The Hetero Ring Shares The 11,12,13-positions Of The Cyclopentanohydrophenanthrene Ring System (i.e., Bridged; E.g., 11,18-oxido Steroids, Etc.) Patents (Class 540/24)
Abstract: The invention relates to a method of alleviating the symptoms of PMS and anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.
Type:
Grant
Filed:
July 23, 1996
Date of Patent:
May 2, 2000
Assignee:
Pherin Corporation
Inventors:
Clive L. Jennings-White, David L. Berliner, Nathan W. Adams, Luis Monti-Bloch
Abstract: There is provided the novel compound 19-hydroxyaldosterone. There is provided a process for its preparation. There are further provided pharmaceutical compositions comprising this compound as active ingredient. These are useful, amongst others, as mineralocorticoid drugs and as drug against Addison's disease.
Type:
Grant
Filed:
May 21, 1985
Date of Patent:
April 21, 1987
Assignee:
Ramot University Authority for Applied Research & Industrial Development Ltd.
Abstract: The present invention relates to (2-nitro-5-aryloxyphenylamino)alkylphosphonic, -alkylphosphinic and -alkylphosphonous acid derivatives of the general formula I ##STR1## wherein X is halogen, CF.sub.3, NO.sub.2, CN, CONH.sub.2 or CSNH.sub.2,Y is nitrogen or --CH.dbd.,R is hydrogen, C.sub.1 -C.sub.4 alkyl or aralkyl containing 1 to 4 carbon atoms in the alkyl moiety,R.sub.1 is C.sub.1 -C.sub.4 alkyl,R.sub.2 is C.sub.1 -C.sub.4 alkyl, phenyl or --PO(OR.sub.6).sub.2,R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl,R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl or a cation,R.sub.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, hydroxyl or an --O-cation group,R.sub.6 is hydrogen or C.sub.1 -C.sub.4 alkyl,m is a value from 0 to 3,n is 0 or 1,p is a value from 0 to 3, andq is 0 or 1,with the proviso that R.sub.1 and R.sub.3 taken together may also be an unsubstituted or substituted C.sub.1 -C.sub.