Phosphorus Containing Acid Patents (Class 536/62)
  • Patent number: 9694343
    Abstract: A process for producing a cellulose based sorbent material for the removal of water soluble contaminants from water and other aqueous solutions comprising reacting one or more biomass based cellulose containing raw materials with dilute phosphoric acid where the reaction mixture containing said cellulose containing materials is heated to a reaction temperature and after completion of the reaction time, separation of the dilute phosphoric acid solution from the remaining insoluble raw material, neutralization of the solution by means of a suitable neutralizing agent resulting in precipitation of the modified cellulose, and then separating, washing and removing excess water from the resultant precipitate.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: July 4, 2017
    Assignee: AUSTRALIAN BIOREFINING PTY LTD
    Inventor: Adam Justin Blunn
  • Patent number: 9624312
    Abstract: In accordance with some embodiments of the present invention, a composite material is prepared by blending a flame retardant modified cellulosic nanomaterial (FR-CN) filler into a polymer, wherein the FR-CN filler comprises a cellulosic nanomaterial (e.g., cellulose nanocrystals (CNCs) and/or cellulose nanofibrils (CNFs)) having a surface functionalized to incorporate a phosphorus-containing moiety. In some embodiments, the FR-CN filler is prepared by reacting hydroxyl groups on the surface of the cellulosic nanomaterial and a halogenated phosphorous-containing monomer (e.g., diphenyl phosphoryl chloride). In some embodiments, the surface of the cellulosic nanomaterial is further functionalized to incorporate an orthogonal functionality selected to enhance the compatibility of the FR-CN filler with the polymer by reacting hydroxyl groups on the surface of the cellulosic nanomaterial and a monomer (e.g., epichlorohydrin when the polymer is an epoxy-based polymer).
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: April 18, 2017
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Joseph Kuczynski, Jason T. Wertz
  • Patent number: 9040682
    Abstract: Flame retardant cellulose is prepared comprising cellulose fibers and an organophosphate compound bonded to the cellulose fibers. Accordingly, the bonded phosphate-functional group provides the cellulose fibers with pendant phosphate ester functionality. Numerous phosphate derivatives can be envisaged that will accomplish the intended task.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: May 26, 2015
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Joseph Kuczynski
  • Patent number: 9000148
    Abstract: Flame retardant cellulose acetate is prepared comprising cellulose acetate flakes and an organophosphate compound bonded to the cellulose acetate flakes. Accordingly, the bonded phosphate-functional group provides the cellulose acetate flakes with pendant phosphate ester functionality. Numerous phosphate derivatives can be envisaged that will accomplish the intended task.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: April 7, 2015
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Joseph Kuczynski
  • Publication number: 20140194617
    Abstract: Flame retardant cellulose is prepared comprising cellulose fibers and an organophosphate compound bonded to the cellulose fibers. Accordingly, the bonded phosphate-functional group provides the cellulose fibers with pendant phosphate ester functionality. Numerous phosphate derivatives can be envisaged that will accomplish the intended task.
    Type: Application
    Filed: January 4, 2013
    Publication date: July 10, 2014
    Applicant: International Business Machines Corporation
    Inventors: Dylan J. Boday, Joseph Kuczynski
  • Publication number: 20140194616
    Abstract: Flame retardant cellulose acetate is prepared comprising cellulose acetate flakes and an organophosphate compound bonded to the cellulose acetate flakes. Accordingly, the bonded phosphate-functional group provides the cellulose acetate flakes with pendant phosphate ester functionality. Numerous phosphate derivatives can be envisaged that will accomplish the intended task.
    Type: Application
    Filed: January 4, 2013
    Publication date: July 10, 2014
    Applicant: International Business Machines Corporation
    Inventors: Dylan J. Boday, Joseph Kuczynski
  • Publication number: 20140155589
    Abstract: The inhibitory fiber against virulence factors production of the present invention comprises a fiber and an inhibitor of virulence factors production fixed to the fiber by chemical bonding. The inhibitor of virulence factors production includes at least one compound selected from the group consisting of a phosphate group-containing compound, a carboxylic acid group-containing compound, and a ketone group-containing compound. The production method of the present invention comprises: irradiating the fiber with an electron beam; and bringing into contact with the fiber at least one compound selected from the group consisting of a phosphate group-containing compound, a carboxylic acid group-containing compound, and a ketone group-containing compound to chemically bond the at least one compound to the fiber.
    Type: Application
    Filed: July 25, 2012
    Publication date: June 5, 2014
    Applicants: KURASHIKI BOSEKI KABUSHIKI KAISHA, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
    Inventors: Kohji Miyazaki, Kunihiro Ohshima, Susumu Katsuen
  • Publication number: 20140073775
    Abstract: A process for producing a cellulose based sorbent material for the removal of water soluble contaminants from water and other aqueous solutions comprising reacting one or more biomass based cellulose containing raw materials with dilute phosphoric acid where the reaction mixture containing said cellulose containing materials is heated to a reaction temperature and after completion of the reaction time, separation of the dilute phosphoric acid solution from the remaining insoluble raw material, neutralisation of the solution by means of a suitable neutralising agent resulting in precipitation of the modified cellulose, and then separating, washing and removing excess water from the resultant precipitate.
    Type: Application
    Filed: February 1, 2012
    Publication date: March 13, 2014
    Applicant: Australian Biorefining PTY Ltd.
    Inventor: Adam Justin Blunn
  • Publication number: 20130330637
    Abstract: The object of an exemplary embodiment of the invention is to provide a separator for an electric storage device which has small thermal shrinkage under high-temperature environment, and in which the increase of the battery temperature can be suppressed. An exemplary embodiment of the invention is a separator for an electric storage device, which comprises a cellulose derivative represented by a prescribed formula. The separator for an electric storage device can be obtained, for example, by treating a cellulose separator containing cellulose with a phosphate or a phosphite.
    Type: Application
    Filed: February 21, 2012
    Publication date: December 12, 2013
    Applicant: NEC CORPORATION
    Inventors: Kazuaki Matsumoto, Kazuhiko Inoue
  • Publication number: 20130303750
    Abstract: Methods for integrating the production of cellulose nanocrystals (CNC) and cellulose nanofibrils (CNF) from cellulose are provided. The methods use milder acid hydrolysis conditions than those for maximal CNC production to achieve reduced degradation of cellulose into soluble sugars. Also provided are negatively charged cellulosic solid residues (CSRs) in the form of cellulose fibers (CF) and/or cellulose microfibrils (CMF) during the acid hydrolysis, as well as CNFs fabricated from the CSRs.
    Type: Application
    Filed: May 15, 2012
    Publication date: November 14, 2013
    Applicant: The United States of America as Represented by the Secretary of Agriculture
    Inventors: JunYong Zhu, Richard S. Reiner
  • Patent number: 8455001
    Abstract: The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R1, R2, and R3 are —H, —CH2—COOH, —CH2—COOX, or —CH2CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH2—COOH and —CH2—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH2CO-phosphatidylethanolamine is 0.001 to 0.05.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: June 4, 2013
    Assignee: Teijin Limited
    Inventors: Masaya Ito, Hiroaki Kaneko, Yukako Fukuhira, Nobuyuki Endo
  • Patent number: 8378091
    Abstract: A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier. The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: February 19, 2013
    Assignee: Teijin Limited
    Inventors: Hiroaki Kaneko, Eiichi Kitazono, Masaya Ito, Yoshihiko Sumi
  • Patent number: 7943761
    Abstract: The present invention discloses a cellulose based optical film material with the following structure: wherein R1 is —H or —C(O)R4, R4 is alkyl or aryl; R2 is —C(O)R5, R5 is alkyl or aryl; R3 comprises one of the group consisting of: phosphinate based group, phosphonate based group, phosphonamide based group, phosphate based group, phosphoramide based group, carbamate based group, carbonate based group, and ester based group. Further, this invention also discloses a method for forming the cellulose based optical film material.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: May 17, 2011
    Assignee: National Taiwan Normal University
    Inventor: Chien-Tien Chen
  • Publication number: 20100279982
    Abstract: A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier. The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).
    Type: Application
    Filed: August 3, 2006
    Publication date: November 4, 2010
    Inventors: Hiroaki Kaneko, Eiichi Kitazono, Masaya Ito, Yoshihiko Sumi
  • Patent number: 7741424
    Abstract: The present invention is directed to a phosphoric ester of 2,3-dihydroxypropyl cellulose or 3-(2,3-dihydroxypropoxy)-2-hydroxypropyl cellulose, the cellulose having optionally undergone partial carbamidation, and to a metal absorbent employing the ester, and to a metal-absorbing apparatus employing the metal adsorbent. The cellulose derivative phosphoric ester serves as a metal adsorbent which exhibits high metal adsorption performance and metal adsorption rate per unit weight; has high mechanical strength; effectively soften water or a similar liquid; removes heavy metals from wastewater or a similar liquid at remarkably high efficiency; has excellent processability and can be formed into a variety of shapes and thus is applicable within a wide range; and can readily be reutilized.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: June 22, 2010
    Assignee: Kowa Co., Ltd.
    Inventors: Ming Lu, Katsumi Yabusaki
  • Publication number: 20100129452
    Abstract: The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R1, R2, and R3 are —H, —CH2—COOH, —CH2—COOX, or —CH2CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH2—COOH and —CH2—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH2CO-phosphatidylethanolamine is 0.001 to 0.05.
    Type: Application
    Filed: February 6, 2008
    Publication date: May 27, 2010
    Applicant: TEIJIN LIMITED
    Inventors: Masaya Ito, Hiroaki Kaneko, Yukako Fukuhira, Nobuyuki Endo
  • Patent number: 7132427
    Abstract: This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: November 7, 2006
    Assignee: Ariad Pharmaceuticals, Inc.
    Inventors: Yihan Wang, Chester A. Metcalf, III, William C. Shakespeare, Tomi K. Sawyer, Regine Bohacek, Rajeswari Sundaramoorthi
  • Patent number: 6761272
    Abstract: Filters and methods for producing filter paper or paper-like nonwoven materially consisting partially or wholly of fibrous cellulose containing material. The filters provided are characterized by high filtration capacity and are capable of absorbing and binding undesirable foreign and attendant substances in the filter medium. The cellulose containing material of the is at least partially carbamided with urea and phosphorylated with phosphoric acid or ammonium phosphate until a nitrogen content in the form of carbamide groups of 1 to 4% and a phosphorous content of 3 to 8% are reached.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: July 13, 2004
    Assignee: Helmut Körber
    Inventors: Friedemann Pieschel, Bckehard Lange, Michael Knieling
  • Patent number: 6579977
    Abstract: A process is disclosed for producing biosorbents by phosphorylation of cellulose-containing materials with phosphoric acid or ammonium phosphate in the presence of urea. Also disclosed are biosorbents with particular good use properties. Biosorbents of this type are used, in particular, for removing heavy metals from aqueous solutions. Proceeding from the disadvantages of the known prior art, purification costs of resultant raw products should be lowered and the formation of unwanted soluble organic polymer phosphates as by-products should be prevented. The biosorbents should have an improved mechanical strength and very good use properties. The disclosed biosorbents contain 5-10 % phosphorus and 1-4 % nitrogen in the form of carbamide groups. The synthesis mixture is mixed with elementary sulphur before starting the reaction in order to produce biosorbents with an increased mechanical strength. The proposed procedure allows reducing the otherwise customary reaction temperatures by about 40° C.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: June 17, 2003
    Assignee: EISU Innovative Gesellschaft fur Technik und Umweltschutz mbH
    Inventors: Friedemann Pieschel, Ekkehard Lange, Juan Camacho, Christine Fieseler, Hendrik Ikier
  • Patent number: 6140497
    Abstract: A spinnable, isotropic solution containing cellulose, phosphoric acid and/or anhydrides of phosphoric acid and water is prepared by dissolving cellulose in a solvent, the solvent being a homogeneous mixture of water and at least one of phosphoric acid and anhydrides of phosphoric acid such that the solvent contains 72-85 wt. % of phosphorous pentoxide, P.sub.2 O.sub.5. The cellulose is mixed with the solvent in a mixing apparatus, the mixing apparatus having mixers, kneaders or the like, and capable of generating high shearing forces. The solution is converted from anisotropic phase to isotropic phase by the addition of water. The water required to convert the solution to the isotropic phase is added either just prior to, during or after the mixing step. The solvent preferably contains 72-80 wt. % P.sub.2 O.sub.5 and 7-20 wt. % of cellulose, and is used to make hollow fibers, membranes, non-woven films, and other articles requiring the use of cellulose-containing solutions.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: October 31, 2000
    Assignee: Akzo Nobel N.V.
    Inventors: Jan Barend Westerink, Marco Ypma, Hendrik Maatman, Hanueke Boerstoel
  • Patent number: 6075139
    Abstract: Sucrose ester and ether products, useful as food or beverage bulking agents, reduced calorie sweeteners, fat replacement agents, stabilizing agents, thickening agents and emulsifying agents; adhesives; biodegradable plastics and films; sizing agents for paper and textiles; ethical pharmaceuticals and new fibers are prepared by using a two-phase reaction system in which sucrose is dissolved in an alkaline, aqueous solution and an acidic reagent such as a bifunctional acid dichloride or epoxide is added to the sucrose in a water-immiscible organic solvent. Several types of products are produced: water-insoluble sucrose ester (ether) copolymers; water-soluble sucrose ester (ether) copolymers; sucrose ester (ether) dimers; and intramolecular, cyclic sucrose esters (ethers). These products can be further varied by using different kinds of acid dichlorides or epoxides that contain different kinds of functional groups.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: June 13, 2000
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: John F. Robyt, Rupendra Mukerjea
  • Patent number: 6005099
    Abstract: The invention relates to .beta.(1.fwdarw.6) glucosamine disaccharides having general formula (I) to a method for preparing these disaccharides, comprising the steps of: i) providing a starting material comprising lipid A moiety of lipopolysaccharide-comprising microorganisms; and ii) subjecting the starting material to an alkaline treatment such as lipid A moiety is O-deacylated at the 3-position and at the 3'-position, to pharmaceutical compositions comprising as an active ingredient these disaccharides, and to these disaccharides for use as an immunomodulating agent, anti-tumor agent, and vaccine component.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: December 21, 1999
    Assignee: Laboratoires OM S.A.
    Inventors: John Gwynfor Davies, Jacques Bauer, Pierre Hirt, Adrian Schulthess
  • Patent number: 5783408
    Abstract: A method for screening a compound as a potential anti-obesity agent by determining whether the compound stimulates micro motion of cells in vitro is described
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 21, 1998
    Inventors: Bradford S. Hamilton, Daniel A. K. Roncari, deceased, by Lubov Roncari, executor
  • Patent number: 5728528
    Abstract: Fluorescent labels are provided employing energy absorber/donor components and energy acceptor/fluorescer components joined together by a spacer which comprises sugar phosphate monomeric units, particularly ribosyl phosphate monomeric units, where the sugar groups are free of active hydroxyl groups. Particularly, an energy transfer component is substituted at the 5' position of the spacer chain, while the other energy transfer component is substituted at the 1' position of the 3' terminal ribosyl group of the label forming an ET cassette for linking to a nucleic acid sequence with any compositions. By employing combinations of ET components, with a common energy absorber/donor and different fluorescers, one can provide for families of labels which can be tagged to any target molecules and which can be excited at a single wavelength and fluoresce at different wavelengths with large Stokes shifts. The compositions find particular application in sequencing.
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: March 17, 1998
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, Alexander N. Glazer, Jingyue Ju
  • Patent number: 5700918
    Abstract: The present invention has for its object to provide a trisaccharide Lewis sugar-chain epitope derivative of the following structural formula, which is of value as a medicine and has a novel structure containing moranoline. ##STR1## wherein R.sup.1 represents hydrogen or lower alkyl; R.sup.2 and R.sup.3 are dissimilar and each represents galactopyranosyl or fucopyranosyl, which is substituted by hydroxysulfonyl or a metal salt thereof. The compounds of the invention have cell adhesion-inhibitory activity and is useful for the prevention and treatment of inflammation, inflammation-associated thrombosis, rheumatism, immune diseases, viral infections, and cancer.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: December 23, 1997
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Akira Hasegawa, Makato Kiso, Yoshiaki Yoshikuni
  • Patent number: 5695738
    Abstract: Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of using the compositions to treat patients by binding to and/or blocking cellular receptors for a variety of diseases including cancer, inflammation, and autoimmune diseases.
    Type: Grant
    Filed: June 15, 1995
    Date of Patent: December 9, 1997
    Assignee: Glycomed Incorporated
    Inventors: Mark Anderson, John Henry Musser
  • Patent number: 5610151
    Abstract: Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicamentsMonomeric bile acid derivatives of the formula IZ--X--GS I,in which GS, X and Z have the meanings given, and processes for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: March 11, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heiner Glombik, Alfons Enhsen, Werner Kramer, G unther Wess
  • Patent number: 5563250
    Abstract: The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded directly to the linker, cleavage can result in release of native agent. The invention also provides methods for producing cleavable conjugates. Preferred agents include drugs, toxins, biological response modifiers, radiodiagnostic compounds, radiotherapeutic compounds, and derivatives thereof. The targeting molecule employed in the invention may be an intact molecule, a fragment thereof, or a functional equivalent thereof. In a particularly preferred embodiment, the targeting molecule is a monoclonal antibody directed towards a tumor-associated antigen in man. The invention further provides methods for delivering to the cytoplasm of a target cell an agent free of its targeting molecule carrier.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: October 8, 1996
    Assignee: NeoRx Corporation
    Inventors: Mark D. Hylarides, Ananthachari Srinivasan, Jeffrey N. Fitzner, Vivekananda M. Vrudhula
  • Patent number: 5525480
    Abstract: The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, G and L are as hereinbefore defined. The present invention also provides intermediates for the preparation of these aminophenol derivatives of general formula (I), as well as the use of the aminophenol derivatives of general formula (I) for the determination of hydrolases, as well as for the preparation of agents for carrying out determinations of hydrolysis.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: June 11, 1996
    Assignee: Boehringer Mannheim GmbH
    Inventors: Gerd Zimmermann, Dieter Mangold
  • Patent number: 5498705
    Abstract: Disclosed is a method for producing a surface-crosslinked, modified polysaccharide having improved absorption properties. The method involves forming a mixture of water and a crosslinking agent, adding a generally water-soluble, modified polysaccharide to said mixture wherein the surface of the polysaccharide becomes crosslinked, and drying the modified polysaccharide. Also described is a surface-crosslinked, modified polysaccharide having improved absorption properties.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: March 12, 1996
    Assignee: Kimberly-Clark Corporation
    Inventor: Jian Oin
  • Patent number: 5470964
    Abstract: Disclosed is a method for producing a surface-crosslinked, modified polysaccharide having improved absorption properties. The method involves forming a mixture of water and a crosslinking agent, adding a generally water-soluble, modified polysaccharide to said mixture wherein the surface of the polysaccharide becomes crosslinked, and drying the modified polysaccharide. Also described is a surface-crosslinked, modified polysaccharide having improved absorption properties.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: November 28, 1995
    Assignee: Kimberly-Clark Corporation
    Inventor: Jian Qin
  • Patent number: 5438124
    Abstract: A novel, efficient glycosylating reagent, R 3,4-O-isopropylidene-2-O-(4-methoxybenzyl)-1-thio-.beta. -L-fucopyranoside wherein R is a lower alkyl or lower alkenyl of 1 to 8 carbons such as methyl or pentenyl, is described. This novel reagent provides for the facile synthesis of linear and other .alpha.-L-fucosyl oligosaccharides. In addition, a method for the preparation of 2'-O-.alpha.-L-fucopyranosyl-lactose, which comprises reacting the abovementioned glycosylating reagent with solvated 4-O-(6-O-acetyl-3,4-O-isopropylidene-.beta.-D-galactopyranosyl)-2,3,5,6-di -O-isopropylidene-D-glucose, dimethyl acetal, a tetrabutylammonium halide and a catalyst and then de-O-acetylating the resulting reaction product with sodium methoxide methanol, is also disclosed.
    Type: Grant
    Filed: July 16, 1991
    Date of Patent: August 1, 1995
    Assignee: Health Research, Inc.
    Inventors: Khushi L. Matta, Rakesh K. Jain, Robert D. Locke
  • Patent number: 5270041
    Abstract: There are described antitumour sterols, their fatty acid esters and glucosides, processes for their preparation, spontaneously dispersible agents containing these sterols, their fatty acid esters and glucosides, and their use for treating tumours.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: December 14, 1993
    Assignee: Marigen S.A.
    Inventors: Carl Eugster, Conrad Eugster, Walter Haldemann, Giorgio Rivara
  • Patent number: 5147859
    Abstract: Complexes of glycyrrhetinic acid with phospholipids are described in which the molar ratio of phospholipids to glycyrrhetinic acid is from 0.5 to 2. The phospholipids are selected from the group consisting of soy lecithins, phospholipids from bovine or swine brain or cutis, phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine in which the acyl groups can be the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids. The phospholipid may be soy phosphatidylcholine or distearoylphosphatidylcholine. Pharmaceutical compositions and a method for producing anti-inflammatory, antiulcer and healing effects in an animal are also described.
    Type: Grant
    Filed: January 15, 1991
    Date of Patent: September 15, 1992
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Gianfranco Patri, Roberto Pozzi
  • Patent number: 5126436
    Abstract: Physiologically active material SN-198C producing bacteria are disclosed which belong to Streptomyces species and products which have the following structural formula: ##STR1##
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: June 30, 1992
    Assignee: Snow Brand Milk Products Company Limited
    Inventors: Kenichi Kimura, Shoji Nakayama, Nobuo Miyata
  • Patent number: 5093489
    Abstract: A modified cellulose and/or chitin for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein Cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, Z corresponds to the following groups of atoms: SR", SO.sub.3 H and salts thereof, SO-R, SONR".sub.2, SO.sub.2 -R, SO.sub.2 NR".sub.2, SO.sub.2 H and salts thereof, F, Cl, Br, I, NR".sub.2, PR".sub.2, PO.sub.3 H.sub.2 and salts thereof, PO.sub.2 H(OR), PO(OR).sub.2, PO.sub.2 HR" and salts thereof, POR"(OR) and POR".sub.2, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and z=0.01 to 0.45. A process for preparation of the cellulose and/or chitin derivatives is also disclosed.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: March 3, 1992
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 5093486
    Abstract: A modified cellulose and/or chitin for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is unmodified cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, m=0.75 to 2.85, and x=0.005 to 2.10. A process for preparation of the cellulose and/or chitin derivatives is also disclosed.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: March 3, 1992
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 5093488
    Abstract: A modified cellulose and/or chitin for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, R"' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose and/or chitin derivatives is also disclosed.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: March 3, 1992
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 5053497
    Abstract: Phospholipid conjugate compounds derived from cardiac glycosides and steroids useful in liposome immunoassays are disclosed as well as their method of preparation.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: October 1, 1991
    Assignee: Technion Instruments Corporation
    Inventors: Deng R. Hwang, Mary E. Scott, Eddie Hedaya
  • Patent number: 5045593
    Abstract: Organophilic polymer adducts which are effective fluid loss control additives for oil base well-working fluids are prepared from an anionic or cationic water soluble polymer and one or more phosphatides. Preferred phosphatides are phosphoglycerides obtained from vegetable oils, most preferably commercial lecithin. Preferred polymers comprise polysaccharides or derivatives thereof and synthetic polymers.
    Type: Grant
    Filed: July 2, 1990
    Date of Patent: September 3, 1991
    Assignee: Venture Chemicals, Inc.
    Inventors: Jack C. Cowan, Roy F. House, Victor M. Granquist
  • Patent number: 5045534
    Abstract: Antitumour anthracycline glycosides of formula I: ##STR1## wherein R.sub.1 is hydrogen or a hydroxyl group, and pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: September 3, 1991
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Alberto Bargiotti, Maria Grandi, Antonino Suarato, Fernando Giuliani
  • Patent number: 5008385
    Abstract: Cellulose derivatives are disclosed which have the following formula: ##STR1## wherein Z is selected from the group consisting of alkylene, alkenylene, alkynylene, cycloalkylene or benzylene or xylylene radicals, which may or may not be substituted;X is selected from the group consisting of --H, --NR.sub.2, --N.sup.+ R.sub.3, --CN, --COOH, --SO.sub.3 H, --SO.sub.3 H, --PO(OR).sub.2, CONR.sub.2 or --Si(OR).sub.3 ;R is selected from the group consisting of hydrogen, alkyl and alkenyl groups having from 1 to 25 carbon atoms, and cycloalkyl, tolyl and phenyl groups;Y is selected from the group consisting of alkyl, alkenyl, alkynyl groups having from 1 to 36 carbon atoms, which may or may not be substituted, cycloalkyl, phenyl, tolyl and benzyl groups, ##STR2## (--CH.dbd.CH--COOH), and NHR, where R has the same meaning as in X, andm=0 to 2.5n=0.01 to 2.95,with the provision that, when m=0, n.gtoreq.1.55, if Y is an alkyl radical with 1 to 5 carbon atoms, 3-(CH.sub.2).sub.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: April 16, 1991
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 4997935
    Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, R"' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose derivatives is also disclosed.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: March 5, 1991
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 4981960
    Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein Cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, Z corresponds to the following groups of atoms: SR", SO.sub.3 H and salts thereof, SO-R, SONR".sub.2, SO.sub.2 -R, SO.sub.2 NR".sub.2, SO.sub.2 H and salts thereof, F, Cl, Br, I, NR".sub.2, PR".sub.2, PO.sub.3 H.sub.2 and salts thereof, PO.sub.2 H(OR), PO(OR).sub.2, PO.sub.2 HR" and salts thereof, POR"(OR) and POR".sub.2, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and z=0.01 to 0.45. A process for preparation of the cellulose derivatives is also disclosed.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: January 1, 1991
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 4981959
    Abstract: A modified cellulose for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is unmodified cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, m=0.75 to 2.85, and x=0.005 to 2.10. A process for preparation of the cellulose derivatives is also disclosed.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: January 1, 1991
    Assignee: Akzo N.V.
    Inventor: Michael Diamantoglou
  • Patent number: 4970199
    Abstract: Disclosed are steroidal derivatives of glycolipids, in which steroids are bridged, via a medium length hydrocarbon chain, to 1-thio-D-mannopyranoses or 1-thio-L-fucopyranoses in combination with an anti-AIDS drug, that protect an immunocomprimised hot, particularly resulting from an AIDS-related virus, against opportunistic infection.
    Type: Grant
    Filed: July 10, 1989
    Date of Patent: November 13, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, William K. Hagmann, Mitree M. Ponpipom
  • Patent number: 4942154
    Abstract: Disclosed are steroidal derivatives of glycolipids, in which steroids are bridged, via a medium length hydrocarbon chain, to 1-thio-D-mannopyranoses or 1-thio-L-fucopyranoses that protect an immunocompromised host, particularly resulting from an AIDS-related virus, against opportunistic infection.
    Type: Grant
    Filed: June 18, 1987
    Date of Patent: July 17, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Mitree M. Ponpipom, William K. Hagmann
  • Patent number: 4863980
    Abstract: Organophilic polymer adducts which are effective fluid loss control additives for oil base well-working fluids are prepared from an anionic or cationic water soluble polymer and one or more phosphatides. Preferred phosphatides are phosphoglycerides obtained from vegetable oils, most preferably commercial lecithin. Preferred polymers comprise polysaccharides or derivatives thereof and synthetic polymers.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: September 5, 1989
    Assignee: Venture Chemicals, Inc.
    Inventors: Jack C. Cowan, Roy F. House, Victor M. Granquist
  • Patent number: 4839113
    Abstract: Composition (M) having a base of a cellulose ester having formate groups, this composition being an anisotropic solution containing:(a) the cellulose ester;(b) formic acid;(c) at least one phosphoric acid.A process for obtaining this composition by dissolving the cellulose and a process for obtaining articles by transformation of this composition, and, for example, regenerating the cellulose of these articles. A cellulose fiber is provided in which a degree of substitution of the cellulose by formate groups is either at least equal to 2% or is zero or less than 2%.
    Type: Grant
    Filed: December 19, 1985
    Date of Patent: June 13, 1989
    Assignee: Michelin Recherche et Technique S.A.
    Inventors: Philippe Villaine, Claude Janin
  • Patent number: 4664806
    Abstract: Novel chemically modified anionic polysaccharides which contain acid radicals of the formula ##STR1## attached to the polysaccharide component, wherein R.sub.1.sup..crclbar. is carboxyalkyl or dicarboxyalkyl containing 1 to 5 carbon atoms in the alkyl moiety, or is carboxyphenyl or ketocarboxymethyl, and Q.sub.1.sup..sym. is a water-soluble cation, are obtained by reacting the polysaccharides with compounds that contain N-methylolamide groups, in particular with novel compounds of formula ##STR2## wherein R.sub.1.sup..crclbar. and Q.sub.1.sup..sym. have the given meanings, and are used for purifying effluents and, in particular, for the separation by chromatography of mixtures of substances which contain amphoteric or cationic components.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: May 12, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Jurg Merz