Additional Chalcogen, Cyano, Or -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Hetero Ring Patents (Class 540/103)
  • 17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6262042
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: July 17, 2001
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley
  • Withajardins
    Patent number: 5681950
    Abstract: Withajardins A-D are new class of withanolides isolated from the leaves of Deprea orinocensis and characterized by having a bicyclic C-17.beta. system and hydroxyl group at C-14 and C-17. The bicyclic system consists of a lactone and a homocyclic ring with six carbon atoms unlike the acnistins which have a five-membered homocyclic ring. The two classes of compounds were differentiated and their structures were identified by a series of HMQC, HMBC and finally X-ray diffraction experiments. Withajardins and acnistins would seem to evolve along quite dissimilar biosynthetic pathways although both types of compound show a marked immunosupressive effect on in vitro cultures of human lymphocytes.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: October 28, 1997
    Assignees: Universidad De Antioquia, Colciencias
    Inventors: Luis F. Echeverri-Lopez, Luis F. Torres-Roldan, Luis F. Garcia-Moreno, Gloria Cardona-Rendon, Winston Quinones-Fletcher, Javier Gutierrez-Luis, Antonio Gonzalez-Gonzalez, Carlos A. Pelaez-Jaramillo, Mauricio Rojas-Lopez
  • Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
    Patent number: 4916241
    Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: April 10, 1990
    Assignee: American Home Products Corporation
    Inventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre