Additional Hetero Ring Attached Indirectly To The Azo Group By Nonionic Bonding Patents (Class 534/774)
  • Patent number: 8293148
    Abstract: An azo pigment showing excellent coloring characteristics such as tinctorial strength and hue and excellent fastness such as light fastness, and a pigment dispersion containing the azo pigment are provided. An azo pigment represented by the following general formula (1) and a pigment dispersion containing the pigment: wherein G represents a hydrogen atom, an aliphatic group, an aryl group, a heterocyclic group, an acyl group, an aliphatic oxycarbonyl group, a carbamoyl group, or a sulfonyl group, R1 represents an amino group, an aliphatic oxy group, an aliphatic group, an aryl group, or a heterocyclic group, R2 represents a substituent, A represents an aromatic 5- to 6-membered heterocyclic group, m represents an integer of from 0 to 5, and n represents an integer of from 1 to 4.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: October 23, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Nobuo Seto, Masahiro Higashi, Keiichi Tateishi
  • Publication number: 20110294993
    Abstract: An azo pigment selected from the group consisting of: an azo pigment represented by the following formula (1), which has: a characteristic X-ray diffraction peak at Bragg angles (2?±0.2°) of 6.9°, 21.5°, and 27.3° in CuK? characteristic X-ray diffraction, a peak height at 11.9° of 0.6 or less relative to a peak height at 10.9° or a tautomer thereof, or a salt, hydrate, or solvate of the azo pigment or tautomer thereof; and an azo pigment represented by the following formula (1), which has: a characteristic X-ray diffraction peak at Bragg angles (2?±0.2°) of 6.9°, 25.8°, and 27.1° in CuK? characteristic X-ray diffraction, a peak height at 10.9° of 0.2 or less relative to a peak height at 11.9° or a tautomer thereof, or a salt, hydrate, or solvate of the azo pigment or tautomer thereof.
    Type: Application
    Filed: May 31, 2011
    Publication date: December 1, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Masahiro HIGASHI, Yoshihiro JIMBO, Keiichi TATEISHI
  • Publication number: 20110286964
    Abstract: The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.
    Type: Application
    Filed: August 19, 2009
    Publication date: November 24, 2011
    Inventors: Cecil D. Kwong, F. George Njoroge, Subramaniam Ananthan, Feng Geng, Hollis S. Kezar, III, Joseph A. Maddry, John J. Piwinski, Robert C. Reynolds, John A. Secrist, III, Neng-Yang Shih
  • Publication number: 20110163283
    Abstract: An azo pigment showing excellent coloring characteristics such as tinctorial strength and hue and excellent fastness such as light fastness, and a pigment dispersion containing the azo pigment are provided. An azo pigment represented by the following general formula (1) and a pigment dispersion containing the pigment: wherein G represents a hydrogen atom, an aliphatic group, an aryl group, a heterocyclic group, an acyl group, an aliphatic oxycarbonyl group, a carbamoyl group, or a sulfonyl group, R1 represents an amino group, an aliphatic oxy group, an aliphatic group, an aryl group, or a heterocyclic group, R2 represents a substituent, A represents an aromatic 5- to 6-membered heterocyclic group, m represents an integer of from 0 to 5, and n represents an integer of from 1 to 4.
    Type: Application
    Filed: September 1, 2009
    Publication date: July 7, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Nobuo Seto, Masahiro Higashi, Keiichi Tateishi
  • Publication number: 20110143270
    Abstract: An azo pigment and a pigment dispersion showing excellent coloring characteristics such as tinctorial strength and hue and excellent fastness such as light fastness are provided. An azo pigment represented by the following general formula (1), its tautomer, a salt or hydrate thereof: (wherein G represents a hydrogen atom, an aliphatic group, an aryl group, a heterocyclic group, an acyl group, an aliphatic oxycarbonyl group, a carbamoyl group, a sulfonyl group, R1 represents an amino group, an aliphatic oxy group, an aliphatic group, an aryl group, or a heterocyclic group, R2 represents a substituent, A represents an aromatic 5- or 6-membered heterocyclic group, m represents an integer of from 0 to 5, n represents an integer of from 1 to 4 and, when n=2, the formula represents a dimer formed through R1, R2, A, or G and, when n=3, the formula represents a trimer formed through R1, R2, A, or G and, when n=4, the formula (1) represents a tetramer formed through R1, R2, A, or G.
    Type: Application
    Filed: July 17, 2009
    Publication date: June 16, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Nobuo Seto, Masahiro Higashi, Keiichi Tateishi, Hideki Takakuwa
  • Patent number: 7956169
    Abstract: The invention provides a novel group of azo quencher compositions that are useful as quenchers of fluorescence and to methods for making and using them. The quenchers contain an azo bond and 1,3,3-trimethyl-2-methyleneindoline ring system. The quenchers can be derivatized to facilitate their conjugation to a variety of biologically relevant compounds, including lipids, nucleic acids, peptides, proteins, and the like.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: June 7, 2011
    Assignee: ChemGenes Corporation
    Inventors: Andrei Laikhter, Suresh C. Srivastava, Naveen P. Srivastava
  • Publication number: 20100311184
    Abstract: Azo heterocyclic compounds that are substantially non-fluorescent or only weakly fluorescent useful as energy acceptors. The chemically reactive compounds possess utility for labeling a wide variety of substances, including biomolecules with the resulted conjugates being highly useful for a variety of energy-transfer assays and applications. The biological conjugates of the disclosure exhibit little or no observable fluorescence and their fluorescence is significantly increased upon a biological stimulation.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 9, 2010
    Applicant: AAT BIOQUEST, INC.
    Inventors: Zhenjun DIWU, Jingfang LIAO
  • Publication number: 20100058545
    Abstract: Disclosed are dyes of Formula (I) wherein D is the radical of anthraquinone, acridine, azo, azomethine, hydrazomethine, benzodifuranone, coumarine, diketopyrrolopyrrol, dioxaxine, diphenylmethane, formazane, indigoid, indophenol, naphtalimide, naphthaquinone, nitroaryl, merocyanine, methine, oxazine, perinone, perylene, pyrenequinone, phtalocyanine, phenazine, quinoneimine, quinacridone, quinophtalone, stilbene, styryl, triphenylmethane, xanthene, thiazine dye and thioxanthene dye; Q is C1-C30alkylene, —C2-C12alkenylene, C5-C10arylene-, C5-C10cycloalkylene- or —C1-C10alkylene(C5-C10arylene)- which may be interrupted and/or terminated at one or both ends by one or more than one —O—, —S—, —N?, —N(R1)—, SO2, —(CH2CH2-O) 1-5-, —(CH2CH2CH2—O) 1-5-, —C(O)—, —C(O)—C1-C12alkenylene, —C(O)O—, —OCO—, A N+R1R2, —CON(R1)—, —C(NR1R2)2—, —(R1)NC(O)—, —CSR1— or an optionally substituted, saturated or unsaturated, fused or non-fused aromatic or nonaromatic (hetero)cyclic) bivalent radical optionally comprising at least one h
    Type: Application
    Filed: January 22, 2008
    Publication date: March 11, 2010
    Applicant: CIBA CORPORATION
    Inventors: Victor Paul Eliu, Beate Frohling, Dominique Kauffmann
  • Publication number: 20100011518
    Abstract: Disclosed are compounds of formula D is an aromatic or a cationic heteroaromatic group, which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, hydroxy-C1-C14alkyl, C3-C8cycloalkyl, —CN, NO2, —NR3R4, halogen, C6-C10aryl, which is optionally substituted or C1-C14alkyl, or by one or more groups Z; E1 and E2 independently from each other are ?CH; or ?N—; K is an aromatic or heteroaromatic group which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, C3-C8cycloalkyl, C6-C10aryl, halogen, hydroxy, NO2, —NR3R4, —N(R3)(CO)R4, —SO2NR1R2, —SONR1R2 or by one or more Z; or a radical of formula —NR1R2; R1 and R2 independently from each other are hydrogen; C1-C14alkyl; cyclo-C1-C14alkyl; C6-C10aryl; an aromatic or heteroaromatic group which is optionally substituted by C1-C14alkyl, C1-C14alkoxy, C3-C8cycloalkyl, C6-C10aryl, halogen, hydroxy, —NR5R6, —N(R5)—(CO)R5 or by Z; Z is a group of the formula (1a) *—X1—Y1—W1, wherein X1 is the direct bond; —NR7—; —O—; —NR7(C?O)—; —(CO)NR7—; —O(C?O)—; —(CO)O—; or —
    Type: Application
    Filed: June 4, 2007
    Publication date: January 21, 2010
    Inventors: Christian Cremer, Olof Wallquist, Victor Paul Eliu, Kishor Ramachandra Nivalkar
  • Publication number: 20090229059
    Abstract: Disclosed are oxazine disulfide dyes of formula (1) D1-(Z1)r-Y1—S-A, wherein A is hydrogen; or a radical of formula (1a)*—S—Y2-(Z2)r-D2; Y1 and Y2 independently from each other are unsubstituted or substituted, straight-chain or branched, interrupted or uninterrupted C—1—C—10alkylene; C5-C10cycloalkylene; C5-C10arylene; or —C5-C10arylene-(C1-C10alkylene); Z1 and Z2 independently from each other are *—(CH2)p—C(O)—**; *—(CH2CH2—O)S—**; *—(CH2)p—C(O)O—**; *—(CH2)p—OCO—**; *—(CH2)P—N(R1)—**; formula 1(g); —(CH2)p—CON(R1)—**; *—(CH2)p—(R1)NC(O)—**; , 0-; —S—; —S(O)—; —S(O)2—; or a cationic biradical of a substituted or unsubstituted aromatic or heteroaromatic compound of the formula (1a); (1b); (1c); (1d); or (1e); wherein the asterix * indicates the linkage to D1 and/or D2; the asterix ** indicates the linkage to Y1 and/or Y2; W1 is N or a radical of CR5; R1, R2, R3, R4 and R5 independently from each other are hydrogen; C1-C14alkyl; C2-C14alkenyl; C5-C10aryl; C5-C10aryl-(C1-C10alkyl); or —C1-C10alkyl(C5-C10aryl);
    Type: Application
    Filed: September 27, 2006
    Publication date: September 17, 2009
    Inventors: Christian Cremer, Olof Wallquist
  • Publication number: 20090088490
    Abstract: A simultaneous two-photon absorption three-dimensional recording material includes at least one kind of dye having at least one polymerizable group.
    Type: Application
    Filed: September 26, 2008
    Publication date: April 2, 2009
    Applicant: FUJIFILM CORPORATION
    Inventors: Masaharu AKIBA, Hiroo TAKIZAWA
  • Patent number: 7452873
    Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: November 18, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Michael J. Arnost, Albert Pierce
  • Patent number: 7198651
    Abstract: The present invention relates to a method to achieve a reversible change of the colour of hair dyed with an azo dye wherein the change of the colour can be effected by, for example, the salonist or the consumer in a simple manner. The colour of the hair thus dyed may be changed simply by treating the dyed hair with an acid treatment composition at any time after the first dyeing treatment. If desired by the consumer, the colour may be returned to substantially the original post dye colour by treating the hair further with an alkaline treatment composition.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: April 3, 2007
    Assignees: Kao Corporation, Fuji Photo Film Co., Ltd.
    Inventors: Dominic Pratt, Masayoshi Nojiri, Toshio Kawagishi
  • Patent number: 6989439
    Abstract: A color-developing agent of the formula (1-1): wherein X represents a hydrogen atom or a substituent, and Z represents a carbamoyl, acyl, alkoxycarbonyl, or aryloxycarbonyl group. An azo dye of the formula (2-1): wherein R1 represents a hydrogen atom or a substituent, and A represents a group of atoms necessary to form the azo dye by the compound of formula (2-1). A silver halide photographic light-sensitive material containing any of the color-developing agent and the azo dye in at least one photographic constitutional layer.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: January 24, 2006
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Osamu Uchida, Yasuhiro Ishiwata, Takayuki Ito, Nobutaka Fukagawa
  • Patent number: 6916798
    Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: July 12, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Michael J. Arnost, Albert Pierce
  • Patent number: 6878196
    Abstract: An ink containing at least one dye represented by formula (1): wherein R1, R2 and R3 are each independently a hydrogen atom or a monovalent group; Z is a nitrogen atom, or a carbon atom to which a hydrogen atom or a monovalent group is bonded; and at least one of R1, R2, R3, and the monovalent group that Z has is a substituent having a heterocyclic group substituted with an azo group.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: April 12, 2005
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Toru Harada, Yoshiharu Yabuki, Manabu Ogawa, Hiroshi Iwanaga
  • Patent number: 6706864
    Abstract: Water-insoluble violet benzimidazolone monoazo pigments of the formula: wherein R1, R2 and R3 each represent hydrogen, chlorine, bromine, methyl, methoxy, ethoxy, nitro or a group of the formula —COOR with R being hydrogen, methyl or ethyl, and R4 represents hydrogen, chlorine, bromine, methyl, methoxy, ethoxy or nitro group. Due to the presence of two 5-membered heterocyclic rings in the molecule, these pigments display very high thermoresistance and excellent fastness to migration.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: March 16, 2004
    Assignee: Dominion Colour Corporation
    Inventors: Mark J. Vincent, Helen Skelton, Jaroslav Slupecky, Justin Yee
  • Publication number: 20030213405
    Abstract: An ink containing at least one dye represented by formula (1): 1
    Type: Application
    Filed: January 15, 2003
    Publication date: November 20, 2003
    Inventors: Toru Harada, Yoshiharu Yabuki, Manabu Ogawa, Hiroshi Iwanaga
  • Patent number: 6582502
    Abstract: A dye which is represented by any of the following general formula (1), (2), (3) or (4), an ink for inkjet recording which contains at least one of the dyes, and an ink jet recording method which uses the ink. The dye has heterocyclic group which may be substituted and has at least one ionic aqueous group in a molecule.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: June 24, 2003
    Assignee: Fuji Photo Film Co., Ltd.
    Inventor: Toshiki Fujiwara
  • Patent number: 5691458
    Abstract: There are described compounds which are represented by the formula ##STR1## The compounds are useful as dyes, and as intermediates and dye moieties in the preparation of compounds, which are particularly useful in imaging applications, such as, for example, diffusion transfer photographic systems.
    Type: Grant
    Filed: September 18, 1996
    Date of Patent: November 25, 1997
    Assignee: Polaroid Corporation
    Inventors: Michael J. Arnost, Peter Viski, David P. Waller, David C. Whritenour
  • Patent number: 5616697
    Abstract: Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a thiazolylazoaniline dye, said thiazolylazoaniline dye containing on the 4-position of the thiazolyl ring a substituent selected from the group consisting of hydroxy, alkoxy, cycloalkoxy, aryloxy, mercapto, thioalkyl, thiocycloalkyl and thioaryl.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: April 1, 1997
    Assignee: Agfa-Gevaert, N.V.
    Inventor: Luc Vanmaele
  • Patent number: 5466790
    Abstract: Azo dyes of the formula ##STR1## where L.sup.1 is hydrogen, C.sub.1 -C.sub.8 -alkyl or phenyl,L.sup.2 and L.sup.3 are each substituted or unsubstituted C.sub.1 -C.sub.8 -alkyl, or together a radical of the formula ##STR2## where n is 0, 1 or 2, Y.sup.1 and Y.sup.4 are hydrogen, hydroxymethyl, 1,2-dihydroxyethyl or a radical of the formula COO.sym.M.sup..crclbar. or SO.sub.3.sup..crclbar. M.sup..sym., Y.sup.2 and Y.sup.3 are halogen or hydroxymethyl, and M.sup..sym. is the equivalent of a cation,L.sup.4 is hydrogen, substituted or unsubstituted C.sub.1 -C.sub.8 -alkyl, substituted or unsubstituted phenyl, halogen, C.sub.1 -C.sub.8 -alkoxy, substituted or unsubstituted phenoxy, C.sub.1 -C.sub.8 -alkylthio, C.sub.1 -C.sub.8 -alkylsulfonyl, substituted or unsubstituted phenylthio, substituted or unsubstituted phenylsulfonyl, C.sub.1 -C.sub.8 -alkoxycarbonyl, C.sub.3 -C.sub.6 -alkenyloxycarbonyl or phenoxycarbonyl,X is nitrogen or the radical C--L.sup.5, where L.sup.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: November 14, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Sabine Gruettner-Merten, Helmut Reichelt, Arno Lange, Helmut Degen
  • Patent number: 5436323
    Abstract: Cationic 1,3,4-thiadiazolyldiphenylamine dyestuffs and corresponding anhydro bases, the dyestuffs having the formula (I) ##STR1## their preparation and their use, and materials dyed with such dyestuffs.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: July 25, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Berneth, Werner Hartwich, Karl-Heinrich Lange
  • Patent number: 5420254
    Abstract: A compound of the formula I ##STR1## in which D is a diazo component,K is an aromatic group of formula a, b or c, ##STR2## Y is C.sub.2-3 alkylene and the remaining symbols are as defined in the specification. These compounds are useful for dyeing or printing textile substrates based on synthetic or semisynthetic, hydrophobic, high molecular weight organic materials. Preferably, the textile substrate is made from a linear aromatic polyester, cellulose 21/2 acetate or cellulose tri-acetate. The dyeings and prints obtained show good all round fastness properties such as good thermomigration properties, lightfastness, thermofixation, blistering properties as well as good wet fastness properties, especially after thermal fixation.
    Type: Grant
    Filed: October 19, 1993
    Date of Patent: May 30, 1995
    Assignee: Sandoz Ltd.
    Inventors: Ruedi Altermatt, Robert Egli, Beat Henzi
  • Patent number: 5298610
    Abstract: Thiazoleazo dyes useful for dyeing or printing textile fibers have the formula ##STR1## where R.sup.1 is hydrogen, substituted or unsubstituted C.sub.1 -.sub.6 -alkyl, halogen, substituted or unsubstituted C.sub.1 -C.sub.6 -alkoxy, substituted or unsubstituted C.sub.1 -C.sub.6 alkythio, substituted or unsubstituted phenylthio, C.sub.1 -C.sub.6 -alkylsulfonyl, substituted or unsubstituted phenylsulfonyl or C.sub.1 -C.sub.4 -alkoxycarbonyl,R.sup.2 is cyano, C.sub.1 -C.sub.4 -alkanoyl, benzoyl, C.sub.1 -C.sub.6 alkylsulfonyl, substituted or unsubstituted phenylsulfonyl or a radical of the formula --CH.dbd.T, where T is the radical of an acidic CH compound,R.sup.3 is hydrogen, substituted or unsubstituted C.sub.1 -.sub.6 -alkoxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, carbamoyl or mono- or di-C.sub.1 -C.sub.4 -alkylcarbamoyl,R.sup.4 is C.sub.1 -C.sub.6 -alkyl, substituted or unsubstituted C.sub.1 -C.sub.6 -alkoxy, substituted or unsubstituted C.sub.1 -C.sub.
    Type: Grant
    Filed: June 4, 1992
    Date of Patent: March 29, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Erwin Hahn, Matthias Wiesenfeldt, Helmut Reichelt, Sabine Gruettner-Merten
  • Patent number: 5270456
    Abstract: Thiopheneazo dye I which are chiefly useful as disperse dyes for dyeing textile material, in particular polyesters, have the formula ##STR1## where the substituents are as defined in the description.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: December 14, 1993
    Assignee: BASF Aktiengesellschaft
    Inventors: Erwin Hahn, Guenter Hansen, Karl-Heinz Etzbach, Helmut Reichelt, Ernst Schefczik, Sabine Greuttner, Helmut Degen
  • Patent number: 5208325
    Abstract: Cationic 1,3,4-thiadiazole dyestuff of the formula ##STR1##in whichR.sup.1 and R.sup.2, independently of one another, denote hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, a heterocycle, said heterocycle having a direct bond to the nitrogen atom, or being bound through a methylene or ethylene group, or R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached form a heterocycle,R.sup.3 denotes alkyl, alkenyl or aralkyl,R.sup.4 denotes hydrogen or alkyl,R.sup.5 denotes acyl,R.sup.6 and R.sup.7, independently of one another, denote hydrogen, alkyl, alkoxy, aryloxy or halogen andR.sup.8 and R.sup.9, independently of one another, denote hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, a heterocycle, said heterocycle having a direct bond to the nitrogen atom, or being bound through a methylene or ethylene group, or R.sup.8 and R.sup.9, together with the nitrogen atom to which they are attached form a heterocycle, orR.sup.6 and R.sup.8 together with the nitrogen to which R.sup.
    Type: Grant
    Filed: December 11, 1991
    Date of Patent: May 4, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Berneth, Klaus Leverenz
  • Patent number: 5116958
    Abstract: Disperse dyes, which produce dyeings of excellent thermomigration fastness, consisting of a chromophore and a lactam or oxime radical which detaches on heating to leave an isocyanate or isothiocyanate group, which reacts with a suitable group in the environment. The disclosed dyes are described by the formula ##STR1## where F is the radical of a dye which is free of water-solubilizing groups,B is a bridge member or a direct bond,Z is O or S andV is the radical of a group H--V, where H--V is an oxime of the formula ##STR2## or a lactam of the formula ##STR3## in which R.sup.1 and R.sup.2 are each independently of the other substituted or unsubstituted alkyl or aryl, orR.sup.1 and R.sup.2 together with the carbon atom linking them form a cycloaliphatic ring,R is hydrogen or alkyl andn is an integer from 4 to 11.
    Type: Grant
    Filed: January 5, 1990
    Date of Patent: May 26, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Liechti, Martin Trottmann
  • Patent number: 5077200
    Abstract: Chromogenic substrates for the detection of hydrolyzing enzymes, processes for the preparation of these chromogenic substrates and the use of the chromogenic substrates.The quantification of hydrolyzing enzymes for diagnostic purposes has to date been carried out by determination of the amounts of a fluorescent or highly absorbent chromogenic dyestuff liberated in the hydrolytic reaction, detection of which has in part been possible exlusively by instruments or in the neutral to alkaline pH range. After enzymatic hydrolysis, the chromogenic substrates according to the invention lead to highly sensitive and specifically measurable signals regardless of the pH range.Azo dyestuff compounds with the general formulaA--N.dbd.N--B (OR)in which A) and B) have the meanings given in claim 1 andR) is a radical which can be liberated by enzymatic hydrolysis, excluding a carbonyl radical,are provided.After enzymatic hydrolysis, highly sensitively and specifically measurable signals are obtained regardless of the pH range.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: December 31, 1991
    Assignee: Behringwerke Aktiengesellschaft
    Inventor: Klaus Habenstein
  • Patent number: 5064637
    Abstract: The present invention involves intradermal, percutaneous, parenteral, or enteral administration of a newly synthesized compound to detect, reduce, or eliminate the occurrence of allergic reactions to sulfonamides. The new compound is a substituted sulfonamide, the substituent being bound to the paraamino (4-position) group through an azo, amide, or other linkage. Because a purpose of the substituent is to make the new compound water soluble, it can take a variety of forms, but it must contain carbon and hydrogen, plus at least one of oxygen and nitrogen. Examples of usable substituents include imidazole, a carbohydrate, or an amino acid such as histidine, tyrosine, tryptophan, lysine, or tyrosine methyl ester; it may also be a synthetic polymer, polypeptde, polysaccharide, or an amino acid homopolymer.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: November 12, 1991
    Assignee: Board of Regents, The University of Texas System
    Inventor: Timothy J. Sullivan
  • Patent number: 4965345
    Abstract: Solvent dyes of the formula ##STR1## where ##STR2## R.sup.1 and R.sup.2 are each, independently of the other, hydrogen, methyl, ethyl, methoxy or ethoxy,n is 0 or 1 andk, if n is 0, is the radical of a coupling component of the pyrazolone series or, if n is 1, is the radical of a coupling component of the pyrazolone, 2-naphthol, hydroxyquinoline, aniline, naphthylamine, pyridone or 2,6-diaminopyridine series,R.sup.3 and R.sup.4 each independently of the other being C.sub.1 -C.sub.22 -alkyl which may be substituted or interrupted by oxygen, imino or C.sub.1 -C.sub.4 -alkylimino, subject to the proviso that COR has more than 8 carbon atoms, are very highly suitable for coloring organic substrates.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: October 23, 1990
    Assignee: BASF Aktiengesellschaft
    Inventor: Hermann Loeffler
  • Patent number: 4960874
    Abstract: Compounds of the general formula I ##STR1## where R is alkyl or unsubstituted or substituted aryl and K is a radical of the formula ##STR2## B is C.sub.1 -C.sub.4 -alkyl or substituted amino, R.sup.1 is hydrogen, methyl, methoxy or ethoxy, R.sup.2 and R.sup.3 independently of one another are each unsubstituted or substituted alkyl, R.sup.3 may furthermore be hydrogen, R.sup.4 is a radical of the formula --A--OCO--Y--R, Z is hydrogen or methyl, X is hydrogen, methyl, methoxy, chlorine or acylamino, A is C.sub.2 - or C.sub.3 -alkylene and Y is --O-- or --NH--, are very useful for dyeing cellulose esters and synthetic polyesters.
    Type: Grant
    Filed: July 1, 1988
    Date of Patent: October 2, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Udo Bergmann, Johannes D. Dix, Guenter Hansen, Ernst Schefczik, Guenther Seybold
  • Patent number: 4952681
    Abstract: Compounds of the formula I ##STR1## where X is fluorine, chlorine, bromine, SO.sub.2 E or unsubstituted or substituted hydroxyl or mercapto, E is alkyl, alkenyl, cycloalkyl, aralkyl, aryl, chlorine or unsubstituted or substituted hydroxyl or amino, Y is cyano, nitro, alkanoyl, aroyl, alkylsulfonyl, arylsulfonyl, carboxyl, a carboxylic ester group or unsubstituted or substituted carbamyl, T is hydrogen, C.sub.1 -C.sub.4 -alkyl, a radical which can be introduced by electrophilic substitution or a radical of the formula --CH.dbd.B, in which B is a radical of a methylene-active compound or of an amine, and K is a radical of a coupling component, are disclosed. They are useful for dyeing synthetic fibers or plastics.
    Type: Grant
    Filed: July 27, 1988
    Date of Patent: August 28, 1990
    Assignee: Sandoz AG
    Inventors: Guenter Hansen, Ernst Schefczik, Karl-Heinz Etzbach, Helmut Reichelt, Hermann Loeffler
  • Patent number: 4877412
    Abstract: Compounds of the formula ##STR1## in free acid or salt form and internal, external and acid addition salts thereof, whereinK is ##STR2## wherein R.sub.3 -R.sub.5, R.sub.20, R.sub.21 and X-Z are as defined in the specification,each of Q.sub.1 and Q.sub.2 is independently hydrogen or --SO.sub.3 M.sub.1,each R.sub.1 and R.sub.2 is independently hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or --COOM, andn is 0 or 1,wherein each M and M.sub.1 is independently hydrogen or a nonchromophoric cation, with the provisos that (i) the compound contains at least one --SO.sub.3 M or --SO.sub.3 M.sub.1 group, (ii) when K is a gruop of Formula (a), at least one of R.sub.4 and R.sub.5 is hydrogen, (iii) the total number of anionic groups equals or exceeds the total number of basic and cationic groups, (iv) the positive charge of each cationic group is balanced by the negative charge of an --SO.sub.3.sup..crclbar. or --COO.sup..crclbar.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: October 31, 1989
    Assignee: Sandoz Ltd.
    Inventor: Reinhard Pedrazzi
  • Patent number: 4861344
    Abstract: Water-soluble azo compounds having useful fiber-reactive dye properties conforming to the general formula ##STR1## in which: A is phenylene which may be substituted or unsubstituted, or is a radical of the formula ##STR2## in which W is a direct bond or a radical of the formula --CH.dbd.CH-- or --NH--CO--NH-- and R* denotes hydrogen, nitro, sulfo, carboxy, methyl, ethyl, methoxy or ethoxy;n is the number zero or 1;B is a radical of the formula ##STR3## where R is equal to carboxy or carbamoyl; M is hydrogen or an alkali metal; andK is one of five radicals described in the specification, each of which contains a fiber-reactive group.These azo compounds produce fast dyeings on carboxamido- and/or hydroxy-containing materials, in particular cellulose fibers. On cellulose, fast dyeings are also obtained in a weakly acid to neutral medium, for example together with disperse dyes for dyeing a polyester fiber portion.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ludwig Schlafer, Hartmut Springer, Reinhard Hahnle
  • Patent number: 4764599
    Abstract: Sulfo-free compounds of the formula ##STR1## where R is hydrogen or C.sub.1 -C.sub.4 -alkyl andK.sup.1 and K.sup.2 independently of one another are a radical of a coupling component, and the rings A and B may furthermore be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, methyl, trifluoromethyl, ethyl, acetyl, benzoyl, a carboxylic ester group, unsubstituted or substituted carbamyl or sulfamyl, an aryl sulfonate group, C.sub.1 -C.sub.4 -alkylsulfonyl, unsubstituted or substituted phenylsulfonyl, cyano or acylamino or a fused ring, are very useful as pigments for coloring printing inks, surface coatings or plastics.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: August 16, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Colberg, Erwin Hahn
  • Patent number: 4681932
    Abstract: Azo dyestuffs of the formula ##STR1## wherein R.sub.1 denotes hydrogen, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkoxyethoxy andX denotes acyl,are distinguished by good levelling properties and good allround fastness properties. They dye polyester fibres in a bright blue shade.
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: July 21, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Winfried Kruckenberg, Klaus Leverenz, Hans-Gunter Otten
  • Patent number: 4678497
    Abstract: Triazine-substituted azobenzenesulfonamides useful as preemergent and postemergent herbicides, selected from compounds of Formulae I or II ##STR1## or agriculturally suitable salts thereof, wherein R, R.sub.1, R.sub.2, R.sub.3 and A are as defined herein.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: July 7, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Wallace C. Petersen
  • Patent number: 4668775
    Abstract: A compound of the formula: ##STR1## wherein K is a radical of a coupling component, R is a radical of a methylene-active compound, X is hydrogen or unsubstituted or substituted alkyl, aryl, or hetaryl and Y is cyano, nitro, alkanoyl, aroyl, alkylsulfonyl, arylsulfonyl, carboxyl, a carboxylic ester group or unsubstituted or substituted carbamyl. The present compound is useful for the dyeing of polyesters, nylons, cellulose esters and blends of polyesters and cellulose fibers.
    Type: Grant
    Filed: July 24, 1985
    Date of Patent: May 26, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Udo Bergmann, Erwin Hahn, Guenter Hansen
  • Patent number: 4656256
    Abstract: Compounds of the formula ##STR1## where Y is chlorine or bromine, Z is hydrogen, chlorine, bromine, a sulfonic ester group, nitro or unsubstituted or substituted sulfamyl, X is --O-- or ##STR2## R is alkylene which may or may not be interrupted by oxygen, ##STR3## m is 1 or 2, n is 0 or 1, p is 0, 1 or 2, q is 1 or 2, R.sup.1 and R.sup.2 independently of one another are each hydrogen, unsubstituted or substituted alkyl, alkenyl, cycloalkyl, aralkyl or aryl, or R.sup.1 and R.sup.2, together with the nitrogen atom, form a heterocyclic structure, R.sup.3 is hydrogen or unsubstituted or substituted alkyl, B is hydrogen or C.sub.1 -C.sub.4 -alkyl, B.sup.1 is hydrogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkyl, A.sup.- is an anion, R.sup.4 is unsubstituted or substituted alkyl, R.sub.5 is hydrogen or C.sub.1 -C.sub.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: April 7, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Horst Colberg, Hans-Juergen Degen, Johannes P. Dix
  • Patent number: 4650861
    Abstract: This invention relates to novel azo dyes containing a 4-nitropyrazole azo moiety which may be substituted, for example, with an alkyl group which itself may be substituted, and an aniline coupler which may be substituted. The dyes produce bright red shades on hydrophobic textile fiber including polyesters, polyamides, and cellulose esters and show unexpected improvements in one or more of such properties as fastness to light, wash, ozone, gas such as oxides of nitrogen, perspiration, crock and sublimation, dyeability at desirable low energy levels to deep shades, build, pH stability, bloom resistance, leveling, migration, dye bath exhaustion, dye transfer, and the like.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: March 17, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Max A. Weaver, Gary T. Clark, Bill A. Eller
  • Patent number: 4638052
    Abstract: An azo-pigment represented by the general formula: ##STR1## where R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, an unsubstituted phenyl group or a substituted phenyl group, R.sub.2 is a residue of a phenylenediamine, and R.sub.3 is a hydrogen atom, a methyl group, a methoxy group or a halogen atom. The azo-pigment of the present invention is useful in applications where azo-pigments are used.
    Type: Grant
    Filed: December 27, 1984
    Date of Patent: January 20, 1987
    Assignee: Dainichiseika Color & Chemicals Mfg. Co., Ltd.
    Inventors: Kimihide Kawamura, Shojiro Horiguchi, Hisao Okamoto
  • Patent number: 4628083
    Abstract: The invention relates to new arylazo compounds of the general formula ##STR1## wherein R.sub.1 and R.sub.2 independently of each other represent hydrogen or C.sub.1-3 alkyl, R.sub.3 represents hydrogen, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, carboxy, C.sub.1-3 alkoxycarbonyl, C.sub.1-3 alkylcarbonyl or a group X--NH--SO.sub.2 --, wherein X represents a heterocyclic ring, R.sub.4 represents hydrogen, halogen or C.sub.1-3 alkyl, and n is the integer 1 or 2, the two groups ##STR2## being the same or different when n is 2, and lactones and salts thereof. The compounds of formula I have a high inhibiting effect on prostaglandin synthetizing and inactivating enzymes and may therefore be used as a drug and anti-fertility agent. The invention also relates to preparation of the compounds of formula I as well as pharmaceutical compositions containing the same.
    Type: Grant
    Filed: January 18, 1985
    Date of Patent: December 9, 1986
    Assignee: Pharmacia AB
    Inventor: Karl H. Agback
  • Patent number: 4593088
    Abstract: Disclosed are new disperse azo dyes prepared from 2-amino-cinnamoylthiophene compounds. These dyes give bright blue shades, for example, on polyester, cellulose acetate and other synthetic fibers and exhibit improvements in one or more of such properties as bathochromic shift, fastness to light, sublimation, chlorine, heat, ozone, gas, perspiration, crock, and wash, build, pH stability, bloom resistance, depth of shade, leveling, strike rate, migration, and the like. The dyes have the general formula: ##STR1## wherein each R is a substituent selected for example from alkyl, substituted alkyl, hydroxy, alkoxy, halogen, nitro, alkoxycarbonyl, alkanoyloxy, alkanoyl, cyano, alkylamino, and dialkylamino, R.sup.14 is hydrogen or alkyl, C.sup.1 represents an aniline, tetrahydroquinoline or benzomorpholine coupling component which may be extensively substituted, and each of R.sup.12 and R.sup.13 is hydrogen or a substituent such as acyl, acylamido, alkyl, halogen, and cyano.
    Type: Grant
    Filed: January 23, 1984
    Date of Patent: June 3, 1986
    Assignee: Eastman Kodak Company
    Inventor: Robert N. Gourley
  • Patent number: 4542207
    Abstract: Monoazo dyes for dyeing polyester fibers represented by the formula: ##STR1## wherein D represents a substituted or unsubstituted thiazolyl, benzothiazolyl, thiadiazolyl or pyridyl group, X represents a hydrogen atom, a chlorine atom, a methyl group, a methoxy group or an acylamino group, Y represents a hydrogen atom, a chlorine atom, a methyl group, an alkoxy group or an alkoxyalkyl group, R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl, alkenyl or aryl group, and R.sup.2 represents a phenoxymethyl group, a phenoxyethyl group, a benzyl group or a tetrahydrofurfuryl group.Fibers which can be dyed with the azo dyes of the present invention include polyester fibers such as polyethylene terephthalate, a polycondensate between terephthalic acid and 1,4-bis (hydroxymethyl) cyclohexane or the like and blended or mixed fibers of the above-described polyester fibers with natural fibers such as cotton, silk or wool.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: September 17, 1985
    Assignee: Research Association Of Synthetic Dyestuffs
    Inventors: Toshio Niwa, Kiyoshi Himeno, Junji Yoshihara
  • Patent number: 4505857
    Abstract: Compounds of the formula ##STR1## in which K is the radical of a coupling component of the aniline, .alpha.-naphthylamine, pyrazolone, aminopyrazole, indole, tetrahydroquinoline, thiazole, phenol, naphthol, pyridine or pyridone series.R is --CHO, --CH.dbd.C(CN)--R.sub.1, --CH.dbd.CH--R.sub.2, --CH.dbd.C(NO.sub.2)--R.sub.3, --CH.dbd.NOH or --CN,wherein R.sub.1 is (C.sub.1-10 alkoxycarbonyl; (C.sub.1-10 alkoxy)carbonyl monosubstituted by chloro, bromo, cyano, hydroxy, C.sub.1-2 alkoxy, (C.sub.1-2 alkyl)carbonyloxy or (C.sub.1-2 alkoxy)carbonyl; (C.sub.1-10 alkoxy)carbonyl disubstituted by hydroxy and by chloro or bromo; (C.sub.3-8 alkenyl)oxycarbonyl; (C.sub.3-8 chloroalkenyl)oxycarbonyl; (C.sub.3-8 bromoalkenyl)oxycarbonyl; propynyloxycarbonyl; benzyloxycarbonyl; chlorobenzyloxycarbonyl; nitrobenzyloxycarbonyl; C.sub.1-4 alkylsulfonyl; phenylsulfonyl; tolylsulfonyl; carbamoyl; (C.sub.1-2 alkyl)carbamoyl; di(C.sub.
    Type: Grant
    Filed: March 10, 1981
    Date of Patent: March 19, 1985
    Assignee: Sandoz Ltd.
    Inventor: Robert Egli