Hetero Ring Patents (Class 544/198)
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Patent number: 12214045Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.Type: GrantFiled: July 12, 2023Date of Patent: February 4, 2025Assignee: Nektar TherapeuticsInventors: Zhongxu Ren, Neel K. Anand, Haiying Cai, Bo-Liang Deng, Bhalchandra V. Joshi, Jonathan Zalevsky, Takahiro Miyazaki, Saul Kivimae
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Patent number: 11744898Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.Type: GrantFiled: January 10, 2018Date of Patent: September 5, 2023Assignee: Nektar TherapeuticsInventors: Zhongxu Ren, Neel K. Anand, Haiying Cai, Bo-Liang Deng, Bhalchandra V. Joshi, Jonathan Zalevsky, Takahiro Miyazaki, Saul Kivimae
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Patent number: 10941123Abstract: The present invention relates to a triazine precondensate according to the general formula (I) where R1 means Q1 or a moiety of the formula R3—N—R4 connected with the nitrogen atom to the triazine ring of the structure of formula (I), where R9 means Q1 or a moiety of the formula R7—N—R8 connected with the nitrogen atom to the triazine ring of the structure of formula (I), where R2, R3, R4 and R6 mean independently from each other H, Q1 or (i), R7 and R8 mean independently from each other H, Q1, (ii) or (iii) or (i), R10 and R11 mean independently from each other R7 or R8; R5 means linear or branched C2-C20-alkyl that can be interrupted by one or more oxygen atoms, sulphur atoms, substituted or non-substituted nitrogen atoms.Type: GrantFiled: June 21, 2017Date of Patent: March 9, 2021Assignee: Borealis Agrolinz Melamine GmbHInventors: Herbert Gabriel, René Dicke, Helmut Puchinger
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Patent number: 10385076Abstract: A surface treatment agent including a compound (?) is provided. The compound (?) has one or more M-OH groups and/or groups capable of forming M-OH (wherein M represents a metal atom), an amino group and a triazine ring; wherein said amino group is bonded to a terminal; one or more said amino groups bonded to the terminal are present; and one or more said triazine rings are present.Type: GrantFiled: August 8, 2017Date of Patent: August 20, 2019Assignees: Sulfur Chemical Laboratory, Inc., Meiko Electronics Co., Ltd.Inventors: Kunio Mori, Yusuke Matsuno, Katsuhito Mori, Takahiro Kudo, Shuukichi Takii, Shigeru Michiwaki, Manabu Miyawaki, Masanori Yanai, Kouichi Kamiyama, Hitomi Chiba, Yasuyuki Masuda
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Patent number: 10160736Abstract: The present invention relates to synthetic methods for 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds. The general synthetic scheme is: R1 substituents are —CH2OH, —CH(CH3)OH, —CH2Ph, —CH3, or —CH2C(O)NH2 optionally substituted with alkyl or aralkyl. R3 substituents are —CH2OH, —CH3, —CH2CH2C(O)OH, —CH2CH2C(O)NH2, —CH2C(O)NH2, or —CH2C(O)OH, wherein the carboxylic acids and amides are optionally substituted with alkyl or aralkyl.Type: GrantFiled: October 2, 2017Date of Patent: December 25, 2018Assignee: Aurigene Discovery Technologies LimitedInventors: Pottayil Govindan Nair Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty Sudarshan Naremaddepalli
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Patent number: 9833768Abstract: Disclosed herein are methods and compositions for purifying proteins from crude solutions.Type: GrantFiled: July 27, 2017Date of Patent: December 5, 2017Assignees: Impossible Foods Inc., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Patrick O'Reilly Brown, R. Edward Watts, Pehr Harbury
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Patent number: 9776978Abstract: The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.Type: GrantFiled: October 18, 2016Date of Patent: October 3, 2017Assignee: Aurigene Discovery Technologies LimitedInventors: Pottayil Govindan Nair Sasikumar, Muralidhara Ramachandra, Seetharamaiah Setty Sudarshan Naremaddepalli
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Patent number: 9751789Abstract: The invention is directed towards methods and compositions for making and using fluorescent monomers which are synthesized by reacting a substituted or non-substituted benzoxanthene anhydride with an amine and with a moiety containing a polymerizable group. Such monomers are useful for the preparation of tagged treatment polymers. Such tagged treatment polymers are useful as scale inhibitors in industrial water systems.Type: GrantFiled: December 28, 2012Date of Patent: September 5, 2017Assignee: ECOLAB USA INC.Inventors: Jeffery M Atkins, Barbara E. Moriarty, Paul J. Zinn
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Patent number: 9233421Abstract: Disclosed is a method of manufacturing nano-sized metal wire having a length-to-diameter ratio of at least 50 by using an ionic liquid in a polyol reduction using a metal salt as a precursor.Type: GrantFiled: November 17, 2009Date of Patent: January 12, 2016Inventors: Kwang Suck Suh, Jong Eun Kim, Tae Young Kim, Won Jung Kim
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Publication number: 20150126510Abstract: The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing triazine rings and suitable spacers. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show improved activity against NNRTI-resistant viruses of HIV-1.Type: ApplicationFiled: March 18, 2013Publication date: May 7, 2015Applicants: Universiteit Antwerpen, Shakturana CVInventors: Jan Heeres, Koen Augustyns, Pieter Van Der Veken, Jurgen Joossens, Venkatraj Muthusamy, Kevin Karel Florentina Arien, Guido Louis Emile Vanham, Paulus Lewi (deceased)
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Publication number: 20150110742Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.Type: ApplicationFiled: May 1, 2013Publication date: April 23, 2015Applicant: Yale UniversityInventors: David Spiegel, Kelly Fitzgerald
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Publication number: 20150080393Abstract: The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.Type: ApplicationFiled: September 5, 2014Publication date: March 19, 2015Inventors: Stéphane De Lombaert, Daniel R. Goldberg, Kenneth Brameld, Eric Brian Sjogren, Andrew Scribner
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Publication number: 20150072894Abstract: The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: ApplicationFiled: September 17, 2014Publication date: March 12, 2015Applicant: Pacific Biosciences of California, Inc.Inventors: Stephen YUE, Gene SHEN, Wei-Chuan (David) SUN
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Publication number: 20150073103Abstract: Multifunctional melamine epoxy resins, methylols and amines are provided. Methods of making multifunctional melamine epoxy resins, methylols and amines are also provided.Type: ApplicationFiled: November 19, 2014Publication date: March 12, 2015Inventor: Georgius Abidal ADAM
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Publication number: 20150057395Abstract: Compounds consisting of an oligomer or a polymer of a 1,3,5-triazine derivative, having the general formula I: wherein: X is selected from: or X is a heterocyclic radical containing in the ring at least one nitrogen atom which radical is linked to the triazine ring through one of such nitrogen atoms, R2 is alkyl or cycloalkyl, R1 is a divalent radical of piperazine of the formula or R2 is a divalent radical according to the formula or R2 is a radical according to the formula Y n is an integer from 2 to 30, inclusive, m is an integer from 2 to 6, inclusive, p is an integer from 2 to 12, inclusive, and X1=OH, NH2 or X whereby X and X1 may be the same or different, and, X2=H or is a C1-C4 alkyl group, and a solvent-free process for the production of the compounds of Formula I as well as the use of the self-extinguishing oligomeric or polymeric compounds as flame retardants and light stabilizers in thermoplastic polymers such as polypropylene or regenerated cellulose or polyester.Type: ApplicationFiled: October 31, 2014Publication date: February 26, 2015Inventor: Bansi Lal Kaul
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Publication number: 20150050659Abstract: Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.Type: ApplicationFiled: August 5, 2014Publication date: February 19, 2015Inventors: Lubomir SEBO, Jeremiah HANES, Gene SHEN, Louis BROGLEY, Stephen YUE, Frank ZHENG, Yuri LAPIN, John LYLE, Honey OSUNA, Andrei FEDOROV
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Publication number: 20150048338Abstract: The compound represented by the following general formula is useful as a light-emitting material for an organic light-emitting device. Z1, Z2 and Z3 in the following general formula each independently represent a substituent.Type: ApplicationFiled: March 7, 2013Publication date: February 19, 2015Inventors: Chihaya Adachi, Tetsuya Nakagawa, Jie Li
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Publication number: 20150045365Abstract: The present invention provides a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment of cancer in a subject comprising administering to said subject an effective amount of a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is the use of a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof in the preparation of a medicament for the treatment of cancer. In addition, the present invention also provides a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof.Type: ApplicationFiled: August 6, 2014Publication date: February 12, 2015Inventors: Antony Wilks Burgess, Francesca Walker, Keith Geoffrey Watson, Helen Witchard, Guillaume Lessene
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Patent number: 8952150Abstract: Disclosed are compounds for inhibiting prostaglandin transporter (PGT) activity, pharmaceuticals compositions including the compounds, and methods of treating subjects using the compounds.Type: GrantFiled: September 20, 2010Date of Patent: February 10, 2015Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Victor L. Schuster, Yuling Chi, Andrew S. Wasmuth, Richard S. Pottorf, Gary L. Olson
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Publication number: 20150031879Abstract: The present invention relates to novel processes for the preparation of sterically hindered amine ethers by the transformation of a corresponding oxo-piperidin to a hydroxy or amino substituted sterically hindered amine ether and the preparation of a N-propoxy or N-propenoxy substituted sterically hindered amine and some novel compounds obtainable by these processes. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.Type: ApplicationFiled: October 14, 2014Publication date: January 29, 2015Applicant: BASF SEInventors: Markus FREY, Valerie Rast, Francisco Martinez, Davide Alvisi
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Publication number: 20150031698Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.Type: ApplicationFiled: August 3, 2014Publication date: January 29, 2015Inventor: Neville Robert KALLENBACH
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Publication number: 20150018328Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.Type: ApplicationFiled: July 11, 2014Publication date: January 15, 2015Applicant: AGIOS PHARMACEUTICALS, INCInventors: Zenon D. Konteatis, Janeta Popovici-Muller, Jeremy Travins, Robert Zahler, Zhenwei Cai, Ding Zhou
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Publication number: 20150017189Abstract: The invention provides methods for attaching drugs, dyes or radiolabels to bis-MTX. This method can be used to prepare bis-MTX analogs that can be used to deliver agents, such as nanoparticles, drugs, dyes or radiolabels, to cells.Type: ApplicationFiled: January 18, 2013Publication date: January 15, 2015Inventors: Carston R. Wagner, Jae Chul Lee, Sidath C. Kumarapperuma
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Patent number: 8912293Abstract: A resin composition is provided. The resin composition comprises: an epoxy resin; a hardener, which comprises a melamine compound of Formula I: wherein, R is the same with or different from each other and has the formula of R1 and R2 are individually selected from a group consisting of H, a halogen, a substituted or unsubstituted C1-C15 alkyl group, a substituted or unsubstituted C1-C15 aloxy group, a substituted or unsubstituted C3-C15 cycloalkyl group, a substituted or unsubstituted C6-C20 aryl group, a substituted or unsubstituted C6-C20 aryloxy group, a substituted or unsubstituted C1-C15 unsaturated hydrocarbyl group, a naphthol group, a phenanthrenol group, and a dicyclopentadiene group, with a proviso that R2 is not H; and m is 1 or 2, wherein the amount of the hardener is about 20 parts by weight to about 150 parts by weight per 100 parts by weight of the epoxy resin.Type: GrantFiled: September 22, 2011Date of Patent: December 16, 2014Assignee: Taiwan Union Technology CorporationInventor: Hsin-Ho Wu
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Patent number: 8895647Abstract: The present invention relates to oxygen-substituted sterically hindered amines of the formulae I or II: (II), wherein, for example, F2, R3, R5, R6, R8, R9, R11, R12, R13, R14 are n-butyl; Z1 to Z10 are propoxy and R1, R4, R7, R10, R13 are 2,2,6,6-tetramethyl-1-propoxy-piperidin-4-yl. Compositions comprising compounds of formulae I or II and an organic material, which is susceptible to oxidative, thermal or light-induced degradation, are further disclosed. Optionally, further additives are contained.Type: GrantFiled: August 31, 2010Date of Patent: November 25, 2014Assignee: BASF SEInventors: Edoardo Menozzi, Massimiliano Sala, Anna Bassi, Holger Hoppe, Björn Ludolph, Gérard Lips
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Patent number: 8895731Abstract: The invention relates to novel intermediates for the preparation of substituted triazines used in particular in the cosmetic, detergent, coating, plastics and textile industries. The invention also relates to the processes for preparation of said intermediates and for the conversion of the latter into final products.Type: GrantFiled: June 8, 2012Date of Patent: November 25, 2014Assignee: 3V Sigma S.p.A.Inventors: Francesco Maestri, Luca Bemporad, Ferruccio Berte′
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Publication number: 20140336313Abstract: The present invention relates to oxygen-substituted sterically hindered amines of the formulae I or II: (II), wherein, for example, F2, R3, R5, R6, R8, R9, R11, R12, R13, R14 are n-butyl: Z1 to Z10 are propoxy and R1, R4, R7, R10, R13 are 2,2,6,6-tetramethyl-1-propoxy-piperidin-4-yl. Compositions comprising compounds of formulae I or II and an organic material, which is susceptible to oxidative, thermal or light-induced degradation, are further disclosed. Optionally, further additives are contained.Type: ApplicationFiled: July 28, 2014Publication date: November 13, 2014Applicant: BASF SEInventors: Edoardo MENOZZI, Massimiliano SALA, Anna BASSI, Holger HOPPE, Björn LUDOLPH, Gérard LIPS
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Patent number: 8877924Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.Type: GrantFiled: June 8, 2010Date of Patent: November 4, 2014Assignee: NantBio Inc.Inventors: Chunlin Tao, Qinwei Wang, David Ho, Laxman Nallan, Tulay Polat, Xiaowen Sun, Neil Desai
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Publication number: 20140323488Abstract: The present invention relates to novel compounds (I) containing two disubstituted triazine rings covalently linked by an organic linker, thereby creating dimers. These compounds show activity against the causative infective agents of infectious diseases such as African trypanosomiasis, Chagas disease, Leishmaniasis, Malaria and HIV. The invention further relates to the prevention and/or treatment of these diseases.Type: ApplicationFiled: November 9, 2012Publication date: October 30, 2014Inventors: Venkatraj Muthusamy, Louis Maes, Jan Heeres, Koen Augustyns, Pieter Van Der Veken, Jurgen Joossens, Paulas Joannes Lewi
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Patent number: 8835629Abstract: The present invention provides a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment of cancer in a subject comprising administering to said subject an effective amount of a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is the use of a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof in the preparation of a medicament for the treatment of cancer. In addition, the present invention also provides a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof.Type: GrantFiled: October 27, 2011Date of Patent: September 16, 2014Assignee: The Walter and Eliza Hall Institute of Medical ResearchInventors: Antony Wilks Burgess, Francesca Walker, Keith Geoffrey Watson, Helen Witchard
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Publication number: 20140252280Abstract: The present invention relates to compounds of formula (I), a process for their production and their use in electronic devices, especially electroluminescent devices. When used as electron transport and/or host material for phosphorescent emitters in electroluminescent devices, the compounds of formula I may provide improved efficiency, stability, manufacturability, or spectral characteristics of electroluminescent devices.Type: ApplicationFiled: November 7, 2012Publication date: September 11, 2014Applicant: BASF SEInventors: Thomas Schaefer, Ute Heinemeyer, Nicolle Langer, Annemarie Wolleb, Christian Lennartz, Soichi Watanabe, Teresa Marina Figueira Duarte, Gerhard Wagenblast, Didier Bauer, Ingo Muenster, Christian Schildknecht, Heinz Wolleb
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Publication number: 20140221646Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.Type: ApplicationFiled: February 12, 2014Publication date: August 7, 2014Applicant: JANUS BIOTHERAPEUTICS, INC.Inventors: Grayson B. LIPFORD, Charles M. ZEPP
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Patent number: 8796449Abstract: Novel s-triazine compounds are disclosed that have a formula represented by the following: L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.Type: GrantFiled: March 17, 2011Date of Patent: August 5, 2014Assignee: New York UniversityInventor: Neville Robert Kallenbach
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Publication number: 20140212364Abstract: Disclosed are oligomeric compounds obtained by condensation of the compound of formula (I) with itself wherein R1 and R2 are C1-C22 alkyl, isoalkyl or cycloalkyl groups.Type: ApplicationFiled: March 13, 2013Publication date: July 31, 2014Applicant: 3V SIGMA S.p.A.Inventors: Massimo Fabbi, Carlo Seccomandi, Luca Bemporad, Ivan Balestra
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Publication number: 20140187772Abstract: This invention describes novel pyrazole compounds of formula III: wherein Z1, Z2, and Z3 are as described in the specification; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R2 and R2? are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.Type: ApplicationFiled: December 24, 2013Publication date: July 3, 2014Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Francoise Pierard
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Publication number: 20140176653Abstract: There is provided a compound represented by formula (1): in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R4 to R24 independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.Type: ApplicationFiled: February 28, 2014Publication date: June 26, 2014Applicant: FUJIFILM CORPORATIONInventors: Yoshihiko FUJIE, Keiichi TATEISHI, Clive Edwin FOSTER
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Publication number: 20140170538Abstract: There is provided a compound represented by Formula (1), and a coloring composition including the compound: wherein, in Formula (1), R0 to R3 each independently represent a hydrogen atom or a substituent, and R0 and R1, R0 and L, or R1 and L may be combined with each other to form a ring, L represents a single bond or a divalent linking group, D represents a residue in which n hydrogen atoms are removed from a compound represented by Formula (2), n represents an integer of 1 or more, provided that when n represents an integer of 2 or more, a plurality of R0's to R3's and L's may be the same or different, the compound represented by Formula (1) has at least one ionic hydrophilic group, and in Formula (2), R4 to R24 each independently represent a hydrogen atom or a substituent.Type: ApplicationFiled: February 25, 2014Publication date: June 19, 2014Applicant: FUJIFILM CorpoartionInventor: Yoshihiko FUJIE
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Patent number: 8754084Abstract: The invention provides compounds, compositions and methods for treating myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit replication of the nucleic acids.Type: GrantFiled: March 27, 2013Date of Patent: June 17, 2014Assignee: The Board of Trustees of the University of IllinoisInventors: Steven C. Zimmerman, Chun-Ho Wong, Paul J. Hergenrother, Jessie Peh
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Publication number: 20140155599Abstract: The invention relates to a process for the purification of a melamine condensation product, comprising the steps of a) making a diluted slurry of a reaction product mixture comprising the melamine condensation product in a solution of a base in water with a pH of at least 9, b) keeping the diluted slurry for a period of at least 1 hour, c) concentrating the diluted slurry, thereby obtaining a concentrated slurry and an eluent, and d) washing the concentrated slurry by diluting the concentrated slurry with aqueous liquid and repeating step c, wherein the washing is performed by counterflow washing wherein eluents of downstream concentration steps are used to wash the slurry in upstream concentration steps.Type: ApplicationFiled: March 27, 2012Publication date: June 5, 2014Applicant: DSM IP ASSETS B.V.Inventors: Christiaan Johannes Cornelis Stoelwinder, Gerard Jan Kwant
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Publication number: 20140155379Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.Type: ApplicationFiled: December 20, 2013Publication date: June 5, 2014Applicant: Ligand Pharmaceuticals IncorporatedInventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
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Patent number: 8742003Abstract: The present invention relates to silylated amino resins, to processes for preparing them, to their use, and to coating compositions comprising them.Type: GrantFiled: July 13, 2012Date of Patent: June 3, 2014Assignee: BASF SEInventors: Christina Haaf, Markus Hickl, Ruediger Stark, Horst Hintze-Bruening, Bernd Bruchmann, Dirk Schmelter, Thomas Gloege, Christine Roesch
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Publication number: 20140142305Abstract: The instant invention relates to novel water soluble bis-(triazinylamino)-stilbene optical brightening agents, a process for their preparation and their use for whitening natural and synthetic materials.Type: ApplicationFiled: April 17, 2012Publication date: May 22, 2014Applicant: CLARIANT INTERNATIONAL LTDInventors: Cedric Klein, Frederic Reveaud, Andrew Clive Jackson, David Atkinson
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Patent number: 8722674Abstract: Disclosed herein are a 1,3,5-triazine-2,4,6-triamine compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for preventing or treating metabolic syndromes, diabetes, or cancers with deletion of P53 gene, which comprises the same.Type: GrantFiled: August 28, 2008Date of Patent: May 13, 2014Assignee: Hanall Biopharma Co., Ltd.Inventors: Hyae Gyeong Cheon, Kwang-Rok Kim, Sang Dal Rhee, Won Hoon Jung, Jong-Cheol Lee, Sung Wuk Kim, Sung Soo Jun
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Patent number: 8657947Abstract: The present invention relates to silylated amino resins, to processes for preparing them, to their use, and to coating compositions comprising them.Type: GrantFiled: September 10, 2012Date of Patent: February 25, 2014Assignee: BASF SEInventors: Bastian Noller, Reinhold Schwalm, Christine Roesch, Thomas Breiner, Jean-Francois Stumbe, Christina Haaf
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Publication number: 20140011923Abstract: Compounds consisting of an oligomer or a polymer of a 1,3,5-triazine derivative, having the general formula I: wherein: X is selected from: or X is a heterocyclic radical containing in the ring at least one nitrogen atom which radical is linked to the triazine ring through one of such nitrogen atoms, R2 is alkyl or cycloalkyl, R1 is a divalent radical of piperazine of the formula or R2 is a divalent radical according to the formula or R2 is a radical according to the formula Y n is an integer from 2 to 30, inclusive, m is an integer from 2 to 6, inclusive, p is an integer from 2 to 12, inclusive, and X1?OH, NH2 or X whereby X and X1 may be the same or different, and, X2?H or is a C1-C4 alkyl group, and a solvent-free process for the production of the compounds of Formula I as well as the use of the self-extinguishing oligomeric or polymeric compounds as flame retardants and light stabilizers in thermoplastic polymers such as polypropylene or regenerated cellulose or polyester.Type: ApplicationFiled: September 9, 2013Publication date: January 9, 2014Applicant: MCA Technologies GmbHInventor: Bansi Lal Kaul
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Publication number: 20140005370Abstract: Disclosed herein is a compound having Formula I: or a salt thereof, in which R1, R2 and R3 are as defined herein. Also disclosed are processes to prepare compounds of Formula I and use of compounds of Formula I to prepare stable glassy phases.Type: ApplicationFiled: December 14, 2012Publication date: January 2, 2014Applicant: Her Majesty the Queen in right of Canada as represented by the Minister of National DefenceInventor: Her Majesty the Queen in right of Canada as represented by the Minister of National Defence
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Patent number: 8608907Abstract: A composition suitable for paper brightening, wherein the composition contains one or more specified fluorescent whitening agents with taurine groups. The composition is used for whitening paper, in particular at the wet-end, in the size press or by coating.Type: GrantFiled: June 10, 2009Date of Patent: December 17, 2013Assignee: Blankophor GmbH & Co. KGInventors: Bernhard Hunke, Michael Kraemer, Andrei Tauber, Günter Klug
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Publication number: 20130323777Abstract: A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.Type: ApplicationFiled: July 16, 2013Publication date: December 5, 2013Applicant: Naval Research LaboratoryInventors: Igor L. Medintz, Kimihiro Susumu, Michael H. Stewart
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Patent number: 8597803Abstract: A light emitting composition includes a light-emitting lumophore-functionalized nanoparticle, such as an organic-inorganic light-emitting lumophore-functionalized nanoparticle. A light emitting device includes an anode, a cathode, and a layer containing such a light-emitting composition. In an embodiment, the light emitting device can emit white light.Type: GrantFiled: May 9, 2012Date of Patent: December 3, 2013Assignee: Nitto Denko CorporationInventors: Jesse Froehlich, Hyun Sik Chae, Amane Mochizuki, Sheng Li
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Patent number: 8580786Abstract: The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.Type: GrantFiled: December 17, 2010Date of Patent: November 12, 2013Assignee: Nant Holdings IP, LLCInventors: Neil P. Desai, Patrick Soon-Shiong, Chunlin Tao, Qinwei Wang