Azo Bonded Directly To The Hetero Ring Or To A Polycyclo Ring System Which Contains The Hetero Ring As One Of The Cyclos Patents (Class 534/753)
  • Patent number: 10259788
    Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 16, 2019
    Assignee: University of Notre Dame du Lac
    Inventors: William F. Schneider, Joan F. Brennecke, Edward J. Maginn, Elaine Vazquez, Burcu Gurkan, Erica Price, Brett Goodrich
  • Patent number: 9951008
    Abstract: Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: April 24, 2018
    Assignee: University of Notre Dame du Lac
    Inventors: William F. Schneider, Joan F. Brennecke, Edward J. Maginn, Elaine Mindrup, Burcu Gurkan, Erica Price, Brett Goodrich
  • Patent number: 9023118
    Abstract: The present invention relates to new azo dyes, a process for their preparation, and their use for dyeing or printing fibrous materials, to produce materials with brownish shades.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: May 5, 2015
    Assignee: Kemira OYJ
    Inventors: Helmut-Martin Meier, Christof Heide, Klaus-Günter Strumpf, Thomas Hübbe
  • Publication number: 20150080560
    Abstract: Laundry care compositions comprising thiophene azo carboxylate fabric shading dyes and methods of treating a textile comprising such laundry care compositions.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 19, 2015
    Inventors: Eduardo Torres, Gregory Scot Miracle
  • Publication number: 20150080561
    Abstract: The present invention relates to laundry care compositions comprising carboxylate dyes. The laundry care compositions can be laundry detergent compositions, laundry additive compositions such as fabric enhancer compositions or bleach additive compositions. Preferably, the laundry care composition is a laundry detergent composition. The composition can be a solid, such as a powder, tablet or bar, or a liquid. The composition can be in the form of a unit dose, such as pouch. Suitable unit dose pouches include single compartment and multi-compartment pouches.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 19, 2015
    Inventors: Eduardo Torres, Sanjeev Kumar Dey, Gregory Scot Miracle
  • Patent number: 8747537
    Abstract: The invention relates to an ink which comprises: a low-polarity solvent having a relative permittivity of 3 or less at a measuring frequency of 1 kHz; and a specific heterocyclic azo dye.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: June 10, 2014
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Yasushi Shiga, Utako Takeda, Shoko Ichinosawa, Mio Ishida
  • Publication number: 20130188238
    Abstract: The invention relates to an ink which comprises: a low-polarity solvent having a relative permittivity of 3 or less at a measuring frequency of 1 kHz; and a specific heterocyclic azo dye.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 25, 2013
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventor: MITSUBISHI CHEMICAL CORPORATION
  • Publication number: 20130078186
    Abstract: The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.
    Type: Application
    Filed: March 23, 2011
    Publication date: March 28, 2013
    Applicant: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN
    Inventors: Erich Wanker, Thomas Wiglenda, Julius Tachu Babila, Annett Boeddrich, Michael Schmidt, Franziska Schiele
  • Publication number: 20120309945
    Abstract: This application relates to thiophene azo carboxylate dyes for use as hueing agents, laundry care compositions comprising such dyes that may serve as hueing agents, processes for making such dyes and laundry care compositions and methods of using the same. The aforementioned dyes contain a formally charged moiety and are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. Suitable chromophore components generally fluoresce blue, red, violet, or purple color when exposed to ultraviolet light, or they may absorb light to reflect these same shades. Such dyes are advantageous in providing a hueing effect, for example, a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. Such dyes are also generally stable to bleaching agents used in laundry care compositions.
    Type: Application
    Filed: May 24, 2012
    Publication date: December 6, 2012
    Inventors: Eduardo Torres, John D. Bruhnke, Sanjeev K. Dey, Gregory S. Miracle
  • Patent number: 8247479
    Abstract: The invention, relates to azo-compounds of formula (I), wherein >N—O—R substituted 2,2,6,6-tetraalkyl-piperidyl groups are present. These azo-compounds have excellent flame retardant properties, either if applied alone, or combined with other compounds, having flame retardant properties.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: August 21, 2012
    Assignee: BASF SE
    Inventors: Michael Roth, Rudolf Pfaendner, Carl-Eric Magnus Wilén, Melanie Aubert
  • Publication number: 20120130058
    Abstract: Method of synthesizing a compound of formula (I), wherein R1, R2 are, independently, chloro or fluoro, and wherein R3 is H, alkyl, aralkyl or is an alkylether or alkylthioether comprising the steps of firstly reducing a diazeny compound of formula (II) non-catalytically or with a catalytic amount of an homogenous organic, non-metal catalyst to the corresponding hydrazo compound of formula (III) and in a second step catalytically hydrogenating said hydrazo compound in with a heterogeneous Ni-catalyst to the compound of formula (I).
    Type: Application
    Filed: January 5, 2012
    Publication date: May 24, 2012
    Inventors: Wilhelm Quittmann, Wei Zhu, Feng Ye, Rongmin Chen
  • Patent number: 8088182
    Abstract: The present invention relates to dyes of formula wherein D, R1, R2, R3, R4 and n are defined as in the claims, to the process for the preparation thereof and to the use thereof in dyeing or printing semi-synthetic and especially synthetic hydrophobic textile materials, more especially textile materials.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: January 3, 2012
    Assignee: Huntsman International LLC
    Inventors: Ralf Petermann, Christian Suppiger, Urs Lauk
  • Publication number: 20110237783
    Abstract: Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
    Type: Application
    Filed: December 23, 2010
    Publication date: September 29, 2011
    Applicant: Valocor Therapeutics, Inc.
    Inventors: Zaihui Zhang, Timothy S. Daynard, Mikhail A. Chafeev, Shisen Wang, Gregory B. Chopiuk, Serguei V. Sviridov
  • Publication number: 20110218330
    Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.
    Type: Application
    Filed: March 24, 2011
    Publication date: September 8, 2011
    Applicant: AstraZeneca AB
    Inventors: Ulf Larsson, Mattias Magnusson, Tibor Musil, Andreas Palmgren
  • Publication number: 20110197377
    Abstract: The present invention relates to dyes of formula wherein R1 and R2 are each independently of the other hydrogen, vinyl, allyl or C1-C6alkyl which is unsubstituted or substituted by cyano, carboxy, hydroxy, C1-C6alkoxy or C6-C24aryl, R3 is hydrogen, C1-C6alkyl or C6-C24aryl, R4 is hydrogen, C1-C6alkyl or C6-C24aryl, 2-Cyano-C1-C6alkyl, 2-Alkoxy-C1-C6alkyl, 2-Oxo-C1-C6alkyl, n is 0, 1 or 2, and D denotes a radical of formula (2), (3), (4), (5), (6) or (7) wherein R5 is hydrogen, nitro, cyano or halogen, R6 and R7 are each independently of the other hydrogen, nitro, cyano or halogen, R8 and R9 are each independently of the other hydrogen, nitro, cyano or halogen, R10 and R11 are each independently of the other nitro, cyano, trifluoromethyl, carboxy, C1-C6alkyl, C1-C6alkoxy, C1-C6acylamino or halogen, R12 and R13 are each independently of the other hydrogen, nitro, cyano, trifluoromethyl, carboxy, C1-C6alkoxycarbonyl, C1-C6alkylsulfonyl, C1-C6alkylsulfonylamino, C1-C6acylamino or halogen, R14 represen
    Type: Application
    Filed: September 23, 2009
    Publication date: August 18, 2011
    Applicant: Huntsman International LLC
    Inventors: Ralf Petermann, Christian Suppiger, Urs Lauk
  • Patent number: 7988776
    Abstract: A coloring composition containing an azo dye of the following formula (1): wherein R1, R2, R3 and R6 represent a monovalent substituent; R5 represents a hydrogen atom or a monovalent substituent; n is 0 to 4.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: August 2, 2011
    Assignee: Fujifilm Corporation
    Inventors: Yoshihiko Fujie, Hisashi Mikoshiba, Naotsugu Muro
  • Patent number: 7838184
    Abstract: An azo dye of the following formula: wherein R1, R2, R4 and R5 represent a hydrogen atom or a substituent; R3 and R6 each independently represent a substituent; n indicates 0 to 3. The dye has an excellent optical characteristic with sharp absorption and excellent fastness.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: November 23, 2010
    Assignee: Fujifilm Corporation
    Inventors: Yoshihiko Fujie, Takashi Hoshimiya, Hisashi Mikoshiba, Naotsugu Muro
  • Patent number: 7806940
    Abstract: Disclosed are oligomeric cationic azo dyes of formula (1), their salts, isomers, hydrates and other solvates, wherein n, R1, R2, X, Y? and Z+ are defined in claims and disclosure. Furthermore, the present invention relates to novel cationic oligomeric azo dyes of formula (1), compositions, thereof, especially comprising other dyes, and to application for hair dyeing.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: October 5, 2010
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Victor Paul Eliu, Beate Fröhling, Dominique Kauffmann
  • Publication number: 20100092670
    Abstract: The present invention provides dyes of the general formula (I) where D, R1 to R7 and n are each as defined in claim 1, processes for their preparation and their use.
    Type: Application
    Filed: October 16, 2007
    Publication date: April 15, 2010
    Applicant: DyStar Textilfarben GmbH & Co. Deutschland KG
    Inventors: Hartwig Jordan, Stefan Neubauer
  • Publication number: 20100076182
    Abstract: The present invention provides dyes of the general formula (I) where D is the residue of a diazo component; R1 to R7 and L are each as defined in claim 1, processes for their preparation and their use.
    Type: Application
    Filed: January 14, 2008
    Publication date: March 25, 2010
    Inventors: Hartwig Jordan, Stefan Neubauer, Anthony Lawrence, Nigel Hall
  • Publication number: 20100011518
    Abstract: Disclosed are compounds of formula D is an aromatic or a cationic heteroaromatic group, which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, hydroxy-C1-C14alkyl, C3-C8cycloalkyl, —CN, NO2, —NR3R4, halogen, C6-C10aryl, which is optionally substituted or C1-C14alkyl, or by one or more groups Z; E1 and E2 independently from each other are ?CH; or ?N—; K is an aromatic or heteroaromatic group which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, C3-C8cycloalkyl, C6-C10aryl, halogen, hydroxy, NO2, —NR3R4, —N(R3)(CO)R4, —SO2NR1R2, —SONR1R2 or by one or more Z; or a radical of formula —NR1R2; R1 and R2 independently from each other are hydrogen; C1-C14alkyl; cyclo-C1-C14alkyl; C6-C10aryl; an aromatic or heteroaromatic group which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, C3-C8cycloalkyl, C6-C10aryl, halogen, hydroxy, —NR5R6, —N(R5)—(CO)R5 or by Z; Z is a group of the formula (1a) *—X1—Y1—W1, wherein X1 is the direct bond; —NR7—; —O—; —NR7(C?O)—; —(CO)NR7—; —O(C?O)—; —(CO)O—; or —
    Type: Application
    Filed: June 4, 2007
    Publication date: January 21, 2010
    Inventors: Christian Cremer, Olof Wallquist, Victor Paul Eliu, Kishor Ramachandra Nivalkar
  • Patent number: 7648943
    Abstract: An azo dye represented by formula (II) as defined in the specification, a process of producing the same and a coloring composition containing the azo dye.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: January 19, 2010
    Assignee: Fujifilm Corporation
    Inventors: Toshiki Fujiwara, Yoshihiko Fujie, Yoshiharu Yabuki, Masaru Takasaki
  • Publication number: 20100000029
    Abstract: Disclosed are thiol dyes of formula (1) wherein L1 is hydrogen; C1-C12alkyl; or phenyl-C1-C4alkyl; X is C1-C12alkylene, C2-C12alkenylene, C5-C10cycloalkylene, C5-C10arylene, or C5-C10arylene-C1-C10alkylene, which may by interrupted by —O—, —NH—, —S—, —CO—, o-SO2—; Y is the residue of an organic dye Z is a group of formula (1b) or —C?N; wherein A is O; S; or N-L2; B is L3; —OL3; —NL3L4; or —SL3; and L2, L3 and L4, independently from other are hydrogen; C1-C12alkyl; C5-C12aryl-C1-C12alkyl. The compounds are useful for the dyeing of organic materials, such as keratin fibers, preferably human hair.
    Type: Application
    Filed: August 8, 2007
    Publication date: January 7, 2010
    Inventors: Victor Paul Eliu, Beate Fröhling, Dominique Kauffmann
  • Publication number: 20090300857
    Abstract: Disclosed are thiol dyes of formula (1), wherein R1, R2, R3, R4 and R5 independently from each other are hydrogen; unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C1-C14alkyl; C2-C14alkenyl; C6-C10aryl; C6-C10aryl-C1-C10alkyl; or C5-C10alkyl(C5-C10aryl); A is a residue of an organic dye; and Y1 is the direct bond; C1-C10alkylene; C5-C10cycloalkylene; C5-C12arylene; or C5-C12arylene-(C1-C10alkylene). The compounds are used to dye hair with or without reducing agents. Furthermore, the present invention relates to compositions comprising thiol dyes of formula (1) and to process for the preparation of theses compounds.
    Type: Application
    Filed: August 21, 2006
    Publication date: December 10, 2009
    Applicant: CIBA CORPORATION
    Inventors: Victor Paul Eliu, Beate Fröhling, Dominique Kauffmann
  • Publication number: 20090293208
    Abstract: Disclosed are oligomeric cationic azo dyes of formula (I), wherein their salts, isomers, hydrates and other solvates, wherein R1 is hydrogen; C1-C12alkyl, which may be substituted by one or more C1-C5alkyl, C1-C5-alkoxy, hydroxy or —(CO)—H; —(CO)—C1-C5alkyl; phenyl or phenyl-C1-C4alkyl, wherein the phenyl moiety may be substituted by one or more C1-C5alkyl, C1-C5alkoxy, halogen, —NH2, mono-C1-C5alkylamino, di-C1-C5alkylamino, —NO2, carboxy or hydroxy; R2 is hydrogen; or C1-C5alkyl; X is C1-C10alkylene, which may be substituted by one or more C1-C5alkyl, hydroxy, C1-C5-alkoxy, amino, mono-C1-C5alkylamino, di-C1-C5alkylamino, —SH, and/or interrupted by one or more —O— or —S—S—; C5-C10cycloalkylene; C5-C12arylene; C5-C12arylene-(C1-C10alkylene); biphenylene, which may be substituted by one or more C1-C5alkyl, hydroxy, C1-C5-alkoxy, amino, mono-C1-C5alkylamino, di-C1-C5alkylamino, —SH, and/or interrupted by one or more —O—, C1-C4-alkylene, —NR3—, —S— or —S—S—; R3 is hydrogen; C1-C12alkyl; C2-C14alkenyl; C6-C12ary
    Type: Application
    Filed: June 7, 2006
    Publication date: December 3, 2009
    Inventors: Victor Paul Eliu, Beate Fröhling, Dominique Kauffmann
  • Publication number: 20090142553
    Abstract: A process for printing an image on a substrate comprising applying thereto by means of an ink jet printer an ink comprising a compound of Formula (1): wherein one of A and B is an optionally substituted heteroaryl group containing a ring sulphur atom and the other is an optionally substituted aryl or heteroaryl group and R1, X and Y are as specified. Also claimed are compounds of Formula (1) and various compositions containing the same.
    Type: Application
    Filed: October 4, 2006
    Publication date: June 4, 2009
    Inventors: Gavin Wright, Roy Bradbury, Lynn Patricia Bradbury
  • Publication number: 20090074825
    Abstract: The present invention includes methods, articles, compositions and colorant dyes and pigments that include biocidal N-halamine dye composition having two or more heterocyclic ring structures attached to one or more N-halamine groups, wherein one or more halogens associate with the one or more one or more N-halamine groups to affect biocidal activity.
    Type: Application
    Filed: September 19, 2008
    Publication date: March 19, 2009
    Applicant: Board of Regents, The University of Texas System
    Inventors: Yuyu Sun, Jie Luo
  • Patent number: 7452874
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: November 18, 2008
    Assignee: SmithKline Beecham Corp.
    Inventors: Kevin J. Duffy, Juan I. Luengo, Antony N. Shaw, Kenneth Wiggall
  • Patent number: 7452873
    Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: November 18, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Michael J. Arnost, Albert Pierce
  • Publication number: 20080274283
    Abstract: [Problem] To provide a coloring matter which has a good hue, and is capable of forming an image high in fastness property under various use conditions and environmental conditions, and particularly suitable for an ink. [Solving Means] A coloring matter represented by the following formula (I): wherein in the formula, G represents a heterocyclic group, and n represents an integer of 1 to 3; when n is 1, R, X, Y, Z, Q, and G each represents a monovalent group; when n is 2, R, X, Y, Z, Q, and G each represents a monovalent or divalent substituent, provided that at least one represents a divalent substituent; and when n is 3, R, X, Y, Z, Q, and G each represents a monovalent, divalent or trivalent substituent, provided that at least two each represents a divalent substituent, or at least one represents a trivalent substituent.
    Type: Application
    Filed: August 5, 2005
    Publication date: November 6, 2008
    Applicant: FUJIFILM CORPORATION
    Inventors: Keiichi Tateishi, Yoshiharu Yabuki
  • Patent number: 7439342
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: October 21, 2008
    Assignee: Smith Kline Beecham Corp.
    Inventors: Kevin J. Duffy, Juan I. Luengo
  • Publication number: 20080248202
    Abstract: A coloring composition containing an azo dye of the following formula (1): wherein R1, R2, R3 and R6 represent a monovalent substituent; R5 represents a hydrogen atom or a monovalent substituent; n is 0 to 4.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 9, 2008
    Applicant: FUJIFILM Corporation
    Inventors: Yoshihiko FUJIE, Hisashi Mikoshiba, Naotsugu Muro
  • Patent number: 7414040
    Abstract: Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: August 19, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Dirk A. Heerding
  • Patent number: 7358345
    Abstract: The present invention claims dyestuffs of formula (I), wherein D, R1 to R7 and n are defined as given in claim 1, a process for their preparation and their use
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: April 15, 2008
    Assignee: Dystar Textilfarben GmbH & Co. Deutschland KG
    Inventor: Nigel Hall
  • Patent number: 7141657
    Abstract: An azo compound or a tautomer thereof, wherein the azo compound is represented by the following Formula (1). In Formula (1), R1 represents a hydrogen atom, alkyl group, aryl group, acyl group, carbamoyl group, alkylsulfonyl group, arylsulfonyl group, or heterocyclic group; R2 represents —NR5R6 or —OR7; R5 and R6 each independently represent a hydrogen atom, alkyl group, aryl group, acyl group, carbamoyl group, alkylsulfonyl group, or arylsulfonyl group; R7 represents an alkyl group or aryl group; R3 represents a hydrogen atom, alkyl group, aryl group, alkoxy group, aryloxy group, acylamino group, carbamoylamino group, alkylsulfonylamino group, or arylsulfonylamino group; n is an integer of 3 to 5; and each R4, of which there are n in number, independently represents an alkyl group, aryl group, alkoxy group, aryloxy group, amino group, alkylthio group, arylthio group, acylamino group, alkylsulfonylamino group, or arylsulfonylamino group, and one R4 may bind to another R4 forming a ring.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: November 28, 2006
    Assignee: Fujifilm Corporation
    Inventors: Akinori Fujita, Makoto Ohmoto
  • Patent number: 7105503
    Abstract: Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: September 12, 2006
    Assignee: QLT Inc.
    Inventors: Zaihui Zhang, Timothy S. Daynard, Serguei V. Sviridov, Mikhail A. Chafeev, Shisen Wang
  • Patent number: 6989439
    Abstract: A color-developing agent of the formula (1-1): wherein X represents a hydrogen atom or a substituent, and Z represents a carbamoyl, acyl, alkoxycarbonyl, or aryloxycarbonyl group. An azo dye of the formula (2-1): wherein R1 represents a hydrogen atom or a substituent, and A represents a group of atoms necessary to form the azo dye by the compound of formula (2-1). A silver halide photographic light-sensitive material containing any of the color-developing agent and the azo dye in at least one photographic constitutional layer.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: January 24, 2006
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Osamu Uchida, Yasuhiro Ishiwata, Takayuki Ito, Nobutaka Fukagawa
  • Patent number: 6916798
    Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: July 12, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Michael J. Arnost, Albert Pierce
  • Patent number: 6878196
    Abstract: An ink containing at least one dye represented by formula (1): wherein R1, R2 and R3 are each independently a hydrogen atom or a monovalent group; Z is a nitrogen atom, or a carbon atom to which a hydrogen atom or a monovalent group is bonded; and at least one of R1, R2, R3, and the monovalent group that Z has is a substituent having a heterocyclic group substituted with an azo group.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: April 12, 2005
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Toru Harada, Yoshiharu Yabuki, Manabu Ogawa, Hiroshi Iwanaga
  • Patent number: 6878792
    Abstract: The present invention provides lenses for eyes having visible light transmission properties near to those of human crystalline lenses, particularly coloring techniques effective for soft lenses for eyes. The present invention is a yellow dye capable of chemical bonding to a silicone which is a material of the intraocular lens or capable of copolymerizing with a radical polymerizable monomer which is a material of the intraocular lens.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: April 12, 2005
    Assignee: Canon-Staar Co. Inc.
    Inventor: Takashi Ichinohe
  • Publication number: 20030213405
    Abstract: An ink containing at least one dye represented by formula (1): 1
    Type: Application
    Filed: January 15, 2003
    Publication date: November 20, 2003
    Inventors: Toru Harada, Yoshiharu Yabuki, Manabu Ogawa, Hiroshi Iwanaga
  • Publication number: 20030195342
    Abstract: A compound which can be used as a dye and is represented by the following general formulae (I), (II) and (III). In the general formulae, A and B each independently represents a monovalent heterocyclic group bonded to an azo group by a carbon atom of the monovalent heterocyclic group; m and n each independently represents one of 0 and 1; and M represents one of a hydrogen atom and a monovalent positive ion.
    Type: Application
    Filed: January 24, 2003
    Publication date: October 16, 2003
    Inventors: Hisashi Mikoshiba, Tadashi Omatsu, Makoto Suzuki, Koushin Matsuoka, Masuji Motoki
  • Patent number: 6607563
    Abstract: Provided is a hair dye composition containing a direct dye A—D═D—B. This hair dye composition has markedly high hair dyeing power, has less color fade over time and undergoes a small change in the color tone of the dye even after storage. A represents any one of the following groups (2) to (8): (in which R1, R4, R5 and R6 each represents H, (substituted) C1-6 alkyl group, etc., R2 and R3 each represents (substituted) C1-6 alkyl group, etc., or form, when taken together with the adjacent C, a cycloalkane ring, Q represents N or group CR′, R7 represents (substituted) aralkyl group or a group CH2—CH(OH)—CH2—OR″, R8 and R9 each represents H, (substituted) C1-6 alkyl, etc., or form, when taken together with the adjacent N, a heterocycle, X− represents an anion, and rings C-I may each have a further substituent or a condensed ring), D represents N or group CR′″, and B represents the residue of a coupling component.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: August 19, 2003
    Assignee: Kao Corporation
    Inventors: Yukihiro Ohashi, Hajime Miyabe, Kenichi Matsunaga, Shintaro Totoki, Yoshinori Saito
  • Publication number: 20030082547
    Abstract: Bis-diazo,triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as polynucleotides, nucleosides, nucleotides, and polypeptides. The quencher moieties are non-fluorescent and accept energy from fluorescent reporter labels by any energy-transfer mechanism, such as FRET.
    Type: Application
    Filed: August 27, 2001
    Publication date: May 1, 2003
    Inventors: Gregory J. Ewing, Khairuzzaman Bashar Mullah, Ronald J. Graham
  • Publication number: 20020193578
    Abstract: Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
    Type: Application
    Filed: December 5, 2001
    Publication date: December 19, 2002
    Inventors: Jayasree Vasudevan, Alan T. Johnson, Dehua Huang, Roshantha A. Chandraratna
  • Patent number: 6200371
    Abstract: An ink comprising water, a water-dissipatable polymer and a dye of the Formula (1): wherein: R1 is optionally substituted alkyl or optionally substituted aryl; R2 is H, optionally substituted alkyl or optionally substituted aryl; R5 is H or optionally substituted alkyl; and R3 and R4 are each independently optionally substituted alkyl or optionally substituted aryl, or R3 and R4 together with the CH group to which they are attached from an optionally substituted 5- or 6- membered ring. Also claimed are dyes and ink jet printing processes.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: March 13, 2001
    Assignee: Zeneca Limited
    Inventors: Barry Huston Meyrick, Mark Holbrook, Roy Bradbury
  • Patent number: 6191265
    Abstract: Azo dyes of the formula wherein the substituents are each as defined in the description, are useful for dyeing and printing synthetic textile materials.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: February 20, 2001
    Assignee: DyStar Textilfarben GmbH & Co. Deutschland KG
    Inventor: Rainer Hamprecht
  • Patent number: 6187084
    Abstract: An ink comprising water, a water-dissipatable polymer and one or more dyes of Formula (1): wherein: R1 is H or a substituent; R2 and R3 are each independently optionally substituted alkyl, aryl or aralkyl, or R2 and R3 together with the carbon atom to which they are attached form an optionally substituted ring; R4 is H or optionally substituted alkyl, aryl or aralkyl; and D is an optionally substituted arylene group. Also claimed are the dyes of Formula (1), ink jet printing processes and cartridges containing the inks.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: February 13, 2001
    Assignee: Zeneca Ltd.
    Inventors: Roy Bradbury, Clive Moscrop, Barry Huston Meyrick, Mark Holbrook
  • Patent number: 6042621
    Abstract: The application is concerned with a compound of the formula (I) ##STR1## and a process for making the same. The compound is useful as fiber-reactive dyestuff in dyeing or printing onto hydroxy- or nitrogen-containing substrates. A printing composition comprising this fiber-reactive dyestuff and a copper phthalocyanine allows to obtain dyeings with less catalytic fading.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: March 28, 2000
    Assignee: Clariant Finance (BV) Limited
    Inventors: Roland Wald, Paul Doswald
  • Patent number: 6022957
    Abstract: Azothiophene disperse dyes of Formula (1) ##STR1## in which R, R.sup.1, R.sup.2 and R.sup.3 each independently is alkyl or alkenyl and mixtures thereof with other dyes are useful for dyeing synthetic textile material or a fiber blend thereof such as secondary cellulose acetate, cellulose triacetate, polyamide, polyacrylonitrile and aromatic polyester.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: February 8, 2000
    Assignee: BASF Aktiengesellschaft
    Inventor: Alan T. Leaver