The Hetero Ring Shares At Least Three Ring Members With One Other Cyclo Of The Polycyclo Ring System (i.e., Bridged) Patents (Class 540/90)
Bridge consisting of oxygen and carbon between the 6- and 10-positions of the cyclopentanohydrophenanthrene ring system (e.g., 6,19-oxido steroids, etc.) (Class 540/91)
Bridge consisting of oxygen and carbon between the 11- and 13-positions of the cyclopentanohydrophenanthrene ring system (e.g., 11,18-oxido steroids, etc.) (Class 540/92)
  • Cucurbitane-triterpenoid compounds, pharmaceutical composition, use and preparation method thereof
    Patent number: 8669244
    Abstract: Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the R1 is oxygen; while a single bond is formed between C8 and C9, R2 is carbonyl group (—C?O), methyl hydroxyl group (—CH(OH)), methyl ketone or methyl dimethoxy group (—CH(OCH3)2); and wherein while R1 is oxygen (—O—) and R2 is carbonyl group (—C?O) or methyl hydroxyl group (—CH(OH)), a single bond is formed between R1 (—O—) and C19 of R2 such that R1 and R2 are formed tetrahydro-2H-pyran-2-one or hemiacetal ring.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: March 11, 2014
    Assignee: National Taiwan University
    Inventors: Ching-Jang Huang, Yueh-Hsiung Kuo, Chin Hsu
  • Cucurbitane-Triterpenoid Compounds, Pharmaceutical Composition, Use and Preparation Method Thereof
    Publication number: 20120252772
    Abstract: Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the R1 is oxygen; while a single bond is formed between C8 and C9, R2 is carbonyl group (—C?O), methyl hydroxyl group (—CH(OH)), methyl ketone or methyl dimethoxy group (—CH(OCH3)2); and wherein while R1 is oxygen (—O—) and R2 is carbonyl group (—C?O) or methyl hydroxyl group (—CH(OH)), a single bond is formed between R1 (—O—) and C19 of R2 such that R1 and R2 are formed tetrahydro-2H-pyran-2-one or hemiacetal ring.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 4, 2012
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: CHING-JANG HUANG, YUEH-HSIUNG KUO, CHIN HSU
  • PROLIFERATION PROMOTING AGENT FOR NEURAL STEM CELLS
    Publication number: 20110020931
    Abstract: A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem cells, which comprises culturing a neural stem cells to proliferate the neural stem cells in a presence of the compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof, and harvesting the neural stem cells from the culture; and the like are provided.
    Type: Application
    Filed: January 29, 2009
    Publication date: January 27, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Hideyuki Onodera, Michio Ichimura, Kouji Baba, Tsutomu Agatsuma, Setsuya Sasho, Makoto Suzuki, Susumu Iwamoto, Shingo Kakita
  • Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them
    Patent number: 4895836
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: January 23, 1990
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari
  • Aminoglycoside steroids, a process for their preparation, their use and pharmaceutical compositions containing them
    Patent number: 4882315
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: November 21, 1989
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari