Containing -c(=x)x- Wherein The X's Are The Same Or Diverse Chalcogens Patents (Class 536/18.2)
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Publication number: 20130288992Abstract: Compounds of formula (I?) wherein: R11, R12, R13, R14 and R15 are hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl-carbonyloxy, or a G-O— group, and at least one of R11, R12, R13, R14 and R15 is a G-O— group, wherein G is a saccharide residue, X1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or —CH?CH—CH2—, X2 is —CO—O— or —O—CO—, p and q are integer ofs 0 to 7, and p+q=0 to 8, Y1 is methylene, ethylene or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, and R16 and R17 are hydrogen, methyl or ethyl, or R16 and R17 form a C3-6 cycloalkyl group, are useful as GLP-1 secretion promoting agents.Type: ApplicationFiled: June 21, 2013Publication date: October 31, 2013Inventors: Wataru KUROSAWA, Takuya Toyoda, Risa Ubagai, Yoshihito Nogusa, Kana Oyama, Yusuke Amino
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Publication number: 20130281393Abstract: The present invention provides novel and advantageous materials and methods for preventing and treating viral infection.Type: ApplicationFiled: April 16, 2013Publication date: October 24, 2013Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITEDInventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG
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Patent number: 8563523Abstract: The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.Type: GrantFiled: September 5, 2008Date of Patent: October 22, 2013Assignee: University of Georgia Research Foundation, Inc.Inventor: Geert-Jan Boons
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Patent number: 8557784Abstract: The present invention provides a pharmaceutically acceptable compound, a pharmaceutical composition comprising the above-mentioned pharmaceutically acceptable compound. The pharmaceutically acceptable compound provided by the present invention is a salt of a basic group-containing morphinan derivative and a carboxyl group-containing glycyrrhizinic acid and has the ability to be used to manufacture medicaments for treating and/or preventing cough, ameliorating pains, treating respiratory system diseases, treating cardiovascular diseases and treating liver diseases.Type: GrantFiled: July 7, 2011Date of Patent: October 15, 2013Assignee: Standard Chem. & Pharm. Co., Ltd.Inventors: Chin-Tsai Fan, Cheng-Shun Lai, Wen-Yen Yeh, Yu-Ying Liu
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Publication number: 20130252909Abstract: The invention provides a method to prevent or treat HIV-infection with synthetic tannins, and pharmaceutical compositions comprising synthetic tannins.Type: ApplicationFiled: March 7, 2013Publication date: September 26, 2013Applicant: University of Iowa Research FoundationInventors: George A. Kraus, Wendy Maury
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Publication number: 20130217068Abstract: The present invention relates to nucleic acid and amino acid sequences from Akkermansia muciniphila and from Bacteroides fragilis, coding for/representing novel alpha-1,3-fucosyltransferases. The invention also provides uses and methods for using the alpha-1,3-fucosyltransferases to generate fucosylated products, such as oligosaccharides, (glyco)proteins, or (glyco)lipids, in particular of 3-fucosyllactose.Type: ApplicationFiled: April 10, 2013Publication date: August 22, 2013Applicant: JENNEWEIN BIOTECHNOLOGIE GMBHInventor: JENNEWEIN BIOTECHNOLOGIE GMBH
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Publication number: 20130217031Abstract: The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.Type: ApplicationFiled: December 28, 2012Publication date: August 22, 2013Applicant: M BIO TECHNOLOGY INC.Inventor: M BIO TECHNOLOGY INC.
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Publication number: 20130203688Abstract: The present document describes a nutraceutical or cosmeceutical composition for the prophylaxis of an ailment comprising a therapeutically effective amount of a sugar plant syrup filtration residue in association with a pharmaceutically acceptable carrier. The present document also describes a nutraceutical or cosmeceutical composition for improving health condition of skin. The present document describes a method of producing a sugar plant syrup-derived product; wherein the improvement is characterized in the step of: collecting a sugar plant syrup residue during the production of sugar or syrup to produce a syrup-derived by-product.Type: ApplicationFiled: August 19, 2011Publication date: August 8, 2013Applicant: FÉDÉRATION DES PRODUCTEURS ACÉRI-COLES DU QUÉBECInventors: Julie Barbeau, Geneviève Béland
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Publication number: 20130203689Abstract: The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.Type: ApplicationFiled: March 15, 2013Publication date: August 8, 2013Applicants: SEPAL PHARMA LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: RAMOT AT TEL-AVIV UNIVERSITY LTD., SEPAL PHARMA LTD.
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Patent number: 8486898Abstract: Compounds extracted from Rhodiola rosea have ability to inhibit gelatinases and collagenases activity. The compounds have the chemical structure as shown below.Type: GrantFiled: June 23, 2011Date of Patent: July 16, 2013Assignees: Taipei Medical University (TMU), China Medical UniversityInventors: Ching-Kuo Lee, Chieh-Chih Hsu, George Hsiao, Shin-Hun Juang
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Publication number: 20130172542Abstract: The present invention has objects to provide a novel crystalline 2-O-?-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-?-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-?-glucosyl-L-ascorbic acid, and their production processes and uses.Type: ApplicationFiled: September 6, 2011Publication date: July 4, 2013Applicant: HAYASHIBARA CO., LTD.Inventors: Takashi Shibuya, Seisuke Izawa, Shigeharu Fukuda
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Patent number: 8476413Abstract: Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.Type: GrantFiled: August 18, 2010Date of Patent: July 2, 2013Assignee: Lexicon Pharmaceuticals, Inc.Inventors: Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
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Publication number: 20130157968Abstract: The invention relates to novel eucomic acid (2-(4-hydroxybenzyl)malic acid) derivatives or plant extracts comprising such derivatives, and also to cosmetic or dermatological compositions containing these compounds or these extracts, and to cosmetic care methods using said compositions.Type: ApplicationFiled: April 14, 2011Publication date: June 20, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, GUERLAINInventors: Charlotte Simmler, Virginie Leplanquais, Emmanuelle Noblesse, Patrice Andre, Annelise Lobstein
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Publication number: 20130143828Abstract: The invention relates to a high molecular weight glycolipid characterized by the presence of rhamnose which has anti-inflammatory activity, particularly in inflammation triggered by ischemia and reperfusion. A further aspect of the invention is a process for preparation of said glycolipid from Cyanobacteria.Type: ApplicationFiled: August 2, 2011Publication date: June 6, 2013Applicant: BLUEGREEN BIOTECH S.R.L.Inventor: Monica Molteni
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Patent number: 8450441Abstract: A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a ?-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.Type: GrantFiled: June 24, 2008Date of Patent: May 28, 2013Assignees: National University Corporation Shizuoka University, Shizuoka Prefectural Universities Corporation, Yamasa CorporationInventors: Taiichi Usui, Takeomi Murata, Takashi Suzuki, Ilpal Jwa, Yusuke Ohba, Tomoki Hamamoto, Toshitada Noguchi
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Patent number: 8426370Abstract: The present invention relates to a diaryl hepatonoid-based compound of formula (1) having viral inhibitory activity; its pharmaceutically acceptable salt; or a hydrate, a solvate or a prodrug of any of the foregoing, and a pharmaceutical composition comprising the same, and the use thereof therapeutic agents. The diaryl hepatonoid-based compounds according to present invention have an excellent effect of inhibiting viral activity, and thus will be useful as therapeutic agents against virus-related diseases.Type: GrantFiled: June 4, 2009Date of Patent: April 23, 2013Assignee: RNL Bio Co., Ltd.Inventors: Jeong Chan Ra, Young Ho Kim, Hyuk Joon Kwon, Huu Tung Nguyen
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Patent number: 8410066Abstract: Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood. More specifically, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described.Type: GrantFiled: April 27, 2010Date of Patent: April 2, 2013Assignee: GlycoMimetics, Inc.Inventors: John L. Magnani, Arun K. Sarkar
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Patent number: 8394774Abstract: The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is disclosed.Type: GrantFiled: February 11, 2010Date of Patent: March 12, 2013Assignee: Dow AgroSciences, LLC.Inventors: Gary D. Crouse, Thomas C. Sparks, CaSandra L. McLeod, Annette V. Brown, Thomas L. Siddall
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Patent number: 8394755Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: GrantFiled: March 30, 2011Date of Patent: March 12, 2013Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20130036939Abstract: The invention relates to enamine resins which are the reaction products of a) an acetoacetylated resin, and a C1-C20 alkyl amine or a mixture of C1-C20 alkyl amines. The acetoacetylated resin is the reaction product of a polyol having 4 or more hydroxyl groups; and at least one acetoacetate. The invention also relates to an acetoacetylated resin which is the reaction product of a polyol having 4 or more hydroxyl groups and at least one acetoacetate, where a portion of the hydroxyl groups of the polyol are replaced by acetoacetate groups and the remaining hydroxyl groups are replaced by a saturated monofunctional carboxylic acid ester, unsaturated monofunctional carboxylic acid ester, or a mixture thereof; as well as to enamine resins prepared from these acetoacetylated resins. The invention also relates to curable coating compositions containing such resins or a mixture of those resins, at least one metallic drier compound; and optionally one or more solvents.Type: ApplicationFiled: February 4, 2011Publication date: February 14, 2013Inventors: Dean C. Webster, Thomas J. Nelson, Xiao Pan
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Publication number: 20130035304Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: January 31, 2011Publication date: February 7, 2013Inventors: Loren D. Walensky, Michelle L. Stewart, Nicole Cohen
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Publication number: 20130029925Abstract: The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention or for the treatment of cancer metastasis.Type: ApplicationFiled: February 17, 2011Publication date: January 31, 2013Applicants: UNIVERSITE DE BRETAGNE OCCIDENTALE (U.B.O.), INSERM ( INSTITUT NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE), UNIVERSITE FRANCOIS-RABELAIS DE TOURSInventors: Christophe Vandier, Philippe Bougnoux, Aurelie Chantome, Bernard Corbel, Alban Girault, Jean-Pierre Haelters, Virginie Joulin, Marie Potier-Cartereau, Gaelle Simon
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Publication number: 20130029923Abstract: The subject invention provides a novel and advantageous method for preventing and treating viral infection. Specifically exemplified herein are therapeutic uses of forsythoside A and jacaranone, compounds isolated from traditional Chinese medicinal material such as Fructus forsythiae (Lian Qiao). Also provided is use of a Yin Qiao San composition for preventing and treating viral infection.Type: ApplicationFiled: December 30, 2010Publication date: January 31, 2013Inventors: Allan Sik-Yin Lau, Lai Hung Cindy Yang, Anna Hing-Yee Law
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Publication number: 20130029924Abstract: Glycosylated valproic acid and its analogs are provided. In some embodiments, the glycosylated valproic acid and its analogs have improved solubility and are ideal for drug delivery to treat a variety of diseases.Type: ApplicationFiled: July 25, 2012Publication date: January 31, 2013Applicant: Chromatin TechnologiesInventors: Norman S. HEYMAN, Brian K. Shull
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Publication number: 20130012461Abstract: Disclosed are a composition for the prophylaxis of influenza viral infection comprising tannic acid, an air filter coated with the same, and an air cleaner comprising the air filter. Having high inhibitory activity against influenza virus, the composition comprising tannic acid can be applied to the prevention of influenza viral infection. Also, the filter coated with the composition can remove influenza virus from the air so that it can be employed in an air cleaner for the prophylaxis of influenza viral infection.Type: ApplicationFiled: September 11, 2012Publication date: January 10, 2013Applicant: WOONGJIN COWAY CO., LTD.Inventors: Hyoung Joon Kim, Chan Jung Park
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Publication number: 20120329737Abstract: The invention relates to hybrid molecules made of two lipids or lipid-analogous compounds which are linked to each other via their lipophilic end. The hybrid molecules thereby have at least one hydrophilic group at their hydrophilic end for increasing the hydration shell of the hybrid molecule. The hybrid molecules according to the invention can be used as pharmaceutical or as a cosmetic preparation.Type: ApplicationFiled: June 23, 2010Publication date: December 27, 2012Inventor: Hans-Uwe Wolf
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Publication number: 20120330000Abstract: Disclosed herein are compositions that include a blend of sucrose polyesters, wherein each sucrose polyester includes a sucrose moiety and a plurality of fatty acid ester moieties, wherein from about 50% to about 90%, by weight, of the combined fatty acid ester moieties of the sucrose polyesters in the blend are palmitic fatty acid ester moieties.Type: ApplicationFiled: May 24, 2012Publication date: December 27, 2012Inventors: Peter Yau-Tak Lin, Deborah Jean Back, Donald Benjamin Appleby, James M. Robertson, Stevn Robert Baker
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Publication number: 20120321566Abstract: Disclosed herein are an anti-biofilm composition and a method to inhibit or prevent cell adhesion and/or biofilm formation by a microorganism, in which use of 1,2,3,4,6-penta-O-galloyl-D-glucopyranose (PGG) is involved therein.Type: ApplicationFiled: September 19, 2011Publication date: December 20, 2012Applicant: Chang Gung UniversityInventors: Shih-Tung Liu, Mei-Hui Lin, Fang-Rong Chang, Mu-Yi Hua, Hung-Wei Yang
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Publication number: 20120309699Abstract: Compounds of general formula (I) for the treatment of inflammatory processes involved in numerous diseases such as intestinal inflammatory diseases. The invention moreover refers to compounds included within such general formula and to the procedure of the obtainment thereof.Type: ApplicationFiled: December 14, 2010Publication date: December 6, 2012Applicant: Consejo Superior de Investigaciones Cientificas (CSIC)Inventors: Juan Carlos Espin De Gea, Juan Carlos Morales Sánchez, Isabel Medina Mendez
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Publication number: 20120309701Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.Type: ApplicationFiled: April 23, 2012Publication date: December 6, 2012Applicant: THE WASHINGTON UNIVERSITYInventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
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Publication number: 20120302515Abstract: Methods are provided for obtaining phytoextracts from vegetation waters and pomaces coming from olive milling. Such methods may be based on combining physical-chemical and enzymatic pre-treatment methods, membrane tangential filtration and vacuum evaporation. Such methods allow eco-sustainable and efficient extraction of the active ingredients involved. Compositions resulting from such methods are also provided.Type: ApplicationFiled: May 24, 2012Publication date: November 29, 2012Applicant: PHENOFARM S.r.l.Inventors: Stefano Germani, Massimo Vitagliano, Daniele Pizzichini, Massimo Pizzichini
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Publication number: 20120283200Abstract: The present invention provides a pharmaceutical composition for preventing or treating a chronic heart disease, comprising a compound of a formula (I): wherein: R1 is one independently selected from a group consisting of a hydrogen, a methyl and an ethyl; R2 is one of a hydrogen and a methyl; and R3 is one selected from a group consisting of a hydrogen, (CH2)nAr and (CH2)nArR?R?, wherein n is one of 1 and 2, R? and R? is located at C-3 and C-4 positions, respectively, R? is a hydrogen and R? is one of a hydroxy, a fluorine, a bromine and a OMe, or R?+R?=—OCH2O—; or R2+R3 is one of wherein n is one of 4 and 5.Type: ApplicationFiled: March 27, 2012Publication date: November 8, 2012Applicants: CHINA MEDICAL UNIVERSITY, National Taiwan UniversityInventors: MING-JAI SU, YUEH-HSIUNG KUO
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Publication number: 20120276108Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of glycolysis, inhibitors of protein glycosylation, anti-virals, and down-regulators of insulin receptor and IGF-1 receptor for the treatment or prevention of inflammatory dermatological diseases or proliferative dermatological diseases.Type: ApplicationFiled: January 11, 2012Publication date: November 1, 2012Applicant: INTERTECH BIOInventor: Waldemar Priebe
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Publication number: 20120270824Abstract: Compounds of the formula (I) wherein n is 0, 1 or 2, R1 is aryl, heteroaryl or heterocyclyl, and R2 and R3 are hydrogen or a substituent as described in the specification, are useful for the prevention and treatment of bacterial infections, in particular of urinary infections caused by E. coli.Type: ApplicationFiled: December 13, 2010Publication date: October 25, 2012Inventors: Beat Ernst, Janno Herold
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Publication number: 20120270821Abstract: Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.Type: ApplicationFiled: December 7, 2010Publication date: October 25, 2012Applicant: The Hong Kong University of Science and TechnologyInventors: Nancy Yuk-Yu IP, Fanny Chui-Fun IP, Wing Yu Fu, Guangmiao Fu
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Publication number: 20120264702Abstract: The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug propofol analogs. This invention relates to a method for the production of a broad group of glycosylated propofol carbohydrate derivatives.Type: ApplicationFiled: April 9, 2012Publication date: October 18, 2012Inventors: Brian Shull, John Baldwin, Ramesh Gopalaswamy, Zishan Haroon
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Publication number: 20120245335Abstract: The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2?R)-2?-deoxy-2?-fluoro-2?-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.Type: ApplicationFiled: June 7, 2012Publication date: September 27, 2012Applicant: GILEAD PHARMASSET LLCInventor: Jeremy Clark
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Publication number: 20120238734Abstract: A method of preparing a ribofuranose derivative essentially free of pyranose compounds includes a step of contacting a solution of MDR containing MDRP as an impurity in a solvent including methanol and/or tetrahydrofuran with at least one alkali metal periodate under conditions sufficient to oxidize at least a portion of the MDRP. MDR containing at most 5 wt % of MDRP based on the total weight of MDR and MDRP may be produced.Type: ApplicationFiled: November 23, 2011Publication date: September 20, 2012Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANYInventors: Xing Fu, Albrecht Zumbrunn
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Patent number: 8268801Abstract: The present invention relates to compounds of the following general formula (I) their process of preparation and their use in the treatment or the prophylaxis of tuberculosis.Type: GrantFiled: January 11, 2008Date of Patent: September 18, 2012Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Germain Puzo, Jacques Prandi, Martine Gilleron, Gennaro De Libero, Julie Guiard, Lucia Mori, Samantha Paoletti
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Publication number: 20120190634Abstract: A lipoteichoic acid (LTA)-derived glycolipid, and a pharmaceutical, food or cosmetic composition and a vaccine adjuvant including the same are provided. The LTA-derived glycolipid can inhibit the production of inflammatory cytokines and thus have anti-inflammatory effects. Therefore, the pharmaceutical, food or cosmetic compositions including the LTA-derived glycolipid can be used to prevent and treat inflammatory diseases, and the LTA-derived glycolipid can be also used as the vaccine adjuvant.Type: ApplicationFiled: August 26, 2010Publication date: July 26, 2012Applicant: RNA INC.Inventors: Dae Kyun Chung, Kyoung Soon Jang, Byung Gee Kim, Han Geun Kim, Na Ra Kim, Hea Young Lee, Bong Jun Jung, Tae Rahk Kim, Ji Hye Jeong
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Publication number: 20120172580Abstract: The present invention provides an anti-plant virus agent which exhibits preventative and therapeutic effects on plant virus diseases. The anti-plant virus agent of the present invention is characterized by containing at least one compound selected from the group consisting of ascorbic acid derivatives represented by Formula (I) (wherein, R1 to R4 each independently represents a hydrogen atom, —SO3H, —PO3H2, a glycosyl group, or —COR11, wherein R11 represents an unsubstituted or substituted C1-30 alkyl group, or an unsubstituted or substituted C2-30 alkenyl group, with the proviso that R1 to R4 may not all be hydrogen atoms at the same time), and salts thereof.Type: ApplicationFiled: September 9, 2010Publication date: July 5, 2012Applicants: Nippon Soda Co., Ltd., National University Corporation hokkaido University Kita 8-jyo Nishi 5-chomeInventors: Chikara Masuta, Hanako Shimura, Shinsuke Sano, Takako Fukagawa
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Patent number: 8211850Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: GrantFiled: March 30, 2011Date of Patent: July 3, 2012Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120165281Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.Type: ApplicationFiled: December 28, 2011Publication date: June 28, 2012Applicants: ARKANSAS STATE UNIVERSITY - JONESBORO, The Board of Trustees of the University of ArkansaInventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
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Publication number: 20120149887Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.Type: ApplicationFiled: June 13, 2011Publication date: June 14, 2012Applicant: ACADEMIA SINICAInventors: Masaaki Sawa, Chi-Huey Wong, Tsui-Ling Hsu, Sarah Hanson
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Publication number: 20120135469Abstract: An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a ? bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.Type: ApplicationFiled: January 21, 2010Publication date: May 31, 2012Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGYInventors: Yoshihiro Ozeki, Nobuhiro Sasaki, Kazuo Nagasawa, Masayuki Tera, Yuki Matsuba, Haruka Nakamura, Yutaka Abe
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Publication number: 20120123103Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120122758Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120123104Abstract: Provided are compositions comprising one or more compounds having a structure comprising a node structure with from four to twelve carbon atoms, one or more (poly)glyceryl groups, and one or more hydrophobic moieties, wherein each of the one or more (poly)glyceryl groups is linked to the node structure by a first primary linking group, the one or more hydrophobic moieties are each independently linked either to the node structure by a primary linking group or to one of the (poly)glyceryl groups by a secondary linking group, and wherein the polyglyceryl thickener has an average degree of glyceryl polymerization of from greater than 3 to less than about 11 and an average number of hydrophobic groups per primary linking group of about 0.35 or greater. Also provided are polyglyceryl compounds, compositions comprising water, a surfactant, and a polyglyceryl thickener, as well as, methods of making polyglyceryl compounds and compositions of the present invention.Type: ApplicationFiled: March 30, 2011Publication date: May 17, 2012Inventors: Sasa Andjelic, Modesto Erneta, Michael J. Fevola, Frank C. Sun
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Publication number: 20120107352Abstract: The present invention relates to the isolation, purification and characterization of the Lipopolysaccharide (LPS) from Ochrobactrum intermedium strain LMG3306, and their use as immunostimulant of mammalians, the process for the preparation of a pharmaceutical compound for the treatment and/or prevention of the sepsis and adjuvant for a vaccine in immunosupressed animals and against Leishmania.Type: ApplicationFiled: December 31, 2009Publication date: May 3, 2012Inventors: Juan Ignacio Ovejero Guisasola, Manuel Fresno Escudero
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Publication number: 20120053330Abstract: Disclosed herein are processes for preparing glucopyranosyloxypyrazole derivatives. In particular, the present invention relates to glucopyranosyloxypyrazole derivatives having SGLT2 inhibitory activity and processes and intermediates for preparing the same.Type: ApplicationFiled: April 29, 2010Publication date: March 1, 2012Inventors: Daniel Edward Patterson, Michael S. McClure, Jeremiah David Powers, Claire Frances Crawford, Malcolm Brian Berry