The Hetero Ring Contains -c(=x)-o-, Wherein X Is Chalcogen, As Part Of The Ring (e.g., Lactones, Etc.) Patents (Class 540/102)
Additional chalcogen, cyano, or -c(=x)-, wherein x is chalcogen, bonded directly to the hetero ring (Class 540/103)
Nitrogen or sulfur attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding (Class 540/104)
Chalcogen bonded directly at the 14-position of the cyclopentanohydrophenanthrene ring system or double bond in the d ring (e.g., cardenolides, etc.) (Class 540/105)
  • Certain chemical entities, compositions, and methods
    Patent number: 10912784
    Abstract: Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: February 9, 2021
    Assignee: SUZHOU NEUPHARMA CO., LTD.
    Inventor: Xiangping Qian
  • Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use
    Patent number: 9018197
    Abstract: Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 28, 2015
    Assignee: Suzhou Neupharma Co. Ltd.
    Inventor: Xiangping Qian
  • Aldosterone induced vascular elastin production
    Patent number: 8618084
    Abstract: Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: December 31, 2013
    Assignees: Human Matrix Sciences, LLC, The Hospital for Sick Children
    Inventors: Aleksander Hinek, Thomas F. Mitts
  • Deoxycorticosterone induced elastin production
    Patent number: 8470774
    Abstract: Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: June 25, 2013
    Assignees: Human Matrix Sciences, LLC, The Hospital for Sick Children
    Inventors: Aleksander Hinek, Thomas F. Mitts
  • Certain chemical entities, compositions, and methods
    Patent number: 8334376
    Abstract: Chemical entities of Formula I, II, or III, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: December 18, 2012
    Inventor: Xiangping Qian
  • Aldosterone induced elastin production
    Patent number: 8148327
    Abstract: Compositions and methods for inducing the deposition of elastin in skin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: April 3, 2012
    Assignees: Human Matrix Sciences, LLC, The Hospital for Sick Children
    Inventors: Thomas Mitts, Aleksander Hinek
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
    Publication number: 20120053162
    Abstract: Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Application
    Filed: August 26, 2011
    Publication date: March 1, 2012
    Inventor: Xiangping Qian
  • 7?-Hydroxyacetyl and 7?-Hydroperoxyacetyl-substituted steroid compounds
    Patent number: 7417140
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 26, 2008
  • 7 ?-Enedione-substituted steroid compounds
    Patent number: 7414127
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 19, 2008
  • 7?-biscarbonyl-substituted steroid compounds
    Patent number: 7411062
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: August 12, 2008
  • Processes to prepare eplerenone
    Patent number: 7235655
    Abstract: The present invention involves intermediates, including a 7?-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: June 26, 2007
  • 11-Beta substituted 19-nor-17-alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring
    Publication number: 20040014735
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring with a long-chain substituent in 11&bgr;-position of general formula II 1
    Type: Application
    Filed: March 27, 2003
    Publication date: January 22, 2004
    Applicant: Schering AG
    Inventors: Alexander Hillisch, Walter Elger, Rolf Bohlmann, Jens Hoffmann
  • Compounds, compositions and methods for treatment of inflammatory diseases and conditions
    Publication number: 20040014685
    Abstract: The present invention relates (a) to new compounds represented by Formula I: 1
    Type: Application
    Filed: July 8, 2003
    Publication date: January 22, 2004
    Applicant: PLIVA Pharmaceutical Industry, Incorporated
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Stribor Markovic, Oresta Makaruha, Visnja Poljak
  • 11Beta-long-chain-substituted 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring
    Publication number: 20030229059
    Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring with a long-chain substituent in 11&bgr;-position of general formula II 1
    Type: Application
    Filed: March 27, 2003
    Publication date: December 11, 2003
    Applicant: Schering AG
    Inventors: Gerd Mueller, Jens Hoffmann, Karl-Heinrich Fritzemeier, Alexander Hillisch
  • 17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6262042
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: July 17, 2001
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley
  • 14-deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical composition comprising same for treating cardiovascular disorders
    Patent number: 5489582
    Abstract: 14-Deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.
    Type: Grant
    Filed: June 24, 1993
    Date of Patent: February 6, 1996
    Assignee: Sigma-Tau Industrie Farmaceutiche Riuntie S.p.A
    Inventors: Mauro Gobbini, Luigi Bernardi, Mara Ferrandi, Piero Melloni, Luisa Quadri, Roberto Villa
  • Digitoxigenin and dihydrodigitoxigenin 3.beta.-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
    Patent number: 5478817
    Abstract: Digitoxigenin and dihydrodigitoxigenin 3.beta.-derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension are disclosed.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: December 26, 1995
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Piero Melloni, Luigi Bernardi, Patrizia Ferrari, Mauro Gobbini, Marco Torri, Loredana Valentino