Halogen, Cyano, Nitrogen Or Sulfur Bonded Directly To The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/22)
  • Publication number: 20100069627
    Abstract: The invention relates to a diastereoselective method for obtaining a primary amine on a steroid, comprising the reduction of an oxime by lithium in ammonia at a low temperature in an ether/alcohol mixture.
    Type: Application
    Filed: June 12, 2009
    Publication date: March 18, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Gilles ODDON, Daniel BERNARD, Gerard CAZENAVE, Andre SIMONNET, Joelle BOUSQUET-FRANCES
  • Patent number: 5731447
    Abstract: A process for the preparation of a compound of the formula ##STR1##
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: March 24, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean Buendia, Patrick Roussel, Michel Vivat
  • Patent number: 5372996
    Abstract: A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4-androstenedione (.DELTA..sup.4 -dione) to natural sex steroida (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: December 13, 1994
    Assignee: Endorecherche, Inc.
    Inventor: Fernand Labrie