Having -c(=x)-, Wherein X Is Chalcogen, Bonded Directly At The 17-position Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/53)
  • Compounds
    Patent number: 8338587
    Abstract: The present invention provides named compounds of formula (I) and pharmaceutical compositions containing them and their use in therapy.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: December 25, 2012
    Assignee: AstraZeneca AB
    Inventors: Frank Burkamp, Peter Hansen, Balint Gabos, Håkan Bladh
  • NOVEL COMPOUNDS
    Publication number: 20120178726
    Abstract: The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: March 12, 2012
    Publication date: July 12, 2012
    Applicant: ASTRAZENECA AB
    Inventors: Håkan Bladh, Frank Burkamp, Balint Gabos, Peter Hansen, Svetlana Ivanova, Karolina Lawitz
  • NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS COMPOSITIONS AND USES THEREOF
    Publication number: 20120171126
    Abstract: The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas (H-A), (II-A1), (II-A2), (II-A2.1), (ll-A-2.2), (ll-A-2.3), (II-A4), (H-B), (H-C), (III), (IV), (V), (VI), as described herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.
    Type: Application
    Filed: June 15, 2010
    Publication date: July 5, 2012
    Inventors: Biju J. Purakkattle, Michael Y. Berlin, Yeon-Hee Lim, Rema D. Bitar, Kevin D. McCormick, Robert G. Aslanian, Yoon Joo Lee, Junying Zheng, Ying Huang, Walter Won
  • NOVEL AMIDE COMPOUNDS
    Publication number: 20100256104
    Abstract: The present invention provides compounds of formula (I) wherein n, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 7, 2010
    Applicant: ASTRAZENECA R&D
    Inventors: Frank Burkamp, Balint Gabos, Svetlana Ivanova, Alice Ingrid Annea Lisius
  • NOVEL COMPOUNDS
    Publication number: 20100256103
    Abstract: The present invention provides named compounds of formula (I) and pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 7, 2010
    Applicant: ASTRAZENECA R&D
    Inventors: Frank Burkamp, Peter Hansen, Balint Gabos, Håkan Bladh
  • NOVEL COMPOUNDS
    Publication number: 20100256105
    Abstract: The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 7, 2010
    Inventors: Frank Burkamp, Peter Hansen