The Hetero Ring Shares The 1,2-positions Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/78)
  • ROR GAMMA MODULATORS
    Publication number: 20140343023
    Abstract: The present invention relates to compounds of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention, suppression or amelioration of a disease mediated by the ROR gamma receptor in a subject in need thereof, in particular diabetes and diabetes-related disorders, specifically type II diabetes, methods of their production, as well as methods of treatment or prevention of such diseases.
    Type: Application
    Filed: September 18, 2012
    Publication date: November 20, 2014
    Inventors: Christian Wolfrum, Erick Carriera, Bettina Meissburger
  • ANTICANCER STEROIDAL LACTONES UNSATURATED IN POSITION 7 (8)
    Publication number: 20130040921
    Abstract: A compound of general formula (I), wherein R1-R17 and the ------ line take various meanings for use in the treatment of cancer.
    Type: Application
    Filed: April 26, 2011
    Publication date: February 14, 2013
    Applicant: PHARMA MAR, S.A.
    Inventors: Rogelio Fernández Rodríguez, José Fernando Reyes Benítez, Andrés Francesch Solloso, María del Carmen Cuevas Marchante
  • Process for preparing beta-ketoester compounds
    Patent number: 7642356
    Abstract: The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: January 5, 2010
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun Ik Shin, Bo Seung Choi, Jae Hoon Lee
  • Wortmannin conjugates and uses thereof
    Publication number: 20090324489
    Abstract: The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3-kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.
    Type: Application
    Filed: August 31, 2006
    Publication date: December 31, 2009
    Inventors: Hushan Yuan, Ji Luo, Ralph Weissleder, Lewis Cantley, Lee Josephson
  • Processes for the synthesis of rocuronium bromide
    Publication number: 20090137794
    Abstract: The invention encompasses processes for synthesizing 1-[17?-acetyloxy-3?-hydroxy-2?-(4-morpholinyl)-5?-androstan-16?-yl]-1-(2-propenyl)pyrrolidinium bromide (rocuronium bromide) and intermediates thereof.
    Type: Application
    Filed: October 16, 2008
    Publication date: May 28, 2009
    Inventors: Juana Araceli Mendez, Marco A. De La Mora, Angel A. Rodriguez, Efrain Barragan, Hugo Herrera, Alejandro Guillen
  • 1-.alpha.-hydroxy vitamin D compounds and process for preparing same
    Patent number: 4670190
    Abstract: The invention provides novel 1.alpha.-hydroxy vitamin D compounds and a method for their preparation from 1.alpha.-hydroxy-25-hydrogen cholesta-5,7-dienes by irradiation and isomerization techniques. The invention also includes the said 1.alpha.-hydroxy-25-hydrogen-cholesta-5,7-dienes and the corresponding cholest-5-enes.The new compounds may be obtained in a crystalline form substantially free from isomeric or other impurities arising from manufacture.
    Type: Grant
    Filed: October 3, 1984
    Date of Patent: June 2, 1987
    Inventors: Robert H. Hesse, Ezzio Rizzardo, Derek H. R. Barton
  • Novel 17-substituted steroids
    Patent number: 4647410
    Abstract: Novel 17-(formamidosulfonylmethylene)-steroids of the formula ##STR1## useful as intermediates for the novel 17-(isocyanosulfonylmethylene)-steroids of the formula ##STR2## which are useful intermediates for 21-hydroxy-20-keto-.DELTA..sup.16 -steroids and 20-keto-.DELTA..sup.16 -steroids.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: March 3, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Albert M. van Leusen, Adriaan M. van Leusen