Phosphorus Containing Patents (Class 544/214)
  • Patent number: 10738176
    Abstract: Phosphate-based polyallyl isocyanurate cross-linker compounds, polyalkenyl isocyanurate cross-linker compounds, and a flame-retardant resin are disclosed. The phosphate-based polyallyl isocyanurate compound can have allyl phosphate substituents with variable functional groups. The phosphate-based polyallyl isocyanurate compound can have three or six allyl phosphate substituents. The brominated polyalkenyl isocyanurate compound can have brominated alkene-terminated substituents. The brominated alkene-terminated substituents can have variable functional groups and variable chain lengths. Both the phosphate-based polyallyl isocyanurate compounds and the brominated polyalkenyl isocyanurate compounds can be cross-linkers for epoxide polymers, acrylate polymers, vinylbenzene-terminated poly(phenyleneoxide) polymers, etc. The phosphate-based polyallyl isocyanurate compounds and the brominated polyalkenyl isocyanurate compounds can also be flame-retardant.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 11, 2020
    Assignee: International Business Machines Corporation
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jason T. Wertz
  • Patent number: 10066083
    Abstract: Phosphate-based polyallyl isocyanurate cross-linker compounds, polyalkenyl isocyanurate cross-linker compounds, and a flame-retardant resin are disclosed. The phosphate-based polyallyl isocyanurate compound can have allyl phosphate substituents with variable functional groups. The phosphate-based polyallyl isocyanurate compound can have three or six allyl phosphate substituents. The brominated polyalkenyl isocyanurate compound can have brominated alkene-terminated substituents. The brominated alkene-terminated substituents can have variable functional groups and variable chain lengths. Both the phosphate-based polyallyl isocyanurate compounds and the brominated polyalkenyl isocyanurate compounds can be cross-linkers for epoxide polymers, acrylate polymers, vinylbenzene-terminated poly(phenyleneoxide) polymers, etc. The phosphate-based polyallyl isocyanurate compounds and the brominated polyalkenyl isocyanurate compounds can also be flame-retardant.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: September 4, 2018
    Assignee: International Business Machines Corporation
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jason T. Wertz
  • Patent number: 9203043
    Abstract: An organic electroluminescence device 1 includes: an anode 3, a cathode 4 opposed to the anode 3 and an emitting layer 5 provided between the anode 3 and the cathode 4. The emitting layer 5 contains first and second host materials and a luminescent material. The first host material has a partial structure represented by at least one of the following formulae (1) and (2) while the second host material has a partial structure represented by the following formula (3). Az represents a substituted or unsubstituted aromatic heterocyclic group containing a nitrogen-containing six-membered ring. WCN is an aromatic hydrocarbon group substituted by at least one cyano group (CN) or an aromatic heterocyclic group substituted by at least one cyano group (CN). Ar1 is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group, but is not an aromatic heterocyclic group containing a nitrogen-containing six-membered ring.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: December 1, 2015
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventors: Kazuki Nishimura, Tetsuya Inoue, Yumiko Mizuki, Nobuhiro Yabunouchi, Mitsuru Eida
  • Publication number: 20150119488
    Abstract: Disclosed herein are methods of making polymerizable resins containing a 1,3,5-hexahydro-1,3,5-triazine moiety and dental compositions comprising such novel hydrolytic stable, polymerizable resins derived from 1,3,5-triacryloyl-hexahydro-1,3,5-triazine (TAT).
    Type: Application
    Filed: October 30, 2014
    Publication date: April 30, 2015
    Inventor: Xiaoming JIN
  • Publication number: 20150065466
    Abstract: The present invention generally concerns particular methods and compositions for antimicrobial therapy. In particular embodiments, the compositions target DXR. In some cases, the antimicrobial agent comprises an electron-deficient hydrophobic group that has interacts with Trp211 of DXR. In specific embodiments, the compound contains electron-deficient heterocyclic rings that specifically interact with the electron-rich indole ring of Trp211. In certain aspects, the compositions comprise a phosphate group, a pyridine group, and a hydroxymate group.
    Type: Application
    Filed: April 18, 2013
    Publication date: March 5, 2015
    Inventor: Yongcheng Song
  • Patent number: 8680267
    Abstract: A process produces an amide or lactam by subjecting an oxime compound to rearrangement in a solvent in the presence of: at least one catalyst selected from the group consisting of an aromatic compound (A1) containing a leaving group bound to a carbon atom constituting the aromatic ring, the aromatic ring including, as a constitutive atom thereof, a heteroatom or including, as a constitutive atom thereof, a carbon atom bound to an electron-withdrawing group, and a compound (A2) containing a structure of Formula (1): -G-LA (1) wherein G represents P, N, S, B or Si atom; and LA represents a leaving group, wherein G is bound to one or more atoms or groups in addition to LA; and a co-catalyst including a halogen-containing organic acid, to give the corresponding amide or lactam, wherein, when the aromatic compound (A1) alone is used as the catalyst, the solvent is at least one solvent selected typically from hydrocarbon solvents.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: March 25, 2014
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Takahiro Iwahama, Tatsuya Nakano, Yasutaka Ishii
  • Publication number: 20140011715
    Abstract: Melamine derivatives and mixtures thereof with aqueous systems, a process for inhibiting corrosion of metals and metal alloys with melamine derivatives and mixtures thereof and the use of melamine derivatives and mixtures thereof as corrosion inhibitors for aqueous systems, for example water/oil mixtures, especially in the field of cleaning compositions, cooling fluids, oilfield chemicals or lubricants.
    Type: Application
    Filed: July 2, 2013
    Publication date: January 9, 2014
    Applicant: BASF SE
    Inventors: Roland BOEHN, Benjamin SCHAEFER, Christian BITTNER, Fabien Jean BRAND, Peter HAENGGI
  • Publication number: 20130344287
    Abstract: Disclosed are sulfur-containing polymers containing copolymerizable adhesion promoters and compositions including sealant compositions useful in aerospace applications comprising sulfur-containing polymers containing copolymerizable adhesion promoters. In particular, polythioethers and polysulfides incorporating copolymerizable adhesion promoters are disclosed.
    Type: Application
    Filed: July 12, 2013
    Publication date: December 26, 2013
    Applicant: PRC-DeSoto International, Inc.
    Inventors: Raquel Keledjian, Renhe Lin, Bruce Virnelson
  • Publication number: 20130225528
    Abstract: The invention features compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 29, 2013
    Applicant: ARIAD PHARMACEUTICALS, INC.
    Inventor: ARIAD Pharmaceuticals, Inc.
  • Publication number: 20130143984
    Abstract: The invention relates to curable compositions which comprise epoxy resins, amino hardeners, and a phosphonate of the formula I. Addition of phosphonate of the formula I can give cured epoxy resins which have not only improved flame retardants but also an increased glass transition temperature when comparison is made with the corresponding resins without said addition.
    Type: Application
    Filed: June 7, 2012
    Publication date: June 6, 2013
    Applicant: BASF SE
    Inventors: Michael Henningsen, Achim Kaffee, Jean-Francois Stumbe, Manfred Doering, Alexander Schmidt, Lin Zang, Volker Altstaedt, Johannes Kraemer
  • Publication number: 20130053347
    Abstract: The present invention relates to the biology and mechanism of action of the naturally occurring compound Narciclasine, especially as an anti-cancer agent for brain tumors. The invention provides new insights on the target molecule of Amaryllidaceae isocarbostyril derivatives as for example Narciclasine and provides new prodrugs of these Amaryllidceae isocabostyril constituents for treating cancer, specifically cancers or tumors located in the brain.
    Type: Application
    Filed: May 3, 2010
    Publication date: February 28, 2013
    Applicant: Universite Libre de Bruxelles
    Inventors: Veronique Mathieu, Gwendoline Van Goietsenoven, Jacques Dubois, Florence Lefranc-Kiss, Laurent Ingrassia, Robert Kiss
  • Publication number: 20130046094
    Abstract: The present invention relates to electronic devices, in particular organic electroluminescent devices, which comprise compounds of the formula (1) or (2), and to the corresponding compounds and to the use thereof in organic electroluminescent devices.
    Type: Application
    Filed: March 24, 2011
    Publication date: February 21, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Philipp Stoessel, Esther Breuning, Dominik Joosten
  • Publication number: 20120235123
    Abstract: Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same. More particularly, the organic electroluminescent compound disclosed herein is represented by Chemical Formula 1: Since the organic electroluminescent compound disclosed herein exhibits good luminous efficiency and excellent life property, it may be used to manufacture OLED devices having very superior operation life.
    Type: Application
    Filed: August 3, 2010
    Publication date: September 20, 2012
    Applicant: ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.
    Inventors: Soo Young Lee, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
  • Patent number: 8212073
    Abstract: This invention relates to flame barrier compositions as well as a method for the preparation of the flame barrier compositions formed from a flame retardant composition and water. A protective barrier comprises a flame barrier composition or a flame barrier polymer on top of a layer or sandwiched between two or more layers of glass, wood, paper, polymer films, and other layered materials as well as mixtures of layers.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: July 3, 2012
    Inventor: Robert Valentine Kasowski
  • Publication number: 20120142918
    Abstract: A caged phosphine product is provided which can act as a ligand to form a metal complex. The metal complex can be used as a catalyst.
    Type: Application
    Filed: January 26, 2010
    Publication date: June 7, 2012
    Inventors: Ranbir Singh Padda, Martin Barry Smith, Gordon Findlay Docherty, Michael John Harrison
  • Patent number: 8153787
    Abstract: The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising such 5-azacytosine derivatives as active ingredients in combination with pharmaceutically acceptable carriers, which are useful for the treatment of subjects suffering from viral infections.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: April 10, 2012
    Assignees: K.U. Leuven Research & Development, Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic
    Inventors: Antonin Holy, Marcela Krecmerova, Alois Piskala, Graciela Andrei, Robert Snoeck, Erik De Clercq, Johan Neyts, Lieve Naesens
  • Publication number: 20120064790
    Abstract: The invention relates to ethylene diphosphinic acids and salts thereof of general formula A-P(O)(OX)—CR1R2—CR3R4—P(O)(OX)-A, in which A, H and/or CR5R6—OH, R1, R2, R3, R4, R5, R6 are the same or different, and denote independently from each other H, C1-C20 alkyl, C6-C20 aryl and or C6-C20 aralkyl, and X denotes H, an alkali metal, an element of the second main and secondary group, an element of the third main and secondary group, an element of the fourth main and secondary group, an element of the fifth main and secondary group, an element of the sixth secondary group, an element of the seventh secondary group, an element of the eight secondary group and/or a nitrogen base. Also disclosed are a method for producing same and the use thereof.
    Type: Application
    Filed: November 22, 2011
    Publication date: March 15, 2012
    Applicant: CLARIANT FINANCE (BVI) LIMITED
    Inventors: Harald BAUER, Werner KRAUSE, Peter STANIEK
  • Patent number: 8058329
    Abstract: Nitrous bridged derivatives of 6H-dibenz[c,e][1,2]-oxaphosphorine-6-oxides, process for the preparation and use thereof. The invention refers to nitrous bridged derivatives of 6H-dibenz[c,e][1,2]-oxaphosphorine-6-oxides, a process for the preparation thereof and their use as flameproofing agents for polymers such as polyesters, polyamides, polycarbonates, polystyrenes, polyethylene, polypropylene, phenolic and epoxy resins.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: November 15, 2011
    Assignee: Schill+Seilacher “Struktol” Aktiengesellschaft
    Inventors: Berthold Just, Uwe Dittrich, Holger Keller, Manfred Doering, Uwe Storzer, Michael Ciesielski
  • Patent number: 7345168
    Abstract: A simple and economical process for the preparation of polyphosphates of organic bases consists of reacting a mixture of phosphorus pentoxide and at least one organic nitrogen base with at least one compound which releases water accompanied by decomposition under the prevailing conditions in such a molar ratio that upon decomposition of the water-releasing compound at most essentially 2 mol. water are produced per mol. phosphorus pentoxide. Thus-prepared polyphosphates are particularly suitable as flame-protection agents for plastics.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: March 18, 2008
    Assignee: Chemische Fabrik Budenheim KG
    Inventors: Liselotte Götzmann, legal representative, Hans-Dieter Nagerl, Thomas Futterer, Karl Gotzmann
  • Patent number: 7186797
    Abstract: The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: March 6, 2007
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Theodore R. West, Thomas J McMurry, Stephane Dumas, Andrew Kolodziej
  • Patent number: 6867250
    Abstract: The invention relates generally to pyrimidines and triazines ultraviolet light absorbers containing a phenolic aromatic group(s) and a non-phenolic aromatic group(s) and the use thereof to protect against degradation by environmental forces, inclusive of ultraviolet light, actinic radiation, oxidation, moisture, atmospheric pollutants, and combinations thereof. The new class of pyrimidines and triazines includes two (one) non-phenolic aromatic groups with hydrocarbyl groups that are ortho to each other and one (two) resorcinol or substituted resorcinol group attached to a triazine or pyrimidine ring. The pyrimidines and triazines may be included in a polymeric structure. A method for stabilizing a material by incorporating the novel pyrimidines and triazines is also disclosed.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: March 15, 2005
    Assignee: Cytec Technology Corp.
    Inventors: Ram B. Gupta, Hargurpreet Singh, Russell C. Cappadona, Mark Paterna, Al Wagner
  • Publication number: 20040260089
    Abstract: A simple and economical process for the preparation of polyphosphates of organic bases consists of reacting a mixture of phosphorus pentoxide and at least one organic nitrogen base with at least one compound which releases water accompanied by decomposition under the prevailing conditions in such a molar ratio that upon decomposition of the water-releasing compound at most essentially 2 mol. water are produced per mol. phosphorus pentoxide. Thus-prepared polyphosphates are particularly suitable as flame-protection agents for plastics.
    Type: Application
    Filed: August 9, 2004
    Publication date: December 23, 2004
    Inventors: Thomas Futterer, Hans-Dieter Nagerl, Liselotte Gotzmann
  • Publication number: 20040209881
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: March 26, 2003
    Publication date: October 21, 2004
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Patent number: 6699855
    Abstract: The present invention relates to compounds of Formula (I): wherein A1 is methylene, ethylene or propylene group and A2 is N or CR5, or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HCV NS3 protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: March 2, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiaojun Zhang, Wei Han
  • Patent number: 6576760
    Abstract: Polyamines containing at least two nitrogen atoms monosubstituted with pendant arms capable of coordinating metal cations, or with precursors of such pendant arms, all nitrogen atoms of the polyamines except two being fully substituted and the remaining two bearing one H atom each, are cyclized by reaction with a bridging agent that contains two sites that each bear a reactive group capable of undergoing a nucleophilic attack by one of the two N-H groups on the polyamine. Unlike the prior art, cyclization occurs in preference over polymerization of the polyamine, even in reaction mixtures in which the polyamine is at high concentration. A process is also disclosed whereby linear polyamines in which the terminal amine groups are primary amines are substituted with methylenephosphonate ester groups, with one such substituent on each nitrogen atom of the polyamine.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: June 10, 2003
    Assignee: Chelator LLC
    Inventors: Harry S. Winchell, Rosa L. Cyjon, Joseph Y. Klein, Elliot D. Simhon, Ofer Klein, Haim Zaklad
  • Publication number: 20030045444
    Abstract: Biphenyl-substituted triazines of the formulae 1
    Type: Application
    Filed: July 31, 2002
    Publication date: March 6, 2003
    Inventors: Ian John Fletcher, Jurgen Kaschig, Georges Metzger, Dieter Reinehr, Pascal Hayoz
  • Patent number: 6399805
    Abstract: Compounds of the formula I R1 and R2 independently of one another are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 independently of one another are hydrogen, C1-C20alkyl, OR1 or halogen; R6, R7, R8, R9 and R10 independently of one another are hydrogen, C1-C20alkyl; C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R6, R7, R8, R9 and R10 are OR11, SR11, N(R12)(R13), phenyl or halogen; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by O or S and which is unsubstituted or substituted by OH and/or SH; R12 and R13 independently of one another are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl which is interrupted once or more than once by nonconsecutive O atoms and which is unsubstituted or substituted by OH and/or SH; or R12 and R13 together are C3-C5alkylene which can be interrupted by O, S or NR14; R14 is hydrog
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: June 4, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Jean-Pierre Wolf, Beat Michael Aebli, Gebhard Hug
  • Patent number: 6380386
    Abstract: The invention relates to novel substituted aminosalicylamides, to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a plurality of processes for their preparation.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: April 30, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Seitz, Uwe Stelzer, Peter Wolfrum, Klaus Stenzel
  • Patent number: 6372435
    Abstract: The present invention provides methods of correlating genetic variants in the beta-chemokine receptor 5 (CCR5) locus, more specifically CCR5 promoter alleles and genotypes, with HIV-1 transmission and/or disease progression in individuals and populations.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: April 16, 2002
    Assignee: UAB Research Foundation
    Inventors: Richard A. Kaslow, Jianming Tang
  • Publication number: 20020002281
    Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.
    Type: Application
    Filed: June 1, 2001
    Publication date: January 3, 2002
    Inventors: Todd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
  • Patent number: 6319922
    Abstract: Propanoic acid derivatives of formula (1) are described: Ar—X1—Ar1—Z—R  (1) in which Ar is a nitrogen base containing group; X1 is linker atom or group; Ar1 is an optionally substituted 5- or 6-membered nitrogen-containing aromatic or non-aromatic monocycle; Z is a group —CH(R13)CH2— [in which R13 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group], —C(R12a)(R13)—CH(R12b)— [in which R12a and R12b together with the carbon atoms to which they are attached form a C3-7cycloalkyl group] or C(R13)═CH—; R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of &agr;V integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: November 20, 2001
    Assignee: Celltech Therapeutics Limited
    Inventors: Rikki Peter Alexander, Barry John Langham, James Thomas Reuberson, Emma Louise Trown, Graham John Warrellow
  • Publication number: 20010039341
    Abstract: Biphenyl-substituted triazines of the formulae 1
    Type: Application
    Filed: May 3, 2001
    Publication date: November 8, 2001
    Inventors: Ian John Fletcher, Jurgen Kaschig, Georges Metzger, Dieter Reinehr, Pascal Hayoz
  • Patent number: 6297377
    Abstract: This invention relates generally to benzocycle-substituted pyrimidines and triazines and the use thereof to protect against degradation by environmental forces, inclusive of ultraviolet light, actinic radiation, oxidation, moisture, atmospheric pollutants and combinations thereof. The new class of benzocycle-substituted pyrimidines and triazines comprises a benzocycle attached to the triazine or pyrimidine ring, and preferably an additional aryl ring containing a hydroxyl group, either free or blocked to form a latent stabilizer, ortho- to the point of attachment to the triazine or pyrimidine ring. These materials may, under the appropriate circumstances, be bonded to formulations comprising coatings, polymers, resins, organic compounds and the like via reaction of the bondable functionality with the materials of the formulation. A method for stabilizing a material by incorporating such benzocycle-substituted pyrimidines and triazines is also disclosed.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: October 2, 2001
    Assignee: Cytec Technology Corporation
    Inventors: Ram B. Gupta, Dennis J. Jakiela, Robert G. Fischer
  • Patent number: 6239275
    Abstract: This invention relates generally to hindered phenol-substituted triazines and the use thereof to protect materials such as coatings, polymers, resins, organic compounds and the like against degradation by environmental forces, inclusive of ultraviolet light, actinic radiation, oxidation, moisture, atmospheric pollutants and combinations thereof. The new class of hindered phenol-substituted triazines includes a trisaryl-1,3,5-triazine in which one of the aryl groups is substituted by a group which comprises a hindered phenol or is a hindered phenol and is further substituted by a hydroxyl group, either free or blocked to form a latent stabilizer, ortho- to the point of attachment to the triazine. These materials may, under the appropriate circumstances, form oligomers. A method for stabilizing a material by incorporating such hindered phenol-substituted triazines is also disclosed.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: May 29, 2001
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Ram Baboo Gupta, Dennis John Jakiela
  • Patent number: 6239276
    Abstract: This invention relates generally to para-tertiary alkyl phenyl substituted pyrimidines and triazines and the use thereof to protect against degradation by environmental forces, inclusive of ultraviolet light, actinic radiation, oxidation, moisture, atmospheric pollutants and combinations thereof. The new class of para-tertiary alkyl phenyl substituted pyrimidines and triazines includes two tertiary alkylated phenyl groups, and a resorcinol or substituted resocinol group attached to the triazine or pyrimidine ring. These materials may, under the appropriate circumstances, be bonded to formulations comprising coatings, polymers, resins, organic compounds and the like via reaction of the bondable functionality with the materials of the formulation. A method for stabilizing a material by incorporating such para-tertiary alkyl phenyl substituted pyrimidines and triazines is also disclosed.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: May 29, 2001
    Assignee: Cytec Technology Corporation
    Inventors: Ram B. Gupta, Dennis J. Jakiela
  • Patent number: 6197750
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: March 6, 2001
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Robert J. Ternansky
  • Patent number: 6194576
    Abstract: Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: wherein n is 0 or an integer; X is O or S, CH2, CH-halogen, CH—N3, or C═CH2; Q and U are independently selected from: O, S, and CH(Ra) wherein Ra is hydrogen, OH, halogen, N3 ,NH2, SH, carboxyl, C1-6 alkyl or Ra is CH2(Rb) wherein Rb is hydrogen, OH, SH, NH2, C1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond; Z is selected from: O, a C1-6 alkoxy, a C1-6 thioalkyl, a C1-6 aminoalkyl, (CH2)m wherein m is 0 or an integer, and N(Rc)2 wherein both Rc are independently hydrogen or a C1-6 alkyl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: February 27, 2001
    Assignee: BioChem Pharma, Inc.
    Inventors: Nghe Nguyen-Ba, Miguel Quimpere, Laval Chan Chun Kong, William L. Brown, Gervais Dionne
  • Patent number: 6136827
    Abstract: The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: October 24, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Charles G. Caldwell, Paul E. Finke, Malcolm Maccoss, Laura C. Meurer, Sander G. Mills, Bryan Oates
  • Patent number: 6057304
    Abstract: The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the disclosure, as well as their production and use in medicinal agents.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 2, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Andreas Huth, Ralph Schmiechen, Ilse Beetz, Ingrid Schumann, Lechoslaw Turski, Peter Andreas Loschmann, David Norman Stephens, Dieter Seidelmann, Martin Kruger, Dieter Rahtz, Peter Holscher
  • Patent number: 5962437
    Abstract: A method of treating viral infections, and in particular HIV-1, hepatitis B virus and herpes viruses, is disclosed. The method comprising administering to a subject in need of such treatment an infection-combating amount of a phospholipid or phospholipid derivative.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: October 5, 1999
    Assignee: Wake Forest University
    Inventors: Louis S. Kucera, Susan L. Morris-Natschke, Khalid S. Ishaq
  • Patent number: 5804583
    Abstract: Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: September 8, 1998
    Assignee: Istituto Luso Farmaco D'Italia
    Inventors: Aldo Salimbeni, Davide Poma, Anna Renzetti, Carlo Scolastico
  • Patent number: 5677432
    Abstract: A compound useful for forming immunoconjugates used in the detection of organophosphate pesticides is provided. The compound has the formula ##STR1## wherein X is selected from the group consisting of R--O--, R--S-- and R--NH--, where R is an optionally substituted aromatic or heterocyclic group, or an optionally substituted alkyl or alkenyl group;Y is O or S;R.sup.1 is H or alkyl; andR.sup.2 is a group of the formula --(CH.sub.2).sub.n -- wherein n is an integer of from 1 to 10, or branched chain alkylene, or a group of the formula R.sup.3 --O--R.sup.4 wherein R.sup.3 and R.sup.4 are both or straight or branched chain alkylene;or a salt or ester thereof.
    Type: Grant
    Filed: August 19, 1994
    Date of Patent: October 14, 1997
    Assignee: The Horticulture and Food Research Institute of New Zealand Limited
    Inventors: William Thomas Jones, Hans Wynberg, Wolter Ten Hoeve
  • Patent number: 5677450
    Abstract: Disclosed are an organic acid salt of melamine represented by the following general formula (1) and a thermosetting and a photocurable and thermosetting coating compositions containing the salt mentioned above. ##STR1## wherein Z represents ##STR2## wherein R.sup.1 represents a hydrogen atom or an alkyl group, alkylene group, alicyclic hydrocarbon, or aromatic hydrocarbon severally having from 1 to 18 carbon atoms, or any of said groups or hydrocarbons whose hydrogen atom is substituted by carboxyl group, hydroxyl group, or a halogen atom, R.sup.2 represents a hydrogen atom or an alkyl group or alkylene group severally having from 1 to 9 carbon atoms, or any of said groups whose hydrogen atom is substituted by acryloyl group or methacryloyl group, R.sup.3 represents an alkyl group or alkylene group severally having from 1 to 9 carbon atoms, or any of said groups whose hydrogen atom is substituted by acryloyl group or methacryloyl group, and R.sup.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: October 14, 1997
    Assignee: Taiyo Ink Manufacturing Co., Ltd.
    Inventors: Nobuyuki Suzuki, Kazunobu Fukushima, Kyo Ichikawa, Teruo Saito, Hitoshi Inagaki
  • Patent number: 5597854
    Abstract: The invention relates to compounds of the formula I ##STR1## in which n is 1 or 2, A is CH or a nitrogen atom, and the other radicals R.sup.1 to R.sup.25 are as defined in claim 1.The compounds of the formula I can advantageously be employed for stabilizing organic material against the harmful effect of light, oxygen and/or heat.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: January 28, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Luc Birbaum, Gerhard Rytz, Vien Van Toan, Andreas Valet, Norbert W urms
  • Patent number: 5571915
    Abstract: This invention provides a process for preparing amide derivatives of acids by the reaction of haloaminotriazines and acid halides.This invention also provides a process for preparing isocyanates and isocyanate adducts from amide derivatives derived from haloaminotriazines and acid halides such as oxalyl chloride, phosgene and phosgene analogs.Melamine derived acid amides are prepared by reaction of trichloro and hexachloromelamines with chloroformates and acid chlorides. The by-product chlorine may be recycled in this process.Amides, carbamates, sulfonamides, phosphoramides, and related amide derivatives may be prepared by the novel processes of the invention.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: November 5, 1996
    Assignee: Cytec Technology Corp.
    Inventor: Ram B. Gupta
  • Patent number: 5550276
    Abstract: Compounds of the general formula I ##STR1## in which n is 1, 2 or 3 and in which X is oxygen or sulfur, T has the meaning of --S--, --S--S--, --S--S--, --S--S--S--S--, --S--S--S--S--S--, ##STR2## and Y has the meaning of ##STR3## in which Z has the meaning of --H, --COR.sup.13, --COOR.sup.13 or --CONHR.sup.13, and Q has the meaning of oxygen or --NR.sup.0 --, and R.sup.1, R.sup.2, R.sup.0, R.sup.4 and R.sup.13 are as defined in claim 1, with the proviso that the compound of the formula C.sub.2 H.sub.5 --S--CH.sub.2 CH(OH)--P(OC.sub.2 H.sub.5).sub.2 is excepted.The invention also relates to compositions containing the compounds of the formula I and organic materials, for example functional liquids and, in particular, lubricants.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 27, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Hermann O. Wirth, Hans-Helmut Friedrich, Kay S. Groninger
  • Patent number: 5512535
    Abstract: This invention relates to herbicidal pyridinesulfonylureas which are highly active as preemergence and postemergence herbicides.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: April 30, 1996
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Paul Hsiao-Tseng Liang
  • Patent number: 5482920
    Abstract: Pyrimidinyloxy- and triazinyloxy- and pyrimidinylthio- and triazinylthio-butyric acid derivatives of formula I ##STR1## wherein Q is ##STR2## A is hydroxy or a group ##STR3## and the other substituents are as described in patent claim 1, and salts of compounds of formula I, have herbicidal action and are suitable as active ingredients in weed control compositions.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: January 9, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Christoph Luthy
  • Patent number: 5405959
    Abstract: This invention provides a process for preparing amide derivatives of acids by the reaction of haloaminotriazines and acid halides.This invention also provides a process for preparing isocyanates and isocyanate adducts from amide derivatives derived from haloaminotriazines and acid halides such as oxalyl chloride, phosgene and phosgene analogs.Melamine derived acid amides are prepared by reaction of trichloro and hexachloromelamines with chloroformates and acid chlorides. The by-product chlorine may be recycled in this process.Amides, carbamates, sulfonamides, phosphoramides, and related amide derivatives may be prepared by the novel processes of the invention.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: April 11, 1995
    Assignee: Cytec Technology Corp.
    Inventor: Ram B. Gupta
  • Patent number: RE36128
    Abstract: Organic materials normally subject to gradual degradation in the presence of oxygen are stabilized by inclusion of an aromatic fluorophosphite having at least one benzene group bonded through oxygen to phosphorus and at least one fluorine atom bonded directly to the same phosphorus. Stabilization is improved by also including a conventional phenolic antioxidant. Many of the aromatic fluorophosphites are new compounds.
    Type: Grant
    Filed: June 13, 1991
    Date of Patent: March 2, 1999
    Assignee: Albemarle Corporation
    Inventor: Lester P. J. Burton