Hetero Ring Is One Of The Cyclos Of The Polycyclo Ring System Patents (Class 540/48)
  • Publication number: 20150050367
    Abstract: Provided herein are timosaponin compounds of Formula I, II, III, I?, II? and III?, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are uses of said timosaponin compounds for preparing medicament for the treatment of diseases associated with beta-amyloid in hosts or subjects in need thereof.
    Type: Application
    Filed: April 2, 2013
    Publication date: February 19, 2015
    Inventors: Chiming Che, Laiking Sy, Chunnam Lok
  • Publication number: 20150031657
    Abstract: The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ?O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ?O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.
    Type: Application
    Filed: December 25, 2012
    Publication date: January 29, 2015
    Inventors: Zhenwen Duan, Shuren Guo, Xuemei Li
  • Publication number: 20130060024
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is as defined and described herein, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: SATORI PHARMACEUTICALS, INC.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Jeffrey Lee Ives, Ruichao Shen
  • Publication number: 20130060013
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein each of the variables listed above are as defined and described herein, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: SATORI PHARMACEUTICALS, INC.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Jeffrey Lee Ives, Ruichao Shen
  • Publication number: 20130060021
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein L and Ring A are as defined and described herein, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: Satori Pharmaceuticals, Inc.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Jeffrey Lee Ives, Ruichao Shen
  • Publication number: 20130060019
    Abstract: The present invention provides methods of making a compound of formula II: or a pharmaceutically acceptable salt thereof, wherein R1, R2, and L are as defined and described herein.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: SATORI PHARMACEUTICALS, INC.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Ruichao Shen
  • Publication number: 20130060023
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein Rx is as defined and described herein, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: Satori Pharmaceuticals, Inc.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Jeffrey Lee Ives, Ruichao Shen
  • Publication number: 20130060020
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein Rx is as defined and described herein, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: Satori Pharmaceuticals, Inc.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Jeffrey Lee Ives, Ruichao Shen
  • Publication number: 20130060022
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1 and R5 are as defined and described herein, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Applicant: Satori Pharmaceuticals, Inc.
    Inventors: Brian Scott Bronk, Wesley Francis Austin, Steffen Phillip Creaser, Nathan Oliver Fuller, Jed Lee Hubbs, Jeffrey Lee Ives, Ruichao Shen
  • Publication number: 20120077777
    Abstract: The present invention relates to a compound of following formula (I): or to a pharmaceutically acceptable salt thereof, as well as to pharmaceutical compositions including same and to the use thereof as a drug, in particular for treating a proliferative disease such as cancer.
    Type: Application
    Filed: May 20, 2010
    Publication date: March 29, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), PIERRE FABRE MEDICAMENT
    Inventors: Christophe Long, Yves Guminski, Fadila Derguini, Joséphine Beck, Frédéric Cantagrel
  • Publication number: 20100144689
    Abstract: As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 10, 2010
    Applicant: Satori Pharmaceuticals, Inc.
    Inventor: Mark A. FINDEIS
  • Publication number: 20090042846
    Abstract: This invention relates to certain sugar esters of phytosterols of formula (I).
    Type: Application
    Filed: September 15, 2008
    Publication date: February 12, 2009
    Applicant: BIODERM RESEARCH
    Inventor: SHYAM K. GUPTA
  • Publication number: 20080293682
    Abstract: The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(?CH2) CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
    Type: Application
    Filed: December 29, 2005
    Publication date: November 27, 2008
    Inventors: Rama Mukherjee, Kumar Srivastava, Mohammad Jamshed Ahmed Siddioui, Manu Jaggi, Anu T. Singh, Anand Vardhan, Manoj Kumar Singh, Praveen Rajendran, Hemant Kumar Jajoo, Anand C. Burman, Vivek Kumar, Nidhi Rani, Shiv Kumar Agarwal
  • Publication number: 20070207989
    Abstract: The present invention relates to useful diterpenes and pharmaceutical compositions containing them of the formula: for use in the treatment of cardiovascular and inflammatory diseases and for cancers susceptible to an NF-?B inhibitor and an endothelin receptor inhibitor. The present invention also relates to compounds and methods useful to inhibit cell proliferation and for the induction of apoptosis.
    Type: Application
    Filed: March 1, 2007
    Publication date: September 6, 2007
    Applicant: SaviPu Pharmaceuticals
    Inventors: Inderjit Kumar Dev, Ven Subbiah
  • Patent number: 7053076
    Abstract: Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administration to provide for enhanced therapeutic, and optionally prolonged therapeutic, systemic blood concentrations of the drugs upon oral administration of the drug-compound conjugate. Also disclosed are pharmaceutical compositions containing and methods of using such compounds.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: May 30, 2006
    Assignee: XenoPort, Inc.
    Inventors: Laxminarayan Bhat, Mark A. Gallop, Bernd Jandeleit
  • Patent number: 6369218
    Abstract: Described herein is the isomerisation process of 6&bgr;-fluorosteroids into the corresponding pharmacologically active 6&agr;-fluoro derivatives, comprising the reaction of 6&bgr;-fluorosteroids, or 6&agr;/6&bgr; isomeric mixtures, with an organic base containing a diazoimino group in a suitable organic solvent.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: April 9, 2002
    Assignee: Farmabios S.r.L
    Inventors: Gianfranco Cainelli, Achille Umani-Ronchi, Michele Contento, Sergio Sandri, Marco Da Col
  • Patent number: 5100882
    Abstract: 5'-Alkylsulfonylsteroido[3,2-b]furans, for example 5'-methylsulfonyl-5.alpha.-pregn-2-en-20-yno[3,2-b]furan-17.beta.-ol having the structural formula, ##STR1## which are useful as antiandrogenic agents, and processes for preparation, method of use and compositions thereof are disclosed.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: March 31, 1992
    Assignee: Sterling Drug Inc.
    Inventors: Robert G. Christiansen, Malcolm R. Bell, Virendra Kumar