Sulfamyl Or Substituted Sulfamyl Containing Patents (Class 544/13)
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Patent number: 4634689Abstract: Phosphinylalkanoyl imino acids useful in the treatment of hypertension are disclosed.Type: GrantFiled: October 31, 1985Date of Patent: January 6, 1987Assignee: Schering CorporationInventors: Joseph T. Witkowski, Michael F. Czarniecki
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Patent number: 4594344Abstract: Disclosed are novel compounds having the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, a lower alkyl, lower alkoxy, lower alkoxy lower alkyl, lower alkenyl, lower alkenyl oxy, cyano, hydroxy, trifluoromethyl, nitro, amino, aminocarbonylmethyl, lower monoalkylamino, lower dialkylamino group;R.sub.2 is a hydrogen or halogen atom, cyano, lower alkyl or lower alkoxy or acylamino group;R.sub.3 is a hydrogen or halogen atom, a lower alkyl or lower alkoxy group, while R.sub.2 and R.sub.3 together can also be a butadienyl or methylene dioxy group;R.sub.4 is a hydrogen atom or a lower alkyl group;R.sub.5 is a chlorine atom or a trifluoromethyl group;X is an alkylene group;and the non-toxic, pharmaceutically acceptable acid addition salts thereof.The compounds are suitable for treatment and prophylaxis of hypertension.Type: GrantFiled: July 15, 1985Date of Patent: June 10, 1986Assignee: Boehringer Ingelheim KGInventors: Herbert Koppe, Wolfgang Abele, deceased, Franz Esser, Wolfram Gaida, Wolfgang Hoefke
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Patent number: 4576941Abstract: Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.Type: GrantFiled: February 29, 1984Date of Patent: March 18, 1986Assignee: USV Pharmaceutical Corp.Inventors: John T. Suh, John J. Piwinski, Howard Jones, Edward S. Neiss
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Patent number: 4559340Abstract: There are disclosed benzothiadiazinyl and quinazolinyl substituted carboxylalkyl dipeptides, wherein the benzothiodiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group. Compounds of this invention are useful as antihypertensive agents, in the treatment of congestive heart failure and in the treatment of glaucoma. In addition, compounds of this invention have diuretic activity.Type: GrantFiled: November 25, 1983Date of Patent: December 17, 1985Assignee: Schering CorporationInventors: Bernard R. Neustadt, David R. Andrews, Paul E. McNamara
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Patent number: 4558044Abstract: Disclosed are compounds of the formulaR.sub.1 --Ar--(CH.sub.2).sub.a --X--(CH.sub.2).sub.b --NH--Hetwherein R.sub.1 is guanidino or substituted guanidino, Ar is furandiyl, thiophendiyl, phenylene, pyridinediyl, pyrimidinediyl, thiazolediyl, thiadiazolediyl or imidazolediyl; a is 0, 1 or 2; b is 2, 3, 4 or 5; and Het is a bicyclic heteroary group, and pharmaceutically acceptable salts, quaternized derivatives, N-oxides and solvates thereof. The compounds are useful for the treatment or prophylaxis of disorders relating to excess gastric acid secretion in mammals.Type: GrantFiled: September 29, 1983Date of Patent: December 10, 1985Assignee: Beecham Group p.l.c.Inventor: Francis D. King
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Patent number: 4556655Abstract: Antihypertensive compounds with angiotensin-converting enzyme inhibitory activity and diuretic activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma.Type: GrantFiled: September 24, 1984Date of Patent: December 3, 1985Assignee: Schering CorporationInventors: David R. Andrews, Federico C. A. Gaeta
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Patent number: 4536501Abstract: Compounds of the formula ##STR1## are disclosed. They possess angiotensin converting enzyme inhibition activity and diuretic activity and are therefore useful as antihypertensive agents.Type: GrantFiled: March 30, 1984Date of Patent: August 20, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Joseph E. Sundeen, Rudiger D. Haugwitz, Peter W. Sprague
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Patent number: 4468396Abstract: This invention relates to benzothiadiazinyl-substituted carboxyalkyl dipeptides useful as combined antihypertensive and diuretic agents.Type: GrantFiled: December 20, 1982Date of Patent: August 28, 1984Assignee: Schering CorporationInventor: Charles V. Magatti
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Patent number: 4431645Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is ##STR2## The compounds are useful as hypertensive agents.Type: GrantFiled: March 8, 1982Date of Patent: February 14, 1984Assignee: Schering CorporationInventors: Elizabeth M. Smith, Joseph T. Witkowski
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Patent number: 4431644Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.4 are independently selected from hydrogen and lower alkyl; R.sup.3 is hydrogen, lower alkyl or amino lower alkyl; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is ##STR2## are disclosed. The compounds are useful as anti-hypertensive agents.Type: GrantFiled: March 8, 1982Date of Patent: February 14, 1984Assignee: Schering CorporationInventors: Elizabeth M. Smith, Joseph T. Witkowski, Ronald J. Doll
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Patent number: 4338435Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy;R.sub.3 is hydrogen, alkyl, or phenylmethyl;R.sub.4 is hydrogen, alkyl, or phenyl, and R.sub.15 is alkyl, phenyl or phenylmethyl, or R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- wherein m is 1 or 2;R.sub.5,R.sub.6,R.sub.7,R.sub.8,R.sub.9,R.sub.10,R.sub.11,R.sub.12,R.sub.13 and R.sub.14 are each independently hydrogen, halogen, alkyl or phenyl;n.sub.1,n.sub.2,n.sub.3,n.sub.4 and n.sub.5 are each independently 0 or 1;with the proviso that if R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- the sum of n.sub.1, n.sub.2, n.sub.3, n.sub.4, n.sub.5 and m is 2 or 3;have diuretic activity.Type: GrantFiled: June 1, 1981Date of Patent: July 6, 1982Assignee: E. R. Squibb & Sons, Inc.Inventor: Rudiger D. Haugwitz
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Patent number: 4302453Abstract: Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxy-lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R.sup.3 and R.sup.4 may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment or arrhythmia.In addition, novel intermediates are provided having the structure ##STR2## wherein R is hydrogen, benzyl or ##STR3## These intermediates are also useful in treating acute myocardial infarction.Type: GrantFiled: October 9, 1980Date of Patent: November 24, 1981Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Rita T. Fox