Plural Oxygens In Both Rings Which Share A Spiro Atom (e.g., 17,20;20,21 Bismethylenedioxy-pregnanes, Etc.) Patents (Class 540/12)
Nitrogen, sulfur, cyano or -c(=x)-, wherein x is chalcogen, bonded directly to the cyclopentanohydrophenanthrene ring system (Class 540/13)
Halogen attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by acyclic nonionic bonding (Class 540/14)
  • Method for preparing 6-alkylated steroidal derivatives and corresponding alkylated 5,6,7,8-tetrahydronaphthalene-2(4 alpha.H)-ones
    Patent number: 9783569
    Abstract: The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding compound halogenated in position 6 with an organometallic alkylating agent.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: October 10, 2017
    Assignee: SANOFI
    Inventors: Stéphanie Duez, Jean-Luc Haesslein, Frédéric Lhermitte, Pauline Quinio
  • Stabilization of organic materials
    Patent number: 8105504
    Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation comprise as stabilizers at least one compound of the formula (I) wherein the general symbols are as defined in claim 1. The compounds of formula I are especially useful as stabilizers for protecting polymers and lubricants against oxidative, thermal or light-induced degradation and as scavengers for oxidized developer in color photographic material.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: January 31, 2012
    Assignee: BASF SE
    Inventors: Michèle Gerster, Peter Nesvadba
  • Tricycle substituted with azaheterocyclic carboxylic acids
    Patent number: 6100253
    Abstract: The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: August 8, 2000
    Assignee: Novo Nordisk A/S
    Inventors: Knud Erik Andersen, Tine Krogh J.o slashed.rgensen, Rolf Hohlweg, Erik Fischer, Uffe Bang Olsen, Zdenek Polivka, Karel Sindelar, Vladimir Valenta
  • Anti-inflammatory carboxy pregnane derivatives
    Patent number: 4762919
    Abstract: Compounds of the formula: ##STR1## wherein one X is COOR, CH.sub.2 COOR, CH(COOR).sub.2, CONHR, CH.sub.2 CONHR, or CNremaining X's are H, F, CH.sub.3, OH, COOR, CH.sub.2 COOR, CH(COOR).sub.2, CONHR, CH.sub.2 CONHR, or CN;Y is ##STR2## R is H, alkyl of 1-5 carbon atoms, or benzyl; R.sub.1 is CH.sub.2 OR.sub.3, COOR, or CONHR;R.sub.2 is H, OR.sub.3, or BR;R.sub.3 is H, COR.sub.4, or tetrahydropyranyl;R.sub.4 is alkyl of 1-5 carbon atoms or benzyl;R.sub.5 is H or COR.sub.4 ;represents a single or double bond;represents .alpha.-position, .beta.-position, or a mixture of .alpha.- and .beta.-positions; and--- represents .alpha.-position;and methods for preparing the same.
    Type: Grant
    Filed: February 12, 1986
    Date of Patent: August 9, 1988
    Assignee: Florida Agricultural and Mechanical University
    Inventor: Henry J. Lee