Abstract: Novel 3'-N-modified 6-O-substituted erythromycin ketolide compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.
Abstract: Provided is a novel improved process for the preparation of .alpha.-D-cellobiose octaacetate via the acetylative degradation of cellulose or cellulose acetate. The title compound is provided in high yield and quality in a facile one-pot process, amenable to large-scale synthesis.
Type:
Grant
Filed:
April 7, 1993
Date of Patent:
March 15, 1994
Assignee:
Eastman Kodak Company
Inventors:
John A. Hyatt, Tony L. Sander, D. Mark Naylor, Bobby L. Bernard
Abstract: Process for reducing the degree of substitution of cellulose esters employing Lewis acids as solvolysis promoters is disclosed. Novel low degree of substitution cellulose esters produced by the invention process are also described.
Type:
Grant
Filed:
April 16, 1990
Date of Patent:
August 25, 1992
Assignee:
Eastman Kodak Company
Inventors:
Michael Bellas, Charles M. Buchanan, Kevin J. Edgar, Ted C. Germroth, Alan K. Wilson
Abstract: A process for producing a cellulose ester support is described which comprises producing said support from an organic solvent solution of a cellulose ester containing 30 ppm or less alkaline earth metal.
Type:
Grant
Filed:
May 6, 1982
Date of Patent:
February 12, 1985
Assignee:
Fuji Photo Film Co., Ltd.
Inventors:
Masao Yabe, Kyoichi Naruo, Kazuhiro Ono
Abstract: A process for preparing porous, spherical cellulose particles which comprises suspending a cellulose organic ester solution dissolved in a chlorinated hydrocarbon solvent into an aqueous medium to form droplets of the solution, evaporating the chlorinated hydrocarbon solvent in the droplets to form cellulose organic ester spherical particles, and saponifying the cellulose organic ester spherical particles. In the aforesaid process, an acid or alkaki is added and mixed with the cellulose organic ester solution prior to suspending the cellulose organic ester solution into the aqueous medium to control the porosity of the porous, spherical cellulose particles with high reproducibility.
Abstract: A process for preparing porous, spherical cellulose particles which comprises suspending a cellulose organic ester solution dissolved in a chlorinated hydrocarbon solvent into an aqueous medium to form droplets of the solution, evaporating the chlorinated hydrocarbon solvent in the droplets to form cellulose organic ester spherical particles, and saponifying the cellulose organic ester spherical particles. In the aforesaid process, an acid or alkali is added and mixed with the cellulose organic ester solution prior to suspending the cellulose organic ester solution into the aqueous medium to control the porosity of the porous, spherical cellulose particles with high reproducibility.