The Hetero Ring Is Five-membered Patents (Class 540/56)
The hetero ring is ortho-fused to the a ring (Class 540/57)
  • ISOXAZOLIDINE DERIVATIVES
    Publication number: 20150057257
    Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: November 10, 2014
    Publication date: February 26, 2015
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Eleonora GHIDINI, Andrea RIZZI
  • Isoxazolidine derivatives
    Patent number: 8835412
    Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: September 16, 2014
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Eleonora Ghidini, Anna Maria Capelli
  • ISOXAZOLIDINE DERIVATIVES
    Publication number: 20140069419
    Abstract: Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.
    Type: Application
    Filed: August 12, 2013
    Publication date: March 13, 2014
    Applicant: Chiesi farmaceutici S.p.A.
    Inventor: Eleonora GHIDINI
  • Isoxazolidine derivatives
    Patent number: 8637662
    Abstract: Novel glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: January 28, 2014
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Eleonora Ghidini, Ilaria Peretto, Andrea Virdis
  • ISOXAZOLIDINE DERIVATIVES
    Publication number: 20120234316
    Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Eleonora GHIDINI, Andrea Rizzi
  • ISOXAZOLIDINE DERIVATIVES
    Publication number: 20120238531
    Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Eleonora GHIDINI, Anna Maria Capelli
  • ISOXAZOLIDINE DERIVATIVES
    Publication number: 20110065678
    Abstract: Novel glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 17, 2011
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Eleonora Ghidini, IIaria Peretto, Andrea Virdis
  • Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
    Patent number: 7479486
    Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: January 20, 2009
    Assignee: Laboratoires Serono SA
    Inventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
  • DITERPENE DERIVATIVES FOR THE TREATMENT OF CARDIOVASCULAR, CANCER AND INFLAMMATORY DISEASES
    Publication number: 20070207989
    Abstract: The present invention relates to useful diterpenes and pharmaceutical compositions containing them of the formula: for use in the treatment of cardiovascular and inflammatory diseases and for cancers susceptible to an NF-?B inhibitor and an endothelin receptor inhibitor. The present invention also relates to compounds and methods useful to inhibit cell proliferation and for the induction of apoptosis.
    Type: Application
    Filed: March 1, 2007
    Publication date: September 6, 2007
    Applicant: SaviPu Pharmaceuticals
    Inventors: Inderjit Kumar Dev, Ven Subbiah
  • Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21 oh-6op)
    Patent number: 7071328
    Abstract: The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate derivatives. 21OH-6OP and its ester derivatives are antiglucocorticoids for the treatment or prophyl axis of diseases associated to an excess of glucocorticoids, in particular for treating Cushing's syndrome, iatrogenic hypercortisolism or depression.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 4, 2006
    Assignee: Applied Research System ARS Holding N.V.
    Inventors: Gerardo Burton, Carlos P. Lantos, Adriana Silvia Veleiro
  • Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
    Publication number: 20040092733
    Abstract: The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate derivatives. 21OH-6OP and its ester derivatives are antiglucocorticoids for the treatment or prophylaxis of diseases associated to an excess of glucocorticoids, in particular for treating Cushing's syndrome, iatrogenic hypercortisolism or depression.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 13, 2004
    Inventors: Gerardo Burton, Carlos P Lantos, Adriana Silvia Veleiro
  • Preparation of (11&bgr;,16&bgr;)-21-(3-carboxy-1-oxopropoxy)-11-hydroxy-2?-methyl-5?H-pregna-1,4-dieno [17,16-D]oxazole-3,20-dione
    Patent number: 6417350
    Abstract: A process for preparing the compound (11&bgr;,16&bgr;)-21-(3-CARBOXY-1-OXOPROPOXY)-11-HYDROXY-2′-METHYL-5′H-PREGNA-1,4-DIENO(17,16-D) OXAZOLE-3,20-DIONE which comprises reacting the compound (11&bgr;,16&bgr;)-11,21-DIHYDROXY-2′-METHYL-5′H-PREGNA-1, 4-DIENO(17,16-D)OXAZOLE-3,20-DIONE with succinic anhydride in a (C1-C4) alkyl ester of a (C1-C4) carboxylic acid as solvent, in the presence of a basic catalyst.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: July 9, 2002
    Assignee: Aventis Bulk S.p.A.
    Inventors: Luigi Forte, Calogero Cancellieri
  • Process for the purification of 11&bgr;-21-dihydroxy-2?-methyl-5?&bgr;H-pregna-1,4-dieno[17,16-D]oxazole-3,20-dione
    Patent number: 6228851
    Abstract: Process for preparing the compound 11&bgr;-21-dihydroxy-2′-methyl-5′&bgr;H-pregna-1,4-dieno[17,16-d]oxazoline-3,20-dione of formula (I): which comprises adsorbing said compound, contained into an aqueous solution resulting from fermentation broths or process streams, on an adsorbent polymeric resin having a styrenic or acrylic matrix and subsequently desorbing the said compound by eluting the resin with suitable mixture of water with a water-miscible organic solvent.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: May 8, 2001
    Assignee: Gruppo Lepetit S.p.A.
    Inventor: Luigi Forte
  • Preparation of (11.beta.,16.beta.)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-d ieno[17,16-d]oxazole-3,20-dione
    Patent number: 6103895
    Abstract: A process for preparing the compound (11.beta.,16.beta.)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-die no[17,16-d]oxazole-3,20-dione (INN deflazacort) which comprises reacting (11.beta.,16.beta.)-11,21 -dihydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione with acetic anhydride in a suitable organic solvent in the presence of a basic catalyst and water.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: August 15, 2000
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Luigi Forte, Calogero Cancellieri