Nitrogen In Aglycone Moiety Patents (Class 536/17.4)
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Publication number: 20090054356Abstract: [Objective] The present invention provides a compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity or the like. [Means to Solve the Problem] It is a 1-substituted-7-(?-D-glycopyranosyloxy)(aza)-indole compound represented by the general formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof: wherein R1 represents a halogen atom or the like; n represents j an integer number from 0 to 3; R2 represents a hydrogen atom or the like; X represents a carbon atom which a hydrogen atom or the like binds to, or a nitrogen atom; Q represents an alkylene group or an alkenylene group each of which may have an oxygen atom or a sulfur atom in the chain; and A represents an aryl or heteroaryl group which may have a substituent.Type: ApplicationFiled: February 14, 2006Publication date: February 26, 2009Applicant: Kissei Pharmaceutical Co., Ltd.Inventors: Nobuhiko Fushimi, Shigeru Yonekubo, Kohsuke Ohno
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Publication number: 20090054352Abstract: Problem: To provide compounds which have an anticoagulation effect based on their ability to inhibit the activated blood coagulation factor X and are useful as coagulation inhibitors or agents for prevention or treatment for diseases caused by thrombi or emboli. Means for Solution: Benzene derivatives or their salts having a characteristic chemical structure with a phenol ring and a benzene ring bonding to each other via an amide bond, in which the phenol ring further bonds to a benzene ring or a heteroaryl ring via an amide bond. They have an excellent effect of inhibiting the activated blood coagulation factor X, and especially have an excellent oral activity.Type: ApplicationFiled: November 7, 2006Publication date: February 26, 2009Applicant: ASTELLAS PHARMA INC.Inventors: Fukushi Hirayama, Jiro Fujiyasu, Daisuke Kaga, Kenji Negoro, Daisuke Sasuga, Norio Seki, Ken-ichi Suzuki
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Publication number: 20090048186Abstract: The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.Type: ApplicationFiled: April 19, 2005Publication date: February 19, 2009Inventors: Vishwajanani Jitendra Sattigeri, Sudershan K. Arora, Mohammad Salman, Venkata P. Palle, Ashis Mukherjee, Abhijit Ray, Raj Kumar Shirumalla
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Publication number: 20090042816Abstract: Synthetic ligand compounds and methods of differentiating between Shiga toxin 1 and Shiga toxin 2 are disclosed herein. Another embodiment includes a kit for differentiating between Shiga toxin 1 and Shiga toxin 2. Assay systems and methods for providing an assay are also provided for herein.Type: ApplicationFiled: April 16, 2008Publication date: February 12, 2009Inventors: Suri Saranathan Iyer, Duane Michael Hatch, Ramesh Ratan Kale, Alison Ann Weiss, Shantini Gamage, Colleen M, McGannon
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Publication number: 20090036657Abstract: The present invention provides novel pyrrolo[2,1-c][1,4]benzodiazepine-glycoside prodrug of general formula 1a-b, useful as selective anticancer agents. The present invention also provides a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine-glycoside prodrugs of general formula 1a-b. This invention also provides activation of these produgs by E. coli ? galactosidase and envisaged that these molecules are toxic to human cancer cell lines in the presence of the enzyme E. coli ?-galactosidase. The prodrugs 1a and 1b were also found to be toxic to human cancer HepG2 cells even in the absence of the E. coli ?-galactosidase. The toxic effect of the molecules when activated was similar to that of the parent molecules 6a and 6b, respectively.Type: ApplicationFiled: January 16, 2008Publication date: February 5, 2009Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Kamal Ahmed, Venkatesh Tekumalla
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Publication number: 20080287663Abstract: The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formulaType: ApplicationFiled: May 8, 2006Publication date: November 20, 2008Applicant: MICROBIA, INC.Inventors: Peter Lee, Stephen Antonelli, Regina Lundrigan, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley
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Publication number: 20080262209Abstract: Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.Type: ApplicationFiled: February 16, 2006Publication date: October 23, 2008Applicant: Lipoxen Technologies LimitedInventors: Sanjay Jain, Ioannis Papaioannou, Smita Thobhani
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Patent number: 7439343Abstract: Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.Type: GrantFiled: September 1, 2005Date of Patent: October 21, 2008Assignee: Rensselaer Polytechnic InstituteInventors: Kaushal Rege, Shanghui Hu, Jonathan S. Dordick, Steven M. Cramer
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Publication number: 20080255057Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein Q, Q2, R1, R2, R2a, R3, R3a, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: April 28, 2008Publication date: October 16, 2008Applicant: WYETHInventors: Sayed Elmarakby, Ping Cai, Appavu Chandrasekaran, Mark Ruppen, Rasmy Talaat
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Publication number: 20080255059Abstract: The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.Type: ApplicationFiled: March 28, 2008Publication date: October 16, 2008Applicant: The Johns Hopkins UniversityInventors: Philip A. Beachy, James K. Chen, Anssi Jussi Nikolai Taipale
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Patent number: 7429568Abstract: The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereoType: GrantFiled: October 12, 2005Date of Patent: September 30, 2008Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Hideki Fujikura, Nobuhiko Fushimi, Toshihiro Nishimura, Takeshi Nakabayashi, Masayuki Isaji
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Patent number: 7423133Abstract: Fluorescent glycosides containing aromatic hydrocarbon groups are useful in labelling and detection methods for a wide array of chemical and biological molecules. Assembly of multiple analogs to form “polyfluors” affords fluorescence properties that are different from the properties of the component analogs. This allows for the design and use of combinatorial libraries of molecules displaying widely varying fluorescence colors.Type: GrantFiled: August 22, 2003Date of Patent: September 9, 2008Assignee: The Board of Trustees of the LeLand Stanford Junior UniversityInventors: Eric T. Kool, Jianmin Gao
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Publication number: 20080207534Abstract: The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic.Type: ApplicationFiled: January 7, 2008Publication date: August 28, 2008Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Wendelin FRICK, Heiner GLOMBIK, Hubert HEUER, Hans-Ludwig SCHAEFER, Stefan THEIS
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Publication number: 20080194494Abstract: The invention relates to a chemical genus of 4-biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia and other disorders, having general formula: Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.Type: ApplicationFiled: April 26, 2006Publication date: August 14, 2008Applicant: MICROBIA, INC.Inventors: Eduardo J. Martinez, John Jeffrey Talley, Regina Lundrigan
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Publication number: 20080194801Abstract: Design and synthesis of a novel library of compounds comprising a spacer with an attachment element on one terminus and a recognition element on the other terminus is presented. The library of compounds can be attached to a solid support and used as an integral component of sensors and biosensors or the library of compounds can be used as antiviral drugs or to isolate pathogens from complex mixtures for further analysis.Type: ApplicationFiled: March 26, 2007Publication date: August 14, 2008Inventors: Basil I. Swanson, Jurgen G. Schmidt, Suri S. Iyer, Ramesh R. Kale
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Publication number: 20080188380Abstract: A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.Type: ApplicationFiled: January 25, 2008Publication date: August 7, 2008Inventors: SUNG-MIN CHI, Jung-hwan Hah, Kyoung-seon Kim, Won-sun Kim, Man-hyoung Ryoo
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Publication number: 20080188426Abstract: The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula R1 represent H, an optionally substituted alkyl group, an alkenyl group, etc.; R2 represent H, a halogen atom or an alkyl group; R3 and R4 represent H, OH, a halogen atom, an optionally substituted alkyl group, etc.; Y represents CH or N; Q represents alkylene, alkenylene, etc.; ring A represents an aryl group or a heteroaryl group; G represents a group represented by the following general formula (G-1) or (G-2) (in which E1 represents H, F or OH; and E2 represents H, F, a methyl group, etc.Type: ApplicationFiled: February 15, 2008Publication date: August 7, 2008Applicant: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Nobuhiko FUSHIMI, Hirotaka Teranishi, Kazuo Shimizu, Shigeru Yonekubo, Fumiaki Ito, Masayuki ISAJI
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Publication number: 20080176261Abstract: Disclosed are compositions and methods capable of facilitating the detection and measurement of poly(ADP-ribose)polymerases (PARP enzymes). PARP enzyme activity can be monitored using a novel calorimetric substrate, ADP-ribose-para-nitrophenol. The substrate can be synthesized from beta nicotinamide adenine dinucleotide (?-NAD+) and para-nitrophenol. In an embodiment, a continuous assay was developed to detect and kinetically monitor activity for PARP enzymes such as PARP-1, tankyrase-1 (PARP-5), and VPARP (PARP-4). The compositions and methods are particularly useful in the screening and identification of specific PARP inhibitors.Type: ApplicationFiled: January 18, 2007Publication date: July 24, 2008Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Amanda C. Nottbohm, Robin Shane Dothager, Karson S. Putt, Mirth T. Hoyt, Paul J. Hergenrother
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Publication number: 20080167255Abstract: 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.Type: ApplicationFiled: December 11, 2007Publication date: July 10, 2008Applicant: MICROBIA, INC.Inventors: Eduardo J. Martinez, John J. Talley, Stephen Antonelli, Timothy C. Barden, Regina Lundrigan-Soucy, Wayne C. Schairer, Jing-Jing Yang, Daniel P. Zimmer, Brian Cali, Mark G. Currie, Peter S. Yorgey
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Patent number: 7393838Abstract: The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereType: GrantFiled: October 12, 2005Date of Patent: July 1, 2008Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Hideki Fujikura, Nobuhiko Fushimi, Toshihiro Nishimura, Takeshi Nakabayashi, Masayuki Isaji
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Publication number: 20080139484Abstract: A compound having SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity, etc. It is a 1-(?-D-glycopyranosyl)-3-substituted nitrogen-containing heterocyclic compound represented by the general formula (I), a prodrug, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof; an SGLT inhibitor containing the same; a pharmaceutical composition containing the same and a medicinal use thereof. In the formula, ring A represents optionally substituted aryl or heteroaryl; Q1 to Q5 independently represent a carbon atom having a hydrogen atom or substituent bonded thereto or a nitrogen atom; E represents a single bond, alkylene, —O—, —S— or —NH—; and R represents methyl, ethyl, fluoromethyl or hydroxymethyl.Type: ApplicationFiled: September 28, 2005Publication date: June 12, 2008Applicant: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Hirotaka Teranishi, Norihiko Kikuchi, Kohsuke Ohno
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Patent number: 7375090Abstract: The present invention relates to glucopyranosyloxy-pyrazoles of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on sodium-dependent glucose cotransporter SGLT, the use thereof for the treatment of diseases, particularly metabolic disorders such as diabetes, and the preparation thereof.Type: GrantFiled: August 24, 2004Date of Patent: May 20, 2008Assignee: Boehringer Ingelheim International GmbHInventors: Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Leon Barsoumian
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Patent number: 7375213Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.Type: GrantFiled: December 23, 2003Date of Patent: May 20, 2008Assignee: Bristol-Myers Squibb CompanyInventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
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Publication number: 20080113922Abstract: Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.Type: ApplicationFiled: September 27, 2007Publication date: May 15, 2008Inventors: Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
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Patent number: 7365055Abstract: The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics.Type: GrantFiled: December 22, 2004Date of Patent: April 29, 2008Assignee: BTG International LimitedInventors: Jamal Temsamani, Roger Lahana, Patrick Mouchet
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Patent number: 7361744Abstract: Compounds having the formula (I): wherein A represents a group such as a cyclic group, R1 and R2 represent groups such as alkyl groups or hydroxymethyl groups, and n represents 1 or 2, or pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof have superior activity and stability, and are useful for the treatment and/or prevention of diabetes mellitus, or the like.Type: GrantFiled: July 28, 2005Date of Patent: April 22, 2008Assignee: Sankyo Company LimitedInventors: Takeshi Honda, Akira Okuno, Masanori Izumi, Xiaoliu Li
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Publication number: 20080020987Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 to R6 and R7a, R7b, R7c are defined according to claim 1. Furthermore the present invention relates to processes for preparing educts and intermediates in the above processes and to intermediates as such.Type: ApplicationFiled: July 20, 2006Publication date: January 24, 2008Inventor: Waldemar Pfrengle
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Patent number: 7288528Abstract: Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and process for their preparation. The compounds are suitable for example as antidiabetics.Type: GrantFiled: December 12, 2003Date of Patent: October 30, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Wendelin Frick, Heiner Glombik, Werner Kramer, Hubert Heuer, Harm Brummerhop, Oliver Plettenburg
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Patent number: 7247616Abstract: The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicineType: GrantFiled: October 24, 2005Date of Patent: July 24, 2007Assignee: Ajinomoto Co., Inc.Inventors: Koji Ohsumi, Takashi Umemura, Hiroyuki Matsueda, Toshihiro Hatanaka, Akiko Onuki, Katsumi Maezono, Yoko Kageyama, Nobuo Kondo
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Patent number: 7223738Abstract: The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.Type: GrantFiled: April 4, 2003Date of Patent: May 29, 2007Assignee: Merck & Co., Inc.Inventors: Mark T. Bilodeau, Mark E. Duggan, John C. Hartnett, Craig W. Lindsley, Peter J. Manley, Zhicai Wu, Zhijian Zhao
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Patent number: 7217697Abstract: The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group represented by the general formula; the other is an optionally substituted alkyl group or a cycloalkyl group; and R2 is a halogen atom, a hydroxy group, an optionally substituted alkyl group, an optionally substituted alkoxy group, an alkylthio group, a group of the general formula: -A-R3 wherein A is a single bond, an oxygen atom, a methylene group, an ethylene group, —OCH2— or —CH2O—; and R3 is a cycloalkyl group, a heterocycloalkyl group, an optionally substituted aryl group, an optionally substituted tiazolyl group or an optionally substituted pyridyl group, pharmaceutically acceptable salts thereof or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT1, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabeticType: GrantFiled: May 27, 2002Date of Patent: May 15, 2007Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Hiroaki Shiohara, Hideki Fujikura, Nobuhiko Fushimi, Fumiaki Ito, Masayuki Isaji
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Patent number: 7189702Abstract: The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; R1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.Type: GrantFiled: February 22, 2006Date of Patent: March 13, 2007Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Toshihiro Nishimura, Nobuhiko Fushimi, Hideki Fujikura, Kenji Katsuno, Yoshimitsu Komatsu, Masayuki Isaji
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Patent number: 7157432Abstract: Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I): [wherein R1, R2, R3 and R4, independently from each other, are a residue of a monosaccharide represented by the formulae: (wherein, R is a hydrogen or a protecting group)], or its salt. The tetraphenylbacteriochlorin derivative or its salt has a large molar extinction coefficient at long wavelengths which are expected to have a high tissue-penetrating property, and exhibits high selectivity to tumor cells and hydrophilicity.Type: GrantFiled: September 7, 2005Date of Patent: January 2, 2007Assignees: San-Ei Gen F.F.I., Inc.Inventors: Shigenobu Yano, Toyoji Kakuchi, Yuji Mikata
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Patent number: 7129220Abstract: Substituted indole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.Type: GrantFiled: July 30, 2004Date of Patent: October 31, 2006Assignee: Janssen Pharmaceutica N.VInventors: Mary Pat Beavers, Mona Patel, Philip Rybczynski, Maud Urbanski, Xiaoyan Zhang
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Patent number: 7129221Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: May 13, 2003Date of Patent: October 31, 2006Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Guoqiang Wang, Ly Tam Phan, Deqiang Niu, Yao-Ling Qiu, Nha Huu Vo, Jay Judson Farmer, Ying Hou
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Patent number: 7122526Abstract: The present invention relates to anti-tumor compounds, compositions and methods.Type: GrantFiled: June 30, 2003Date of Patent: October 17, 2006Assignee: Nanosphere, Inc.Inventors: Ze-Qi Xu, Yasheen Zhou, Michael T. Flavin
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Patent number: 7112671Abstract: The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, as well as other polypyrrolic macrocycles, prepared using tripyrranes of Formula I as a precursor. These macrocycles are characterized by a tripyrrolic portion of the macrocyclic ring having substituents that cause the heterocycle to lack a plane of symmetry perpendicular to the plane of the macrocycle.Type: GrantFiled: August 28, 2001Date of Patent: September 26, 2006Assignee: Pharmacyclics, Inc.Inventors: Tarak D. Mody, Joshua Galanter
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Patent number: 7098327Abstract: A process for the production of dual-functional ion exchange resins from lignocellulosic agricultural material involving anionization of the lignocellulosic agricultural material with citric acid and then cationization of the lignocellulosic agricultural material with dimethyloldihydroxyethylene urea (DMDHEU) and choline chloride, or cationization of the lignocellulosic agricultural material with DMDHEU and choline chloride and then anionization of the lignocellulosic agricultural material with citric acid.Type: GrantFiled: August 19, 2004Date of Patent: August 29, 2006Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Wayne E. Marshall, Lynda H. Wartelle
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Patent number: 7094764Abstract: This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.Type: GrantFiled: July 30, 2004Date of Patent: August 22, 2006Assignee: Janssen Pharmaceutica N.V.Inventor: Maud Urbanski
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Patent number: 7087579Abstract: The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; R1 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkenyl group, a cyclic lower alkyl group, etc.; R2 represents a hydrogen atom, an optionally substituted lower alkyl group, a lower alkoxy group, a lower alkenyl group, a cyclic lower alkyl group, a cyclic lower alkoxy group, etc., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.Type: GrantFiled: February 26, 2002Date of Patent: August 8, 2006Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Toshihiro Nishimura, Nobuhiko Fushimi, Hideki Fujikura, Kenji Katsuno, Yoshimitsu Komatsu, Masayuki Isaji
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Patent number: 7084124Abstract: Substituted indazole-O-glucosides, compositions containing them, and methods of using them, for example for the treatment of diabetes and Syndrome X are disclosed.Type: GrantFiled: July 30, 2004Date of Patent: August 1, 2006Assignee: Janssen Pharmaceutica, N.V.Inventors: Mona Patel, Philip J. Rybczynski, Maud Urbanski, Xiaoyan Zhang
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Patent number: 7084123Abstract: The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug: one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereoType: GrantFiled: December 25, 2001Date of Patent: August 1, 2006Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Hideki Fujikura, Nobuhiko Fushimi, Toshihiro Nishimura, Takeshi Nakabayashi, Masayuki Isaji
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Patent number: 7071181Abstract: The present invention provides methods of treating diabetes and associated conditions by administering a composition including at least one sterol or 5?-stanol absorption inhibitor or compositions or therapeutic combinations including: (a) at least one antidiabetic medication; and (b) at least one sterol or 5?-stanol absorption inhibitor.Type: GrantFiled: September 19, 2002Date of Patent: July 4, 2006Assignee: Schering CorporationInventors: Harry R. Davis, Teddy Kosoglou, Gilles J. Picard, Rudyard J. Ress, John T. Strony, Enrico P. Veltri
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Patent number: 7067494Abstract: This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.Type: GrantFiled: June 25, 2002Date of Patent: June 27, 2006Assignee: The University of British ColumbiaInventors: Raymond J. Andersen, Michel Roberge, Robert A. Britton, E. Dilip De Silva
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Patent number: 7056906Abstract: The present invention provides compositions, therapeutic combinations and methods including: (a) at least one hormone replacement therapy composition; and (b) at least one sterol absorption inhibitor which can be useful for treating vascular conditions in post-menopausal women and lowering plasma levels of sterols or 5?-stanols.Type: GrantFiled: September 19, 2002Date of Patent: June 6, 2006Assignee: Schering CorporationInventor: John T. Strony
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Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
Patent number: 7053080Abstract: The present invention provides methods for the treatment of obesity using sterol or 5?-stanol absorption inhibitors and compositions and therapeutic combinations including sterol or 5?-stanol absorption inhibitors and at least one obesity control medication.Type: GrantFiled: September 19, 2002Date of Patent: May 30, 2006Assignee: Schering CorporationInventors: Harry R. Davis, Rudyard J. Ress, John T. Strony, Enrico P. Veltri -
Patent number: 7022678Abstract: In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression, anxiety, sleep disorders, consumptive disorders, psychosis, tardive dyskinesia, Huntington's disease, or Parkinson's disease in a subject by administering to the subject a pharmaceutically effective amount of a pregabalin lactose conjugate.Type: GrantFiled: January 28, 2002Date of Patent: April 4, 2006Assignee: Warner-Lambert CompanyInventors: Timothy Robert Hurley, Michael James Lovdahl, Brian Tobias
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Patent number: 7019131Abstract: The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile one-pot synthesis of oligosaccharides. The influence on reactivity of the structural effects of different monosaccharide cores and different protecting groups on each glycoside donor is characterized and quantified. In addition, a correlation between glycosyl donor reactivity and the chemical shift of the anomeric proton by 1 H NMR has been established. A database of thioglycosides as glycosyl donors has been created using this reactivity data. The utility is demonstrated by the easy and rapid one-pot assembly of various linear and branched oligosaccharide structures.Type: GrantFiled: March 25, 2003Date of Patent: March 28, 2006Assignee: The Scripps Research InstituteInventors: Chi-Huey Wong, Zhiyuan Zhang, Ian Ollmann, Timor Baasov, Xin-Shan Ye
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Patent number: 7015201Abstract: The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine.Type: GrantFiled: September 9, 2004Date of Patent: March 21, 2006Assignee: Ajinomoto Co., Inc.Inventors: Koji Ohsumi, Takashi Umemura, Hiroyuki Matsueda, Toshihiro Hatanaka, Akiko Onuki, Katsumi Maezono, Yoko Kageyama, Nobuo Kondo
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Patent number: 6992067Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.Type: GrantFiled: December 19, 2001Date of Patent: January 31, 2006Assignee: Aventis Pharma Deutschland GmbHInventors: Heiner Glombik, Werner Krame, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schäfer