Abstract: The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene hydrochloride, as well as processes for their preparation.
Abstract: Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be antiproliferative against human estrogen-dependent cancer cells and to have good binding affinity for the estrogen receptor.
Type:
Application
Filed:
August 21, 2001
Publication date:
October 24, 2002
Inventors:
Jonathan Martin Schmidt, Julie Mercure, Jeffry Lawrence Lowell, Stefan Kwiatkowski, Krzysztof Pupek, Shuguang Zhu, John Whelan, Natalie Lazarowych
Abstract: The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT1A receptor and antagonizing the 5-HT2A receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.
Type:
Grant
Filed:
November 28, 2000
Date of Patent:
October 15, 2002
Assignee:
Eli Lilly and Company
Inventors:
Kenneth Lee Hauser, Larry Wayne Hertel, Yao-Chang Xu
Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states.
Type:
Grant
Filed:
July 5, 2001
Date of Patent:
October 8, 2002
Assignee:
American Home Products Corporation
Inventors:
Aranapakam Mudumbai Venkatesan, George Theodore Grosu, Jamie Marie Davis, Jannie Lea Baker, Jeremy Ian Levin
Abstract: The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are &agr;-substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.
Abstract: Compounds, compositions, and methods for treating multidrug resistance are disclosed. Suitable compounds are 2-substituted heterocyclic compounds.
Type:
Application
Filed:
December 19, 2000
Publication date:
August 29, 2002
Inventors:
Charles Raymond Degenhardt, David Joseph Eickhoff
Abstract: A nitrogen-containing heterocyclic compound represented by the following formula (I) or (II):
wherein X1 and X2 are the same or different, each representing a hydrogen atom, an alkyl group, or an electron attractive group and at least one of which being an electron attractive group; R1 and R2 are the same or different, each representing a hydrogen atom, an alkyl group, an aryl group, an aralkyl group, or an alkoxy group, and the ring Z represents a hydrocarbon ring which may have a substituent or a heterocycle which may have a substituent. The compound of the present invention is capable of emitting light or changing its color upon irradiation of light or under the action of an electric field.
Abstract: This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation of the acrylic and propionic acid compounds.
Type:
Grant
Filed:
June 25, 1996
Date of Patent:
August 27, 2002
Assignee:
Eli Lilly and Company
Inventors:
Charles David Jones, Alan David Palkowitz, Kenneth Jeff Thrasher
Abstract: The instant invention provides compound of formula I
wherein:
R1 is —H, —OH, —O(C1-C4 alkyl), —O—CO—(C1-C6 alkyl), —O—CO—O(C1-C6 alkyl), —O—CO—Ar in which Ar is optionally substituted phenyl, or —O—SO2—(C4-C6 alkyl);
R2 is —H, —OH, —O(C1-C4 alkyl), —O—CO—(C1-C6 alkyl), —O—CO—O(C1-C6 alkyl), —O—CO—Ar in which Ar is optionally substituted phenyl, —O—SO2—(C4-C6 alkyl), —F, —Cl, or —Br;
n is an integer from 5 to 8;
R3 and R4 each are independently C1-C4 alkyl, or combine to form, with the nitrogen to which they are attached, piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or hexamethyleneimino;
or a pharmaceutically acceptable salt or solvate thereof, intermediates, pharmaceutical formulations, processes, and methods of use.
Type:
Grant
Filed:
June 30, 1997
Date of Patent:
August 13, 2002
Assignee:
Eli Lilly and Company
Inventors:
George Joseph Cullinan, Kennan Joseph Fahey
Abstract: Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist.
Type:
Application
Filed:
November 28, 2001
Publication date:
July 25, 2002
Applicant:
Shin-Etsu Chemical Co., Ltd.
Inventors:
Jun Hatakeyama, Tomohiro Kobayashi, Takeru Watanabe, Takeshi Nagata
Abstract: The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1):
and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are a-substituted with ether, thioether amino, hydrazino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.
Abstract: Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing
copper, wherein the catalytically active mass of the catalyst contains, before the reduction with hydrogen,
20 to 85% by weight of oxygen-containing compounds of zirconium, calculated as ZrO2,
1 to 30% by weight of oxygen-containing compounds of copper, calculated as CuO,
14 to 70% by weight of oxygen-containing compounds of nickel, calculated as NiO,
0 to 5% by weight of oxygen-containing compounds of molybdenum, calculated as MoO3,
and 0 to 10% by weight of oxygen-containing compounds of aluminum, calculated as Al2O3.
Type:
Grant
Filed:
March 7, 2000
Date of Patent:
July 9, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Frank Funke, Joachim Wulff-Döring, Gerhard Schulz, Wolfgang Siegel, Andreas Kramer, Johann-Peter Melder, Arthur Höhn, Philipp Buskens, Wolfgang Reif, Jan Nouwen
Abstract: The present invention provides novel compound of the formula:
wherein
Ra is —OH or
—O—(C1-C4 alkyl);
R1a is —OH or
—O—(C1-C4 alkyl);
n is 2 or 3;
R2 and R3 are each independently:
—C1-C4 alkyl, or
combine to form
1-piperidinyl,
1-pyrrolidinyl,
1-pyrrolidinyl substituted with one or two methyl groups,
4-morpholino or
1-hexamethyleneimino;
or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
May 10, 1995
Date of Patent:
June 18, 2002
Assignee:
Eli Lilly and Company
Inventors:
Henry U. Bryant, George J. Cullinan, Jeffrey A. Dodge, Kennan J. Fahey, Charles D. Jones
Abstract: This invention provides novel benzothiophene compounds of formula I:
which are useful for the inhibition of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further. relates to pharmaceutical formulations of compounds of formula I.
Type:
Grant
Filed:
September 30, 1998
Date of Patent:
June 11, 2002
Assignee:
Eli Lilly and Company
Inventors:
Jeffrey Alan Dodge, Mark Gregory Stocksdale
Abstract: The invention relates to novel cyclic imines of the formula (I)
in which
Ar1 and Ar2 each represent substituted phenyl and n represents 1, 2 and 3, to a plurality of processes for their preparation and to their use as pesticides.
Type:
Grant
Filed:
September 9, 2000
Date of Patent:
June 4, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Andrew Plant, Gerd Kleefeld, Thorsten Pötter, Christoph Erdelen, Norbert Mencke, Andreas Turberg, Ulrike Wachendorff-Neumann
Abstract: The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene hydrochloride, as well as processes for their preparation.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
June 4, 2002
Assignee:
Eli Lilly and Company
Inventors:
Elizabeth Smith LaBell, John McNeill McGill, Randal Scot Miller
Abstract: The present invention provides method of treating endometriosis using novel benzothiophene compounds of formula I
wherein
R is —H, —OH, —O(C1-C4 alkyl), —O—CO—(C1-C6 alkyl), —O—CO—Ar in which Ar is optionally substituted phenyl, or —O—SO2—(C4-C6 alkyl);
R1 is —H, —OH, —O(C1-C4 alkyl),, —O—CO—(C1-C6 alkyl), —O—CO—Ar in which Ar is optionally substituted phenyl, —O—SO2—(C4-C6 alkyl) chloro or bromo;
R2 is —H or —OH;
n is 2 or 3; and
R3 and R4 each are independently C1-C4 alkyl, or combine to form 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, or 1-hexamethyleneimino;
or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
April 19, 1995
Date of Patent:
June 4, 2002
Assignee:
Eli Lilly and Company
Inventors:
Henry U. Bryant, George J. Cullinan, Jeffrey A. Dodge, Kennan J. Fahey, Charles D. Jones
Abstract: Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Type:
Application
Filed:
June 22, 2001
Publication date:
May 30, 2002
Applicant:
Amgen Inc.
Inventors:
Kevin Koch, Andreas Termin, John A. Josey
Abstract: The present invention provides a compound of formula I
wherein
R1 is H, OH, halo, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2;
R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl, or 4-cyclohexanol;
R3 is O(CH2)2 or O(CH2)3;
R4 and R5 are optionally CO(CH2)3, CO(CH2)4, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3-dimethylpyrrolidine, 3,4-dimethylpyrrolidine, azepine, or pipecoline;
R6 is
and pharmaceutically acceptable salts thereof; useful in treating estrogen deficient pathology.
Abstract: The present invention provides a compound of formula I
wherein
R1 is H, OH, halo, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2;
R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl, or 4-cyclohexanol;
R3 is O(CH2)2 or O(CH2)3;
R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3-dimethylpyrrolidine, 3,4-dimethylpyrrolidine, azepine, or pipecoline;
and pharmaceutically acceptable salts thereof.
The invention further provides pharmaceutical compositions containing compounds of formula I and methods of use for the compounds of formula I.
Abstract: The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
Type:
Application
Filed:
December 21, 2000
Publication date:
May 16, 2002
Inventors:
Steven J. Coats, Louis J. Fitzpatrick, Dennis J. Hlasta, Carolina L. Lanter, Mark J. Macielag, Ke Pan, Ralph A. Rivero, Stephen S. Palmer
Abstract: Compounds of formula (I):
or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line represents an optional bond; A is C or CH; B is CH2, O or absent; R1 and R2 are each independently selected from hydrogen, C1 to C6 alkyl optionally substituted with C1 to C4 alkoxy or phenyl, and C1 to C6 alkenyl; or, together with the carbon atom to which they are attached, form a C3 to C6 cycloalkyl group which optionally incorporates a heteroatom linkage selected from O, SO, SO2 and NR6 or which is optionally benzo-fused; R3 is hydrogen, halo, R7 or OR7; R4 is hydrogen, C1 to C4 alkyl, C1 to C4 alkoxy, trifluoromethyl or halo; R6 is hydrogen or C1 to C4 alkyl; R7 is an optionally substituted monocyclic or bicyclic ring system; m is 1 or 2; and n is 0, 1 or 2; with the proviso that B is not O when A is C; are MMP inhibitors useful in the treatment of, inter alia, tissue ulceration, wound repair and skin di
Type:
Grant
Filed:
October 12, 2001
Date of Patent:
May 14, 2002
Assignee:
Pfizer INC
Inventors:
Kevin Neil Dack, Gavin Alistair Whitlock
Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are &agr;-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.
Abstract: The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
Abstract:
A compound represented by the general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. These compounds inhibit the action of chemokines such as MIP-1&agr; and/or MCP-1 on target cells, and are useful as therapeutic and/or preventative drugs in diseases, such as atheroclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
Type:
Grant
Filed:
July 16, 2001
Date of Patent:
March 26, 2002
Assignees:
Teijin Limited, Dupont Pharmaceuticals Research Laboratories
Abstract: Aza- and diazacyclohexane and -cyclooctane compounds of the following formula:
Ar1—A—B—Ar2 (I)
where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
Abstract: Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Type:
Grant
Filed:
December 16, 1998
Date of Patent:
January 1, 2002
Assignee:
Amgen Inc.
Inventors:
Kevin Koch, Andreas Termin, John A. Josey
Abstract: This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
Type:
Grant
Filed:
December 2, 1999
Date of Patent:
December 18, 2001
Assignee:
GPI Nil Holdings, Inc.
Inventors:
Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
Abstract: Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Type:
Grant
Filed:
June 7, 2000
Date of Patent:
September 18, 2001
Assignee:
Amgen Inc.
Inventors:
Kevin Koch, Andreas Termin, John A. Josey
Abstract: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
Type:
Grant
Filed:
August 5, 1999
Date of Patent:
July 24, 2001
Assignee:
Eli Lilly and Company
Inventors:
Kenneth Jeff Thrasher, Kenneth Lee Hauser, Alan David Palkowitz
Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below.
The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, epilepsy, asthma, amyotrophic lateral sclerosis, or pain and to pharmaceutical compositions that contain the compounds of Formula I.
Type:
Grant
Filed:
June 14, 1999
Date of Patent:
June 26, 2001
Assignee:
Warner-Lambert
Inventors:
Lain-Yen Hu, Michael Francis Rafferty, Todd Robert Ryder
Abstract: Compounds of formula I are useful antidepressant agents
demonstrating potent inhibition of 5-HT reuptake. Z is selected from among various phenyl and hetaryl moieties while Y is benzyl or indolyl.
Type:
Grant
Filed:
December 21, 1999
Date of Patent:
May 1, 2001
Assignee:
Bristol-Myers Squibb Company
Inventors:
Michael A. Poss, David R. Tortolani, Ronald J. Mattson, Joseph P. Yevich
Abstract: 1,2-Bis-adducts of stable hindered nitroxide compounds with substituted ethylenes are prepared by reacting two equivalents of nitroxyl compound with an ethylenically unsaturated compound such as styrene or an acrylate ester. These adducts are very effective inhibitors to prevent the premature polymerization of ethylenically unsaturated monomers when such monomers are distilled, processed or stored.
Type:
Grant
Filed:
October 7, 1998
Date of Patent:
April 17, 2001
Assignee:
Ciba Specialty Chemcials Corporation
Inventors:
Glen Thomas Cunkle, Thomas F. Thompson, Volker H. von Ahn, Roland A. E. Winter
Abstract: The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1):
and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
Type:
Grant
Filed:
October 29, 1997
Date of Patent:
February 27, 2001
Assignee:
Aventis Pharmaceuticals Inc.
Inventors:
John M. Kane, George D. Maynard, Timothy P. Burkholder, Larry D. Bratton, Christopher R. Dalton, Elizabeth M. Kudlacz, Braulio Santiago
Abstract: Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the blockade of ion channels and the treatment of arrhythmias.
Type:
Grant
Filed:
March 17, 1999
Date of Patent:
January 16, 2001
Assignee:
University of British Columbia
Inventors:
Bernard A. MacLeod, Michael J. A. Walker, Richard A. Wall
Abstract: A compound of the formula:
wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.
Abstract: The present invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof: ##STR1## where A is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, arylC.sub.1-6 alkyl, aryl, S(O),R.sup.1, OR.sup.1 or NR.sup.1 R.sup.6 ;R.sup.1 is hydrogen; C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl or C.sub.3-6 cycloalkenyl each of which is optionally substituted by amino, C.sub.1-6 alkylamino, di(C.sub.1-6 alkyl)amino, C.sub.1-6 alkoxy, C.sub.1-6 alkylaminocarbonyl, one, two or three hydroxy groups, one, two or three halogen atoms or a four, five or six-membered saturated heterocyclic ring containing a nitrogen atom and optionally either an oxygen atom or a further nitrogen atom which ring is optionally substituted by C.sub.1-4 alkyl on the further nitrogen atom; aryl, arylC.sub.1-6 alkyl, arylC.sub.2-6 alkenyl or arylC.sub.2-6 alkynyl optionally substituted on the aryl ring by halogen, nitro, cyano, C.sub.
Type:
Grant
Filed:
April 22, 1999
Date of Patent:
December 5, 2000
Assignee:
Merck Sharp & Dohme Limited
Inventors:
Howard Barff Broughton, Mark Stuart Chambers
Abstract: Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.
Abstract: The present invention relates to novel substituted phenols and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing the compounds are also includes.
Type:
Grant
Filed:
January 23, 1998
Date of Patent:
September 26, 2000
Assignee:
Warner-Lambert Company
Inventors:
Thomas C. Malone, Robert M. Schelkun, Po-Wai Yuen
Abstract: Selected novel azepine and larger medium ring compounds are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Type:
Grant
Filed:
December 16, 1998
Date of Patent:
August 22, 2000
Assignee:
Amgen Inc.
Inventors:
Sandra E. Russo-Rodriguez, Kevin Koch, Andreas Termin, Conrad Hummel