Cyano Or -coo- Containing Patents (Class 536/16.3)
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Patent number: 9533973Abstract: The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.Type: GrantFiled: December 7, 2012Date of Patent: January 3, 2017Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Jia Zhou, Chunyong Ding, Kathryn A. Cunningham
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Patent number: 7879808Abstract: An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; R1 represents N-optionally substituted C1-6 alkyl-N-optionally substituted C1-6 alkylamino-C1-6 alkyl; R2 represents a hydrogen atom or optionally substituted C1-6 alkyl; R3 represents optionally substituted C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant Streptococcus pneumoniae, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.Type: GrantFiled: May 30, 2008Date of Patent: February 1, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yoshinari Wakiyama, Kou Kumura, Satomi Masaki, Kazutaka Ueda, Yasuo Sato, Chika Kikuchi, Eijirou Umemura, Yoko Hirai, Hiroshi Kondo
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Patent number: 7871982Abstract: This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R1 represents a halide, nitro, substituted C1-6 alkyl, optionally substituted amino, C1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, all of R4, R5, and R6 represent a hydrogen atom, R7 represents C1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.Type: GrantFiled: December 11, 2006Date of Patent: January 18, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Eijirou Umemura, Yoshinari Wakiyama, Kazutaka Ueda, Kou Kumura, Satomi Masaki, Takashi Watanabe, Mikio Yamamoto, Chizuko Kaji, Keiichi Ajito
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Patent number: 7867980Abstract: An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.Type: GrantFiled: May 30, 2008Date of Patent: January 11, 2011Assignee: Meiji Seika Kaisha, Ltd.Inventors: Eijirou Umemura, Kou Kumura, Satomi Masaki, Kazutaka Ueda, Yoshinari Wakiyama, Yasuo Sato, Mikio Yamamoto, Keiichi Ajito, Takashi Watanabe, Chizuko Kaji
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Patent number: 7485689Abstract: Disclosed are glucoside alkyl urethanes composed of units of the formula: A(O—CO—NH—R)3 wherein A represents a glucosyl unit of a starch hydrolysate molecule, the starch hydrolysate having a Dextrose Equivalent (D.E.) ranging from 1 to 47, (O—CO—NH—R) represents an N-alkyl aminocarbonyloxy group replacing a hydroxyl group of the glucosyl unit A, and wherein R represents a linear or branched, saturated or unsaturated alkyl group containing from 3 to 22 carbon atoms, and s represents the number of alkyl carbamate groups per glucosyl unit which number is expressed as degree of substitution (DS) with said DS value ranging from about 0.01 to about 2.0 which are useful as surface-active agents. Also disclosed are a method for their manufacture and compositions containing one or more glucoside alkyl urethanes. The glucoside alkyl urethanes have good to excellent tensio-active properties in combination with good biodegrability and they are suitable as surfactants for use in household and industrial applications, e.g.Type: GrantFiled: December 12, 2000Date of Patent: February 3, 2009Assignee: Tiense Suikerraffinaderij N.V.Inventors: Christian Victor Stevens, Alessia Meriggi, Karl Booten
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Patent number: 7361743Abstract: Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.Type: GrantFiled: August 31, 2005Date of Patent: April 22, 2008Assignee: Pfizer IncInventors: Jason G. Lewis, Sampath K Anandan, Hardwin O'Dowd, Mikhail F Gordeev, Liansheng Li
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Patent number: 7256177Abstract: Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.Type: GrantFiled: November 17, 2004Date of Patent: August 14, 2007Assignee: Vicuron Pharmaceuticals, Inc.Inventors: Jason G. Lewis, Sampath K. Anandan, Hardwin O'Dowd, Mikhail F. Gordeev
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Patent number: 7199106Abstract: Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.Type: GrantFiled: June 17, 2004Date of Patent: April 3, 2007Assignee: Vicuron Pharmaceuticals, Inc.Inventors: Jason G. Lewis, Sampath-Kumar Anandan, Hardwin O'Dowd, Mikhail F. Gordeev
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Patent number: 7199105Abstract: Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.Type: GrantFiled: February 11, 2004Date of Patent: April 3, 2007Assignee: Vicuron Pharmaceuticals, Inc.Inventors: Jason G. Lewis, Dinesh V. Patel, Sampath Kumar Anandan, Mikhail F. Gordeev