Carbonyl Bonded Directly To Kanamycin Nitrogen Patents (Class 536/13.8)
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Patent number: 10617704Abstract: A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.Type: GrantFiled: July 29, 2016Date of Patent: April 14, 2020Assignees: MICROBIAL CHEMISTRY RESEARCH FOUNDATION, MEIJI SEIKA PHARMA CO., LTD.Inventors: Yoshiaki Takahashi, Eijiro Umemura, Takashi Ida, Masayuki Igarashi
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Patent number: 10576094Abstract: A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.Type: GrantFiled: July 29, 2016Date of Patent: March 3, 2020Assignees: MICROBIAL CHEMISTRY RESEARCH FOUNDATION, MEIJI SEIKA PHARMA CO., LTD.Inventors: Yoshiaki Takahashi, Eijiro Umemura, Takashi Ida, Masayuki Igarashi
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Patent number: 8999942Abstract: In some aspects, the present invention provides aminoglycoside derivatives thereof that exhibit antibacterial activity. In some aspects, the aminoglycoside derivatives comprise compounds consisting of (a) an ammoglycoside group and (b) at least one hydrophobic carbamate and alkoxy group to the primary or secondary hydroxy position of the aminolvcoside group and salts thereof. Additionally, methods of treating and preventing bacterial infections using the aminoglycoside derivatives are also provided.Type: GrantFiled: April 5, 2011Date of Patent: April 7, 2015Assignee: University of ManitobaInventors: Frank Schweizer, Smritilekha Bera, George Zhanel
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Publication number: 20140343005Abstract: The invention provides aqueous liquid pharmaceutical compositions comprising arbekacin and chloride ions. The compositions are well tolerable for use in a method for treatment or prevention of a disease of the upper or lower respiratory tract, wherein the composition is aerosolized and inhaled by the patient. Furthermore, the invention provides arbekacin hydrochloride.Type: ApplicationFiled: August 3, 2012Publication date: November 20, 2014Applicants: PARI PHARMA GMBH, MEIJI SEIKA PHARMA CO., LTD.Inventors: Manfred Keller, Yukihiro Yagi, Masashi Tanaka, Toshie Sugano, Kuniko Shoji, Nao Sano, Michael Hahn, Roman Egle
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Patent number: 8742078Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.Type: GrantFiled: January 15, 2013Date of Patent: June 3, 2014Assignee: Isis Pharmaceuticals, Inc.Inventors: Michael T. Migawa, Xiaojing Wang, Eric E. Swayze, Richard H. Griffey
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Patent number: 8586552Abstract: Aminoglycoside antibiotics of the formula are disclosed. The compounds are useful for treating bacterial infections, particularly infections resistant to known antibiotics.Type: GrantFiled: January 31, 2013Date of Patent: November 19, 2013Assignee: SelectX Pharmaceuticals, Inc.Inventors: Michael G. Chaparian, Michael Brady, Scott Moe, Babu Rao Renikuntla, Srinivas Gadthula, Srinivasarao Meneni, Venkata Sai Prakash Chaturvedula
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Patent number: 8524689Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: GrantFiled: November 14, 2011Date of Patent: September 3, 2013Assignee: Achaogen, Inc.Inventors: Adam Aaron Goldblum, Paola Dozzo, James Bradley Aggen, Martin Sheringham Linsell
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Publication number: 20130144044Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.Type: ApplicationFiled: January 15, 2013Publication date: June 6, 2013Applicant: ISIS PHARMACEUTICALS, INC.Inventor: ISIS PHARMACEUTICALS, INC.
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Publication number: 20130096078Abstract: Vectors expressing kanA-kanB-kanK and other kanamycin production-related genes, Streptomyces<i/> species recombinant bacteria transformed with the vectors, a method of producing kanamycin antibiotics by the bacteria, and a new kanamycin compound produced by the bacterium are provided. With the use of the recombinant bacteria of the present invention, the direct fermentative biosynthesis of amikacin and tobramycin as semi-synthetic kanamycins is possible, and the yield of kanamycin B as a precursor of the semi-synthetic kanamycin is improved.Type: ApplicationFiled: October 14, 2010Publication date: April 18, 2013Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATIONInventors: Yeo Joon Yoon, Sung Ryeol Park, Je Won Park, Jae Kyung Sohng
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Publication number: 20130053337Abstract: Guanadinylated aminoglycoside-lipid conjugates are prepared. Such conjugates may comprise an aminoglycoside such as an aminoglyucoside antibiotic like neomycin or kanamycin, at least one guanidino group attached to a primary or secondary carbon atom of the aminoglyucoside group and at least one lipid group attached through a bond or a linker to a branched carbon atom of the aminoglycoside. These conjugates exhibit improve antibacterial activity and may be used in conjunction with another antibiotic.Type: ApplicationFiled: March 4, 2011Publication date: February 28, 2013Applicant: UNIVERSITY OF MANITOBAInventors: Frank Schweizer, Smritilekha Bera, George Zhanel
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Patent number: 8377896Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.Type: GrantFiled: March 9, 2011Date of Patent: February 19, 2013Assignee: Isis Pharmaceuticals, IncInventors: Michael T. Migawa, Xiaojing Wang, Eric E. Swayze, Richard H. Griffey
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Publication number: 20130005953Abstract: A readthrough inducing agent for inducing readthrough of a premature stop codon generated by nonsense mutations, the readthrough inducing agent comprising a compound having a structure expressed by the following Structural Formula (A), and a drug for treating a genetic disease caused by nonsense mutations, the drug comprising the readthrough inducing agent.Type: ApplicationFiled: August 1, 2012Publication date: January 3, 2013Inventors: Ryoichi MATSUDA, Masataka SHIOZUKA, Akira WAGATSUMA, Yoshikazu TAKAHASHI, Daishiro IKEDA, Yoshiaki NONOMURA, Masafumi MATSUO, Atsushi NISHIDA
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Publication number: 20120165283Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: ApplicationFiled: March 7, 2012Publication date: June 28, 2012Inventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20120135948Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.Type: ApplicationFiled: November 14, 2011Publication date: May 31, 2012Applicant: Achaogen, Inc.Inventors: Adam Aaron Goldblum, Paola Dozzo, James Bradley Aggen, Martin Sheringham Linsell
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Patent number: 8148504Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.Type: GrantFiled: June 1, 2007Date of Patent: April 3, 2012Assignees: Meiji Seika Pharma Co., Ltd., Microbial Chemistry Research FoundationInventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
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Publication number: 20110245476Abstract: The present invention is directed to analogs of aminoglycoside compounds as well as their preparation and use as prophylactic or therapeutics against microbial infection.Type: ApplicationFiled: March 9, 2011Publication date: October 6, 2011Applicant: ISIS Pharmaceuticals, Inc.Inventors: Michael T. Migawa, Xiaojing Wang, Eric E. Swayze, Richard H. Griffey
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Patent number: 7635685Abstract: A novel group of aminoglycosides which share some structural features of currently available aminoglycosides with regard to the backbone, while also having significant structural differences, is disclosed. The similarity enables these aminoglycosides to be highly potent and effective antibiotics, while the significant differences enable these aminoglycosides to reduce or even block antibiotic resistance. The aminoglycosides of the present invention are suitable for inhibition of antrax lethal factor, hence are suitable for use as a cure for anthrax.Type: GrantFiled: March 8, 2005Date of Patent: December 22, 2009Assignee: Technion Research & Development Foundation Ltd.Inventors: Timor Baasov, Micha Fridman, Valery Belakhov, Sima Yaron
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Patent number: 7439343Abstract: Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.Type: GrantFiled: September 1, 2005Date of Patent: October 21, 2008Assignee: Rensselaer Polytechnic InstituteInventors: Kaushal Rege, Shanghui Hu, Jonathan S. Dordick, Steven M. Cramer
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Patent number: 6288028Abstract: The present invention discloses new pharmaceutical compositions useful for the treatment of various human and animal diseases. These pharmaceutical compositions contain one or more peptides.Type: GrantFiled: February 15, 2000Date of Patent: September 11, 2001Inventors: Predrag Sikiric, Marijan Petek, Sven Seiwerth, Branko Turkovic, Zeljko Grabarevic, Ivo Rotkvic, Stjepan Mise, Marko Duvnjak, Ivan Udovicic