intermediates to pesticidally active compounds.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: October 17, 2000
    Assignee: Rhone-Poulenc Agro
    Inventors: David William Hawkins, David Alan Roberts, John Harry Wilkinson, Jean-Louis Clavel
  • Patent number: 6046312
    Abstract: Disclosed are water soluble azo dyes, represented by Formula I or II, and their synthesis and use. The water soluble azo dyes are synthesized by diazotizing 4-aminopyridine and coupling the resulting diazo intermediate with alkylated metanilic or orthanilic acid. To be suitable for measuring blood glucose levels, the dyes are combined with m-nitrophenyl boronic acid in an aqueous solvent. A combined ao form of the dyes with glucose shows a peak at 540 nm. At this wavelength, the absorptivity has a tendency to increase with the increasing of glucose level, which allows the measurement of blood glucose levels. ##STR1## wherein R has a 1-4 carbon atom length and is an alkyl, a hydroxy alkyl, a carboxyl-containing alkyl, or a sulfonyl-containing alkyl.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: April 4, 2000
    Assignee: Dongil Technology Ltd.
    Inventors: Han-chul Song, Kwang-nak Koh, Shin-won Kang, Jin-ho Cho, Joohg-hun Kim, Su-mi Lee
  • Patent number: 5747345
    Abstract: Diaza-18-crown-6 compounds of the formula I: ##STR1## wherein X is a phenol, naphthol or quinolinol moiety selected from those of the formulae: ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from hydrogen, halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, acetamido, mercapto, alkyl or arylsulfonyl, trifluoromethyl, aryl, and substituted aryl wherein the aryl moiety is selected from phenyl and naphthyl and the aryl substituent is selected from halo, cyano, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.2 -C.sub.8) acyl, phenyl, acetamido, mercapto, alkyl or arylsulfonyl and trifluoromethyl; provided that when R.sub.1, R.sub.2, R.sub.3 and R.sub.5 are hydrogen and X is phenol, R.sub.4 is not nitro; and provided that when X is phenol and R.sub.5 is hydrogen, R.sub.1 (or R.sub.2) and R.sub.4 are not both nitro.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: May 5, 1998
    Assignee: Johnson & Johnson Clinical Diagnostics, Inc.
    Inventors: Wayne Woodrow Weber, II, Calvin Roman Messing, Margaret Elizabeth Logan
  • Patent number: 5723586
    Abstract: Disperse dyes of the general formula I ##STR1## wherein D signifies a diazo component which is usual with disperse dyes,K signifies an aromatic radical of formula ##STR2## Y signifies ##STR3## and the other symbols have the meanings as defined in claim 1, are useful for dyeing or printing hydrophobic, fully or half-synthetic organic fiber materials.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: March 3, 1998
    Assignee: Clariant Finance (BVI) Limited
    Inventor: Ruedi Altermatt
  • Patent number: 5633355
    Abstract: The disperse dyes of formula I ##STR1## wherein the symbols D, K, R.sub.3-5, R.sub.10, m, z, n and Y possess the significances given in claim 1, are eminently suitable for dyeing or printing hydrophobic, fully or semi-synthetic, organic fiber materials.
    Type: Grant
    Filed: November 7, 1995
    Date of Patent: May 27, 1997
    Assignee: Sandoz Ltd.
    Inventor: Ruedi Altermatt
  • Patent number: 5612221
    Abstract: Avidin-binding azo reagents which alter the spectrophotometric properties of avidin and the use of such reagents in homogeneous assays are described.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: March 18, 1997
    Assignee: Dade Chemistry Systems Inc.
    Inventors: Donald M. Simons, Susan Y. Tseng, Patricia C. Weber
  • Patent number: 5545400
    Abstract: A deodorant containing an azo metal complex expressed by the following structural formula 1, which is produced by mixing a solution in which azo compounds to be ligands are dissolved with a solution in which a metal salt is dissolved: ##STR1## In the structural formula 1, M represents a metal element, R.sub.1 and R.sub.2 represent aromatic compounds, which may be the same or different from each other, and R.sub.3 and R.sub.4 represent aromatic compounds or heterocyclic compounds, which may be the same or different from each other. In addition, either one or both of nitrogen atoms in an azo base in each of the legends may be coordinated to the metal M.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 13, 1996
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Masakazu Sakata, Hiroyuki Fujii, Yuji Hamada, Kenichi Shibata, Yoshitaka Nishio
  • Patent number: 5532342
    Abstract: An azo metal chelate compound of an azo compound of the formula (I) with a metal: ##STR1## wherein A is a residue forming a heterocyclic ring together with the carbon atom and the nitrogen atom to which it is bonded, X is a residue forming an aromatic group together with the two carbon atoms to which it is bonded, R.sup.1 is an alkyl group which may be substituted, an aryl group which may be substituted, an alkenyl group which may be substituted, or a cycloalkyl group which may be substituted, Y is a hydrogen atom or a cation, and n is an integer of from 1 to 3.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: July 2, 1996
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Tameichi Ochiai, Yutaka Kurose, Takumi Nagao, Takako Tsukahara, Satoru Imamura
  • Patent number: 5468848
    Abstract: The new basic azo dyestuffs of the formula ##STR1## wherein the symbols have the meaning given in the description, are suitable for dyeing synthetic and naturally occurring substrates which can be dyed with basic dyestuffs.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: November 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karin Hassenruck, Peter Wild
  • Patent number: 5328994
    Abstract: New azinoneutromethines of the formula ##STR1## in which the symbols used have the meaning given in the description, a process for their preparation and their use in thermal and photochromic recording materials, as nonlinear optical materials, as photoconductors in electrophotography and for dyeing fibres and woven fabrics of polyester and plastics.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: July 12, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Berneth, Karin Hassenruck
  • Patent number: 5310888
    Abstract: Disclosed are arylazo chromoionophores characterized by the formula: ##STR1## wherein X is hydrogen or a monovalent cation, Y is H or methoxy and R is a ringed aromatic organic structure which affects the optical absorption properties of the compounds. Also disclosed is a method for the detection of calcium ion using these compounds.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: May 10, 1994
    Assignee: Miles Inc.
    Inventors: Michael L. Bloczynski, Thomas Boecker, Paul F. Corey
  • Patent number: 5298608
    Abstract: A metal chelate compound comprising a monoazo compound of the following formula (I): ##STR1## (wherein A is a residue forming a hetero ring together with the carbon atom and the nitrogen atom to which it is bonded, B is a residue forming an aromatic group together with the two carbon atoms to which it is bonded, and X is a hydrogen atom or a cation), and a metal, and an optical recording medium comprising a substrate and a recording layer formed thereon for information to be written in and/or read out by laser, wherein said recording layer contains the metal chelate compound comprising a monoazo compound of the above formula (I) and a metal.
    Type: Grant
    Filed: January 16, 1992
    Date of Patent: March 29, 1994
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Tetsuo Murayama, Shuichi Maeda, Chiyoko Fukabori, Takumi Nagao
  • Patent number: 5290756
    Abstract: Compounds of the formula: ##STR1## wherein X is hydrogen, halo, trihalomethyl, alkyl, nitroor cyano; X.sup.1 is hydrogen, halo, or trihalomethyl; R.sup.1 and R.sup.2 are hydrogen, alkyl phenyl or benzyl; n is 1 to 5, and Z is halo, cyano, nitro, trihalomethyl, methylthio, methylsulfinyl, methylsulfonyl, acetyl, phenyl, or heterocycle, and compositions containing these compounds exhibit herbicidal activity.
    Type: Grant
    Filed: June 8, 1982
    Date of Patent: March 1, 1994
    Assignee: Rohm and Haas Company
    Inventors: Colin Swithenbank, Ted Fujimoto
  • Patent number: 5278294
    Abstract: A monoazodye of the following formula (I): ##STR1## wherein X is CN, Cl or Br, one of R.sup.1 and R.sup.2 is phenyl and the other is --C.sub.2 H.sub.4 OC.sub.2 H.sub.4 OR.sup.3, wherein R.sup.3 is C.sub.1 -C.sub.5 alkyl, formyl, C.sub.2 -C.sub.6 alkylcarbonyl or C.sub.2 -C.sub.6 alkoxycarbonyl.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: January 11, 1994
    Assignee: Hoechst Mitsubishi Kasei Co., Ltd.
    Inventors: Kiyoshi Himeno, Ryouichi Sekioka
  • Patent number: 5262330
    Abstract: A chromogenic compound found to be especially selective in the determination of calcium in blood of the general formula (I): ##STR1## where: R is hydrogen or lower alkyl;X is CH.sub.2, CH.sub.2 CH.sub.2, CH.dbd.CH, O, S, SO.sub.2, S--S, or NR;X is CH, C--OH or N;M is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinoneimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo, or isothiazolyl-5-azo;k is 1;l is 0 or 1; andn is 0 or 1.
    Type: Grant
    Filed: February 27, 1992
    Date of Patent: November 16, 1993
    Assignee: Miles Inc.
    Inventors: Eddy Chapoteau, Bronislaw P. Czech, Wolodymyr I. Zazulak
  • Patent number: 5245021
    Abstract: Named compounds are useful in making dry analytical elements for assaying lithium in serum. The compounds have the general structure: ##STR1## wherein R, R.sub.1, R.sub.2 and X are as presented below:______________________________________ R R.sub.1 R.sub.2 X ______________________________________ n-C.sub.12 H.sub.25 SO.sub.2 CH.sub.3 CH.sub.3 CH n-C.sub.12 H.sub.25 NO.sub.2 CH.sub.3 CH CH.sub.3 SO.sub.2 N(n-C.sub.6 H.sub.13).sub.2 CH.sub.3 CH CH.sub.2 C.sub.6 H.sub.5 SO.sub.2 N(n-C.sub.6 H.sub.13).sub.2 CH.sub.3 CH CH.sub.2 C.sub.6 H.sub.5 SO.sub.2 N(CH.sub.3)-n-C.sub.18 H.sub.37 CH.sub.3 CH CH.sub.3 NO.sub.2 n-C.sub.7 H.sub.15 CH n-C.sub.12 H.sub.25 H CH.sub.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: September 14, 1993
    Assignee: Eastman Kodak Company
    Inventors: Ronald H. Engebrecht, Thomas R. Welter
  • Patent number: 5215578
    Abstract: An ink composition that includes water, a water-soluble organic solvent and a dye. The dye is represented by the following Formula, in which the number of sulfonic acid groups and the number of amino groups are each not less than 2, and the number of sulfonic acid groups is less than that of amino groups: ##STR1## Q.sub.1 denotes a substituted phenyl group, pyridyl group or naphthyl group; Q.sub.2 denotes a substituted or unsubstituted p-phenylene group or 1,4-naphthylene group; Q.sub.3 is a SO.sub.3 M-substituted or unsubstituted diaminopyridyl group or a diaminophenyl group substituted by COOM or SO.sub.3 M; M denotes an alkaline metal, ammonium or organic ammonium; and n denotes 0 or 1.
    Type: Grant
    Filed: January 2, 1992
    Date of Patent: June 1, 1993
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tsuyoshi Eida, Mayumi Yamamoto, Takao Yamamoto
  • Patent number: 5196521
    Abstract: The dyes of the formula ##STR1## in which R.sub.1 is hydrogen, halogen or CF.sub.3 and R.sub.2 is substituted or unsubstituted alkyl, where R.sub.2 must not be ethoxycarbonylethyl if R.sub.1 is hydrogen are suitable for the dyeing of polyester material in red hues having very good lightfastness.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: March 23, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Visvanathan Ramanathan, Angelo D. Casa
  • Patent number: 5093308
    Abstract: Azo dyes useful for thermotransfer printing have the formula ##STR1## where R.sup.1 and R.sup.2 are each H; alkyl, alkoxyalkyl, alkanoyloxyalkyl, alkoxycarbonyloxyalkyl, alkoxycarbonylalkyl, haloalkyl, hydroxyalkyl or cyanoalkyl each of up to 20 carbon atoms and each of which may be substituted by phenyl, C.sub.1 -C.sub.4 -alkylphenyl, C.sub.1 -C.sub.4 -alkoxyphenyl, halophenyl, benzyloxy, C.sub.1 -C.sub.4 -alkylbenzyloxy, C.sub.1 -C.sub.4 -alkoxybenzyloxy, halobenzyloxy, halogen, hydroxyl or cyano; phenyl or cyclohexyl which may each be substituted by C.sub.1 -C.sub.15 -alkyl, C.sub.1 -C.sub.15 -alkoxy, halogen or benzyloxy; or a radical II[--W--O].sub.n --R.sup.4 IIwhere W is identical or different C.sub.2 -C.sub.5 -alkylene, n is 1-6, R.sup.4 is C.sub.1 -C.sub.4 -alkyl or phenyl which may be substituted by C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, R.sup.3 is H, NH.sub.2, OH or C.sub.1 -C.sub.3 -alkyl, X is H, Cl, Br, No.sub.2, methyl, phenoxy, tolyloxy, dimethylphenyloxy, chlorophenoxy or C.sub.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: March 3, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Ruediger Sens, Gunther Lamm, Karl-Heinz Etzbach
  • Patent number: 5077200
    Abstract: Chromogenic substrates for the detection of hydrolyzing enzymes, processes for the preparation of these chromogenic substrates and the use of the chromogenic substrates.The quantification of hydrolyzing enzymes for diagnostic purposes has to date been carried out by determination of the amounts of a fluorescent or highly absorbent chromogenic dyestuff liberated in the hydrolytic reaction, detection of which has in part been possible exlusively by instruments or in the neutral to alkaline pH range. After enzymatic hydrolysis, the chromogenic substrates according to the invention lead to highly sensitive and specifically measurable signals regardless of the pH range.Azo dyestuff compounds with the general formulaA--N.dbd.N--B (OR)in which A) and B) have the meanings given in claim 1 andR) is a radical which can be liberated by enzymatic hydrolysis, excluding a carbonyl radical,are provided.After enzymatic hydrolysis, highly sensitively and specifically measurable signals are obtained regardless of the pH range.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: December 31, 1991
    Assignee: Behringwerke Aktiengesellschaft
    Inventor: Klaus Habenstein
  • Patent number: 5071968
    Abstract: Azo dyes of the formula ##STR1## where D is a diazo component, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of the others hydrogen or substituted or unsubstituted C.sub.1 -C.sub.8 alkyl, and n is 1,2,3,4 or 5, produce dyeings of good fastness properties on nitrogen-containing or hydroxyl-containing fibre materials.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: December 10, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Harald Walter
  • Patent number: 5043269
    Abstract: A novel chromogenic substrate to peroxidase enzymes is provided which is comprised of a mixture of a colorless mixture of two compounds, such as, 3-methyl-2-benzothiazolinone hydrazone and 2-hydroxy-2,4,6-cycloheptatrienone, which undergo an oxidative coupling in the presence of peroxidase and hydrogen peroxide forming a purple indamine dye. Under certain circumstances the dye will precipitate out from the buffered solution and thus provide a permanent record of the determination. The mixture is also stable and unaffected by oxygen of the air or by hydrogen peroxide.
    Type: Grant
    Filed: February 16, 1988
    Date of Patent: August 27, 1991
    Inventor: Spyros Theodoropulos
  • Patent number: 5038415
    Abstract: A disperse dye composition comprising (a) a pyridone monoazo compound of the formula (I), ##STR1## wherein X.sup.1 and X.sup.2 are each hydrogen, halogen, alkyl, alkoxy or others, and R.sup.1 is alkyl, alkenyl, cycloalkyl, phenyl or anilino, and (b) a pyridone monoazo compound of the formula (II). ##STR2## wherein X.sup.3 and X.sup.4 are each hydrogen, halogen, alkyl, alkoxy or others, and R.sup.2 is alkyl, alkenyl, cycloalkyl, phenyl or anilino, optionally together with (c) a quinophthalone compound of the formula (III), ##STR3## wherein Y is hydrogen or bromine, and the ring A is unsubstituted or substituted benzene or naphthalene ring, which is useful as a yellow dye component for dyeing or printing hydrophobic fiber materials with superior dye bath stability and level dyeing property.
    Type: Grant
    Filed: January 9, 1990
    Date of Patent: August 13, 1991
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yasuyoshi Ueda, Junichi Sekihachi, Takashi Omura, Hideo Hattori, Kiyoharu Nakatsuka
  • Patent number: 5037968
    Abstract: Keto compounds in which to the carbon atom in the neighboring position to the keto compounds there is bonded at least one strongly electron attracting substituent and/or in which there is conjugating with the carbon-oxygen-double bond of the keto group a .pi.-electron system have the ability of interacting selectively with the anions of oxa acids yielding adducts, chelates or complexes.Provided that in the corresponding keto compounds the keto group is a part of a chromophore, then the shifting of the absorption in the visible range or the ultraviolet range of the wave lengths is observed, compared with the corresponding absorption of the free keto compound.The corresponding keto compounds are used for the determination of the anions of the oxa acids and they e.g. can be the ion sensitive component of a corresponding ions sensitive part for the determination of said anions. Several of said keto compounds can be also used as color indicator for the anions of the oxa acids.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: August 6, 1991
    Assignee: Willi Moller
    Inventors: Wilhelm Simon, Erno Pretsch
  • Patent number: 4880431
    Abstract: A monoazo compound of the following formula, ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen or alkyl, R.sub.4 is alkyl or carboxy, A is ##STR2## in which R.sub.5 is hydrogen, methyl, methoxy, ethoxy, sulfo or carboxy, X is hydrogen or sulfo, n is 0 or 1, and the asterisked linkage bonds to the azo group, B.sub.1 and B.sub.2 are independently phenylene or naphthylene, W is hydrogen, carbamoyl, sulfoalkyl, cyano, sulfo, chloro or bromo, and Y.sub.1 and Y.sub.2 are independently --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.2 OSO.sub.3 H or the like, which is useful for dyeing hydroxy group- or carbonamide group-containing materials in a deep yellow color excellent in various fastness properties such as light fastness, perspiration-light fastness and chlorine fastness.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: November 14, 1989
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kazufumi Yokogawa, Naoki Harada, Takashi Omura
  • Patent number: 4861344
    Abstract: Water-soluble azo compounds having useful fiber-reactive dye properties conforming to the general formula ##STR1## in which: A is phenylene which may be substituted or unsubstituted, or is a radical of the formula ##STR2## in which W is a direct bond or a radical of the formula --CH.dbd.CH-- or --NH--CO--NH-- and R* denotes hydrogen, nitro, sulfo, carboxy, methyl, ethyl, methoxy or ethoxy;n is the number zero or 1;B is a radical of the formula ##STR3## where R is equal to carboxy or carbamoyl; M is hydrogen or an alkali metal; andK is one of five radicals described in the specification, each of which contains a fiber-reactive group.These azo compounds produce fast dyeings on carboxamido- and/or hydroxy-containing materials, in particular cellulose fibers. On cellulose, fast dyeings are also obtained in a weakly acid to neutral medium, for example together with disperse dyes for dyeing a polyester fiber portion.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ludwig Schlafer, Hartmut Springer, Reinhard Hahnle
  • Patent number: 4837308
    Abstract: A universally usable process for preparing azo dyestuffs by oxidative coupling consists in carrying out the oxidation in the presence of redox mediators with a standard potential of 0.2-1.5 volts and, if appropriate, an additional oxidizing agent with a standard potential of 0.25-2.5 volts, wherein the sum of the oxidation equivalents should be at least 4. The preferred redox mediator is iodine. The process is particularly suitable for the preparation of heteroaromatic azo dyestuffs using an aniline coupling component.
    Type: Grant
    Filed: January 12, 1988
    Date of Patent: June 6, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventor: Rainer Gerlach
  • Patent number: 4826531
    Abstract: Acrylic acid derivatives having the formula (I): ##STR1## and stereoisomers thereof, wherein W is R.sup.1 O.sub.2 C--C.dbd.CH--ZR.sup.2, R.sup.1 and R.sup.2 are alkyl or fluoroalkyl groups, and Z is oxygen or sulphur; A, B, D and E are hydrogen, halogen, hydroxy or optionally substituted alkyl, alkoxy, aralkyl, arylalkoxy, alkenyl, alkynyl, aryl, aryloxy, arylthio, heteroaryloxy, heteroarylthio, acyloxy, amino, arylazo or acylamino, nitro, cyano, --CO.sub.2 R.sup.3, --CONR.sup.3 R.sup.4, --COR.sup.3, --CR.sup.3 .dbd.NR.sup.4, --N.dbd.CR.sup.3 R.sup.4 or --S(O).sub.n R.sup.3 groups; any two of the groups A, B, D and E, when they are in adjacent positions on the ring, optionally join to form a fused ring, n is 0, 1 or 2; and R.sup.3 and R.sup.4 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl or optionally substituted aryl or aralkyl; and metal complexes thereof. These compounds are useful as fungicides, insecticides, nematicides or plant growth regulators.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: May 2, 1989
    Assignee: Imperial Chemical Industries PLC
    Inventors: Vivienne M. Anthony, John M. Clough, Paul DeFraine, Christopher R. A. Godfrey, Patrick J. Crowley, Kenneth Anderton
  • Patent number: 4800195
    Abstract: Novel N-phenyl-N'benzoylureas which are useful as insecticides and acaricides.
    Type: Grant
    Filed: October 13, 1983
    Date of Patent: January 24, 1989
    Assignee: The Dow Chemical Company
    Inventors: Michael J. Burgess, Robert A. Sewell, David P. Clifford
  • Patent number: 4795746
    Abstract: Novel N-phenyl-N'benzoylureas which are useful as insecticides and acaricides.
    Type: Grant
    Filed: March 4, 1988
    Date of Patent: January 3, 1989
    Assignee: The Dow Chemical Company
    Inventors: Michael J. Burgess, David P. Clifford, Robert A. Sewell
  • Patent number: 4704452
    Abstract: Monoazo compounds of the formula ##STR1## in which one of the two substituents R.sub.1 or R.sub.2 or both substituents are C.sub.3 -C.sub.8 -alkyl or a group of the formula ##STR2## in which R.sub.3 and R.sub.4 are independently of each other hydrogen or C.sub.1 -C.sub.4 -alkyl and R.sub.5 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkyl and the other of the two substitutents R.sub.1 or R.sub.2, when the two are not C.sub.3 -C.sub.8 -alkyl or a group of the formula (1a), is hydrogen, halogen or C.sub.1 -C.sub.4 -alkyl, and KK is the radical of a coupling component which is free of water-solubilizing groups the two described. These compounds can be used as dyes for dyeing or printing for example polyester fibre materials.
    Type: Grant
    Filed: December 19, 1985
    Date of Patent: November 3, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Peter Liechti